Nanobio - Nanomechanics Group
Welcome to the nanomechanics laboratory at Trinity College Dublin. As the leader of this group I welcome you to visit our website, correspond with members of our group and discuss your technical interests with us. Our laboratory is focused on the dynamics and kinetics of interacting biomolecules, the mechanics of protein imported to mitochondria membranes, the kinetics of molecular motors under external strain and the nanomechanical action at ribosomal complexes during translation.
We use state-of-the-art optical tweezers to explore fundamental biological molecular processes such as ribosome translation. These experiments provide unprecedented insights at single biomolecule level, fundamental for subsequent understanding of e.g. protein folding, gene regulation or drug effects. We leverage our leading position in the ﬁeld of bionanomechanical cantilever array sensors to develop rapid and label‐free sensing platforms for small miRNA biomarker molecules from serum, and immunogenic – vaccine and haemostasis diagnostics. These research projects are pursued with partners from industry, hospitals and specialized research institutions. Nanoscale scientiﬁc approaches deliver innovative, fast, sensitive assays for basic and applied research. A next generation of young interdisciplinary scientists is trained and educated to address major societal challenges related to healthcare.