Miscellaneous and Unknown Causes of Lymphadenopathy

Lymphadenopathy may occur in association with a number of other clinical conditions. These include: -

Dermatopathic lymphadenopathy :

  • A variety of dermatologic conditions, especially exfoliative dermatitis.

  • Involved nodes are characterized by presence of large numbers of atypical macrophage-like cells and foamy cells containing lipoid material or melanin.

  • Dermatopathic lymphadenopathy is self limited and improves with regression of the underlying skin disease.


  • Generalized lymphadenopathy and hepatosplenomegaly are common findings in Gaucher's disease and Niemann-Pick disease.

  • Bone marrow examination can provide important diagnostic information by revealing the lipid laden macrophages characteristic of each condition.


  • Generalized lymphadenopathy rarely may accompany thyrotoxicosis and adrenal insufficiency.

  • Lymph nodes are usually small (< 1.0 cm) and soft in consistency and regress in size once the underlying endocrine disorder has been adequately treated.

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