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Prof Mani Ramaswami

Professor Mani Ramaswami

  • Position: Professor of Neurogenetics & Director, Trinity College Institute of Neuroscience
  • Contact details: Department of Genetics, Trinity College Dublin
  • Email:
  • Lab page: Ramaswami Lab
  • Telephone: 353-01-896-8400

Research Interests

My research is in genetic, molecular, cellular and behavioral neuroscience. I am interested in linking molecular and circuit mechanisms of simple learned behaviors. We work in primarily in the genetic model organism Drosophila melanogaster studying synaptic mechanisms, miRNA mediated translational control in neurons, and mechanisms of simple memory. An obvious extension of these studies to to ask how these mechanisms are affected in disease and we currently study disease models for fragile-X mental retardation and spinocerebellar ataxia. A wide range of collaborations, particularly with top research groups in Biosciences in India, expands our work into other fields including natural products, peptide neurotoxins and stem cell biology. My research group comprises 6 post-doctoral researchers and 4 postgraduate students. They use a number of in vivo approaches including Drosophila behavior, electrophysiology, optical and electron microscopy and a range of biochemical & molecular techniques.

Selected Publications

Chiang A, Priya R, Ramaswami M, Vijayraghavan K and Rodrigues V (2009). Neuronal activity andWnt signaling act through Gsk3β to regulate axonal integrity in mature Drosophila olfactory sensory neurons. Development.136:1273-1282.

Kumar V, Fricke R, Bhar D, Reddy-Alla S, Krishnan KS, Bogdan S and Ramaswami M (2009). Syndapin promotes formation of a postsynaptic membrane system in Drosophila. Mol. Biol. Cell. 20: 2254-2264.

Kim SM, Kumar V, Lin YQ, Karunanithi S and Ramaswami M (2009). Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse. Proc. Natl. Acad. Sci. U S A. 106: 4000-4005.

Kumar V, Alla SR, Krishnan KS, Ramaswami M (2009). Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction. Mol. Cell Neurosci. 40: 234-241.

Beckham C, Hilleker A, Cziko AM, Noueiry A, Ramaswami M and Parker R (2008). The DEAD-Box RNA helicase Ded1p affects and accumulates in yeast P-bodies. Mol. Biol. Cell. 9: 984-993.

Wu CF and Ramaswami M (2007). The Origins of Neurogenetics. J. Neurogenet. 21: 165-167

Research Funding

Science Foundation Ireland, Wellcome Trust, Department of Biotechnology (India)