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Dr. Maeve Caldwell

Position: Professor in Neuroscience
Contact: Department of Physiology, School of Medicine, Trinity College Dublin
Email: caldwelm@tcd.ie
Tel: 353-01-896-4852

Research Interests

My research interest is in utilising human induced pluripotent stem cell technology to understand complex neurodegenerative diseases; having a particular interest in Parkinson's and Alzheimer's disease. I am also interested in adult neurogenesis and how that is affected in animal models of both of these diseases.

Recent Publications

1: Zhu B, Caldwell M, Song B. Development of stem cell-based therapies for
Parkinson's disease. Int J Neurosci. 2016 Feb 28:1-8. [Epub ahead of print]

2: Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA, Cullen PJ, Liu J,
Zhu X. Parkinson's disease-associated mutant VPS35 causes mitochondrial
dysfunction by recycling DLP1 complexes. Nat Med. 2016 Jan;22(1):54-63. doi:
10.1038/nm.3983. Epub 2015 Nov 30.

3: Nistor PA, May PW, Tamagnini F, Randall AD, Caldwell MA. Long-term culture of
pluripotent stem-cell-derived human neurons on diamond--A substrate for
neurodegeneration research and therapy. Biomaterials. 2015 Aug;61:139-49. doi:
10.1016/j.biomaterials.2015.04.050. Epub 2015 May 20.

4: Damseh N, Danson CM, Al-Ashhab M, Abu-Libdeh B, Gallon M, Sharma K, Yaacov B,
Coulthard E, Caldwell MA, Edvardson S, Cullen PJ, Elpeleg O. A defect in the
retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and
neurodegeneration. Neurogenetics. 2015 Jul;16(3):215-21. doi:
10.1007/s10048-015-0446-0. Epub 2015 Apr 17.

5: Cordero-Llana Ó, Houghton BC, Rinaldi F, Taylor H, Yáñez-Muñoz RJ, Uney JB,
Wong LF, Caldwell MA. Enhanced efficacy of the CDNF/MANF family by combined
intranigral overexpression in the 6-OHDA rat model of Parkinson's disease. Mol
Ther. 2015 Feb;23(2):244-54. doi: 10.1038/mt.2014.206. Epub 2014 Nov 5.

6: McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL,
Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ. Retromer binding to FAM21 and the
WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
Curr Biol. 2014 Jul 21;24(14):1670-6. doi: 10.1016/j.cub.2014.06.024. Epub 2014
Jul 3. Erratum in: Curr Biol. 2014 Jul 21;24(14):1678. Whone, Alan L [added].

7: Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA. Galanin
promotes neuronal differentiation from neural progenitor cells in vitro and
contributes to the generation of new olfactory neurons in the adult mouse brain.
Exp Neurol. 2014 Jun;256:93-104. doi: 10.1016/j.expneurol.2014.04.001. Epub 2014
Apr 12. PubMed PMID: 24726665.

8: Rinaldi F, Caldwell MA. Modeling astrocytic contribution toward
neurodegeneration with pluripotent stem cells: focus on Alzheimer's and
Parkinson's diseases. Neuroreport. 2013 Dec 18;24(18):1053-7. doi:
10.1097/WNR.0000000000000064. Review. PubMed PMID: 24201446.

9: Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL,
Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA. Stepwise,
non-adherent differentiation of human pluripotent stem cells to generate basal
forebrain cholinergic neurons via hedgehog signaling. Stem Cell Res. 2013
Nov;11(3):1206-21. doi: 10.1016/j.scr.2013.08.002. Epub 2013 Aug 9. PubMed PMID:
24013066.

10: Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB, Caldwell MA. Hypoxic
culture of human pluripotent stem cell lines is permissible using mouse embryonic
fibroblasts. Regen Med. 2012 Sep;7(5):675-83. doi: 10.2217/rme.12.55. PubMed
PMID: 22954438.

11: Höglinger GU, Barker RA, Hagg T, Arias-Carrión O, Caldwell MA, Hirsch EC.
Quantitative evaluation of the human subventricular zone. Brain. 2012 Aug;135(Pt
8):e221, 1-4; author reply e222, 1-6. doi: 10.1093/brain/aws087. Epub 2012 Apr
25. PubMed PMID: 22539257.

12: Hartfield EM, Rinaldi F, Glover CP, Wong LF, Caldwell MA, Uney JB. Connexin
36 expression regulates neuronal differentiation from neural progenitor cells.
PLoS One. 2011 Mar 9;6(3):e14746. doi: 10.1371/journal.pone.0014746. PubMed

13: Barraud P, He X, Zhao C, Caldwell MA, Franklin RJ. FGF but not EGF induces
phosphorylation of the cAMP response element binding protein in olfactory
mucosa-derived cell cultures. Exp Cell Res. 2010 May 15;316(9):1489-99. doi:
10.1016/j.yexcr.2010.03.001. Epub 2010 Mar 6.

14: Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA, Newson R,
Lyng F, Case CP. DNA damaging bystander signalling from stem cells, cancer cells
and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutat
Res. 2010 Jan 5;683(1-2):1-8. doi: 10.1016/j.mrfmmm.2009.09.012. Epub.

15: O'Keeffe GC, Barker RA, Caldwell MA. Dopaminergic modulation of neurogenesis
in the subventricular zone of the adult brain. Cell Cycle. 2009 Sep
15;8(18):2888-94. Epub 2009 Sep 14. Review.

16: O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA.
Dopamine-induced proliferation of adult neural precursor cells in the mammalian
subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A. 2009 May
26;106(21):8754-9. doi: 10.1073/pnas.0803955106. Epub 2009 May 11. PubMed

17: Kelly S, Caldwell M, Keasey MP, Cooke JA, Uney JB. Identifying neural
progenitor cells in the adult brain. Methods Mol Biol. 2009;549:217-30. doi:
10.1007/978-1-60327-931-4_15.

18: Thomas M, Tyers P, Lazic SE, Caldwell MA, Barker RA, Beazley L, Ziman M.
Graft outcomes influenced by co-expression of Pax7 in graft and host tissue. J
Anat. 2009 Mar;214(3):396-405. doi: 10.1111/j.1469-7580.2009.01049.x. Erratum in:
J Anat. 2009 Aug;215(2):225. Caldwell, Maeve A

19: Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB. Twist-1
regulates the miR-199a/214 cluster during development. Nucleic Acids Res. 2009
Jan;37(1):123-8. doi: 10.1093/nar/gkn920. Epub 2008 Nov 23.

20: Hall PE, Lathia JD, Caldwell MA, Ffrench-Constant C. Laminin enhances the
growth of human neural stem cells in defined culture media. BMC Neurosci. 2008
Jul 23;9:71. doi: 10.1186/1471-2202-9-71.

21: Barraud P, He X, Caldwell MA, Franklin RJ. Secreted factors from olfactory
mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory
bulb neurosphere cultures. BMC Neurosci. 2008 Feb 18;9:24. doi:
10.1186/1471-2202-9-24.

22: O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell
MA. Induction of A9 dopaminergic neurons from neural stem cells improves motor
function in an animal model of Parkinson's disease. Brain. 2008 Mar;131(Pt
3):630-41. doi: 10.1093/brain/awm340. Epub 2008 Jan 17.

23: Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin
RJ. Contrasting effects of basic fibroblast growth factor and epidermal growth
factor on mouse neonatal olfactory mucosa cells. Eur J Neurosci. 2007
Dec;26(12):3345-57.

24: Prosser HM, Bradley A, Caldwell MA. Olfactory bulb hypoplasia in Prokr2 null
mice stems from defective neuronal progenitor migration and differentiation. Eur
J Neurosci. 2007 Dec;26(12):3339-44. Epub 2007 Dec 4.

25: Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA,
Rao MS, Mattson MP, ffrench-Constant C. Patterns of laminins and integrins in the
embryonic ventricular zone of the CNS. J Comp Neurol. 2007 Dec 20;505(6):630-43.

26: Anderson L, Caldwell MA. Human neural progenitor cell transplants into the
subthalamic nucleus lead to functional recovery in a rat model of Parkinson's
disease. Neurobiol Dis. 2007 Aug;27(2):133-40. Epub 2007 May 23.

27: Lim JC, Wolpaw AJ, Caldwell MA, Hladky SB, Barrand MA. Neural precursor cell
influences on blood-brain barrier characteristics in rat brain endothelial cells.
Brain Res. 2007 Jul 23;1159:67-76. Epub 2007 May 26.

28: Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE,
Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S.
Environmental signals regulate lineage choice and temporal maturation of neural
stem cells from human embryonic stem cells. Brain. 2007 May;130(Pt 5):1263-75.

29: Ormerod BK, Palmer TD, Caldwell MA. Neurodegeneration and cell replacement.
Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):153-70. Review.

30: Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P,
Menon DK, Caldwell MA. Gene expression changes in long term expanded human neural
progenitor cells passaged by chopping lead to loss of neurogenic potential in
vivo. Exp Neurol. 2007 Apr;204(2):512-24. Epub 2007 Jan 17.

31: Chandran S, Caldwell M, Allen N. Introduction: stem cells and brain repair.
Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):5-7. Review.

32: Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C. Integrins are
markers of human neural stem cells. Stem Cells. 2006 Sep;24(9):2078-84. Epub 2006
May 11.

33: Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N,
Chandran S. Automated mechanical passaging: a novel and efficient method for
human embryonic stem cell expansion. Stem Cells. 2006 Feb;24(2):230-5.

34: Caldwell MA, He X, Svendsen CN. 5-Bromo-2'-deoxyuridine is selectively toxic
to neuronal precursors in vitro. Eur J Neurosci. 2005 Dec;22(11):2965-70.

35: Strappe PM, Hampton DW, Brown D, Cachon-Gonzalez B, Caldwell M, Fawcett JW,
Lever AM. Identification of unique reciprocal and non reciprocal cross packaging
relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2
lentiviral vector system with highly favourable features for in vivo testing and
clinical usage. Retrovirology. 2005 Sep 16;2:55.

36: Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN. Heparin stabilizes
FGF-2 and modulates striatal precursor cell behavior in response to EGF. Exp
Neurol. 2004 Aug;188(2):408-20.

37: Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA.
Differentiation and migration of long term expanded human neural progenitors in a
partial lesion model of Parkinson's disease. Int J Biochem Cell Biol. 2004
Apr;36(4):702-13.

38: Lewis SJ, Caldwell MA, Barker RA. Modern therapeutic approaches in
Parkinson's disease. Expert Rev Mol Med. 2003 Mar 28;5(10):1-20. Review. PubMed

39: Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. Gene
expression in human neural stem cells: effects of leukemia inhibitory factor. J
Neurochem. 2003 Jul;86(1):179-95. PubMed PMID: 12807438.

40: Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN.
Regional specification of rodent and human neurospheres. Brain Res Dev Brain Res.
2002 Mar 31;134(1-2):43-55.

41: Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN,
Emson P. Neuronal target genes of the neuron-restrictive silencer factor in
neurospheres derived from fetuses with Down's syndrome: a gene expression study.
Lancet. 2002 Jan 26;359(9303):310-5.

Research Funding

ESPRC, BRACE