Publications
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102 peer reviewed publications from 2019
Alex M. Liddicoat, Ed C. Lavelle, Modulation of innate immunity by cyclosporine A, Biochemical Pharmacology, 2019
Eckenhoff, M.F. and Cunningham, C., Animal Models and Cognitive Testing of Perioperative Neurocognitive Disorders, 2019, 61-81pp
Keenan A. Lacey, Alice Prince, Michelle E. Mulcahy, Aisling M. Towell, Joan A. Geoghegan, Rachel M. McLoughlin, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLOS Pathogens, 15, (4), 2019, pe1007713
BÀckhed, F. and Bugianesi, E. and Christofk, H. and Dikic, I. and Gupta, R. and Mair, W.B. and Oâ Neill, L.A.J. and Ralser, M. and Sabatini, D.M. and Tschöp, M., The next decade of metabolism, Nature Metabolism, 1, (1), 2019, p2-4
McElvaney, O.J. and Zaslona, Z. and Becker-Flegler, K. and Palsson-McDermott, E.M. and Boland, F. and Gunaratnam, C. and Gulbins, E. and O'Neill, L.A. and Reeves, E.P. and McElvaney, N.G., Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosis, American Journal of Respiratory and Critical Care Medicine, 200, (11), 2019, p1381-1391
Barton, S.J. and O'Dwyer, K. and Butler, M. and Dignam, A. and Byrne, H.J. and O'Neill, L. and Hennelly, B.M., Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples, Analytical Methods, 11, (47), 2019, p6023-6032
Torvell, M. and Hampton, D.W. and Connick, P. and MacLullich, A.M.J. and Cunningham, C. and Chandran, S., A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy, Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5, 2019, p579-591
Leavey, N. and Hammond, S.P. and Shepstone, L. and Cross, J. and Zetterberg, H. and Cunningham, C. and MacLullich, A. and Leiv Otto Watne and Minihane, A.M. and Ballard, C. and Knapskog, A.-B. and Hall, R. and Howard, G. and Hammond, M. and Fox, C., Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: A study in acute hip fracture patients, BMC Neurology, 19, (1), 2019
Skelly, D.T. and Griffin, Ã .W. and Murray, C.L. and Harney, S. and Oâ Boyle, C. and Hennessy, E. and Dansereau, M.-A. and Nazmi, A. and Tortorelli, L. and Rawlins, J.N. and Bannerman, D.M. and Cunningham, C., Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms (Molecular Psychiatry, (2019), 24, 10, (1533-1548), 10.1038/s41380-018-0075-8), Molecular Psychiatry, 24, (10), 2019, p1566
Mark M Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C Runtsch, Anne F McGettrick, Caroline E Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G Casarotto, Jane E Dahlstrom, Eva M Palsson-McDermott, Sinead C Corr, Kingston H G Mills, Roger J S Preston, Luke A J O'Neill, Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 2019
Richard K. Porter, Cellular Oxygen Consumption as an Index of Metabolic Activity , Clinical Research Development Ireland (CRDI), Trinity College Dublin & live feed to NUI Galway, 2-3 December, 2019, Gael Parent
G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., ''Involvement of caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma, 11th International Cancer Conference, TCD, TTMI, Dublin, Ireland, September 2019, 2019
G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., Caspase-1 involvement during Barrett's and OAC progression., Oesophageal Cancer Symposium, Cancer Research UK (CRUK), London, UK, April, 2019, 2019
G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Identifying a role for caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma., IACR 55th Annual Conference, Belfast, Northern Ireland, February 2019, 2019
Creagh, E.M., Inflammatory caspases during colorectal cancer, Cancer Biology & Immunology World Congress, Milan, Italy, March 11-13th 2019, 2019
Ding B, Haidurov A, Chawla A, Parmigiani A, Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, and Budanov AV., p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis., Oncotarget, 10, (65), 2019, p6997 - 7009
Budanov A, Dalina A, Kovaleva I, Haidurovs A, Tokarchuk A, Zheltukhin A., Sestrins regulate respiration and cell death through interaction with mitochondria., FEBS Open Bio, The 44th FEBS Congress, Krakow, Poland, July 6-11, 2019, 9, 2019, pp144 - 145
Gardiner, C.M., NK cell metabolism, Journal of Leukocyte Biology, 105, (6), 2019, p1235-1242
Gardiner, C.M., How to wake a killer, Nature Immunology, 20, (12), 2019, p1561-1563
Hartnell, F. and Brown, A. and Capone, S. and Kopycinski, J. and Bliss, C. and Makvandi-Nejad, S. and Swadling, L. and Ghaffari, E. and Cicconi, P. and Sorbo, M.D. and Sbrocchi, R. and Esposito, I. and Vassilev, V. and Marriott, P. and Gardiner, C.M. and Bannan, C. and Bergin, C. and Hoffmann, M. and Turner, B. and Nicosia, A. and Folgori, A. and Hanke, T. and Barnes, E. and Dorrell, L., A novel vaccine strategy employing serologically different chimpanzee adenoviral vectors for the prevention of HIV-1 and HCV coinfection, Frontiers in Immunology, 10, (JAN), 2019
Cluxton, C.D. and Spillane, C. and Oâ Toole, S.A. and Sheils, O. and Gardiner, C.M. and Oâ Leary, J.J., Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade, PLoS ONE, 14, (3), 2019
Slattery, K. and Gardiner, C.M., NK Cell Metabolism and TGFβ â" Implications for Immunotherapy, Frontiers in Immunology, 10, (2915), 2019
Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U., Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis., EBioMedicine. , Sep;47:, 2019, p402 - 413
Moran B, Gallagher C, Tobin AM, Fletcher JM., Enrichment of polyfunctional IL-17 producing T cells in paradoxical psoriasis skin lesions., The Journal of investigative dermatology, 2019
J. Musilova, B. Moran, C.M. Sweeney, A. Malara, A. Zaborowski, R. Hughes, D.C. Winter, J.M. Fletcher, B. Kirby, Enrichment of Plasma Cells in the Peripheral Blood and Skin of Patients with Hidradenitis Suppurativa, Journal of Investigative Dermatology, 2019
Campbell NK, Williams DG, Fitzgerald HK, Barry PJ, Cunningham CC, Nolan DP, Dunne A., Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages , Frontiers in Immunology-Microbial Immunology, 11, 2019
Musilova, J. and Mulcahy, M.E. and Kuijk, M.M. and McLoughlin, R.M. and Bowie, A.G., Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type i interferon and promotes intracellular survival, Journal of Biological Chemistry, 294, (45), 2019, p17031-17042
Ui Mhaonaigh, A. and Coughlan, A.M. and Dwivedi, A. and Hartnett, J. and Cabral, J. and Moran, B. and Brennan, K. and Doyle, S.L. and Hughes, K. and Lucey, R. and Floudas, A. and Fearon, U. and McGrath, S. and Cormican, S. and De Bhailis, A. and Molloy, E.J. and Brady, G. and Little, M.A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies, Frontiers in Immunology, 10, (2603), 2019
Longet, S. and Abautret-Daly, A. and Davitt, C.J.H. and McEntee, C.P. and Aversa, V. and Rosa, M. and Coulter, I.S. and Holmgren, J. and Raghavan, S. and Lavelle, E.C., An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses, npj Vaccines, 4, (1), 2019
Zurita, M.E. and Wilk, M.M. and Carriquiriborde, F. and Bartel, E. and Moreno, G. and Misiak, A. and Mills, K.H.G. and Hozbor, D., A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains, Frontiers in Cellular and Infection Microbiology, 9, (APR), 2019
Quinn, S.M. and Cunningham, K. and Raverdeau, M. and Walsh, R.J. and Curham, L. and Malara, A. and Mills, K.H.G., Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease, Frontiers in Immunology, 10, (MAY), 2019
Diavatopoulos, D.A. and Mills, K.H.G. and Kester, K.E. and Kampmann, B. and Silerova, M. and Heininger, U. and van Dongen, J.J.M. and van der Most, R.G. and Huijnen, M.A. and Siena, E. and Mielcarek, N. and Ochs, M.M. and Denoël, P. and Berbers, G. and Buisman, A.M. and de Jonge, M.I. and Fenwick, C. and Gorringe, A. and He, Q. and Kelly, D. and Le Grand, R. and Locht, C. and Mascart, F. and Mertsola, J. and Orfao, A. and Pantaleo, G. and Pollard, A.J. and Preston, A. and Read, R. and Sebo, P. and van Els, C. and Vecerek, B. and Londoño-Hayes, P. and de Groot, R., PERISCOPE: road towards effective control of pertussis, The Lancet Infectious Diseases, 19, (5), 2019, pe179-e186
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and AndrÀ, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and BÃŒscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Ä iÄ in-Å ain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De Biasi, S. and Del Zotto, G. and Dela Cruz, G.V. and Delacher, M. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di Santo, J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and Dörner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, A. and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and GrÃŒtzkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and HÀmmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and JÀck, H.-M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and KÃŒhne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGu, Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), European Journal of Immunology, 49, (10), 2019, p1457-1973
Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5
Richard K. Porter, The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses., MITOEAGLE Meeting, , Coimbra, Portugal. , July, 2019, Carlos Palmiera
Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C and Stevenson NJ, The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3, The FASEB Journal, 33, (8), 2019, p8732 - 8744
Nidhi Kedia-Mehta, Chloe Choi, Aisling McCrudden, Elisabeth Littwitz-Salomon, Proinnsias G. Fox, Clair M. Gardiner, and David. K Finlay, Natural Killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses, Immunmetabolism, (2), 2019, pe190014
Darren O'Hara, Gavin M. Davis, Natalie A. Adlesic, Jerrard M. Hayes and Gavin P. Davey, Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration, frontiers in Molecular Neuroscience, 2019
Sinevici N, Mittermayer S, Davey GP, Bones J, O'Sullivan J, Salivary N-glycosyalation as a biomarker of Oral Cancer: A pilot study., Glycobiology, 2019
Kufer, T.A., Creagh, E.M. & Bryant C., Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense, Trends in Immunology, 11, (10), 2019
KEDIA MEHTA, NIDHI , NK1.1 receptor ligation or tumour interactions prime NK cells for IL2-mediated metabolic and functional responses, Trinity College Dublin.School of Biochemistry & Immunology, 2019
Pignatelli, M. and Ryan, T.J. and Roy, D.S. and Lovett, C. and Smith, L.M. and Muralidhar, S. and Tonegawa, S., Engram Cell Excitability State Determines the Efficacy of Memory Retrieval, Neuron, 101, (2), 2019, p274-284.e5
Bowie, A.G., Harnessing poxviral know-how for anti-cytokine therapies, Journal of Biological Chemistry, 294, (13), 2019, p5228-5229
Silveira, A.A.A. and Mahon, O.R. and Cunningham, C.C. and Corr, E.M. and Mendonça, R. and Saad, S.T.O. and Costa, F.F. and Dunne, A. and Conran, N., S100A8 acts as an autocrine priming signal for heme-induced human MÏ. pro-inflammatory responses in hemolytic inflammation, Journal of Leukocyte Biology, 106, (1), 2019, p35-43
Geiger, S.S. and Curtis, A.M. and O'Neill, L.A.J. and Siegel, R.M., Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production, Immunology, 157, (2), 2019, p122-136
Ketelhuth, D.F.J. and Lutgens, E. and BÀck, M. and Binder, C.J. and Van den Bossche, J. and Daniel, C. and Dumitriu, I.E. and Hoefer, I. and Libby, P. and O'Neill, L. and Weber, C. and Evans, P.C., Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology, Cardiovascular research, 115, (9), 2019, p1385-1392
Hooftman, A. and O'Neill, L.A.J., The Immunomodulatory Potential of the Metabolite Itaconate, Trends in Immunology, 40, (8), 2019, p687-698
WaschbÃŒsch, D. and HÃŒbel, N. and Ossendorf, E. and Lobbestael, E. and Baekelandt, V. and Lindsay, A.J. and McCaffrey, M.W. and Khan, A.R. and Barnekow, A., Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking, PLoS ONE, 14, (1), 2019
Garg, R.R. and Jackson, C.B. and Rahman, M.M. and Khan, A.R. and Lewin, A.S. and McFadden, G., Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs, Journal of Biological Chemistry, 294, (21), 2019, p8480-8489
Campbell, N.K. and Fitzgerald, H.K. and Fletcher, J.M. and Dunne, A., Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1, Frontiers in Immunology, 10, (MAR), 2019, p00345-
Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019, p2389 - 2393
Jiménez, J.M. and Salazar, M.L. and Arancibia, S. and Villar, J. and Salazar, F. and Brown, G.D. and Lavelle, E.C. and MartÃnez-Pomares, L. and Ortiz-Quintero, J. and Lavandero, S. and Manubens, A. and Becker, M.I., TLR4, but neither dectin-1 nor dectin-2, participates in the mollusk hemocyanin-induced proinflammatory effects in antigen-presenting cells from mammals, Frontiers in Immunology, 10, (MAY), 2019
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019
Liddicoat, A.M. and Lavelle, E.C., Modulation of innate immunity by cyclosporine A, Biochemical Pharmacology, 163, 2019, p472-480
Lebre, F. and Lavelle, E.C. and Borges, O., Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies, Journal of Pharmacy and Pharmacology, 71, (6), 2019, p920-928
Davitt, C.J.H. and Longet, S. and Albutti, A. and Aversa, V. and Nordqvist, S. and Hackett, B. and McEntee, C.P. and Rosa, M. and Coulter, I.S. and Lebens, M. and Tobias, J. and Holmgren, J. and Lavelle, E.C., Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines, Mucosal Immunology, 12, (4), 2019, p1055-1064
O'Boyle, N.M. and Ana, G. and Kelly, P.M. and Nathwani, S.M. and Noorani, S. and Fayne, D. and Bright, S.A. and Twamley, B. and Zisterer, D.M. and Meegan, M.J., Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates, Organic and Biomolecular Chemistry, 17, (25), 2019, p6184-6200
Coyle, R. and Slattery, K. and Ennis, L. and O'Sullivan, M.J. and Zisterer, D.M. , The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway, International Journal of Oncology, 55, (1), 2019, p191-202
Wang, S., Malebari, A.M., Greene, T.F., O'Boyle, N.M., Fayne, D., Nathwani, S.M., Twamley, B., McCabe, T., Keely, N.O., Zisterer, D.M. and Meegan, M.J., 3-Vinylazetidin-2-Ones: Synthesis, antiproliferative and tubulin destabilizing activity in MCF-7 and MDA-MB-231 Breast Cancer Cells, Pharmaceuticals, 12, (2), 2019
O'Neill, S. and Porter, R.K., McNamee, N. and Martinez, V.G. and O'Driscoll, L., 2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype, Scientific Reports, 9, (1), 2019, p3788 - 3798
Browe, D.C. and Mahon, O.R. and DÃaz-Payno, P.J. and Cassidy, N. and Dudurych, I. and Dunne, A. and Buckley, C.T. and Kelly, D.J., Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering, Journal of Biomedical Materials Research - Part A, 2019
Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃ"rtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6
Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, (FEB), 2019, p1--
Meade, K.G. and O'Farrelly, C., Î'-Defensins: Farming the microbiome for homeostasis and health, Frontiers in Immunology, 10, (JAN), 2019
Galván-Peña, S., Carroll, R.G., Newman, C., (...), Modis, L.K., O'Neill, L.A., Malonylation of GAPDH is an inflammatory signal in macrophages, Nature Communications, 10, (1), 2019, p338-
Qasim Warraich M, Ghion A, Perdisatt L, Oâ Neill L, Casey A, Oâ Connor C, In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line, Drug and Chemical Toxicology, 2019
Gul S.-E, Oâ neill L, Cassidy J, Naydenova I, Modified surface relief layer created by holographic lithography: Application to selective sodium and potassium sensing, Sensors (Switzerland), 19, (5), 2019
Oâ Neill L.A.J, Artyomov M.N, Itaconate: the poster child of metabolic reprogramming in macrophage function, Nature Reviews Immunology, 19, (5), 2019, p273 - 281
Finlay, D.K., N-myristoylation of AMPK controls T cell inflammatory function, Nature Immunology, 20, (3), 2019, p252-254
Saraswati AP, Relitti N, Brindisi M, Gemma S, Zisterer D, Butini S & Campiani G, Raising the bar in anticancer therapy:recent advances in, and perspectives on, telomerase inhibitors, Drug Discovery Today, 2019
Jones N, Vincent EE, Cronin JG, Panetti S, Chambers M, Holm SR, Owens SE, Francis NJ, Finlay DK, Thornton CA, Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation, Nature Communications, 10, (1), 2019, p2042-
O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D Hogan AE, Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses, Journal of Immunology, 202, (12), 2019, p3404 - 3411
Neher J.J, Cunningham C, Priming Microglia for Innate Immune Memory in the Brain, Trends in Immunology, 40, (4), 2019, p358 - 374
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Mary F Rooney, Emmeline W Hill, Vincent Kelly and Richard K Porter, Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses., Cell Symposium: Exercise Metabolism, Sitges, Barcelona, Spain, May, 2019
Richard K. Porter, Oxygen Consumption as a measure of Cellular Energy Metabolism, Institute of Genomics and Integrative Biology, New Delhi, India, February, 2019
Richard K. Porter, Oxygen Consumption as a measure of Cellular Energy Metabolism, Indian Institute of Science, Bangalore, India, February, 2019
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Chang Y.-H., Nishimura S., Oishi H., Kelly V.P., Kuno A., Takahashi S., TRMT2A is a novel cell cycle regulator that suppresses cell proliferation, Biochemical and Biophysical Research Communications, 508, (2), 2019, p410 - 415, p410-415
Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674
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Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma,Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Maria Rosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Sullivan, Lucia Morbidelli, Roberta Spaccapelo, Cosima Baldari, Stefania Butini, Ettore Novellino, Giuseppe Campiani, Lucia Altucci, Michel Steinmetz, Simone Brogi, Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, p290-320
Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ, Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials. , 188, 2019, p63-73
Sadhbh O'Neill, Richard K. Porter, Vanesa G. Martinez, Lorraine, O'Driscoll , 2-Deoxy-D-Glucose preferentially inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype , Scientific Reports, 9, (1), 2019, p3788 - 3798