Research Activities – Professor J. Geoghegan
Joan Geoghegan, B.A., Ph.D.
- Research Interests
Our research focuses on Staphylococcus aureus , an important cause of invasive infection in humans. Methicillin-resistant S. aureus (MRSA) causes significant morbidity and mortality and new therapeutic approaches are urgently needed.
Our group are studying the bacterial factors that allow S. aureus to successfully colonise and infect the human host. Our approach involves the molecular analysis of virulence-associated proteins of staphylococci and characterisation of factors influencing protein secretion and processing, antibiotic resistance, survival in neutrophils and macrophages and bacterial adhesion and biofilm formation.
One aim of our work is to identify new targets for the treatment and prevention of S. aureus infection.
- Recent Publications
Formosa-Dague C, Speziale P, Foster TJ, Geoghegan JA * ,Dufrêne YF* (2016) Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG. Proceedings of the National Academy of Sciences. 113(2):410-5.
Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA * and Speziale P * (2016) Molecular interactions of human plasminogen with FnBPB, a fibrinogen/fibronectin-binding protein from Staphylococcus aureus . Journal of Biological Chemistry. 291(35):18148-62.
Ganesh VK #, Liang X#, Geoghegan JA#, Cohen ALV, Venugopalan N, Foster TJ, Hook M (2016) Lessons from the crystal structure of the Staphylococcus aureus surface protein clumping factor A in complex with tefibazumab, an inhibiting monoclonal antibody. EBioMedicine (http://dx.doi.org/10.1016/j.ebiom.2016.09.027)
Formosa-Dague C, Fu ZH, Feuillie C, Derclaye S, Foster TJ, Geoghegan JA*, Dufrene YF* (2016) Forces between Staphylococcus aureus and human skin. NanoScale Horizons. 1:298-303.
O'Halloran DP, Wynne K, Geoghegan JA. (2015) Protein A is released into the Staphylococcus aureus culture supernatant with an unprocessed sorting signal. Infection and Immunity. 83(4):1598-609.
- Click here for full list of publications (publications)
- Research Personnel
Dr Marta Zapotoczna email@example.com
- Financial support