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Professor Kumlesh Dev

Professor Kumlesh K. Dev

  • Position: Professor of Neuroscience
  • Contact details: Department of Physiology, School of Medicine, Trinity College Dublin
  • Email: devk@tcd.ie
  • Telephone: 353-01-896-4180


Research Interests

The Molecular Neuropharmacology group focuses on understanding the mechanisms underlying early events of Multiple Sclerosis, Parkinson’s Disease and Alzheimer’s Disease. We aim to identify novel drug targets for these diseases by utilising a range of functional genomic screens, biochemical and cellular assays, siRNA/lentiviral gene therapy and in vivo approaches. Our aim is to characterise novel proteins involved in the trafficking of sphingosine- 1-phosphate and glutamate receptors. By controlling the surface expression of these proteins in a spatial and temporal manner, we aim to correct glial cell dysfunction and promote early events of neuronal survival. The eventual goal is to develop drugs that regulate receptor trafficking and thereby alter their function in a cell-specific and use-dependent fashion. Our ultimate objective is to identify new molecular pathways and targets, biomarkers and lead compounds for drug discovery purposes. The research activities draw upon collaborations in the academic, medical and industrial arenas.

Recent Publications

K.E. O’Connell, P. Frei, K.K. Dev. The premium of a big pharma license deal. Nature Biotechnology (2014) in press

K.E. O’Connell, T.H. Mok, B. Sweeney, A. Ryan, K.K. Dev. Cytokine signature patterns in patients with Multiple Sclerosis. Autoimmunity (2014) in press

A.J. Pritchard, A.K. Mir, K.K. Dev. S1P receptor modulation attenuates splenocyte-induced demyelination in cerebellar slice cultures. PLoS ONE(2014) 9, e99444.

G.K. Sheridan, K.K. Dev. Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. Scientific Reports (2014)23, 5051.

P. Dutta, K.E. O’Connell, S.B. Ozkan, A.W. Sailer, K.K. Dev. The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. J Neurochemistry(2014) in press

K.E. O’Connell, J. Thakore, K.K. Dev. Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine. Schizophrenia Research (2014) 156, 1-8.

G. Elain, K. Jeanneau, A. Rutkowska, A.K. Mir, and K.K. Dev. The Selective Anti-IL17A Monoclonal Antibody Secukinumab (AIN457) Attenuates IL17A-Induced Levels of IL6 in Human Astrocytes. Glia (2014) 62, 725-735.

G. Muirhead, K.K. Dev. The expression of neuronal Sorting Nexin 8 (SNX8) exacerbates abnormal cholesterol levels. J. Mol. Neurosci. (2014) 53, 125-134.

TCIN publications 2007-2009

Research Funding

Science Foundation Ireland, Health Research Board, Enterprise Ireland, Wellcome Trust, Egyptian Government Travel Awards, Novartis Pharma Basel.


Email: neuroscience@tcd.ie
Last updated 18 June 2014

Associations

In association with:
Ireland's EU Structural Funds Programmes 2007-2013, NDP, European Union Structural Funds and HEA