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David Hoey

Associate Professor, Mechanical & Manufacturing Engineering

Email: dahoey@tcd.ie
Tel: +353 1896 1359
Twitter:@hoeyd83


Biography

Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Bioengineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.

Publications and Further Research Outputs

Peer-Reviewed Publications

Stavenschi, E., Labour, M.-N., Hoey, D.A., Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration, Journal of Biomechanics, 55, 2017, p99-106Journal Article, 2017

Johnson, G.P., English, A.-M., Cronin, S., Hoey, D.A., Meade, K.G., Fair, S., Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine, Biology of Reproduction, 97, (2), 2017, p302-312Journal Article, 2017

Flanagan AM, Stavenschi E, Basavaraju S, Gaboriau D, Hoey DA, Morrison CG, Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification., 2017Journal Article, 2017

All 34 peer-reviewed publications

Research Expertise

Description

Orthopaedic Biomechanics and Mechanobiology Mechanotransduction mechanisms Biomaterials Primary Cilia Cancer Mechanobiology

Recognition

Awards and Honours

Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz)2016

Marie-Skłodowska Curie COFUND Excellence award2015

University of Limerick Award for Research Excellence (Early Career)2014

European Research Council Starting Grant2013