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Dr Vincent Kelly

tRNA Biology

Rakovich T, Boland C, Bernstein I, Chikwana VM, Iwata-Reuyl D, Kelly VP. (2011) Queuosine Deficiency in Eukaryotes Compromises Tyrosine Production through Increased Tetrahydrobiopterin Oxidation. J Biol Chem. 286(22):19354-63.

Kawatani Y, Suzuki T, Kelly VP, and Yamamoto M (2010) Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. Blood. 2011 Jan 20;117(3):986-96.

Chen YC, Kelly VP, Stachura SV, Garcia GA. (2010) Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. RNA. 16: 958

Rakovich A, Savateeva D, Rakovich T, Donegan JF, Rakovich YP, Kelly VP, Lesnyak V, and Eychmuller A. (2010) CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy. Nanoscale Research Letters 5:753-760

Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF (2010) Photosensitizer Methylene Blue-Semiconductor Nanocrystals Hybrid System for Photodynamic Therapy J. Nanosci. Nanotechnol. 10:2656–2662

MacLeod KA, Kelly VP , Higgins LG, Kelleher MO, Price S, Bigley AL, Betton GR, Hayes JD (2010) Expression and localisation of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants. Drug Metab Dispos. 38:341-6.

Boland C, Hayes PA, Santa-Maria I, Nishimura S and Kelly VP, (2009) Queuosine formation in eukaryotic tRNA occurs via a mitochondrial localized heteromeric transglycoslase. J. Biol. Chem. 284(27):18218-18227

Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M. (2008) Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J. Biol. Chem. 283(4):2021-30.

Arai T, Kelly VP, Minowa O, Noda T, Nishimura S. (2006) The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA. Toxicology 221:179-186

Kobayashi T, Takimura T, Sekine R, Kelly VP, Kamata K, Sakamoto K, Nishimura S, Yokoyama S. (2005) Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase J. Mol. Biol.346:105-117

Kobayashi T, Sakamoto K, Takimura T, Sekine R, Kelly VP, Kamata K, Nishimura S, Yokoyama S. (2005) Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion Proc. Natl. Acad. Sci. USA 102 : 1366-1371

Kelly VP, Takafumi S, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M. (2005) The distal sequence element of the selenocysteine tRNA gene is a tissue dependant enhancer essential for mouse embryogenesis. Mol. Cell Biol. 25: 3658-3669

Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly VP, Sekizawa K, Uchida K, Yamamoto M. (2004) Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-prostaglandin J 2 Mol. Cell Biol. 24 :36-45

Kelly VP, O’Connor T, Ellis EM, Ireland LS, Slattery CM, Sherratt PJ, Crouch DH, Cavin C, Schilter B, Gallina A, Hayes JD (2004) Aflatoxin Aldehyde Reductases. In Penning TM, Petrash JM (ed.), Aldo-Keto Reductases and toxicant metabolism. Oxford University Press, Oxford, UK, pp. 155-170.

Arai T, Kelly VP, Komoro K, Minowa O, Noda T, Nishimura S.(2003) Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res.63:4287-92.

Arai T, Kelly VP, Minowa O, Noda T and Nishimura S (2002) High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis 23:2005-10

Kelly VP, Sherratt PJ, Crouch DH and Hayes JD (2002) Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct class of aldo-keto reductase 7 family proteins. Biochemical Journal 366:847-61

Grant A, Staffas L, Mancowiz L, Kelly VP, Manson MM, DePierre JW, Hayes JD, Ellis EM (2001) Expression of rat aldehyde reductase AKR7A1: influence of age and sex and tissue-specific inducibility Biochemal Pharmacology62: 1511-1519

Kelly VP, Ellis EM, Manson MM, Chanas S A, Graeme JM, McLeod R, Neal GE and Hayes JD (2000) Chemoprevention of aflatoxin B 1 hepato-carcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of Aflatoxin B 1-Aldehyde Reductase, the Glutathione S-Transferase A5 and P1 Subunits and NAD(P)H:Quinone Oxidoreductase in Rat Liver. Cancer Research60: 957-969

Kelly VP, Ireland LS, Ellis EM and Hayes JD (2000) Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extra-hepatic tissues. Biochemical Journal 348: 389-400

Kelly VP and O'Neill LA (1995) Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma. Biochemical Society Transactions 23: (4) 597S


Last updated 8 November 2013 bbutler@tcd.ie (Email).