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New publication involving the Kröger Lab

High-resolution intracellular transcriptome of Salmonella enterica unveiled by Liverpool and Dublin microbiologists.

A comprehensive picture of gene expression of Salmonella enterica surviving inside macrophages has just been published. The study involved Jay Hinton (Professor of Microbial Pathogenesis, Institute of Integrative Biology, University of Liverpool), Carsten Kröger (Assistant Professor in Microbiology, Moyne Institute of Preventive Medicine, Department of Microbiology, TCD) and Dr Shabarinath Srikumar (Centre for Food Safety, UCD).

The Salmonella coding genes and transcriptional start sites that are expressed within macrophages during infection were defined. The transcriptional landscape of 280 small RNA molecules was determined at the level of the individual nucleotide. These data contribute to our understanding of the intricate transcriptional network that controls the “right time/ right place” expression of Salmonella virulence genes during intra-macrophage replication.

The study was funded by Science Foundation Ireland (SFI; Grants 08/IN.1/B2104 and 07/IN.1/B918) and the University of Liverpool.

The data have been made publically available in the “SalComMac” database with the help of Dr Karsten Hokamp (SFI Bioinformatics Research Officer, Smurfit Institute of Genetics, TCD): http://tinyu rl.com/SalComMac

The full study, published in PLoS Pathogens, can be accessed here: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005262