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7 Tesla Small Bore Scanner

The 7T MRI lab houses a Bruker BioSpec 7T system with a 1H MRI Cryoprobe, AVANCE III HD architecture and Paravision 6 Software. This state-of-the-art scanner can reach a spatial resolution of 25 microns, while the non-invasive nature of MRI permit serial studies to be performed in the living animal. The system is a Bruker BioSpec 70/30 (i.e. 7T, 30 cm bore) with an actively shielded USR Magnet with the following specifications: mri

Gradients available include:
  • Large (200 mT/m, ID 152 mm)
  • Medium (400 mT/m, ID 72mm)
  • Small (1000 mT/m, ID 35 mm)

(ID = maximum usable internal diameter)

A variety of volume resonators and surface coils are available to allow for imaging and spectroscopy of 1 H and a range of other MR-active nuclei such as 31 P, 23 Na, 19 F and 13 C. A wide range of pulse sequences and image processing tools are available on the Bruker system, and support is available from an experienced team. Examples of studies which can be carried out on the 7T system include:

  • 'Conventional' MR images based on T 1 , T 2 or proton density, typically used to show anatomical detail;
  • Blood flow in arteries or veins (magnetic resonance angiography or MRA);
  • Blood perfusion through tissue, giving cerebral blood flow (CBF) and cerebral blood volume (CBV) maps;
  • Molecular diffusion of water through tissue such as white matter tracts (tractography and diffusion tensor imaging (DTI));
  • Relative degrees of bound and unbound water via magnetisation transfer contrast (MTC);
  • Tissue movement, such as motion of the heart to yield measures of ejection fraction and myocardial wall motion;
  • Tissue temperature and intracellular pH measurements;
  • Oxygenation of blood to show areas of brain activated by stimuli - functional MRI (fMRI);
  • Changes in blood perfusion through tissues in response to pharmacological intervention (phMRI);
  • Cell tracking following the labelling of cells with magnetic nanoparticles.