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Research Vacancy


Post Doctoral Research Fellow Investigating Host-Pathogen Interactions


Position description:
Applications are invited for an ambitious postdoctoral research position in cellular immunology funded by the Wellcome Trust. The postdoctoral fellow will lead an exciting new project investigating the impact of the bacterium Staphylococcus aureus on the immune system during commensal colonisation. This project will employ a range of immunological techniques to investigate immune memory associated with S. aureus colonisation in the healthy population.

The successful candidate will join the Host-Pathogen Interactions group led by Dr Rachel McLoughlin at the School of Biochemistry and Immunology at Trinity College Dublin (https://www.tcd.ie/Biochemistry/research/r_mcloughlin.php) The School of Biochemistry and Immunology provides a dynamic and stimulating environment and the candidate will have the opportunity to interact with world-class immunology researchers working in areas such as innate immunity, vaccine development and immuometabolism.

We are looking for a highly motived candidate with a strong background in immunology, ideally in the context of infection. Candidates should also have experience with in vivo models, flow cytometery and working with primary human cells. The postdoc will actively support PhD students and undergraduate students in the lab, present at national and international meetings and publish in leading international journals.

Scientific Background: The WHO highlights the epidemic of antibiotic resistance in Staphylococcus aureus (MRSA) as a particular threat to society, strongly advocating for the development of alternatives to antibiotics. Over the past 15 years significant efforts have been made to develop an anti-S. aureus vaccine but to-date none have been successful. What is it about S. aureus that makes it so difficult to vaccinate against? The primary goal in the lab is to address this question. Specifically, this program will investigate the influence of S. aureus colonisation on the host immune system. In addition to causing severe invasive disease, S. aureus lives innocuously in the nasal passages of the majority of the population. However, we understand very little about how exposure to S. aureus in this context affects our immune system or how this exposure might influence our ability to respond to a vaccine against this organism.

Requirements: A PhD in Immunology or cell biology with proven publication record and excellent communication skills.

Closing Date for applications: Jan 31st 2018 or until a suitable candidate is identified

Please submit a covering letter and CV (include the names and contact details of 2 referees) to: rachel.mcloughlin@tcd.ie
Trinity College Dublin is an equal opportunities employer.


Last updated 15 February 2018 bbutler@tcd.ie (Email).