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Research Activities – Marta Martins, Assistant Professor in Microbiology

Antimicrobial Resistance and Host Modulation

Dr. Marta Martins, PhD  

Email:   mmartins@tcd.ie
Phone: +353-1-896 1194

https://www.tcd.ie/genetics-microbiology/assets/pdf/Martins.pd

Google Scholar link: Google Scholar Profile – Marta Martins 
(https://scholar.google.com/citations?user=BGd0aV4AAAAJ&hl=en)

Research Interests

My research addresses the significant problem of antibiotic resistance in bacteria along with aspects of the infection biology. For that, we use a combination of classical microbiology, biochemistry, cell biology, immunology and functional genomic techniques. I am particularly interested in developing novel therapeutic approaches to treat multidrug resistant bacteria associated infections.

Key Themes

•  Antibiotic resistance and New antibacterial compounds

Reversal of multidrug resistance in bacteria of clinical relevance

Efflux pump inhibitors

Novel therapeutic approaches to treat multidrug resistant bacteria (Adjuvant therapy)

•  Host modulation

Macrophage activation

Immunomodulation of infected macrophages 

•  Research Personnel

Postgraduate Students

Niamh Mohan

Daniela Alves Ferreira

•  Collaborators

Prof. Miguel Viveiros, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal.

Prof. Jean-Marie Pagès, Aix-Marseille Université, Marseille, France.

Prof. Alexandra Fernandes, New University of Lisbon, Lisbon, Portugal.

Dr. Thamarai Schneiders, University of Edinburgh, Edinburgh, UK.

•  Financial Support

Irish Research Council - Employment Based Postgraduate Programme

 

•  Interested in working with us?

We are always interested in recruiting talented people to the lab and in supporting applications for personal PhD and Postdoctoral fellowships. For further information please contact Marta directly (mmartins@tcd.ie)

 

•  Selected Publications

Martins M. and McCusker MP. 2016. Editorial: “Alternative therapeutics against MDR bacteria – fighting the epidemic of antibiotic resistance”. Frontiers in Microbiology 7:1559. doi: 10.3389/fmicb.2016.01559

Brennan E*, Martins M* , McCusker MP, Wang J, Martins Alves B, Hurley D, El Garch F, Woehrlé F, Miossec C, McGrath L, Sriumar S, Wall P, Fanning S. 2016. Characterisation of multidrug-resistant Escherichia coli cultured from bovine animals in Europe: identification of the mcr-1 gene in a bacterium of animal origin co-resistant to ß-lactams, florfenicol and fluoroquinolones. Emerging Infectious Diseases. 22(9): 1650-1652. *equal contribution by the authors.

Machado D, Pires D, Perdigão J, Couto I, Portugal I, Martins M , Amaral L, Anes E, Viveiros M. 2016. Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis . PLoS One. 26;11(2):e0149326.

João Anes, Matthew P. McCusker, Séamus Fanning and Marta Martins. 2015. The Ins and Outs of RND Efflux pumps in Escherichia coli . Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy. Research Topic Title: Bad bugs in the XXIth century: resistance mediated by multi-drug efflux pumps. Front Microbiol. 6: 587.

I. Roca, M. Akova, F. Baquero, J. Carlet, M. Cavaleri, S. Coenen, J. Cohen, D. Findlay, I. Gyssens, O. E. Heure, G. Kahlmeter, H. Kruse, R. Laxminarayan, E. Liébana, L. López-Cerero, A. MacGowan, M. Martins , J. Rodríguez-Baño, J.-M. Rolain, C. Segovia, B. Sigauque, E. Taconelli, E. Wellington and J. Vila. 2015. The global threat of Antimicrobial Resistance: Science for Intervention. New Microbe and New Infect 2015; 6: 22–29.

Click here for full list of publications  (publications)


Last updated 12 January 2017 by Microbiology (Email).