New technique that rapidly quantifies immune response following vaccination
05 February 2021
A global team of researchers has developed a new strategy for fast and reliable antibody tests, which can quantify the immune response induced by vaccination and reveal the timeline and stage of pathogen infection.
Led by Professor Martin Hegner, Principal Investigator in CRANN and Trinity College Dublin’s School of Physics, the team’s one-step quantitative antibody tests are conducted using (blood) serum and are on a par with the gold-standard, enzyme-linked immunosorbent assay (ELISA) technique. The major advantage of the newly developed nano technique with respect to ELISA tests is that it is equally sensitive and able to simultaneously detect multiple target molecules – but in a fraction of the time.
As a global multidisciplinary research consortium from Europe, Africa and the US, Professor Hegner and his co-workers focused on malaria vaccines and their generated humoral immune response for case study analysis. Malaria is a life-threatening epidemic disease with 228 million estimated annual cases occurring worldwide. It caused over 400,000 deaths last year.
The team’s findings have been published today in the interdisciplinary journal, Nanoscale, which is a high-impact, peer-reviewed journal of the Royal Society of Chemistry.