Joan Geoghegan
Assistant Professor, Microbiology
Publications and Further Research Outputs
Peer-Reviewed Publications
Zapotoczna M, Riboldi GP, Moustafa AM, Dickson E, Narechania A, Morrissey JA, Planet PJ, Holden MTG, Waldron KJ, Geoghegan JA., Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes., mBio, 9, (5), 2018
Herman-Bausier P, Labate C, Towell AM, Derclaye S, Geoghegan JA, Dufrêne YF, Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion, Proceedings of the National Academy of Sciences of the United States, 2018, p10.1073/pnas.1718104115
Fleury, O.M., McAleer, M.A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D.E., Towell, A.M., McLean, W.H.I., Kezic, S., Robinson, D.A., Fallon, P.G., Foster, T.J., Dufrêne, Y.F., Irvine, A.D., Geoghegan, J.A., Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis, Infection and Immunity, 85, (6), 2017, ppii: e00994-16
O Halloran DP, Wynne K, Geoghegan JA, Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal., Infection and immunity, 83, (4), 2015, p1598-609
Feuillie C, Formosa-Dague C, Hays LM, Vervaeck O, Derclaye S, Brennan MP, Foster TJ, Geoghegan JA, Dufrêne YF., Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC., Proceedings of the National Academy of Sciences of the United States of America, 114, (14), 2017, p3738-3743
Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF., Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels., mBio, 9, (4), 2018
Purves J, Thomas J, Riboldi GP, Zapotoczna M, Tarrant E, Andrew PW, Londoño A, Planet PJ, Geoghegan JA, Waldron KJ, Morrissey JA., A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages., Environmental microbiology, 20, (4), 2018, p1576-1589
Vitry P, Valotteau C, Feuillie C, Bernard S, Alsteens D, Geoghegan JA, Dufrêne YF., Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin., mBio, 8, (6), 2017
Speziale P, Geoghegan JA, Biofilm formation by staphylococci and streptococci: structural, functional, and regulatory aspects and implications for pathogenesis., Frontiers in cellular and infection microbiology, 5, 2015, p31
Geoghegan JA, Irvine AD, Foster TJ., Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship., Trends in microbiology, 2017
Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17 -
McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA., Fibronectin binding proteins are required for biofilm formation by community-associated methicillin resistant Staphylococcus aureus strain LAC, FEMS Microbiology Letters, 353, (2), 2014, p157 - 164
Formosa-Dague C, Fu ZH, Feuillie C, Derclaye S, Foster TJ, Geoghegan JA, Dufrene YF, Forces between Staphylococcus aureus and human skin, Nanoscale Horizons, 2016, p298 - 303
McCormack N, Foster TJ, Geoghegan JA, A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display., Microbiology (Reading, England), 160, (4), 2014, p659-670
Pietrocola G, Nobile G, Alfeo MJ, Foster TJ, Geoghegan JA, De Filippis V, Speziale P., Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones., The Journal of biological chemistry, 2019, p3588-3602
Speziale P, Pietrocola G, Foster TJ, Geoghegan JA, Protein-based biofilm matrices in Staphylococci., Frontiers in cellular and infection microbiology, 4, 2014, p171
Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P, Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus., The Journal of biological chemistry, 291, (35), 2016, p18148-62
Foster TJ, Geoghegan JA, Ganesh VK, Höök M, Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus., Nature reviews. Microbiology, 12, (1), 2014, p49-62
Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Foster TJ, Dufrêne YF, The binding force of the staphylococcal adhesin SdrG is remarkably strong., Molecular microbiology, 93, (2), 2014, p356-368
Missineo A, Di Poto A, Geoghegan JA, Rindi S, Heilbronner S, Gianotti V, Arciola CR, Foster TJ, Speziale P, Pietrocola G, IsdC from Staphylococcus lugdunensis Induces Biofilm Formation under Low-Iron Growth Conditions., Infection and immunity, 82, (6), 2014, p2448-59
Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484
Geoghegan JA, Monk IR, O'Gara JP, Foster TJ, Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms., Journal of bacteriology, 195, (11), 2013, p2675-83
Hair PS, Foley CK, Krishna NK, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM, Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing., Results in immunology, 3, 2013, p114-21
Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Vanzieleghem T, Foster TJ, Hols P, Mahillon J, Dufrêne YF, Forces driving the attachment of Staphylococcus epidermidis to fibrinogen-coated surfaces., Langmuir, 29, (42), 2013, p13018 - 13022
Planet PJ, Larussa SJ, Dana A, Smith H, Xu A, Ryan C, Uhlemann AC, Boundy S, Goldberg J, Narechania A, Kulkarni R, Ratner AJ, Geoghegan JA, Kolokotronis SO, Prince A, Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin., mBio, 4, (6), 2013
Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489
Pietrocola G, Geoghegan JA, Rindi S, Di Poto A, Missineo A, Consalvi V, Foster TJ, Speziale P, Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins., PloS one, 8, (6), 2013, pe66901
Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092
Caly DL, Coulthurst SJ, Geoghegan JA, Malone JG, Ryan RP, Socializing, networking and development: a report from the second 'Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis'., Molecular microbiology, 86, (3), 2012, p501-12
Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM, Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic., PloS one, 7, (5), 2012, pe38407
Gruszka DT, Wojdyla JA, Bingham RJ, Turkenburg JP. Manfield IW, Steward A, Leech AP, Geoghegan JA, Foster TJ, Clarke J, Potts JR., Staphylococcal biofilm-forming protein has a contiguous rod-like structure , Proceedings of the National Academy of Sciences USA, 109, (17), 2012, p1011 - 1018
Smith EJ, Corrigan RM, van der Sluis T, Gründling A, Speziale P, Geoghegan JA, Foster TJ, The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid, Molecular Microbiology, 83, (4), 2012, p789 - 804
Heilbronner S, Holden MT, van Tonder A, Geoghegan JA, Foster TJ, Parkhill J, Bentley SD, Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors., FEMS microbiology letters, 322, (1), 2011, p60-7
Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ, Role of surface protein SasG in biofilm formation by Staphylococcus aureus., Journal of bacteriology, 192, (21), 2010, p5663-5673
Provenza G, Provenzano M, Visai L, Burke FM, Geoghegan JA, Stravalaci M, Gobbi M, Mazzini G, Arciola CR, Foster TJ, Speziale P, Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus., The FEBS journal, 277, (21), 2010, p4490-505
Hair, PS, Echague, CG, Sholl, AM, Watkins, JA, Geoghegan, JA, Foster, TJ, Cunnion, KM, Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis, Infection and Immunity, 78, (4), 2010, p1717 - 1727
Geoghegan JA, Ganesh VK, Smeds E, Liang X, Hook M, Foster TJ, Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen, Journal of Biological Chemistry, 285, (9), 2010, p6208 - 6216
Geoghegan, J.A., Smith, E.J., Speziale, P., Foster, T.J., Staphylococcus pseudintermedius expresses surface proteins that closely resemble those from Staphylococcus aureus, Veterinary Microbiology, 138, (3-4), 2009, p345-352
O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445-
Pietrocola G, Gianotti V, Richards A, Nobile G, Geoghegan JA, Rindi S, Monk IR, Bordt AS, Foster TJ, Fitzgerald JR, Speziale P, Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius., Infection and immunity, 83, (10), 2015, p4093-102
Kwiecinski J, Peetermans M, Liesenborghs L, Na M, Björnsdottir H, Zhu X, Jacobsson G, Johansson BR, Geoghegan JA, Foster TJ, Josefsson E, Bylund J, Verhamme P, Jin T, Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation., The Journal of infectious diseases, 2015, p139-148
Herman-Bausier P, El-Kirat-Chatel S, Foster TJ, Geoghegan JA, Dufrêne YF, Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds., mBio, 6, (3), 2015, pe00413-15
Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226
Conlon, B.P. Geoghegan, J.A. Waters, E.M. McCarthy, H. Rowe, S.E. Davies, J.R. Schaeffer, C.R. Foster, T.J. Fey, P.D. O'Gara, J.P., Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype, Journal of Bacteriology, 196, (24), 2014, p4268 - 4275
Formosa-Dague C, Speziale P, Foster TJ, Geoghegan JA, Dufrêne YF, Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG., Proceedings of the National Academy of Sciences of the United States of America, 113, (2), 2016, p410-5
Geoghegan JA, Foster TJ, Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions., Current topics in microbiology and immunology, 2016, p1 - 26
Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22-
Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P, CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria., Cell host & microbe, 20, (1), 2016, p99-106
Nugent M, Wang J, Lawrence G, Zurawski T, Geoghegan JA, Dolly JO., Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF., Bioconjugate chemistry, 28, (6), 2017, p1684-1692
Geoghegan JA, Foster TJ, Speziale P, Dufrêne YF., Live-Cell Nanoscopy in Antiadhesion Therapy., Trends in microbiology, 25, (7), 2017, p512-514
Ganesh VK, Liang X, Geoghegan JA, Cohen AL, Venugopalan N, Foster TJ, Hook M., Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody., EBioMedicine, 13, 2016, p328-338
Frontiers in Cellular and Infection Microbiology, (2015), Speziale P, Geoghegan JA, [eds.]
Tarowski A, Foster T, Higgins J, Josefsson E, Geoghegan J, 'Treatment of Microbial Infections', International Patent Publication, 2014
Miajlovic, H., Zapotoczna, M., Geoghegan, J.A., Kerrigan, S.W., Speziale, P., Foster, T.J., Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets, Microbiology, 156, (3), 2010, p920-928
Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG., The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis., The British journal of dermatology, 2018
Geoghegan JA, Dufrêne YF., Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion., Trends in microbiology, 26, (8), 2018, p645-648
Pickering AC, Vitry P, Prystopiuk V, Garcia B, Höök M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR., Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion., PLoS pathogens, 15, (6), 2019, pe1007816
Non-Peer-Reviewed Publications
Staphylococcus aureus in, editor(s)Tang Y, Sussman M, Liu D, Poxton I and Schwartzman , Molecular Medical Microbiology, Boston, J. Academic Press, 2015, pp655 - 674, [Foster TJ, Geoghegan JA]
Research Expertise
Recognition
Representations
Chair-elect, Irish Division of the Microbiology Society
Memberships
Chair-elect of the Irish Division of Microbiology Society
Society Conferences Committee Member, Microbiology Society, UK
Microbiology Society (Member)
American Society for Microbiology (Member)
Society for Applied Microbiology (Member)
Healthcare Infection Society
European Society of Clinical Microbiology and Infectious Diseases