- Oct 2019: A new Siemens PRISMA 3T MRI scannerwill be installed in early 2020. This is funded by an SFI Infrastructure Grant. See the announcments from Trinity
Fantastic to see funding for a Siemens PRISMA MRI scanner for Trinity College Institute of Neuroscience, Trinity College Dublin. This will accelerate infant, pediatric, and dementia research. @tcddublin @TCINeuroscience @pjprendergast @ismrm @OHBM @SiemensHealth https://t.co/49oLhKyxKX— Rhodri Cusack (@rhodricusack) October 21, 2019
Imaging Interest Group
Join the TCIN Imaging Interest Group (IIG) mailing list to receive the latest notifications.
Meetings are at 1.30pm on Thursdays in the Visualisation Room of the Lloyd Building (LB 2.01) unless otherwise stated.
|10 Oct 2019||Laura Finnegan||The School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin||Manganese-enhanced MRI to asses optic nerve integrity in a mouse model of retinal degeneration.|
|4 Jul 2019||Judit Carrusta||Centre for the Developing Brain, Kings' College London||Early development of the brain functional architecture|
|6 Jun 2019||Oliviero Gobbo||The School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin||Development of a mouse model of glioblastoma for the study of local treatments, post-resection|
|23 May 2019||Vyacheslav (Slava) Karolis||FMRIB, Oxford||Structural and functional architectures in brain development and ageing.|
13 May 2019
|Jonathan Smallwood||Psychology, The University of York||The neural basis of on-going conscious experience|
|9 May 2019||John Butler||School of Mathematical Sciences, TU Dublin||Contradicting Neural Unreliability Thesis in Autism: Embracing the Null Hypothesis with Confidence|
|7 May 2019||Johann Kruschwitz||Volition and Cognitive Control, Dresden University of Technology||Graph theoretical modeling of brain connectivity: Concepts and workflow of brain connectivity analysis using graph theory.|
|28 Mar 2019||Dara Cannon||Medicine, NUI Galway||Psychiatry and the Human Connectome: Diffusion MRI Research Advances|
|14 Mar 2019||Alan Stone||Biomedical Engineering, Trinity College Dublin||Progressing quantitative MRI towards the clinic: Application of novel methods for insight into atherosclerosis, stroke, tumor and traumatic brain injury|
|28 Feb 2019 (joint with below)||Evie Regan||MEng Biomedical Engineering, University College Dublin||Investigating the Deformation of the Masseter Muscle during Teeth Clenching and Grinding" and Dr. Catherine Jordan, a GBHI and Atlantic Fellow at TCD will be presenting: 'An fMRI pilot study exploring the influence of personally meaningful music on mild Alzheimer's Disease|
|28 Feb 2019||Catherine Jordan||GBHI and Atlantic Fellow at Trinity College Dublin||An fMRI pilot study exploring the influence of personally meaningful music on mild Alzheimer's Disease|
|31 Jan 2019||Erik O'Hanlon||Trinity College Dublin and RCSI||Imaging. What have you done for me lately?? What can your data do for you?|
For human imaging, we have a 3T MRI. The scanner will be upgraded to a Siemens PRISMA in early 2020. The new scanner has:
- much bettter signal-to-noise ratio, as the signal is digitised close the participant's head
- stronger gradients (80 mT/m rather than 40 mT/m) for much better signal during diffusion MRI
- faster scanning through simultaneous multi-slice functional MRI and diffusion MRI
- force-compensated gradients to reduce vibration and noise, and methods for quieter scanning
For animal imaging, we have a small-bore 7 T MRI. This has:
- a resolution of down to 25 microns (that's 0.025 mm)
- a cryocoil for high signal-to-noise
- three gradient sets (200-1000 mT/m) that trade off the diameter of the useable bore
Major Scientific Directions
Our centre is engaged in a wide range of imaging research, including for example:
- Infant development: The development of the brain and mind in infants, and how they can be disrupted in infants from the neonatal intensive care unit.
- Childhood MRI: The development of the brain in childhood, with a particular focus on autism, ADHD and psychosis.
- Aging: How the brain changes through the lifespan, and early markers of dementia.
- Brainstem function: How lesions to the brainstem affect the rest of the brain, and resulting behaviour.
- In-vitro imaging: Arterial tissue mechanics, vascular imaging, vascular mechanobiology
MRI Acquisition Methods
Our teams measure many aspects of the brain:
- Functional MRI: The activity in the brain evoked when a person watches or listens to something, or does a mental task.
- Functional Connectomics: The connections between different brain regions, .
- Diffusion MRI: A way to trace the white matter that connects different brain regions - the brain's wiring.
- Structural MRI: The anatomy of the brain.
We study many populations:
- Young adults: Many of our studies are conducted in university students
- Older adults: To characterise how the brain changes through the lifespan.
- Infants and children: To study how the brain and mind develop.
- Autism and ADHD
- Psychiatric populations
- Disorders of consciousness
- Neuropsychological patients with lesions of the cortex or subcortical regions
We have expertise in many areas of analysis:
- Structural morphometry: assessing changes in brain structure (e.g., cortical thickness, lesions)
- Functional MRI: measuring changes in brain activity, using volumetric and surface-based analyses
- Functional Connectomics: measuring the connections between brain regions by examing correlated changes in activation
- Tractography: tracing the connective tracts that join brain regions
- Multi-voxel pattern analysis: analysing the patterns of brain activity evoked by different stimuli or tasks, through representational similarity analysis and decoding methods
- Machine learning: using machine learning methods to classify activity or structrual chanes in the brain
- Deep learning: testing computational models of brain function
The MRI Management Committee designs strategy and policy at TCIN, and implements it. The current committee members are:
Rhodri Cusack (Chair)
Cliona O'Doherty (Minutes)
Discounted Scanning Policy
1. Proposals for discounted scanning will be considered by the MRI Management Committee (MRI-MC) for the following:
Additional criteria used by committee
Cost per participant
Will lead to a grant application that will pay for future MRI projects.
Will create methods that will be shared with all other users and enhance our science.
A primary goal of the project is training (e.g., Masters projects)
3T scanner - €100/hour
7T scanner - €50/hour
2. Incidental findings fee. According to TCIN SOPs, all participants will also have their scans read by a neurologist for incidental findings (unless they have had their MRI scan at TCIN read within the previous 6 months). This costs €50/participant, which will still have to be covered in all cases.
3. End of project report. At the end of your project - or within 1 year of the approval from the MRI-MC (whichever is sooner), you must give a 15 minute presentation to the Imaging Interest Group, describing the outcomes of your project, and submit an end of project form to the MRI-MC.
4. To apply, you must
Give a 15 minute presentation describing your project, followed by 5-10 minutes discussion, to the Imaging Interest Group
Fill in the Discounted Scanning Proposal form.
5. To evaluate a proposal, the MRI MC will assess how busy the scanner is, how many previous discounts a PI has received, and the expected value of the outcomes.
Dr. Christian Kerskens, Principal MRI Physcist
Mr. Sojo Joseph, Radiographer
Directory of Users
|Alan Stone||Postdoc||Biomedical Engineering, TCD||Developing new MRI methods to quantify physiology in the human body and translating these methods into the clinc|
|Andrew Harkin||PI||Pharmacology, TCD||Neuropharmacology, Animal models of CNS disorders, 7T imaging|
|Arun Bokde||PI||Psychiatry, TCD||neuroimaging, neurodevelopment, depression, dementia|
|Bill Morrisey||Group leader||Glanbia||Food additives and nutraceuticals with neuroprotective or enhancing effects on human cognition|
|Brain Lawlor||PI||GBHI, TCD||Neuroscience of dementia prevention.|
|Brooke Tornifoglio||Graduate student||Biomedical Engineering, TCD||DTI, quantitative measures,|
|Chiara Caldinelli||Graduate student||Psychology, TCD||Infant neuroimaging|
|Christian Kerskens||Physicist||TCIN, TCD||quantum coherence, quantum biology|
|Claire Gillan||PI||Psychology, TCD||big data, psychiatry, prediction, habits, goal-directed control, antidepressant, machine learning|
|Clare Kelly||PI||Psychology and Psychiatry, TCD||
task, task-free, & naturalistic viewing analysis, big data, techniques and methods, programming
|Clíona O'Doherty||Research Assistant||Psychology, TCD||Investigating how deep neural networks can help in Neuroimaging of the ventral visual stream|
|Connie Sanchez Morillo||Group leader||Alkermes Inc||Diagnostics in pre-clinical and clinical cohorts|
|David Henshall||PI||Future Neuro SFI Centre||Noise-sensitive cohorts including ADHD, Psychosis, Depression and Alzheimer’s Disease. Future planned work on blood-brain barrier dysfunction.|
|David Loane||PI||Biochemistry and Immunology, TCD||Traumatic brain injury, chronic neurodegeneration, dementia, neuroinflammation, pre-clinical animal models|
|Declan McLoughlin||PI||St. Patricks University Hospital||Clinical MRI in collaboration wth other European and American centres of excellence.|
|Eleanor Molloy||PI||Tallaght Hospital||Consequences of neonatal hypoxic-ischaemic encephalopathy, characterised using resting state and functional MRI.|
|Feng Deng||Graduate student||Psychology, TCD||brain mechanism, neuroimaging, machine learning/deep learning, computational modelling|
|Fiona Newell||PI||Psychology, TCD||Cognitive neuroscience approach to research on multisensory perception in humans|
|Geraldine Boylan||Director, PI||INFANT Centre, UCC||Characterising perinatal brain injury using structural, diffusion and functional MRI, and to develop deep learning algorithms to analyse infant MRI data (SFI-funded DELPHI project)|
|James Murphy||Group leader||Impact Gumshields Inc.||Printed and machined MRI mouthmolds|
|Jane McGrath||PI||Psychiatry, TCD||Precursors of ADHD in infancy|
|John Butler||PI||TU Dublin||
Mathematical methods to model human perception and decision making, in healthy adults, and those with clinical diagnoses such as autism and dystonia.
|Kathy Ruddy||PI||TCIN, TCD||
Neuroimaging, EEG, Brain computer interface, stroke, MR-spectroscopy
|Lorina Naci||PI||Psychology, TCD||neuroimaging, cognition|
|Louise Gallagher||PI||Psychiatry, TCD||
Childhood and adolescent psychiatry, and in particular autism and ADHD
Homeostatic mechanisms that match inhibition with excitation are essential for habituation and memory silencing, both of contribute to multiple cognitive processes known to be altered in psychiatric conditions (e.g. autism and PTSD).We will utilise paradigms developed by collaborators in Oxford and Birmingham using similar scanners to investigate mechanisms, functions and dysfunctions of inhibitory homeostasis with funding from the Wellcome Trust and other agencies.
Developmental research programme in psychosis, (iHEAR ERC Consolidator).
Drug discovery in psychiatric (depression and schizophrenia) and neurodegenerative (Alzheimer’s, Mild Cognitive Impairment, Parkinson’s) diseases.
|Matthew Campbell||PI||Genetics, TCD||
Clinical research programmes in my lab that are focused on understanding the nature and etiology of repetitive mild traumatic brain injury on regulation of the blood brain barrier".
|Megan Ni Bhroin||Graduate student||Psychiatry, TCD||
I'm interested in the functional network architecture of neonate encephalopathy patients. I use rs-fMRI to measure the resting state networks and use graph methods to quantify the global structure of the brain. I also plan to investigate the linear association between the functional connectome and inflammatory markers.
|Michael Hutchinson||PI||St. Vincent’s Hospital||
Movement disorders especially the imaging of our noise sensitive cohorts in Dystonia and Multiple Sclerosis.
Pathways in the brain affected in Alzheimer’s disease and other neurodegenerative diseases.
|Nicola Taylor||Graduate student||Psychology, TCD||
Disorders of consciousness, Covert consciousness, fMRI
|Nigel Vahey||Postdoc||Psychology, TCD||Addiction; impulsivity; habits|
|Owen Smith||PI||UCD, Research Lead for new National Children’s Hospital||
Cutting-edge neuroimaging methods for infant and pediatric MRI in Dublin will provide an excellent foundation for powerful academic-clinical collaborations at the National Children’s Hospital, which will be Europe’s largest pediatric hospital when it opens in 2020.
|Paul Dockree||PI||Psychology, TCD||
MRI voxel-based lesion-symptom mapping, characterise lesions in stroke, TBI and tumour resection patients and how they related to dissociable aspects of sustained attention impairment.
|Redmond O’Connell||PI||Psychology, TCD||
Neural mechanisms of decision making. Decision making capabilities in several noise sensitive cohorts including ADHD, normal aging and dementia, work that will be greatly facilitated by the new low noise MRI scanner.
|Rhodri Cusack||PI||Psychology, TCD||
neurodevelopment; MRI acquisition and analysis methods
|Richard Carson||PI||Psychology, TCD||
human motor control; cognitive neuroscience; ageing; stroke; ALS
|Richard O'Conaill||Postdoc||Psychology, TCD||
Neurodevelopmental disorders, developmental cognitive neuroscience, clinical phenotyping, neural biomarkers
|Richard Reilly||PI||Biomedical Engineering, TCD||
electrophysiology and MR based imaging of movement disorders. Active implantable devies and neuroimaging based objective measure for their evaluation
|Robert Johnston||Graduate student||Biomedical Engineering, TCD||
Atherosclerosis, Arterial Structure, Computational Biomechanics, Diffusion MRI
|Tim Lynch||PI||MMUH||Rare diseases.
|Veronica O’Keane||PI||Psychiatry, TCD||
Interested in BOLD measurements, bt-ASL and spectroscopy and the enhancements the new scanner can offer in these areas will be particularly important.