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Professor Andrew Davies
Prof Consultant of Palliative Medicine, Clinical Medicine

Biography

Professor Andrew Davies is Professor of Palliative Medicine at Trinity College Dublin, University College Dublin, and Our Lady's Hospice in Dublin. His undergraduate training was at St. George's Hospital Medical School (University of London), and postgraduate (specialty) training in Palliative Medicine was undertaken in London and Surrey. His clinical / research interests encompass supportive care (in cancer), palliative care, and end-of-life care. Current research projects involve cancer-related anorexia, opioid-induced constipation, symptom assessment, deprescribing, circadian rhythm disorders, remote patient monitoring (photoplethysmography), and clinically-assisted hydration. He is Immediate Past President of the Multinational Association of Supportive Care in Cancer, and Past-President of the Association for Palliative Medicine of Great Britain and Ireland.

Publications and Further Research Outputs

Peer-Reviewed Publications

Alderman B, Allan L, Amano K, Bouleuc C, Davis M, Lister-Flynn S, Mukhopadhyay S, Davies A, Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer, Supportive Care in Cancer, 2022, p2983 - 2992 Journal Article, 2022 DOI TARA - Full Text

Power J, Gouldthorpe C, Davies A, Palliative care in the era of novel oncological interventions: needs some "tweaking", Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30, (7), 2022, p5569 - 5570 Journal Article, 2022 DOI TARA - Full Text

Mulcahy Symmons S, Ryan K, Aoun SM, Selman LE, Davies AN, Cornally C, Lombard J, McQuillan R, Guerin S, O'Leary N, Connolly M, Rabbitte M, Mockler D, Foley G., Decision-making in palliative care - patient and family caregiver concordance and discordance: systematic review and narrative synthesis, BMJ Supportive & Palliative Care, Online First, 2022 Journal Article, 2022 DOI TARA - Full Text

Cleary N, Gouldthorpe C, Power J, Davies A., Correspondence re MASCC evidence-based recommendations for the management of malignant bowel obstruction., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30, (10), 2022, p7823 - 7824 Journal Article, 2022 DOI

Cleary N, Munnelly Mulkerrin O, Davies A, Oral symptom assessment tools in patients with advanced cancer: a scoping review, Supportive Care in Cancer, 30, (9), 2022, p7481 - 7490 Journal Article, 2022 DOI

Davies A, Cinieri S, Dupoiron D, España Fernandez S, Leclerc J, Montesarchio V, Mystakidou K, Serna J, Tack J, A prospective, real-world, multinational study of naloxegol for patients with cancer pain diagnosed with opioid-induced constipation - the NACASY Study, Cancers (Basel) , 14, (5), 2022, p1128 Journal Article, 2022 TARA - Full Text DOI

Jones JA, Chavarri-Guerra Y, Corrêa LBC, Dean DR, Epstein JB, Fregnani ER, Lee J, Matsuda Y, Mercadante V, Monsen RE, Rajimakers NJH, Saunders D, Soto-Perez-de-Celis E, Sousa MS, Tonkaboni A, Vissink A, Yeoh KS, Davies AN., MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30, (11), 2022, p8761 - 8773 Journal Article, 2022 DOI

Oral care in, editor(s)Cherny NI, Fallon MT, Kaasa S, Portenoy RK, Currow DC , Oxford Textbook of Palliative Medicine, Oxford, Oxford University Press, 2021, pp656 - 669, [Andrew N Davies] Book Chapter, 2021

Román Romero-Ortuño, Nicolás Martínez-Velilla, Richard Sutton, Andrea Ungar, Artur Fedorowski, Rose Galvin, Olga Theou, Andrew Davies, Richard B Reilly, Jurgen Claassen, Áine M Kelly, Plamen Ch. Ivanov, Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults, Frontiers in Network Physiology: Networks in Aging and Frailty, 2021 Journal Article, 2021 TARA - Full Text DOI

Davis M, Hui D, Davies A, Ripamonti C, Capela A, DeFeo G, Del Fabbro E, Bruera E, MASCC antiemetics in advanced cancer updated guideline, Supportive Care in Cancer, 29, 2021, p8097 - 8107 Journal Article, 2021 DOI

Davies A, Leach C, Butler C, Gregory A, Henshaw S, Minton O, Shorthose K, Batsari KM, Opioid-induced constipation in patients with cancer: a "real-world," multicentre, observational study of diagnostic criteria and clinical features., Pain, (162), 2021, p309 - 318 Journal Article, 2021 DOI

Davies A, Buchanan A, Todd J, Gregory A, Batsari KM, Oral symptoms in patients with advanced cancer: an observational study using a novel oral symptom assessment scale, Supportive Care in Cancer, 29, 2021, p4349 - 4356 Journal Article, 2021 DOI

Davis M, Hui D, Davies A, Ripamonti C, Capela A, DeFeo G, Del Fabbro E, Bruera E, Medical management of malignant bowel obstruction in patients with advanced cancer: 2021 MASCC guideline update, Supportive Care in Cancer, 29, 2021, p8089 - 8096 Journal Article, 2021 DOI

Davies A, Leach C, Butler C, Patel SD, Shorthose K, Batsari KM, Opioid-induced constipation: a stepwise treatment algorithm feasibility study, BMJ Supportive & Palliative Care, 2021 Journal Article, 2021 DOI

Webber K, Davies AN, Leach C, Waghorn M, Symptom prevalence and severity in palliative cancer medicine, BMJ Supportive & Palliative Care, 2021 Journal Article, 2021 DOI

Romero Ortuño R, Martínez Velilla N, Sutton R, Ungar A, Fedorowski A, Galvin R, Theou O, Davies A, Reilly RB, Kelly AM, Ivanov PC, The grand challenge of physiological reserve in older adults, Frontiers in Network Physiology, 1, 2021 Journal Article, 2021 DOI

Bryony Alderman, Katherine Webber, Andrew Davies, An audit of end-of-life symptom control in patients with corona virus disease 2019 (COVID-19) dying in a hospital in the United Kingdom, Palliative Medicine, 34, (9), 2020, p1249--1255 Journal Article, 2020 DOI

Webber K, Davies AN, Leach C, Bradley A, Alcohol and drug use disorders in patients with cancer and caregivers: effects on caregiver burden, BMJ Supportive & Palliative Care, 10, (2), 2020, p242--247 Journal Article, 2020 DOI

Hall S, Thompson J, Phair T, Davies AN, Clinical nurse specialist prescribing in a cancer centre supportive and palliative care team, BMJ Supportive & Palliative Care, 10, (1), 2020, p111--113 Journal Article, 2020 DOI

Davies A, Hayes J, Palliative care in the context of a pandemic: similar but different., Clinical medicine (London, England), 2020 Journal Article, 2020 DOI

Berman R, Davies A, Cooksley T, Gralla R, Carter L, Darlington E, Scotté F, Higham C, Supportive Care: An Indispensable Component of Modern Oncology., Clinical oncology (Royal College of Radiologists (Great Britain)), 2020 Journal Article, 2020 DOI

Davies A, Leach C, Caponero R, Dickman A, Fuchs D, Paice J, Emmanuel A, MASCC recommendations on the management of constipation in patients with advanced cancer, Supportive Care in Cancer, 28, (1), 2020, p23--33 Journal Article, 2020 DOI

Davies A, Cancer-related Breakthrough Pain, 3rd edition, Third, Oxford, Oxford University Press, 2019, 1-100pp Book, 2019

Multidisciplinary team working in, editor(s)Watkinson JC, Clarke RW , Scott-Brown's Otorhinolaryngology Head and Neck Surgery, 8th edition, Boca Rato, CRC Press, 2019, pp509-515 , [Davies A, Beasley N, Hamilton D] Book Chapter, 2019

Davies A, Todd J, Bailey F, Gregory A, Waghorn M, Good concordance between patients and their non-professional carers about factors associated with a 'good death' and other important end-of-life decisions, BMJ Supportive and Palliative Care, 9, (3), 2019, p340-345 Journal Article, 2019 DOI

Andrew N Davies, Melanie Waghorn, Katherine Webber, Sigurd Johnsen, Jeewaka Mendis, Julia Boyle, A cluster randomised feasibility trial of clinically assisted hydration in cancer patients in the last days of life, Palliative Medicine, 32, (4), 2018, p733--743 Journal Article, 2018 DOI

Andrew Neil Davies, Frank Elsner, Marilène Jeanne Filbet, Josep Porta-Sales, Carla Ripamonti, Daniele Santini, Kath Webber, Breakthrough cancer pain (BTcP) management: a review of international and national guidelines, BMJ Supportive & Palliative Care, 8, (3), 2018, p241--249 Journal Article, 2018 DOI

Andrew Neil Davies, Shuchita D Patel, Amanda Gregory, Bernadette Lee, Observational study of sleep disturbances in advanced cancer, BMJ Supportive & Palliative Care, 2017, pbmjspcare--2017--001363 Journal Article, 2017 DOI

Davies A, Buchanan A, Zeppetella G, Porta-Sales J, Likar R, Weismayr W, Slama O, Korhonen T, Filbet M, Poulain P, Mystakidou K, Ardavanis A, O'Brien T, Wilkinson P, Caraceni A, Zucco F, Zuurmond W, Andersen S, Damkier A, Vejlgaard T, Nauck F, Radbruch L, Sjolund KF, Stenberg M, Breakthrough cancer pain: an observational study of 1000 European oncology patients, Journal of Pain and Symptom Management, 46, (5), 2013, p619 - 628 Journal Article, 2013 DOI

Davies A, Cancer-related Breakthrough Pain, 2nd edition, Second, Oxford, Oxford University Press; 2012., 2012, 1-113pp Book, 2012

Davies AN, Epstein JB, Oral Complications of Cancer and its Management., First, Oxford, Oxford University Press , 2010, 1-312pp Book, 2010

Davies A, Cancer-related Bone Pain, First, Oxford, Oxford University Press , 2007, 1-118pp Book, 2007

Davies A, Cancer-related Breakthrough Pain, First, Oxford, Oxford University Press, 2006, 1-114pp Book, 2006

Booth S, Davies A, Palliative Care Consultations in Head and Neck Cancer, First, Oxford, Oxford University Press, 2006, 1-195pp Book, 2006

Davies A, Finlay I, Oral Care in Advanced Disease, First, Oxford, Oxford University Press, 2005, 1-221pp Book, 2005

Research Expertise

Description

Research interests: 1) Supportive care in cancer; 2) Palliative care; 3) End-of-life care; 4) Cancer survivorship; 5) Cancer pain; 6) Cancer symptoms; 7) Adverse effects cancer treatment; 8) Clinically-assisted hydration; 9) Opioid-induced constipation; 10) Cancer-related anorexia / cachexia; 11) Circadian rhythm disorders; 12) Remote patient monitoring; 13) Symptom assessment; 14) Deprescribing

Projects

  • Title
    • A cluster randomised trial of clinically-assisted hydration in patients in the last days of life (CHELsea II study)
  • Summary
    • Research question Our hypothesis is clinically-assisted hydration (CAH) in the last days of life reduces the frequency of delirium (aka terminal agitation ), as a result of preservation of renal function, and prevention of build-up of drugs/toxins. Furthermore, CAH will prevent death due to dehydration before death due to the underlying disease. Background Provision of CAH at the end-of-life is one of the most contentious issues in medicine. The reasons include: a) lack of evidence; b) disparate opinions of healthcare professionals (HCPs); and c) generally positive opinions of patients and their carers (and negative opinions about withholding/withdrawing CAH). Unsurprisingly, the provision of CAH at the end-of-life is extremely variable in clinical practice (e.g. 12-88% cancer patients in the last week of life). This definitive study leads on from a RfPB-funded feasibility study, which achieved all of its predetermined criteria for success. Aim and objectives The aim is to evaluate CAH in the last days of life. The objectives are to assess: effect of CAH on hyperactive delirium; effect of CAH on audible upper airway secretions ( death rattle ); effect of CAH on pain and other symptoms; tolerability of CAH; effect of CAH on survival; and health economic impact of CAH. Methodology The study is a cluster randomised trial, where the sites are randomised to an intervention: the intervention will become the standard of care at the site, and will be given to all patients unless there is a valid clinical reason. The study will recruit 1600 subjects from 80 sites (mainly hospices). The consent process follows the Mental Capacity Act: if the patient has capacity then consent will be sought in the normal way; if the patient does not have capacity, then a personal or nominated consultee will be approached for advice about the patient entering the study. Intervention A is: continuance of oral intake; regular mouth care; and usual management of symptoms. Intervention B is: continuance of oral intake; regular mouth care; usual management of symptoms; and CAH, i.e. parenteral fluids. The fluids may be given intravenously or subcutaneously. The fluid will be dextrose saline (4% dextrose, 0.18% sodium chloride), and the volume depends on the patient's weight (as per NICE guidance). Participants will be reviewed every 4 hr, and an assessment made as to whether relevant problems are present. A study-specific clinical observation document will be completed by the clinical team. Indications for medication will also be recorded by the clinical team. The primary endpoint is the proportion of subjects that develop delirium using the Nursing Delirium Screening Scale. Timelines The study will start in October 2021, and last for 42 months: the first 12 months will be to set up the study (including site training/initiation), the next 24 months to recruit participants, and the final 6 months to analyse data, write reports/publications, and close down the study. Anticipated impact and dissemination The study will provide much needed evidence on CAH, which will lead to more consistent management in the NHS, and reduce the distress/conflict around decision making. The results will be disseminated to HCPs via scientific meetings/journal articles, and to the public via usual media sources.
  • Funding Agency
    • NIHR (UK)
  • Date From
    • 01/10/2021
  • Date To
    • 30/04/2025
  • Title
    • EU-Navigate
  • Summary
    • EU-Navigate is a European, multicentre, randomised controlled trial that will evaluate the European adaptation of the Canadian NavCare intervention (volunteer navigators) with regard to its effects on older cancer patients", and their family caregivers", quality of life and well-being.
  • Funding Agency
    • European Health and Digital Executive Agency
  • Date From
    • 01/09/2022
  • Date To
    • 31/08/2027
  • Title
    • An observational study of diagnostic criteria, clinical features and management of opioid-induced constipation (OIC) in European patients with cancer pain
  • Summary
    • This multicentre, European observational study will investigate opioid-induced constipation in patients with cancer, and will assess management of this condition, and particularly patient use of non prescribed interventions, and adherence with prescribed interventions. The study will also assess diagnosis, clinical features, and impact (on quality of life).
  • Funding Agency
    • Kyowa Kirin International
  • Date From
    • 31/07/2021
  • Date To
    • 28/02/2023

Keywords

Clinical research, trials; End-of-life ; End-of-life care; Medical Sciences, Research; Medical technology; Oral diseases and Oral medicine; Oral microbiology; Pain measurement, pain relief, pain recovery; PALLIATION; PALLIATIVE; Palliative and end of life care; PALLIATIVE CARE; Palliative care ; Palliative Medicine ; Saliva and Salivary gland; Supportive care

Recognition

Awards and Honours

FRCP 05/2004

Memberships

Fellow of Royal College of Physicians (London) 05/2004 – Current

Multinational Association of Supportive Care in Cancer 07/2006 – Current