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You are here Research > Research Groups > Staphylococcal Pathogenesis

Dr. Joan Geoghegan
Assistant Professor, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Zapotoczna M, Riboldi GP, Moustafa AM, Dickson E, Narechania A, Morrissey JA, Planet PJ, Holden MTG, Waldron KJ, Geoghegan JA., Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes., mBio, 9, (5), 2018 Journal Article, 2018 DOI

Herman-Bausier P, Labate C, Towell AM, Derclaye S, Geoghegan JA, Dufrêne YF, Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion, Proceedings of the National Academy of Sciences of the United States, 2018, p10.1073/pnas.1718104115 Journal Article, 2018 URL

Fleury, O.M., McAleer, M.A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D.E., Towell, A.M., McLean, W.H.I., Kezic, S., Robinson, D.A., Fallon, P.G., Foster, T.J., Dufrêne, Y.F., Irvine, A.D., Geoghegan, J.A., Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis, Infection and Immunity, 85, (6), 2017, ppii: e00994-16 Journal Article, 2017 TARA - Full Text

O Halloran DP, Wynne K, Geoghegan JA, Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal., Infection and immunity, 83, (4), 2015, p1598-609 Journal Article, 2015 TARA - Full Text

Feuillie C, Formosa-Dague C, Hays LM, Vervaeck O, Derclaye S, Brennan MP, Foster TJ, Geoghegan JA, Dufrêne YF., Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC., Proceedings of the National Academy of Sciences of the United States of America, 114, (14), 2017, p3738-3743 Journal Article, 2017 DOI

Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF., Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels., mBio, 9, (4), 2018 Journal Article, 2018 DOI

Purves J, Thomas J, Riboldi GP, Zapotoczna M, Tarrant E, Andrew PW, Londoño A, Planet PJ, Geoghegan JA, Waldron KJ, Morrissey JA., A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages., Environmental microbiology, 20, (4), 2018, p1576-1589 Journal Article, 2018 DOI

Vitry P, Valotteau C, Feuillie C, Bernard S, Alsteens D, Geoghegan JA, Dufrêne YF., Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin., mBio, 8, (6), 2017 Journal Article, 2017 DOI

Speziale P, Geoghegan JA, Biofilm formation by staphylococci and streptococci: structural, functional, and regulatory aspects and implications for pathogenesis., Frontiers in cellular and infection microbiology, 5, 2015, p31 Journal Article, 2015 DOI TARA - Full Text

Geoghegan JA, Irvine AD, Foster TJ., Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship., Trends in microbiology, 2017 Journal Article, 2017 DOI

Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17 - Journal Article, 2017 DOI TARA - Full Text

McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA., Fibronectin binding proteins are required for biofilm formation by community-associated methicillin resistant Staphylococcus aureus strain LAC, FEMS Microbiology Letters, 353, (2), 2014, p157 - 164 Journal Article, 2014 TARA - Full Text

Formosa-Dague C, Fu ZH, Feuillie C, Derclaye S, Foster TJ, Geoghegan JA, Dufrene YF, Forces between Staphylococcus aureus and human skin, Nanoscale Horizons, 2016, p298 - 303 Journal Article, 2016

McCormack N, Foster TJ, Geoghegan JA, A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display., Microbiology (Reading, England), 160, (4), 2014, p659-670 Journal Article, 2014 DOI TARA - Full Text

Pietrocola G, Nobile G, Alfeo MJ, Foster TJ, Geoghegan JA, De Filippis V, Speziale P., Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones., The Journal of biological chemistry, 2019, p3588-3602 Journal Article, 2019 TARA - Full Text DOI

Speziale P, Pietrocola G, Foster TJ, Geoghegan JA, Protein-based biofilm matrices in Staphylococci., Frontiers in cellular and infection microbiology, 4, 2014, p171 Journal Article, 2014 TARA - Full Text DOI

Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P, Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus., The Journal of biological chemistry, 291, (35), 2016, p18148-62 Journal Article, 2016 DOI TARA - Full Text

Foster TJ, Geoghegan JA, Ganesh VK, Höök M, Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus., Nature reviews. Microbiology, 12, (1), 2014, p49-62 Journal Article, 2014 DOI

Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Foster TJ, Dufrêne YF, The binding force of the staphylococcal adhesin SdrG is remarkably strong., Molecular microbiology, 93, (2), 2014, p356-368 Journal Article, 2014 DOI

Missineo A, Di Poto A, Geoghegan JA, Rindi S, Heilbronner S, Gianotti V, Arciola CR, Foster TJ, Speziale P, Pietrocola G, IsdC from Staphylococcus lugdunensis Induces Biofilm Formation under Low-Iron Growth Conditions., Infection and immunity, 82, (6), 2014, p2448-59 Journal Article, 2014 TARA - Full Text DOI

Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484 Journal Article, 2014 TARA - Full Text DOI

Geoghegan JA, Monk IR, O'Gara JP, Foster TJ, Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms., Journal of bacteriology, 195, (11), 2013, p2675-83 Journal Article, 2013 DOI TARA - Full Text

Hair PS, Foley CK, Krishna NK, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM, Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing., Results in immunology, 3, 2013, p114-21 Journal Article, 2013 TARA - Full Text DOI

Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Vanzieleghem T, Foster TJ, Hols P, Mahillon J, Dufrêne YF, Forces driving the attachment of Staphylococcus epidermidis to fibrinogen-coated surfaces., Langmuir, 29, (42), 2013, p13018 - 13022 Journal Article, 2013

Planet PJ, Larussa SJ, Dana A, Smith H, Xu A, Ryan C, Uhlemann AC, Boundy S, Goldberg J, Narechania A, Kulkarni R, Ratner AJ, Geoghegan JA, Kolokotronis SO, Prince A, Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin., mBio, 4, (6), 2013 Journal Article, 2013 DOI TARA - Full Text

Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489 Journal Article, 2013 DOI

Pietrocola G, Geoghegan JA, Rindi S, Di Poto A, Missineo A, Consalvi V, Foster TJ, Speziale P, Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins., PloS one, 8, (6), 2013, pe66901 Journal Article, 2013

Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092 Journal Article, 2012 DOI TARA - Full Text

Caly DL, Coulthurst SJ, Geoghegan JA, Malone JG, Ryan RP, Socializing, networking and development: a report from the second 'Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis'., Molecular microbiology, 86, (3), 2012, p501-12 Journal Article, 2012

Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM, Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic., PloS one, 7, (5), 2012, pe38407 Journal Article, 2012 DOI TARA - Full Text

Gruszka DT, Wojdyla JA, Bingham RJ, Turkenburg JP. Manfield IW, Steward A, Leech AP, Geoghegan JA, Foster TJ, Clarke J, Potts JR., Staphylococcal biofilm-forming protein has a contiguous rod-like structure , Proceedings of the National Academy of Sciences USA, 109, (17), 2012, p1011 - 1018 Journal Article, 2012 DOI

Smith EJ, Corrigan RM, van der Sluis T, Gründling A, Speziale P, Geoghegan JA, Foster TJ, The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid, Molecular Microbiology, 83, (4), 2012, p789 - 804 Journal Article, 2012 TARA - Full Text

Heilbronner S, Holden MT, van Tonder A, Geoghegan JA, Foster TJ, Parkhill J, Bentley SD, Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors., FEMS microbiology letters, 322, (1), 2011, p60-7 Journal Article, 2011 TARA - Full Text DOI

Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ, Role of surface protein SasG in biofilm formation by Staphylococcus aureus., Journal of bacteriology, 192, (21), 2010, p5663-5673 Journal Article, 2010 DOI TARA - Full Text

Provenza G, Provenzano M, Visai L, Burke FM, Geoghegan JA, Stravalaci M, Gobbi M, Mazzini G, Arciola CR, Foster TJ, Speziale P, Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus., The FEBS journal, 277, (21), 2010, p4490-505 Journal Article, 2010 TARA - Full Text DOI

Hair, PS, Echague, CG, Sholl, AM, Watkins, JA, Geoghegan, JA, Foster, TJ, Cunnion, KM, Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis, Infection and Immunity, 78, (4), 2010, p1717 - 1727 Journal Article, 2010 TARA - Full Text

Geoghegan JA, Ganesh VK, Smeds E, Liang X, Hook M, Foster TJ, Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen, Journal of Biological Chemistry, 285, (9), 2010, p6208 - 6216 Journal Article, 2010 TARA - Full Text DOI

Geoghegan, J.A., Smith, E.J., Speziale, P., Foster, T.J., Staphylococcus pseudintermedius expresses surface proteins that closely resemble those from Staphylococcus aureus, Veterinary Microbiology, 138, (3-4), 2009, p345-352 Journal Article, 2009 DOI

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445- Journal Article, 2015 DOI TARA - Full Text

Pietrocola G, Gianotti V, Richards A, Nobile G, Geoghegan JA, Rindi S, Monk IR, Bordt AS, Foster TJ, Fitzgerald JR, Speziale P, Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius., Infection and immunity, 83, (10), 2015, p4093-102 Journal Article, 2015 DOI

Kwiecinski J, Peetermans M, Liesenborghs L, Na M, Björnsdottir H, Zhu X, Jacobsson G, Johansson BR, Geoghegan JA, Foster TJ, Josefsson E, Bylund J, Verhamme P, Jin T, Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation., The Journal of infectious diseases, 2015, p139-148 Journal Article, 2015 DOI TARA - Full Text

Herman-Bausier P, El-Kirat-Chatel S, Foster TJ, Geoghegan JA, Dufrêne YF, Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds., mBio, 6, (3), 2015, pe00413-15 Journal Article, 2015 TARA - Full Text

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226 Journal Article, 2015 DOI TARA - Full Text

Conlon, B.P. Geoghegan, J.A. Waters, E.M. McCarthy, H. Rowe, S.E. Davies, J.R. Schaeffer, C.R. Foster, T.J. Fey, P.D. O'Gara, J.P., Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype, Journal of Bacteriology, 196, (24), 2014, p4268 - 4275 Journal Article, 2014 URL DOI

Formosa-Dague C, Speziale P, Foster TJ, Geoghegan JA, Dufrêne YF, Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG., Proceedings of the National Academy of Sciences of the United States of America, 113, (2), 2016, p410-5 Journal Article, 2016 DOI

Geoghegan JA, Foster TJ, Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions., Current topics in microbiology and immunology, 2016, p1 - 26 Journal Article, 2016

Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22- Journal Article, 2016 DOI TARA - Full Text

Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P, CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria., Cell host & microbe, 20, (1), 2016, p99-106 Journal Article, 2016 DOI

Nugent M, Wang J, Lawrence G, Zurawski T, Geoghegan JA, Dolly JO., Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF., Bioconjugate chemistry, 28, (6), 2017, p1684-1692 Journal Article, 2017 DOI

Geoghegan JA, Foster TJ, Speziale P, Dufrêne YF., Live-Cell Nanoscopy in Antiadhesion Therapy., Trends in microbiology, 25, (7), 2017, p512-514 Journal Article, 2017 DOI

Ganesh VK, Liang X, Geoghegan JA, Cohen AL, Venugopalan N, Foster TJ, Hook M., Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody., EBioMedicine, 13, 2016, p328-338 Journal Article, 2016 DOI

Frontiers in Cellular and Infection Microbiology, (2015), Speziale P, Geoghegan JA, [eds.] Journal, 2015

Tarowski A, Foster T, Higgins J, Josefsson E, Geoghegan J, 'Treatment of Microbial Infections', International Patent Publication, 2014 Patent, 2014 Other

Miajlovic, H., Zapotoczna, M., Geoghegan, J.A., Kerrigan, S.W., Speziale, P., Foster, T.J., Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets, Microbiology, 156, (3), 2010, p920-928 Journal Article, 2010 TARA - Full Text DOI

Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG., The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis., The British journal of dermatology, 2018 Journal Article, 2018 DOI

Geoghegan JA, Dufrêne YF., Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion., Trends in microbiology, 26, (8), 2018, p645-648 Journal Article, 2018 DOI

Pickering AC, Vitry P, Prystopiuk V, Garcia B, Höök M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR., Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion., PLoS pathogens, 15, (6), 2019, pe1007816 Journal Article, 2019 DOI

Non-Peer-Reviewed Publications

Staphylococcus aureus in, editor(s)Tang Y, Sussman M, Liu D, Poxton I and Schwartzman , Molecular Medical Microbiology, Boston, J. Academic Press, 2015, pp655 - 674, [Foster TJ, Geoghegan JA] Book Chapter, 2015

Research Expertise

Keywords

Bacteria; BACTERIAL ADHESION; BACTERIAL BIOFILMS; BACTERIAL-ANTIGENS; BACTERIOLOGY; COMPLEMENT; Infection; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; Molecular Biology; Molecular Genetics; STAPHYLOCOCCI; Vaccines

Recognition

Representations

Chair-elect, Irish Division of the Microbiology Society 2018

Memberships

Chair-elect of the Irish Division of Microbiology Society 2018 – 2020

Society Conferences Committee Member, Microbiology Society, UK 2018 – 2022

Microbiology Society (Member) 2006

American Society for Microbiology (Member) 2012

Society for Applied Microbiology (Member) 2012

Healthcare Infection Society 2017 – 2018

European Society of Clinical Microbiology and Infectious Diseases 2017 – 2018