Dr Juan-Pablo Labrador
- Position:Lecturer in Genetics
- Contact details: Smurfit Institute of Genetics, Trinity College Dublin
- Email: email@example.com
- Telephone: 353-01-896-8429
It is estimated that in an adult human there are of the order of hundreds of billions of neurons, each of which establishes specific connections. Surface molecules expressed by each neuron will largely determine how these connections take place. Many transcription factors that control neuronal subtype specification have been identified. However, how do they ultimately control the specification of the vast array of different neurons, and how the expression of surface molecules is regulated in them is unknown. My lab is trying to understand how transcriptional codes specify neuronal identity and regulate the expression of membrane molecules. I employ a number of in vitro and in vivo approaches including high-throughput mRNA profiling, ChIP-chip, ChIP-Seq, primary neuronal culture, confocal laser scanning microscopy and a range of biochemical & molecular techniques. My research group comprises 2 post-doctoral researchers and 2 postgraduate students.
Fares, M. A., Ruiz-Gonzalez, M. X., and Labrador, J. P. (2011) Protein coadaptation and the design of novel approaches to identify protein-protein interactions, IUBMB Life 63, 264-271.
Coleman, H. A., Labrador, J. P., Chance, R. K., and Bashaw, G. J. (2010) The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline, Development 137, 2417-2426.
Science Foundation Ireland, Enterprise Ireland, Deutsche- Forschungsgemeinschaft, Irish Research Council for Science, Engineering and Technology