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Professor Colin Doherty
Professor Consultant, Clinical Medicine
Head of School of Medicine, School Office - Medicine

Biography

Colin Doherty holds the Ellen Mayston Bates Chair in Epileptology at Trinity College Dublin School of Health Sciences.He is a Consultant Neurologist and Director of the Epilepsy Service at St James's Hospital, Dublin and the Ellen Mayston Bates, Professor of Epileptology at TCD. His undergraduate degree was awarded by UCD (1991) and he trained in Medicine and Neurology at St Vincent's and Beaumont Hospitals an later at the Partners Neurology Residency Programme at Harvard Medical School, Boston (Brigham and Women's Hospital and Massachusetts General Hospital) where he was Chief Resident in my final year (1998-2001). He has completed Fellowships in Epilepsy and Cognition at MGH (2001-2003). He has published widely in the areas of brain imaging in epilepsy, the genetics of epilepsy, functional imaging of language, dementia, clinical neurology and epileptology and traumatic brain injury. In the last few years hh has become interested in the challenges of population health, health services research and care delivery in epilepsy. He published recently on national issues regarding epilepsy care including; evidence based pathways, national mortality estimates, hospital access restrictions and national prescribing rates. He has 105 peer reviewed publications, 4211 citations, a H-index of 35 and i10index of 78. Between co-applicant, Co-PI and PI grant applications he has been collaboratively responsible for >7 Million Eu in funding I has authored chapters in three textbooks and co-edited one.

He was a member of the Irish government's expert group on resource allocation in the health sector (2011). He was a member of the National Clinical Effectiveness Committee in Ireland since its inception in 2011 to 2015 and represented the RCPI on The Irish Patient Safety Steering Group 2012-2016. He was a board member of the Health Research Board (2010-15) and is a founder member and Medical Director of Epilepsy Research Ireland (ERI). He is the Irish representative to the International League Against Epilepsy (ILAE) committee for the Global Campaign Against Epilepsy and a co-applicant on a large EU funded study on the epidemiology of epilepsy in Europe (ESBASE). He was National Clinical Lead for the Epilepsy Care Programme in Ireland from 2010-2018, with a charge to develop epilepsy services nationally to improve quality of care and access for patients. He has recently moved from that role to take up a specific remit around Women's Health in Epilepsy with the evolution of the Valproate in Pregnancy story.

he states that he has learned a lot in the last five years about the urgent issue of healthcare reform and see medical education, both postgraduate and undergraduate in urgent need of firstly protection of its core mission and values but also innovation and development to meet the challenges of 21st century medical care: Amongst the challenges are underpinning the funding of basic, translation and clinical research; Teamwork and its effect of professionalism, the role of the patient in the design and delivery of healthcare, and the rise of technology.

Publications and Further Research Outputs

Peer-Reviewed Publications

McGillivray MK, Haldane C, Doherty C, Berger MJ, Evaluation of muscle strength following peripheral nerve surgery: a scoping review., PM & R : the journal of injury, function, and rehabilitation, 2021 Journal Article, 2021 DOI

Osborne D, Doherty C, Blame the pandemic: Why you need to raise your fees for 2021., The Canadian veterinary journal = La revue veterinaire canadienne, 2021 Journal Article, 2021

Mizrahi Rodriguez K, Lin S, Wu AX, Han G, Teesdale JJ, Doherty CM, Smith ZP, Leveraging Free Volume Manipulation to Improve the Membrane Separation Performance of Amine-Functionalized PIM-1., Angewandte Chemie (International ed. in English), 2021 Journal Article, 2021 DOI

Doran E, Barron E, Healy L, O'Connor L, Synnott C, Ni Cheallaig, Doherty C, Improving access to epilepsy care for homeless patients in the Dublin Inner City: a collaborative quality improvement project joining hospital and community care, British Jorurnal of Medicine Open Quality, 2021, pe001367- Journal Article, 2021 TARA - Full Text DOI

Delaney, C. and Farrell, M. and Doherty, C.P. and Brennan, K. and O†Keeffe, E. and Greene, C. and Byrne, K. and Kelly, E. and Birmingham, N. and Hickey, P. and Cronin, S. and Savvides, S.N. and Doyle, S.L. and Campbell, M., Attenuated CSF-1R signalling drives cerebrovascular pathology, EMBO Molecular Medicine, 13, (2), 2021 Journal Article, 2021 DOI TARA - Full Text

Büttner F, Howell DR, Doherty C, Blake C, Ryan J, Delahunt E, Clinical Detection and Recovery of Vestibular and Oculomotor Impairments Among Amateur Athletes Following Sport-Related Concussion: A Prospective, Matched-Cohort Study., The Journal of head trauma rehabilitation, 2021 Journal Article, 2021 DOI

Scarboro CG, Ruzsa SM, Doherty CJ, Kudenov MW, Quantification of gray mold infection in lettuce using a bispectral imaging system under laboratory conditions., Plant direct, 2021 Journal Article, 2021 DOI

Quinn NP, García-Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks DB, Matallanas D, IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway., Cells, 2021 Journal Article, 2021 DOI

Jacquemard T, Doherty CP, Fitzsimons MB, The anatomy of electronic patient record ethics: a framework to guide design, development, implementation, and use., BMC medical ethics, 2021 Journal Article, 2021

Gale C, Quigley MA, Placzek A, Knight M, Ladhani S, Draper ES, Sharkey D, Doherty C, Mactier H, Kurinczuk JJ, The ability of the neonatal immune response to handle SARS-CoV-2 infection - Authors' reply., The Lancet. Child & adolescent health, 2021 Journal Article, 2021 DOI

Speaker SL, Doherty CM, Pfoh E, Dunn A, Hair B, Daboul L, Shaker V, Rothberg M, Social Behaviors Associated With a Positive COVID-19 Test Result., Cureus, 2021 Journal Article, 2021 DOI

Bheemanahalli R, Knight M, Quinones C, Doherty CJ, Jagadish SVK, Genome-wide association study and gene network analyses reveal potential candidate genes for high night temperature tolerance in rice., Scientific reports, 2021 Journal Article, 2021 DOI

Büttner F, Howell DR, Doherty C, Blake C, Ryan J, Delahunt E, Longitudinal Vestibular and Oculomotor Impairments Among Amateur Athletes 1 Year Following Sport-Related Concussion: A Prospective Follow-Up., The Journal of head trauma rehabilitation, 2021 Journal Article, 2021 DOI

Doherty C, Quinn N, Mistry S, Diacono J, Walker R, Harrison A, Bateman N, Bruce I, LID Study: Plasma lidocaine levels following airway topicalisation for paediatric microlaryngobronchoscopy (MLB), 2021 Journal Article, 2021 DOI

Büttner F, Howell DR, Iverson GL, Doherty C, Blake C, Ryan J, Delahunt E, Participation in pre-injury level sport one-year following sport-related concussion: A prospective, matched cohort study., Journal of science and medicine in sport, 2021 Journal Article, 2021 DOI

Loaiza VM, Doherty C, Howlett P, The long-term consequences of retrieval demands during working memory., Memory & cognition, 2021 Journal Article, 2021 DOI

Quinn N, García-Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Matallanas D, IQGAP is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway, 2021 Journal Article, 2021 DOI

COVIDSurg Collaborative, GlobalSurg Collaborative , SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study., The British journal of surgery, 2021 Journal Article, 2021 DOI

Doherty CA, Diegmiller R, Kapasiawala M, Gavis ER, Shvartsman SY, Coupled oscillators coordinate collective germline growth., Developmental cell, 2021 Journal Article, 2021 DOI

Doherty C, Nowacki AS, McAndrews MP, McDonald CR, Reyes A, Kim MS, Hamberger M, Najm I, Bingaman W, Jehi L, Busch RM, Response: Predicting mood decline following temporal lobe epilepsy surgery in adults., Epilepsia, 2021 Journal Article, 2021 DOI

McKenna MC, Al-Hinai M, Bradley D, Doran E, Hunt I, Hutchinson S, Langan Y, O'Rourke D, Qasem R, Redmond J, Troy E, Doherty CP., Patients' Experiences of Remote Neurology Consultations during the COVID-19 Pandemic, European Neurology, 83, (6), 2021, p622 - 625 Journal Article, 2021 DOI

Doherty C, Nowacki AS, Pat McAndrews M, McDonald CR, Reyes A, Kim MS, Hamberger M, Najm I, Bingaman W, Jehi L, Busch RM, Predicting mood decline following temporal lobe epilepsy surgery in adults., Epilepsia, 2021 Journal Article, 2021 DOI

Kong XZ, ENIGMA Laterality Working Group, Francks C, Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research., Human brain mapping, 2020 Journal Article, 2020

Elashkar AH, Parasar D, Muñoz-Castro A, Doherty CM, Cowan MG, Dias HVR, Isolable 1-Butene Copper(I) Complexes and 1-Butene/Butane Separation Using Structurally Adaptable Copper Pyrazolates., ChemPlusChem, 2020 Journal Article, 2020

Kelleher E, McNamara P, Dunne J, Fitzmaurice B, Heron EA, Whitty P, Walsh R, Mooney C, Hogan D, Conlon N, Gill M, Vincent A, Doherty CP, Corvin A., Prevalence of N-Methyl-d-Aspartate Receptor antibody (NMDAR-Ab) encephalitis in patients with first episode psychosis and treatment resistant schizophrenia on clozapine, a population based study., Schizophrenia research, 222, 2020, p455-461 Journal Article, 2020 DOI

Banks J, Varley J, Fitzsimons M, Doherty CP, Self-reported antiepilepsy medication adherence and its connection to perception of medication error., Epilepsy & behavior : E&B, 2020 Journal Article, 2020

O'Gorman, P., Strahan, O., Ferguson, D., Monaghan, A., Kennedy, M., Forde, C., Melo, A., Doherty, D., O'Brien, K., McKiernan, S., Kenny, R., Coen, R.F., Doherty, C., Bergin, C., Gormley, J., Norris, S. , Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C., Journal of Viral Hepatitis , 2020 Journal Article, 2020 TARA - Full Text

Doherty C, Joorabchi A, Megyesi P, Flynn A, Caulfield B, Physiotherapists' Use of Web-Based Information Resources to Fulfill Their Information Needs During a Theoretical Examination: Randomized Crossover Trial., Journal of medical Internet research, 2020 Journal Article, 2020

Hatton SN, Huynh KH, Bonilha L, Abela E, Alhusaini S, Altmann A, Alvim MKM, Balachandra AR, Bartolini E, Bender B, Bernasconi N, Bernasconi A, dummy-AUTHOR_name, McDonald CR, White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study., Brain : a journal of neurology, 2020 Journal Article, 2020

Power K, McCrea Z, White M, Breen A, Dunleavy B, O'Donoghue S, Jacquemard T, Lambert V, El-Naggar H, Delanty N, Doherty C, Fitzsimons M, The development of an epilepsy electronic patient portal: Facilitating both patient empowerment and remote clinician-patient interaction in a post-COVID-19 world., Epilepsia, 2020 Journal Article, 2020

McCrea Z, Power K, Kiersey R, White M, Breen A, Murphy S, Healy L, Kearney H, Dunleavy B, O'Donoghue S, Lambert V, Delanty N, Doherty C, Fitzsimons M, Coproducing health and well-being in partnership with patients, families, and healthcare providers: A qualitative study exploring the role of an epilepsy patient portal., Epilepsy & behavior : E&B, 2020 Journal Article, 2020

Jack Banks, Derek Corrigan, Roger Grogan, Hany El-Naggar, Máire White, Elisabeth Doran, Cara Synnott, Mary Fitzsimons, Norman Delanty, Colin P. Doherty, LoVE in a time of CoVID: Clinician and patient experience using telemedicine for chronic epilepsy management. Epilepsy and Behaviour, Epilepsy and behaviour, 2020 Journal Article, 2020

Benson KA, White M, Allen NM, Byrne S, Carton R, Comerford E, Costello D, Doherty C, Dunleavey B, El-Naggar H, Gangadharan N, Heavin S, Kearney H, Cavalleri GL, A comparison of genomic diagnostics in adults and children with epilepsy and comorbid intellectual disability., European journal of human genetics : EJHG, 2020 Journal Article, 2020

Steinhoff BJ, Christensen J, Doherty CP, Majoie M, De Backer M, Hellot S, Leunikava I, Leach JP, Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: Second interim analysis of 6-month data from a prospective observational study in Europe., Epilepsy research, 2020 Journal Article, 2020

Larivière S, Rodríguez-Cruces R, Royer J, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda C, Bonilha L, Gleichgerrcht E, Focke NK, dummy-AUTHOR_name, Bernhardt BC, Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study., Science advances, 2020 Journal Article, 2020

Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, dummy-AUTHOR_name, Seshadri S, Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults., Nature communications, 2020 Journal Article, 2020

Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, dummy-AUTHOR_name, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)"Genetics working group, The genetic architecture of the human cerebral cortex., Science (New York, N.Y.), 2020 Journal Article, 2020

Tiernan S, Meagher A, O'Sullivan D, O'Keeffe E, Kelly E, Wallace E, Doherty CP, Campbell M, Liu Y, Domel AG, Concussion and the severity of head impacts in mixed martial arts., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 234, 2020, 1472 - 1483 Journal Article, 2020 TARA - Full Text

Laksari K, Fanton M, Wu LC, Nguyen TH, Kurt M, Giordano C, Kelly E, O'Keeffe E, Wallace E, Doherty C, Campbell M, Tiernan S, Grant G, Ruan J, dummy-AUTHOR_name, Camarillo DB, Multi-Directional Dynamic Model for Traumatic Brain Injury Detection., Journal of neurotrauma, 2020 Journal Article, 2020

Gardner RC, Rivera E, O'Grady M, Doherty C, Yaffe K, Corrigan J, Bogner J, Kramer J, Wilson F, Screening for lifetime history of traumatic brain injury among American and Irish adults ar risk for dementia: Development and validation of a web-based survey, Journal of Alzheimer's Disease, 2020 Journal Article, 2020 DOI

Niestroj LM, Perez-Palma E, Howrigan DP, Zhou Y, Cheng F, Saarentaus E, Nürnberg P, Stevelink R, Daly MJ, Palotie A, Lal D, Epi25 Collaborative, Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17"458 subjects., Brain : a journal of neurology, 2020 Journal Article, 2020

Banks J, Corrigan D, Grogan R, El-Naggar H, White M, Doran E, Synnott C, Fitzsimons M, Delanty N, Doherty CP, LoVE in a time of CoVID: Clinician and patient experience using telemedicine for chronic epilepsy management., Epilepsy & behavior : E&B, 2020 Journal Article, 2020

O'Keeffe, E. and Kelly, E. and Liu, Y. and Giordano, C. and Wallace, E. and Hynes, M. and Tiernan, S. and Meagher, A. and Greene, C. and Hughes, S. and Burke, T. and Kealy, J. and Doyle, N. and Hay, A. and Farrell, M. and Grant, G.A. and Friedman, A. and Veksler, R. and Molloy, M.G. and Meaney, J.F. and Pender, N. and Camarillo, D. and Doherty, C.P. and Campbell, M., Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury, Journal of neurotrauma, 37, (2), 2020, p347-356 Journal Article, 2020 DOI

Jacquemard T, Doherty CP, Fitzsimons MB, Examination and diagnosis of electronic patient records and their associated ethics: a scoping literature review., BMC medical ethics, 2020 Journal Article, 2020

Crotty GF, Doherty C, Solomon IH, Berry JD, Samuels MA, Learning from history: Lord Brain and Hashimoto's encephalopathy., Practical neurology, 2019 Journal Article, 2019

Alhusaini S, Kowalczyk M.A, Yasuda C.L, Semmelroch M.K, Katsurayama M, Zabin M, Zanão T, Nogueira M.H, Alvim M.K.M, Ferraz V.R, Tsai M.-H, Fitzsimons M, Lopes-Cendes I, Doherty C.P, Cavalleri G.L, Cendes F, Jackson G.D, Delanty N, Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients, Neurology, 92, (4), 2019, pE351 - E358 Journal Article, 2019 DOI URL

Epi25 Collaborative. Electronic address: s.berkovic@unimelb.edu.au, Epi25 Collaborative, Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals., American journal of human genetics, 2019 Journal Article, 2019

Power R, Byrne JP, Kiersey R, Varley J, Doherty CP, Lambert V, Heffernan E, Saris AJ, Fitzsimons M, Are patients ready for integrated person-centered care? A qualitative study of people with epilepsy in Ireland., Epilepsy & behavior : E&B, 2019 Journal Article, 2019

Graham M, Wallace E, Doherty C, McCann A, Naci L, From Awareness to Prognosis: Ethical Implications of Uncovering Hidden Awareness in Behaviorally Nonresponsive Patients., Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees, 2019 Journal Article, 2019

Higgins A, Downes C, Varley J, Doherty C, Begley C, Elliott N, Supporting and empowering people with epilepsy: Contribution of the Epilepsy Specialist Nurses (SENsE study), Seizure: European Journal of Epilepsy, 71, 2019, p42 - 49 Journal Article, 2019 TARA - Full Text URL

Delaney S, O'Connor G, Reardon W, Murphy SJX, Tierney S, Ryan BM, Delaney H, Doherty CP, Guiney M, Brennan P, Tobin WO, McCabe DJH., Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome., Frontiers in neurology, 9, 2019, p1194 Journal Article, 2019 TARA - Full Text DOI

Stevelink R, Pangilinan F, Jansen FE, Braun KPJ, International League Against Epilepsy Consortium on Complex Epilepsies, Molloy AM, Brody LC, Koeleman BPC., Assessing the genetic association between vitamin B6 metabolism and genetic generalized epilepsy., Molecular genetics and metabolism reports, 21, 2019, p100518 Journal Article, 2019 DOI

Varley J, Kiersey R, Power R, Byrne JP, Doherty C, Saris J, Lambert V, Fitzsimons M, Igniting intersectoral collaboration in chronic disease management: a participatory action research study on epilepsy care in Ireland., Journal of interprofessional care, 2019 Journal Article, 2019

Byrne JP, Power R, Kiersey R, Varley J, Doherty CP, Saris AJ, Heffernan E, Lambert V, Fitzsimons M, Corrigendum to "The rhetoric and reality of integrated patient-centered care for healthcare providers: An ethnographic exploration of epilepsy care in Ireland" [Epilepsy & Behavior (2019) 87-92]., Epilepsy & behavior : E&B, 2019 Journal Article, 2019

Delanty N, White M, Benson K, McCormack M, Heavin S, Comerford E, Gangadharan N, Power K, Dunleavey B, El-Naggar H, Doherty C, Greally M, dummy-AUTHOR_name, Fitzsimons M, Development of a genomics module within an epilepsy-specific electronic health record: Toward genomic medicine in epilepsy care., Epilepsia, 2019 Journal Article, 2019

Doherty, C.P., O'Keeffe. E., Keaney, J., Lawlor, B.A., Coen, R.F., Farrell, M., Campbell, M., Neuropolypathology as a result of severe traumatic brain injury? , Clinical Neuropathology, 38, (1), 2019, p14 - 22 Journal Article, 2019 DOI

Doherty C.P, Rheims S, Assenza G, Boero G, Chaves J, McMurray R, Villanueva V, Eslicarbazepine acetate in epilepsy patients with psychiatric comorbidities and intellectual disability: Clinical practice findings from the Euro-Esli study, Journal of the Neurological Sciences, 402, 2019, p88 - 99 Journal Article, 2019 URL DOI

Byrne J.-P, Power R, Kiersey R, Varley J, Doherty C.P, Saris A.J, Lambert V, Fitzsimons M, The rhetoric and reality of integrated patient-centered care for healthcare providers: An ethnographic exploration of epilepsy care in Ireland, Epilepsy and Behavior, 94, 2019, p87 - 92 Journal Article, 2019 URL DOI

Heavin SB, McCormack M, Wolking S, Slattery L, Walley N, Avbersek A, Novy J, Sinha SR, Radtke R, Doherty C, Auce P, Craig J, Johnson MR, dummy-AUTHOR_name, Delanty N, Genomic and clinical predictors of lacosamide response in refractory epilepsies., Epilepsia open, 2019 Journal Article, 2019

Silvennoinen K, de Lange N, Zagaglia S, Balestrini S, Androsova G, Wassenaar M, Auce P, Avbersek A, Becker F, Berghuis B, Campbell E, Coppola A, dummy-AUTHOR_name, EpiPGX Consortium, Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy., Epilepsia open, 2019 Journal Article, 2019

Higgins, A., Downes, C., Varley, J., Doherty, C. P., Begley, C., & Elliott, N., Rising to the challenge: Epilepsy specialist nurses as leaders of service improvements and change (SENsE study)., Seizure: European Journal of Epilepsy, 63, 2018, p40 - 47 Journal Article, 2018 DOI

Zaporojan, L. and McNamara, P.H. and Williams, J.A. and Bergin, C. and Redmond, J. and Doherty, C.P., Seizures in HIV: The case for special consideration, Epilepsy and Behavior Case Reports, 10, 2018, p38-43 Journal Article, 2018 DOI TARA - Full Text

Williams, J. and Doherty, J. and Di Blasi, C. and Mabarak, D. and Kennedy, U. and Doherty, C.P., Seizure care in the emergency department. Identifying and bridging the gaps. A study of care and outcomes from 644 seizure presentations, Epilepsy and Behavior, 78, 2018, p226-231 Journal Article, 2018 DOI

International League Against Epilepsy Consortium on Complex Epilepsies., Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies., Nature communications, 9, (1), 2018, p5269 Journal Article, 2018 DOI TARA - Full Text

Higgins, A., Downes, C., Varley, J., Tyrell, E., Normand, C., Doherty, C., Begley, C. & Elliott, N, Patients with epilepsy care experiences: Comparison between services with and without an epilepsy specialist nurse., Epilepsy & Behavior, 85, 2018, p85 - 94 Journal Article, 2018 DOI TARA - Full Text

Kong, X.-Z., Mathias, S.R., Guadalupe, T., (...), Hedberg, M., Orhan, F. , Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium, Proceedings of the National Academy of Sciences of the United States of America, 115, (22), 2018, pE5154-E5163 Journal Article, 2018 DOI

Graham, M., Doherty, C., & Naci, L, Using neuroimaging to detect covert awareness and determine prognosis of comatose patients: informing surrogate decision-makers of individual patient results., Seminars in Neurology, 38, (5), 2018, p555-560 Journal Article, 2018 DOI

Whelan, C.D. and Altmann, A. and Botía, J.A. and Jahanshad, N. and Hibar, D.P. and Absil, J. and Alhusaini, S. and Alvim, M.K.M. and Auvinen, P. and Bartolini, E. and Bergo, F.P.G. and Bernardes, T. and Blackmon, K. and Braga, B. and Caligiuri, M.E. and Calvo, A. and Carr, S.J. and Chen, J. and Chen, S. and Cherubini, A. and David, P. and Domin, M. and Foley, S. and França, W. and Haaker, G. and Isaev, D. and Keller, S.S. and Kotikalapudi, R. and Kowalczyk, M.A. and Kuzniecky, R. and Langner, S. and Lenge, M. and Leyden, K.M. and Liu, M. and Loi, R.Q. and Martin, P. and Mascalchi, M. and Morita, M.E. and Pariente, J.C. and Rodríguez-Cruces, R. and Rummel, C. and Saavalainen, T. and Semmelroch, M.K. and Severino, M. and Thomas, R.H. and Tondelli, M. and Tortora, D. and Vaudano, A.E. and Vivash, L. and Von Podewils, F. and Wagner, J. and Weber, B. and Yao, Y. and Yasuda, C.L. and Zhang, G. and Bargalló, N. and Bender, B. and Bernasconi, N. and Bernasconi, A. and Bernhardt, B.C. and BlÌmcke, I. and Carlson, C. and Cavalleri, G.L. and Cendes, F. and Concha, L. and Delanty, N. and Depondt, C. and Devinsky, O. and Doherty, C.P. and Focke, N.K. and Gambardella, A. and Guerrini, R. and Hamandi, K. and Jackson, G.D. and KÀlviÀinen, R. and Kochunov, P. and Kwan, P. and Labate, A. and McDonald, C.R. and Meletti, S. and O'Brien, T.J. and Ourselin, S. and Richardson, M.P. and Striano, P. and Thesen, T. and Wiest, R. and Zhang, J. and Vezzani, A. and Ryten, M. and Thompson, P.M. and Sisodiya, S.M., Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study, Brain, 141, (2), 2018, p391-408 Journal Article, 2018 DOI TARA - Full Text

Haque, A. and Doherty, C. and Williams, J., Non-attendance of vulnerable populations within epilepsy outpatient services in Ireland, Irish Journal of Medical Science, 2017, p1-4 Journal Article, 2017 DOI

Kinsella JA, Oliver Tobin W, Tierney S, Feeley TM, Egan B, Coughlan T, Ronan Collins D, O'Neill D, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJH, Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis., J Neurol Sci., 376, 2017, p133 - 139 Journal Article, 2017 URL DOI

Keller C, Arsenault S, Lamothe M, Bostan SR, O'Donnell R, Harbison J, Doherty CP., Patient safety ward round checklist via an electronic app: implications for harm prevention., Ir J Med Sci, 2017 Journal Article, 2017 DOI

McDermott A, Zaporojan L, McNamara P, Doherty C.P, Redmond J, Forde C, Gormley J, Egaña M, Bergin C, The effects of a 16-week aerobic exercise programme on cognitive function in people living with HIV, AIDS Care , 29, (6), 2017, p. 667-674 Journal Article, 2017 URL DOI

Williams, J. and Petrov, G. and Kennedy, U. and Halpenny, J. and Doherty, C.P., Moving evidence based guidelines for seizures into practice in the emergency department: What's stopping us?, Epilepsy and Behavior, 72, 2017, p72-77 Journal Article, 2017 DOI

Williams JA, Bede P, Doherty CP, An exploration of the spectrum of peri-ictal MRI change; a comprehensive literature review., Seizure, 50, 2017, p19-32 Journal Article, 2017 DOI

McNamara, P.H. and Coen, R. and Redmond, J. and Doherty, C.P. and Bergin, C., A high prevalence rate of a positive screen for cognitive impairment in patients with human immunodeficiency virus attending an Irish clinic, Open Forum Infectious Diseases, 4, (1), 2017, p1-9 Journal Article, 2017 DOI

Jennifer Williams, Gerard Mullins, Norman Delanty, Peter Bede, Colin Doherty , The spectrum of peri-ictal MRI changes; four Illustrative cases., Seizure: European Journal of Epilepsy , 50, 2017, p189-193 Journal Article, 2017 DOI

Lynn E, Lyons S, Langan Y, Craig S, Doherty C, The role of alcohol dependency in deaths among people with epilepsy recorded by the National Drug-Related Deaths Index (NDRDI) in Ireland, 2004-2013, Seizure, 45, 2017, p52 - 55 Journal Article, 2017 DOI URL

Doherty CP, Hardiman O., Handboook of Neurodegeneration, 1&2, UK, Springer Verlag, 2016 Book, 2016

Murphy S, Bennett K, Doherty C.P, Prescribing trends for sodium valproate in Ireland, Seizure, 36, 2016, p44 - 48 Journal Article, 2016 URL DOI

Alhusaini S, Whelan C.D, Doherty C.P, Delanty N, Fitzsimons M, Cavalleri G.L, Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings, Cerebral Cortex, 26, (3), 2016, p1234 - 1241 Journal Article, 2016 TARA - Full Text URL DOI

Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662 Journal Article, 2016 DOI URL

Whelan C.D, Alhusaini S, O'Hanlon E, Cheung M, Iyer P.M, Meaney J.F, Fagan A.J, Boyle G, Delanty N, Doherty C.P, Cavalleri G.L, White matter alterations in patients with MRI-negative temporal lobe epilepsy and their asymptomatic siblings, Epilepsia, 56, (10), 2015, p1551 - 1561 Journal Article, 2015 DOI URL

Kenny RA, Brignole M, Dan GA, Deharo JC, van Dijk JG, Doherty C, Hamdan M, Moya A, Parry SW, Sutton R, Ungar A, Wieling W; External contributors to the Task Force:, Asgari M, Baron-Esquivias G, Blanc JJ, Casagranda I, Cunnigham C, Fedorowski A, Furlan R, Gall N, De Lange FJ, Mcmahon G, Mitro P, Pietrucha A, Podoleanu C, Raviele A, Benditt D, Krahn A, Morillo CA, Olshansky B, Raj S, Sheldon R, Shen WK, Sun B, Hachul D, Abe H, Furukawa T;, Syncope Unit: rationale and requirement - the European Heart Rhythm Association position statement endorsed by the Heart Rhythm Society, Europace, 17, (9), 2015, p1328 - 1340 Journal Article, 2015 TARA - Full Text DOI

Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins DR, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased thrombin generation potential in symptomatic versus asymptomatic moderate or severe carotid stenosis and relationship with cerebral microemboli., Journal of Neurology, Neurosurgery, and Psychiatry, 86, 2015, p460-467 Journal Article, 2015 DOI

Bennett, L., Bergin, M., Gooney, M., (...), Synnott, C., Wells, J.S.G., Epilepsy services in Ireland: 'A survey of people with epilepsy in relation to satisfaction, preferences and information provision', Epilepsy Research, 113, 2015, p11-18 Journal Article, 2015 DOI

Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins RD, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups., European Journal of Neurology, 2014, p460-467 Journal Article, 2014 TARA - Full Text DOI

Scanlon, C. Ronan, L. Doherty, C.P. Cavalleri, G.L. Tirupati, S. Alhusaini, S. Maguire, S. Delanty, N. Iyer, P.M. Chaila, E. Fitzsimons, M., MRI-Based Brain Structure Volumes in Temporal Lobe Epilepsy Patients and their Unaffected Siblings: A Preliminary Study, Journal of Neuroimaging, 23, (1), 2013, p64 - 70 Journal Article, 2013 URL DOI

, Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A, Brain : a journal of neurology, 2013 Journal Article, 2013

O'Connor, G. Doherty, C.P., Folic acid: When to supplement and by how much, European Neurological Journal, 4, (2), 2013 Journal Article, 2013 URL

Alhusaini S, Scanlon C, Ronan L, Maguire S, Meaney JF, Fagan AJ, Boyle G, Borgulya G, Iyer PM, Brennan P, Costello D, Chaila E, Fitzsimons M, Doherty CP, Delanty N, Cavalleri GL, Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy., PloS one, 8, (4), 2013, pe61880 Journal Article, 2013 DOI TARA - Full Text

Donohue F, Doherty C, Langan Y, White M, Morrow S, White M, Hayes CB , Mortality from SUDEP and Status Epilepticus in Ireland, Irish Medical Journal, 106, (3), 2013, p91 - 92 Journal Article, 2013 Other TARA - Full Text URL

Alhusaini, S. Ronan, L. Scanlon, C. Whelan, C.D. Doherty, C.P. Delanty, N. Fitzsimons, M., Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy, Epilepsia, 54, (9), 2013, pe138 - e141 Journal Article, 2013 URL DOI

McNamara PH, Toner M, Kearns G, Keohane C, Daly P, Doherty CP, Focal seizures secondary to cortical dysplasia associated with isolated oral morphea and odontogenic carcinoma., Seizure : the journal of the British Epilepsy Association, 22, (2), 2013, p159-61 Journal Article, 2013 DOI

Kinsella J, Tobin W, Tierney S, Feeley T, Egan B, Collins D, Coughlan T, O'Neill D, Harbison J, Madhavan P, Moore D, O'Neill S, Colgan M, Doherty C, Murphy R, Saqqur M, Moran N, Hamilton G, McCabe D, Increased platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study., Journal of Thrombosis and Haemostasis : JTH, 11, (7), 2013, p1407-16 Journal Article, 2013 TARA - Full Text DOI URL

Mc Cormack O, Cooney JM, Doherty CP, Muldoon C, Reynolds JV, Paraneoplastic limbic encephalitis from esophagogastric squamous cell carcinoma successfully managed by radical gastrectomy., Surgery, 154, (3), 2013, p638-40 Journal Article, 2013 DOI

, A seizure care pathway in the emergency department: preliminary quality and safety improvements, Epilepsy research and treatment, 2012 Journal Article, 2012

Alhusaini, S. Doherty, C.P. Scanlon, C. Ronan, L. Maguire, S. Borgulya, G. Brennan, P. Delanty, N. Fitzsimons, M. Cavalleri, G.L., A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis, Epilepsy Research, 99, (1-2), 2012, p156 - 166 Journal Article, 2012 URL DOI

Omer TA, Fitzgerald DE, Sheehy N, Doherty CP, Neurosyphilis presenting with unusual hippocampal abnormalities on magnetic resonance imaging and positron emission tomography scans: a case report., Journal of medical case reports, 6, (1), 2012, p389 Journal Article, 2012 DOI

McNamara, P. Redmond, J. Bergin, C. Doherty, C., The case for cognitive screening in HIV clinics, Irish Medical Journal, 105, (7), 2012 Journal Article, 2012 URL

Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849 Journal Article, 2012 DOI

Ronan, L. Alhusaini, S. Scanlon, C. Doherty, C.P. Delanty, N. Fitzsimons, M., Widespread cortical morphologic changes in juvenile myoclonic epilepsy: Evidence from structural MRI, Epilepsia, 53, (4), 2012, p651 - 658 Journal Article, 2012 DOI URL

Alhusaini, S. Doherty, C.P. Palaniyappan, L. Scanlon, C. Maguire, S. Brennan, P. Delanty, N. Fitzsimons, M. Cavalleri, G.L., Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis, Epilepsia, 53, (6), 2012, p995 - 1003 Journal Article, 2012 DOI URL

Iyer PM, McNamara PH, Fitzgerald M, Smyth L, Dardis C, Jawad T, Plunkett PK, Doherty CP,, A seizure care pathway in the emergency department: preliminary quality and, Epilepsy Research and Treatment, (Epub May 29 2012 ), 2012, p273175 Journal Article, 2012 URL DOI DOI

Naughton, M., Coen, R.F., Doherty, C., Lawlor, B.A, An unusual cause of autobiographical memory loss, Irish Journal of Psychological Medicine, 28, (2), 2011, p97 - 99 Journal Article, 2011

Omer, T.A. Doherty, C., Posterior reversible encephalopathy syndrome (PRES) complicating the 'legal high' mephedrone, BMJ Case Reports , 2011 Journal Article, 2011 URL DOI

Ronan, L. Scanlon, C. Murphy, K. Maguire, S. Delanty, N. Doherty, C.P. Fitzsimons, M., Cortical curvature analysis in MRI-negative temporal lobe epilepsy: A surrogate marker for malformations of cortical development, Epilepsia, 52, (1), 2011, p28 - 34 Journal Article, 2011 DOI URL

Coker, M.F. Bhargava, S. Fitzgerald, M. Doherty, C.P., What do people with epilepsy know about their condition? Evaluation of a subspecialty clinic population, Seizure, 20, (1), 2011, p55 - 59 Journal Article, 2011 DOI URL

Buckley, A. Fitzgerald, M. Hoerold, D. Davey, G.P. Doherty, C., Effects of the anticonvulsant topiramate on language abilities in people with epilepsy: A cross-sectional study, Irish Journal of Psychological Medicine, 27, (4), 2010, p179 - 183 Journal Article, 2010 URL

Breen, P. Murphy, K. Browne, G. Molloy, F. Reid, V. Doherty, C. Delanty, N. Connolly, S. Fitzsimons, M., Formative evaluation of a telemedicine model for delivering clinical neurophysiology services part I: Utility, technical performance and service provider perspective, BMC Medical Informatics and Decision Making, 10, (1), 2010, p48- Journal Article, 2010 TARA - Full Text URL DOI

O'Connor, G. Ryan, T. Redmond, J. Doherty, C., The value of motor response versus neuroimaging in predicting outcome post cardiac arrest: A retrospective study, Journal of Neurology, 257, (8), 2010, p1400 - 1401 Journal Article, 2010 URL DOI

Dunlea, O. Doherty, C.P. Farrell, M. Fitzsimons, M. O'Brien, D. Murphy, K. MacMackin, D. Pender, N. Staunton, H. Phillips, J. Delanty, N., The Irish epilepsy surgery experience: Long-term follow-up, Seizure, 19, (4), 2010, p247 - 252 Journal Article, 2010 DOI URL

Sundram, F. Cannon, M. Doherty, C.P. Barker, G.J. Fitzsimons, M. Delanty, N. Cotter, D., Neuroanatomical correlates of psychosis in temporal lobe epilepsy: Voxel-based morphometry study, The British Journal of Psychiatry, 197, (6), 2010, p482 - 492 Journal Article, 2010 URL DOI

Kasperavi-iüte, D. Catarino, C.B. Heinzen, E.L. Depondt, C. Cavalleri, G.L. Caboclo, L.O. Tate, S.K. Jamnadas-Khoda, J. Chinthapalli, K. Clayton, L.M.S. Shianna, K.V. Radtke, R.A. Mikati, M.A. Gallentine, W.B. Husain, A.M. Alhusaini, S. Leppert, D. Middleton, L.T. Gibson, R.A. Johnson, M.R. Matthews, P.M. Hosford, D. Heuser, K. Amos, L. Ortega, M. Zumsteg, D. Wieser, H.-G. Steinhoff, B.J. Krämer, G. Hansen, J. Dorn, T. Kantanen, A.-M. Gjerstad, L. Peuralinna, T. Hernandez, D.G. Eriksson, K.J. Kälviäinen, R.K. Doherty, C.P. Wood, N.W. Pandolfo, M. Duncan, J.S. Sander, J.W. Delanty, N. Goldstein, D.B. Sisodiya, S.M., Common genetic variation and susceptibility to partial epilepsies: A genome-wide association study, Brain, 133, (7), 2010, p2136 - 2147 Journal Article, 2010 URL DOI TARA - Full Text

Heinzen, E.L. Radtke, R.A. Urban, T.J. Cavalleri, G.L. Depondt, C. Need, A.C. Walley, N.M. Nicoletti, P. Ge, D. Catarino, C.B. Duncan, J.S. Kasperavi-iute, D. Tate, S.K. Caboclo, L.O. Sander, J.W. Clayton, L. Linney, K.N. Shianna, K.V. Gumbs, C.E. Smith, J. Cronin, K.D. Maia, J.M. Doherty, C.P. Pandolfo, M. Leppert, D. Middleton, L.T. Gibson, R.A. Johnson, M.R. Matthews, P.M. Hosford, D. Kälviäinen, R. Eriksson, K. Kantanen, A.-M. Dorn, T. Hansen, J. Krämer, G. Steinhoff, B.J. Wieser, H.-G. Zumsteg, D. Ortega, M. Wood, N.W. Huxley-Jones, J. Mikati, M. Gallentine, W.B. Husain, A.M. Buckley, P.G. Stallings, R.L. Podgoreanu, M.V. Delanty, N. Sisodiya, S.M. Goldstein, D.B., Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes, AJHG, 86, (5), 2010, p707 - 718 Journal Article, 2010 TARA - Full Text DOI URL

Richard AP Roche, Sinéad L Mullally, Jonathan P McNulty, Judy Hayden, Paul Brennan, Colin P Doherty, Mary Fitzsimons, Deirdre McMackin, Julie Prendergast, Sunita Sukumaran, Maeve A Mangaoang, Ian H Robertson and Shane M O'Mara, Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain , BMC Neuroscience , 10, 2009, art. no. 136 Journal Article, 2009 DOI TARA - Full Text

Lynch, J.M. Tate, S.K. Kinirons, P. Weale, M.E. Cavalleri, G.L. Depondt, C. Murphy, K. O'Rourke, D. Doherty, C.P. Shianna, K.V. Wood, N.W. Sander, J.W. Delanty, N. Goldstein, D.B. Sisodiya, S.M., No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy, Epilepsy Research, 83, (1), 2009, p44 - 51 Journal Article, 2009 URL DOI

Rational Approach to Status Epilepticus in, editor(s)Jacqueline French and Norman Delanty , Therapeutic Strategies in Epilepsy , USA, Clinical Publishing, 2008, [Doherty C] Book Chapter, 2008

Dardis, S. Farid, S. Doherty, C., Re: New lessons: Classic treatments in convulsive status epilepticus, Irish Medical Journal, 101, (2), 2008 Journal Article, 2008 URL

Kinirons, P. Doherty, C.P., Status epilepticus: A modern approach to management, European Journal of Emergency Medicine: , 15, (4), 2008, p187 - 195 Journal Article, 2008 URL DOI

Shahwan, A. Murphy, K. Doherty, C. Cavalleri, G.L. Muckian, C. Dicker, P. McCarthy, M. Kinirons, P. Goldstein, D. Delanty, N., The controversial association of ABCB1 polymorphisms in refractory epilepsy: An analysis of multiple SNPs in an Irish population, Epilepsy Research, 73, (2), 2007, p192 - 198 Journal Article, 2007 DOI URL

Connolly RM, Doherty CP, Beddy P, O'Byrne K, Chemotherapy induced reversible posterior leukoencephalopathy syndrome., Lung cancer (Amsterdam, Netherlands), 56, (3), 2007, p459-63 Journal Article, 2007

Cavalleri, G.L. Walley, N.M. Soranzo, N. Mulley, J. Doherty, C.P. Kapoor, A. Depondt, C. Lynch, J.M. Scheffer, I.E. Heils, A. Gehrmann, A. Kinirons, P. Gandhi, S. Satishchandra, P. Wood, N.W. Anand, A. Sander, T. Berkovic, S.F. Delanty, N. Goldstein, D.B. Sisodiya, S.M., A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy, Epilepsia, 48, (4), 2007, p706 - 712 Journal Article, 2007 URL DOI

O'Rourke, D. Delanty, N. Doherty, C. White, M. Flynn, C., Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: Retrospective evidence from an Irish compassionate-use case series, Irish Medical Journal, 100, (4), 2007 Journal Article, 2007 URL

Cavalleri, G.L. Weale, M.E. Shianna, K.V. Singh, R. Lynch, J.M. Grinton, B. Szoeke, C. Murphy, K. Kinirons, P. O'Rourke, D. Ge, D. Depondt, C. Claeys, K.G. Pandolfo, M. Gumbs, C. Walley, N. McNamara, J. Mulley, J.C. Linney, K.N. Sheffield, L.J. Radtke, R.A. Tate, S.K. Chissoe, S.L. Gibson, R.A. Hosford, D. Stanton, A. Graves, T.D. Hanna, M.G. Eriksson, K. Kantanen, A.-M. Kalviainen, R. O'Brien, T.J. Sander, J.W. Duncan, J.S. Scheffer, I.E. Berkovic, S.F. Wood, N.W. Doherty, C.P. Delanty, N. Sisodiya, S.M. Goldstein, D.B., Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study, The Lancet Neurology, 6, (11), 2007, p970 - 980 Journal Article, 2007 URL DOI

Ronan, L. Murphy, K. Delanty, N. Doherty, C. Maguire, S. Scanlon, C. Fitzsimons, M., Cerebral cortical gyrification: A preliminary investigation in temporal lobe epilepsy, Epilepsia, 48, (2), 2007, p211 - 219 Journal Article, 2007 DOI URL

McHugh, J.C. Singh, H.W. Phillips, J. Murphy, K. Doherty, C.P. Delanty, N., Outcome measurement after vagal nerve stimulation therapy: Proposal of a new classification, Epilepsia, 48, (2), 2007, p375 - 378 Journal Article, 2007 URL DOI

Ronan, L. Doherty, C.P. Delanty, N. Thornton, J. Fitzsimons, M., Quantitative MRI: A reliable protocol for measurement of cerebral gyrification using stereology, Magnetic Resonance Imaging, 24, (3), 2006, p265 - 272 Journal Article, 2006 URL DOI

Kinirons, P. McCarthy, M. Doherty, C.P. Delanty, N., Predicting drug-resistant patients who respond to add-on therapy with levetiracetam, Seizure, 15, (6), 2006, p387 - 392 Journal Article, 2006 URL DOI

Kinirons, P. Cavalleri, G.L. Singh, R. Shahwan, A. Acheson, J.F. Wood, N.W. Goldstein, D.B. Sisodiya, S.M. Doherty, C.P. Delanty, N., A pharmacogenetic exploration of vigabatrin-induced visual field constriction, Epilepsy Research, 70, (2-3), 2006, p144 - 152 Journal Article, 2006 DOI URL

Kinirons, P. Cavalleri, G.L. O'Rourke, D. Doherty, C.P. Reid, I. Logan, P. Liggan, B. Delanty, N., Vigabatrin retinopathy in an irish cohort: Lack of correlation with dose, Epilepsia, 47, (2), 2006, p311 - 317 Journal Article, 2006 DOI URL

Kinirons, P. Cavalleri, G.L. Shahwan, A. Wood, N.W. Goldstein, D.B. Sisodiya, S.M. Delanty, N. Doherty, C.P., Examining the role of common genetic variation in the -2 subunit of the GABAA receptor in epilepsy using tagging SNPs, Epilepsy Research, 70, (2-3), 2006, p229 - 238 Journal Article, 2006 DOI URL

The Neurology of Thyroid Disease in, editor(s)John Noseworthy , Neurological Therapeutics, Principles and Practice , USA, Mayo Clinic Publications, 2006, pp1455 - 1463, [Doherty CP] Book Chapter, 2006

Doherty, C.P., Possibly, probably definitely, Hashimoto encephalopathy, Journal of the Neurological Sciences, 228, (1), 2005, p1 - 2 Journal Article, 2005 DOI URL

Doherty, C.P. Cole, A.J. Grant, P.E. Fischman, A. Dooling, E. Hoch, D.B. White, T.H. Cosgrove, G.R., Multimodal longitudinal imaging of focal status epilepticus, Canadian Journal of Neurological Sciences, 31, (2), 2004, p276 - 281 Journal Article, 2004 URL

Doherty, C.P. West, W.C. Dilley, L.C. Shattuck-Hufnagel, S. Caplan, D., Question/statement judgments: An fMRI study of intonation processing, Human Brain Mapping, 23, (2), 2004, p85 - 98 Journal Article, 2004 URL DOI

Oster, J. Doherty, C. Grant, P.E. Simon, M. Cole, A.J., Diffusion-weighted imaging abnormalities in the splenium after seizures, Epilepsia, 44, (6), 2003, p852 - 854 Journal Article, 2003 URL DOI

Paulus, W. Nolte, K.W. Doherty, C.P. Folkerth, R., Neuropathology of Hashimoto's encephalopathy [7] (multiple letters), J Neurol Neurosurg Psychiatry , 74, (7), 2003, p1009- Journal Article, 2003 URL DOI

Doherty, C.P. Fitzsimons, M. Meredith, G. Thornton, J. McMackin, D. Farrell, M. Phillips, J. Staunton, H., Rapid stereological quantitation of temporal neocortex in TLE, Magnetic Resonance Imaging, 21, (5), 2003, p511 - 518 Journal Article, 2003 URL DOI

Portera-Cailliau, C. Doherty, C.P. Buonanno, F.S. Feske, S.K., Middle cerebral artery territory infarction sparing the precentral gyrus: Report of three cases, J Neurol Neurosurg Psychiatry , 74, (4), 2003, p510 - 512 Journal Article, 2003 URL DOI

, Surgery for temporal-lobe epilepsy, The New England journal of medicine, 2002 Journal Article, 2002

Doherty, C.P. Schlossmacher, M. Torres, N. Bromfield, E. Samuels, M.A., Hashimoto's encephalopathy mimicking Creutzfeldt-Jakob disease: Brain biopsy findings [6], J Neurol Neurosurg Psychiatry , 73, (5), 2002, p601 - 602 Journal Article, 2002 URL DOI

St. George, E.J. Plowman, P.N. Doherty, C.P. Hoch, D. Cole, A.J. Richards, T.A. Stephen, L.J. Brodie, M.J. Wiebe, S. Blume, W.T. Engel Jr., J., Surgery for temporal-lobe epilepsy [3] (multiple letters), New England Journal of Medicine, 346, (4), 2002, p292 - 295 Journal Article, 2002 URL DOI

, The requirement for ictal EEG recordings prior to temporal lobe epilepsy surgery, Archives of neurology, 2001 Journal Article, 2001

Doherty, C., Neurologic manifestations of thyroid disease, Neurologist, 7, (3), 2001, p147 - 157 Journal Article, 2001 URL

Doherty, C.P. Cole, A.J. Cendes, F. Andermann, F. Dubeau, F., The requirement for ictal EEG recordings prior to temporal lobe epilepsy surgery [3] (multiple letters), Archives of Neurology, 58, (4), 2001, p678 - 680 Journal Article, 2001 URL

, Accuracy and validity of stereology as a quantitative method for assessment of human temporal lobe volumes acquired by magnetic resonance imaging, Magnetic resonance imaging, 2000 Journal Article, 2000

Doherty, C.P. Fitzsimons, M. Asenbauer, B. Staunton, H., Discrimination of prosody and music by normal children, European Journal of Neurology, 6, (2), 1999, p221 - 226 Journal Article, 1999 URL

Doherty, C.P. Fitzsimons, M. Asenbauer, B. McMackin, D. Bradley, R. King, M. Staunton, H., Prosodic preservation in Landau-Kleffner syndrome: A case report, European Journal of Neurology, 6, (2), 1999, p227 - 234 Journal Article, 1999 URL

, Radiological determination of the posterior limits of the temporal lobe for volumetric analysis, Brain research. Brain research protocols, 1999 Journal Article, 1999

O'Riordan, J.I. Doherty, C. Javed, M. Brophy, D. Hutchinson, M. Quinlan, D., Do Alpha-Blockers Have a Role in Lower Urinary Tract Dysfunction in Multiple Sclerosis?, The Journal of Urology, 153, (4), 1995, p1114 - 1116 Journal Article, 1995 URL DOI

O'Riordan, J. Javed, M. Doherty, C. Hutchinson, M., Worsening of myasthenia gravis on treatment with imipenem/cilastatin [4], Journal of Neurology Neurosurgery and Psychiatry, 57, (3), 1994, p383- Journal Article, 1994 URL

Non-Peer-Reviewed Publications

McNamara, P.H. Redmond, J.M.T. Doherty, C.P., Varicella-zoster virus encephalitis and vasculopathy in a patient treated with fingolimod, Neurology, 81, (3), 2013, p306- Journal Article, 2013 DOI URL

Research Expertise

Description

I have published widely in the areas of brain imaging in epilepsy, the genetics of epilepsy, functional imaging of language, dementia, clinical neurology and epileptology and traumatic brain injury. In the last few years I have become interested in the challenges of population health, health services research and care delivery in epilepsy. I have published recently on national issues regarding epilepsy care including; evidence based pathways, national mortality estimates, hospital access restrictions and national prescribing rates. I have 105 peer reviewed publications, 4211 citations, a H-index of 35 and i10index of 78. My latests research projects are 1. Brain imaging in CoVID brain Fog and Anosmia 2. Brain imaging in retired contact sports players 3. Brain imaging in patients with epilepsy and rare genetic disorders 4. Evaluating the e-health needs of the epilepsy population 5. Evaluating a patient portal for epilepsy patients 6. Evaluating an outreach service for vulnerable patients with epilepsy 7. Evaluating the mental, social and physical health of patients with epilepsy during CoVID 8. Exam sequencing for rare forms of epilepsy and intellectual disability 9. Collecting biomarkers of seizures for diagnosis and prognosis

Projects

  • Title
    • Circulating Biomarkers in Epilepsy
  • Summary
    • During the first two years of operation, research in WP3, 4 and 7 led to the identification of circulating microRNAs in plasma that are biomarkers of epilepsy and acute seizures 1, three tRNA fragments (or 'tsRNAs') that increase in advance of epileptic seizures 2, and the development of rapid-detection technology for these 3,4. FutureNeuro genomics work in WP1 has shown that 1-3% of sporadic epilepsy is caused by identifiable monogenic causes (unpublished/in preparation). We also have an increased understanding of the contribution of genetic burden to disease risk. For example, over the past 3 years the community has illustrated how focal and generalised epilepsies show an enrichment for both common and rare genetic burden 5,6. The predictive ability of genetic burden for disease state will increase steadily as ever larger collaborative studies emerge. The challenge now is to understand how these signatures correlated with treatment outcome. In addition, bioinformatics studies have shown mechanistic links between some of the targets of these circulating miRNAs and proteins present in plasma that can be measured that may correlate with neurophysiological phenotypes or responses to anti-miRNA therapies in epilepsy and Rett syndrome, a neurodevelopmental disorder accompanied by seizures (Henshall/Tropea, unpublished data). There are significant industry interests in these advances with negotiations underway with UCB Pharma to perform microRNA and genetic profiling to define the molecular landscape of drug-resistant epilepsy. Together, these discoveries have led to FutureNeuro having a leading position in the area of circulating diagnostic biomarkers that was recognised during the recent two-year Site Visit. We propose to capitalise on our leading position in this field and genomics during the remaining funding period. Broadly, we want to explore the value of these biomarkers at the earliest stage of the patient journey (i.e. upon first presentation of a seizure), test the benefits of different combinations of the biomarkers for epilepsy and rare diseases (Rett syndrome), extend evidence for pathophysiological links to disease, and begin the process of commercialisation toward a clinical/diagnostic test using either existing technology or techniques developed by the Centre. Background to proposal for years 3-6 Epilepsy affects 40,000 people in Ireland and the majority will present to the emergency room at some point in the course of their illness. However, more than half of the 7,000 or so admissions in Ireland every year are not people with epilepsy but those with symptomatic seizures related to intoxication with alcohol and other drugs; head injuries; brain infections and other serious illnesses. There are also a large number of mimic syndromes such as psychogenic non-epileptic seizures, recurrent fainting and collapses of unknown cause. Finding biomarkers that can distinguish between a. Epileptic seizures and non-epileptic attacks as well as other mimic disorders. b. Epileptic seizures and symptomatic seizures (such as alcohol withdrawal seizures). c. Epileptic seizures that will result in severe refractory disease as opposed to an isolated event. would be extremely scientifically interesting, clinically valuable, timesaving and economically beneficial for the health system.
  • Funding Agency
    • SFI
  • Date From
    • Sept 2020
  • Date To
    • Sept 2023
  • Title
    • From the Outside-In' - Co-Designing Tools to Promote Independence and Wellbeing in Epilepsy Care
  • Summary
    • Qualitative Study 'From the Outside-In': A qualitative study involving PWE, their carers and healthcare practitioners (HCP) This study will be an in-depth examination of the thoughts, opinions and behaviours of PWE, carers and HCP with regard to how they approach self-management of the condition, what supports they use and where they believe improvement is needed. This research will utilise 'co-production' to generate ideas for the future of epilepsy care provision in Ireland. Patients seldom are given a voice when it comes to such design of healthcare services - hence the study being provisionally titled 'From the Outside-In: Co-Designing Tools to Promote Independence and Wellbeing in Epilepsy Care'. Within the cohort recruited for qualitative research will be homeless PWE, keyworkers and clinicians working with Safetynet Homeless Service. I have become a member of the All Ireland Inclusion Health forum's Research Advisory Group (AIHF RAG) with a view to researching the challenges faced specifically by homeless PWE and clinicians working in the care of homeless patients. There are three work-streams planned for this study. Work-stream 1 involves obtaining ethical approval, creating consent forms, participant information leaflets and a data protection impact assessment. It also involves design of the ethnography, interviews and focus groups.
  • Funding Agency
    • SFI
  • Date From
    • Sept 2018
  • Date To
    • Sept 2021
  • Title
    • Analysing blood-brain barrier integrity to inform on protection from CoVID-19 associated encephalopathy.
  • Summary
    • Rationale: The CoVID-19 virus is genetically similar to other zoonotic coronaviruses that can cause brain damage in animals. The ACE-2 receptor, thought to be the cellular invasion point, is widely expressed in the cerebral vasculature. Despite this, clinical observations in Ireland and elsewhere of the spectrum of neurological complications are large enough now to tell us, at least in this acute phase, that there is no unique neurological signature of CoVID-19 apart possibly from anosmia (loss of the sense of smell) that has been observed in 30-50% of cases. This indicates some protective processes in the human brain and the presence of anosmia points to one possible candidate, the Blood Brain Barrier (BBB) which is heterogeneous within the olfactory bulb with areas of less evolved barrier integrity. Aim: To determine the integrity of the BBB in acute and convalescent cases of CoVID-19 patients, with and without neurological symptoms in particular anosmia. Significance: A strong protective function for the BBB in supressing brain invasion may have significance for future therapies as well as policy and health service planning for any future pandemics. Objective neurological imaging combined with serological assessments may also hold enormous prognostic value in the short term.
  • Funding Agency
    • SFI/EI
  • Date From
    • August 2020
  • Date To
    • April 2021

Keywords

Ageing, memory and other cognitive processes; Consequences of ischemia or hypoxia, convulsive disorders; Neurobiology; Neurochemistry and neuropharmacology; Neurodegeneration; Neurogenetics; Neurology; Neurophysiology; Neuropsychology; Vision

Recognition

Representations

Clinical Lead for the National Epilepsy Programme 2010-2018

I have been a member of the board of the health research board (HRB) 2012-217

I was a member of the governments National Clinical Effectiveness Committee. 2015

Irish representative to the International League Against Epilepsy (ILAE) committee for the Global Campaign Against Epilepsy 2014

Founder member of Epilepsy Research Ireland 2010-2020

Clinical Lead for Women's Health in Epilepsy 2018

Member of Irish government's expert group on resource allocation 2011

adjunct Professor department of Disability, University College Dublin 2020

Awards and Honours

Epilepsy Prize Irish Neurological Association 01/05/2016

Lundbeck Research Prize 01/02/2015

Care Challenge Award 01/02/2016

Fritz Dreifuss Award for Clinical Research 02/05/2007

Merritt-Putnam Fellowship Award 01/07/2002

Epifellows Foundation Fellowship Award 2001 02/06/2001

AAN Resident Traveling Scholarship Award 02/05/2001

Daniel C. Federman Award for Outstanding Clinical Teaching. 20/02/2000

Harold Millar Medal 020/05/2000

Memberships

Fellowship of RCPI 01/01/2005 – 01/04/2021

Fellow of the faculty of exercise and Sports medicine 01/01/2018 – 01/04/2021

American Epilepsy Society 01/01/2000 – 01/04/2021

Irish Institute of Clinical Neuroscience 01/02/1994 – 01/04/2021

Irish Epilepsy League 01/02/2019 – 01/04/2021

European Academy of Neurology 01/02/2019 – 01/04/2021