Publications
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123 peer reviewed publications from 2017
Zas"ona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ., The Induction of Pro-IL-1ß by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production., Journal of immunology (Baltimore, Md. : 1950), 198, (9), 2017, p3558-3564
Daniel Johnston, A role for microRNA-21 in the regulation of gastrointestinal health and disease, Trinity College Dublin, 2017
Daniel GW Johnston, A role for microRNA-21 in gastrointestinal health and disease, Trinity College Dublin, 2017
Nikiphorou E, Studenic P, Alunno A, Canavan M, Jani M, Berenbaum F, 'Twitterland': a brave new world?, Annals of the rheumatic diseases, 2017
Nikiphorou E, Studenic P, Ammitzbøll CG, Canavan M, Jani M, Ospelt C, Berenbaum F, EMEUNET., Social media use among young rheumatologists and basic scientists: results of an international survey by the Emerging EULAR Network (EMEUNET)., Annals of the rheumatic diseases, 76, (4), 2017, p712-715
Malebari, A.M. and Greene, L.M. and Nathwani, S.M. and Fayne, D. and O'Boyle, N.M. and Wang, S. and Twamley, B. and Zisterer, D.M. and Meegan, M.J., β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285
Koh D, Jung Y, Ahn S, Mok KH, Shin SY, Lim Y, Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors., Magnetic resonance in chemistry : MRC, 2017
Mary Francis Rooney, The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses, 2017
Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG., Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma., Science Translational Medicine, 9, (396), 2017, peaak9969-
Malebari, A.M., Greene, L.M., Nathwani, S.M., Fayne, D., O'Boyle, N.M., Wang, S., Twamley, B., Zisterer, D.M., Meegan, M.J., ß-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285
Pankaj, S.K. and Bueno-Ferrer, C. and Misra, N.N. and O'Neill, L. and Bourke, P. and Cullen, P.J., Effects of cold plasma on surface, thermal and antimicrobial release properties of chitosan film, Journal of Renewable Materials, 5, (1), 2017, p14-20
Pankaj, S.K. and Bueno-Ferrer, C. and O'Neill, L. and Tiwari, B.K. and Bourke, P. and Cullen, P.J., Characterization of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Journal of Food Processing and Preservation, 41, (1), 2017
Marilena Karavyraki & Richard K. Porter, Mitochondrial Function and Morphology Linked to Metabolic Differences in Normal, Dysplastic and Cancerous Oral Cells , Mitochondria in Physiology Workshop (MiPs) , Obergurgl, Austria, June, edited by Erich Gnaiger , 2017
Marilena Karavyraki & Richard K. Porter, A bioenergetic comparison of dysplastic and cancerous oral cells, Irish Division of the International Dental Research Association (IADR) Annual Division Meeting, Belfast, Northern Ireland, November, edited by Irish Division of the International Dental Research Association (IADR , 2017
Mary F. Rooney, The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thoroughbred Horses, Trinity College Dublin, 2017
Queenan BN, Ryan TJ, Gazzaniga MS, Gallistel CR, On the research of time past: the hunt for the substrate of memory., Annals of the New York Academy of Sciences, 2017
McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Hardingham GE, Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1., eLife, 2017
Kinoshita M, Kim JY, Kume S, Lin Y, Mok KH, Kataoka Y, Ishimori K, Markova N, Kurisu G, Hase T, Lee Y-H, Energetic basis on interactions between ferredoxin and ferredoxin NADP+ reductase at varying physiological conditions, Biochemistry Biophysics Research Communications, 482, (4), 2017, p909 - 915
Richard K. Porter, Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells, , 'Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment (MITOEAGLE)',, Barcelona University, Institut D'Estdies Catalan, Spain, Mar 2017, 2017, COST MITOEAGLE
Richard K. Porter, Discovering Bioenergetic Anticancer Targets in vitro , Measuring Metabolic Engines and Fuels-Seahorse Users Meeting 18.5.17, Weizmann Institute, Israel, May 2017, 2017, Agilent & Weizmann Institute
Richard K. Porter, Mitochondrial function and dysfunction in cancer , MiPs School, , Obergurgl, Austria , July 2017, 2017, Mitochondria in Physiology Society (MiPS)
Richard K. Porter, Bioenergetics in Cancer , "The role of mitochondria in lifestyle and metabolic syndrome - MITOEAGLE perspectives", Hradec Králové University Czech Republic., Nov 2017, 2017, COST MITOEAGLE
Richard K. Porter, Cellular Oxygen Consumption as an index of Metabolic Activity,, Clinical Research Development Ireland Workshop, Trinity Biomedical Research Institute, Dec 2017, 2017, CRDI
Richard K. Porter, Mary Rooney, Emmeline Hill, Lisa Katz, '"A Genotype Specific Neutraceutical for Horses". ', Murgitroyd, European Patent No. 17190252.1 , 2017
Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter, Genotype variation at the MSTN locus is associated with skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses., Gruppo Italiano di Biomembrane e Bioenergetica, Cantania, Italy, June 14-16, 2017, edited by Paolo Bernardi (Padova), Alessandro Giuffrè (Roma), Giovanna Lippe (Udine), Vito De Pinto (Catania), Francesco Francia (Bologna), Cesare Indiveri (Calabria), Luigi Palmieri (Bari), Claudia Piccoli (Foggia). , 2017
Taglauer, E.S. and Artemiuk, P.A. and Hanscom, S.R. and Lindsay, A.J. and Wuebbolt, D. and Breathnach, F.M. and Tully, E.C. and Khan, A.R. and McCaffrey, M.W., Rab11 family expression in the human placenta: Localization at the maternal-fetal interface, PLoS ONE, 12, (9), 2017
Emma B. O'Connor, Richard K. Porter and Patrick T. Walsh , A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, Keystone Meeting, Dublin, Ireland, Royal Dublin Society, May 29-June 2, 2017, 2017
Kacprzyk, J. and Hughes, G.M. and Palsson-Mcdermott, E.M. and Quinn, S.R. and Puechmaille, S.J. and O'Neill, L.A.J. and Teeling, E.C., A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance, Acta Chiropterologica, 19, (2), 2017, p219-228
Wiktor, M. and Weichert, D. and Howe, N. and Huang, C.-Y. and Olieric, V. and Boland, C. and Bailey, J. and Vogeley, L. and Stansfeld, P.J. and Buddelmeijer, N. and Wang, M. and Caffrey, M., Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nature Communications, 8, 2017, p15952-
Caffrey, M. and Drew, D., Editorial overview: Membranes, Current Opinion in Structural Biology, 45, 2017, pvii-ix
Ma, P. and Weichert, D. and Aleksandrov, L.A. and Jensen, T.J. and Riordan, J.R. and Liu, X. and Kobilka, B.K. and Caffrey, M., The cubicon method for concentrating membrane proteins in the cubic mesophase, Nature Protocols, 12, (9), 2017, p1745-1762
Parker, J.L. and Li, C. and Brinth, A. and Wang, Z. and Vogeley, L. and Solcan, N. and Ledderboge-Vucinic, G. and Swanson, J.M.J. and Caffrey, M. and Voth, G.A. and Newstead, S., Proton movement and coupling in the POT family of peptide transporters, Proceedings of the National Academy of Sciences of the United States of America, 114, (50), 2017, p13182-13187
Geoghegan, F. and Buckland, R.J. and Rogers, E.T. and Khalifa, K. and O'Connor, E.B. and Rooney, M.F. and Behnam-Motlagh, P. and Nilsson, T.K. and Grankvist, K. and Porter, R.K., Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells, Oncotarget, 8, (55), 2017, p94711-94725
Rooney, M.F., Porter, R.K., Katz, L.M. , Hill, E.W., Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse, PLoS ONE, 12, (11), 2017
Creagh, E.M., Oesophageal Cancer & Inflammation, Cologne University Research Hospital Seminar Series, Cologne University Research Hospital, Germany, 2nd June, 2017, Dr. H. Fuchs & Prof. J. Beers, Cologne
Barry Moran, Cheryl M. Sweeney, Rosalind Hughes, Anna Malara, Shivashini Kirthi, Anne-Marie Tobin, Brian Kirby, Jean M. Fletcher, Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy, Journal of Investigative Dermatology, 137, (11), 2017, p2389--2395
Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM, Porter RK., Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells., Oncology letters, 14, (5), 2017, p6298-6306
Kelly PM, Keely NO, Bright SA, Yassin B, Ana G, Fayne D, Zisterer DM, Meegan MJ., Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation., Molecules (Basel, Switzerland), 22, (9), 2017, p1440-
Kennelly, K.P. and Holmes, T.M. and Wallace, D.M. and Oâ Farrelly, C. and Keegan, D.J., Early subretinal allograft rejection is characterized by innate immune activity, Cell Transplantation, 26, (6), 2017, p983-1000
Hall, T.J. and McQuillan, C. and Finlay, E.K. and O'Farrelly, C. and Fair, S. and Meade, K.G., Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome, BMC Genomics, 18, (1), 2017, p278-
Adnane, M. and Chapwanya, A. and Kaidi, R. and Meade, K.G. and O'Farrelly, C., Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?, Theriogenology, 103, 2017, p117-122
Garvey, P. and Murphy, N. and Flanagan, P. and Brennan, A. and Courtney, G. and Crosbie, O. and Crowe, J. and Hegarty, J. and Lee, J. and McIver, M. and McNulty, C. and Murray, F. and Nolan, N. and O'Farrelly, C. and Stewart, S. and Tait, M. and Norris, S. and Thornton, L., Disease outcomes in a cohort of women in Ireland infected by hepatitis C-contaminated anti-D immunoglobulin during 1970s, Journal of Hepatology, 67, (6), 2017, p1140-1147
Whiston, R. and Finlay, E.K. and McCabe, M.S. and Cormican, P. and Flynn, P. and Cromie, A. and Hansen, P.J. and Lyons, A. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility, Scientific Reports, 7, (1), 2017, p12287 -
Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS, Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections, Frontiers in Immunology, 8, 2017, p1311-
Pandharipande, P.P. and Ely, E.W. and Arora, R.C. and Balas, M.C. and Boustani, M.A. and La Calle, G.H. and Cunningham, C. and Devlin, J.W. and Elefante, J. and Han, J.H. and MacLullich, A.M. and Maldonado, J.R. and Morandi, A. and Needham, D.M. and Page, V.J. and Rose, L. and Salluh, J.I.F. and Sharshar, T. and Shehabi, Y. and Skrobik, Y. and Slooter, A.J.C. and Smith, H.A.B., The intensive care delirium research agenda: a multinational, interprofessional perspective, Intensive Care Medicine, 43, (9), 2017, p1329-1339
Ni Cheallaigh Cliona, Sheedy Frederick J., Shields Up: Systemic Protection Provided by microRNA-21 During Sepsis?, 45 , (7 ), 2017
Rudkin, J.K. and McLoughlin, R.M. and Preston, A. and Massey, R.C., Bacterial toxins: Offensive, defensive, or something else altogether?, PLoS Pathogens, 13, (9), 2017, e1006452.-
PrÃŒss, H. and Tedeschi, A. and Thiriot, A. and Lynch, L. and Loughhead, S.M. and Stutte, S. and Mazo, I.B. and Kopp, M.A. and Brommer, B. and Blex, C. and Geurtz, L.-C. and Liebscher, T. and Niedeggen, A. and Dirnagl, U. and Bradke, F. and Volz, M.S. and DeVivo, M.J. and Chen, Y. and Von Andrian, U.H. and Schwab, J.M., Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex, Nature Neuroscience, 20, (11), 2017, p1549-1559
Boulenouar, S. and Michelet, X. and Duquette, D. and Alvarez, D. and Hogan, A.E. and Dold, C. and O'Connor, D. and Stutte, S. and Tavakkoli, A. and Winters, D. and Exley, M.A. and O'Shea, D. and Brenner, M.B. and von Andrian, U. and Lynch, L., Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity, Immunity, 46, (2), 2017, p273-286
Chang, S.K. and Kohlgruber, A.C. and Mizoguchi, F. and Michelet, X. and Wolf, B.J. and Wei, K. and Lee, P.Y. and Lynch, L. and Duquette, D. and Ceperuelo-Mallafré, V. and Banks, A.S. and Brenner, M.B., Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes, Journal of Clinical Investigation, 127, (9), 2017, p3300-3312
Wu, B.X. and Li, A. and Lei, L. and Kaneko, S. and Wallace, C. and Li, X. and Li, Z. and O'Neill, L., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis, Journal of Biological Chemistry, 292, (44), 2017, p18091-18097
Thom, S.R. and Bhopale, V.M. and Yu, K. and Huang, W. and Kane, M.A. and Margolis, D.J. and O'Neill, L., Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability, Journal of Biological Chemistry, 292, (44), 2017, p18312-18324
Nakhleh, J. and Christophides, G.K. and Osta, M.A. and O'Neill, L., The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae, Journal of Biological Chemistry, 292, (44), 2017, p18217-18226
Kim, R.Y. and Pinkerton, J.W. and Essilfie, A.T. and Robertson, A.A.B. and Baines, K.J. and Brown, A.C. and Mayall, J.R. and Ali, M.K. and Starkey, M.R. and Hansbro, N.G. and Hirota, J.A. and Wood, L.G. and Simpson, J.L. and Knight, D.A. and Wark, P.A. and Gibson, P.G. and O'Neill, L.A.J. and Cooper, M.A. and Horvat, J.C. and Hansbro, P.M., Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma, American Journal of Respiratory and Critical Care Medicine, 196, (3), 2017, p283-297
Chen, W. and Foo, S.-S. and Zaid, A. and Teng, T.-S. and Herrero, L.J. and Wolf, S. and Tharmarajah, K. and Vu, L.D. and Van Vreden, C. and Taylor, A. and Freitas, J.R. and Li, R.W. and Woodruff, T.M. and Gordon, R. and Ojcius, D.M. and Nakaya, H.I. and Kanneganti, T.-D. and O'Neill, L.A.J. and Robertson, A.A.B. and King, N.J. and Suhrbier, A. and Cooper, M.A. and Ng, L.F.P. and Mahalingam, S., Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation, Nature Microbiology, 2, (10), 2017, p1435-1445
Ryan, D.G. and O'Neill, L.A.J., Krebs cycle rewired for macrophage and dendritic cell effector functions, FEBS Letters, 591, (19), 2017, p2992-3006
To, E.E. and Vlahos, R. and Luong, R. and Halls, M.L. and Reading, P.C. and King, P.T. and Chan, C. and Drummond, G.R. and Sobey, C.G. and Broughton, B.R.S. and Starkey, M.R. and Van Der Sluis, R. and Lewin, S.R. and Bozinovski, S. and O'Neill, L.A.J. and Quach, T. and Porter, C.J.H. and Brooks, D.A. and O'Leary, J.J. and Selemidis, S., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy, Nature Communications, 8, (1), 2017
Menon, D. and Innes, A. and Oakley, A.J. and Dahlstrom, J.E. and Jensen, L.M. and BrÃŒstle, A. and Tummala, P. and Rooke, M. and Casarotto, M.G. and Baell, J.B. and Nguyen, N. and Xie, Y. and Cuellar, M. and Strasser, J. and Dahlin, J.L. and Walters, M.A. and Burgio, G. and O'Neill, L.A.J. and Board, P.G., GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity, Scientific Reports, 7, (1), 2017
Sisquella, X. and Ofir-Birin, Y. and Pimentel, M.A. and Cheng, L. and Abou Karam, P. and Sampaio, N.G. and Penington, J.S. and Connolly, D. and Giladi, T. and Scicluna, B.J. and Sharples, R.A. and Waltmann, A. and Avni, D. and Schwartz, E. and Schofield, L. and Porat, Z. and Hansen, D.S. and Papenfuss, A.T. and Eriksson, E.M. and Gerlic, M. and Hill, A.F. and Bowie, A.G. and Regev-Rudzki, N., Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors, Nature Communications, 8, (1), 2017, p1985-
Munoz-Wolf, N. and Lavelle, E.C., Hippo interferes with antiviral defences, Nature Cell Biology, 19, (4), 2017, p267-269
Barnes, D.D. and Lundahl, M.L.E. and Lavelle, E.C. and Scanlan, E.M., The Emergence of Phenolic Glycans as Virulence Factors in Mycobacterium tuberculosis, ACS Chemical Biology, 12, (8), 2017, p1969-1979
Harte, C., Gorman, A.L., McCluskey, S., Carty, M., Bowie, A.G., Scott, C.J., Meade, K.G. and Lavelle, E.C., Alum activates the bovine NLRP3 inflammasome, Frontiers in Immunology, 8, 2017, p1494-
Lundahl, M.L.E. and Scanlan, E.M. and Lavelle, E.C., Therapeutic potential of carbohydrates as regulators of macrophage activation, Biochemical Pharmacology, 146, 2017, p23-41
Longet, S., Aversa, V., O'Donnell, D., Tobias, J., Rosa, M., Holmgren, J., Coulter, I.S. and Lavelle, E.C., Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine formulation, International Journal of Pharmaceutics, 534, (1-2), 2017, p60-70
Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831
Misiak, A. and Leuzzi, R. and Allen, A.C. and Galletti, B. and Baudner, B.C. and D'Oro, U. and O'Hagan, D.T. and Pizza, M. and Seubert, A. and Mills, K.H.G., Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model, Vaccine, 35, (39), 2017, p5256-5263
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Akdis, M. and AndrÀ, I. and Annunziato, F. and Bacher, P. and Barnaba, V. and Battistini, L. and Bauer, W.M. and Baumgart, S. and Becher, B. and Beisker, W. and Berek, C. and Blanco, A. and Borsellino, G. and Boulais, P.E. and Brinkman, R.R. and BÃŒscher, M. and Busch, D.H. and Bushnell, T.P. and Cao, X. and Cavani, A. and Chattopadhyay, P.K. and Cheng, Q. and Chow, S. and Clerici, M. and Cooke, A. and Cosma, A. and Cosmi, L. and Cumano, A. and Dang, V.D. and Davies, D. and De Biasi, S. and Del Zotto, G. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Diefenbach, A. and Di Santo, J. and Dieli, F. and Dolf, A. and Donnenberg, V.S. and Dörner, T. and Ehrhardt, G.R.A. and Endl, E. and Engel, P. and Engelhardt, B. and Esser, C. and Everts, B. and Dreher, A. and Falk, C.S. and Fehniger, T.A. and Filby, A. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frenette, P.S. and Galbraith, D. and Garbi, N. and GarcÃa-Godoy, M.D. and Geginat, J. and Ghoreschi, K. and Gibellini, L. and Goettlinger, C. and Goodyear, C.S. and Gori, A. and Grogan, J. and Gross, M. and GrÃŒtzkau, A. and Grummitt, D. and Hahn, J. and Hammer, Q. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Herrera, G. and Herrmann, M. and Hiepe, F. and Holland, T. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Hunter, C.A. and Iannone, A. and JÀck, H.-M. and Jávega, B. and Jonjic, S. and Juelke, K. and Jung, S. and Kaiser, T. and Kalina, T. and Keller, B. and Khan, S. and Kienhöfer, D. and Kroneis, T. and Kunkel, D. and Kurts, C. and Kvistborg, P. and Lannigan, J. and Lantz, O. and Larbi, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Levings, M.K. and Litwin, V. and Liu, Y. and Lohoff, M. and Lombardi, G. and Lopez, L. and Lovett-Racke, A. and Lubberts, E. and Ludewig, B. and Lugli, E. and Maecker, H.T. and Martrus, G. and Matarese, G. and Maueröder, C. and McGrath, M. and McInnes, I. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Mills, K. and Mirrer, D. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, A. and Moretta, L. and Mosmann, T.R. and MÃŒller, S. and MÃŒller, W. and MÃŒnz, C. and Multhoff, G. and Munoz, L.E. and Murphy, K.M. and Nakayama, T. and Nasi, M. and Neudörfl, C. and Nolan, J. and Nourshargh, S. and O'Connor, J.-E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Peterson, P. and Peth, C. and Petriz, J. and Philips, D. and Pickl, W. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Pucillo, C. and Quataert, S.A. and Radstake, T.R.D.J. and Rajwa, B. and Rebhahn, J.A. and Recktenwald, D. and Remmerswaal, E.B.M. and Rezvani, K. and Rico, L.G. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruckert, B. and Ruland, J. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sawitzki, B. and Scheffold, A. and Schiemann, M. and Schildberg, F. and Schimisky, E. and Schmid, S.A. and Schmitt, S. and Schober, K. and SchÃŒler, T. and Schulz, A.R. and Schumacher, T. and Scotta, C. and Shankey, T.V. and Shemer, A. and Simon, A.-K. and Spidlen, J. and Stall, A.M. and Stark, R. and Stehle, C. and Stein, M. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Tarnok, A. and Tian, Z. and Toldi, G. and Tornack, J. and Traggiai, E. and Trotter, J. and Ulrich, H. and van der Braber, M. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and, Guidelines for the use of flow cytometry and cell sorting in immunological studies, European Journal of Immunology, 47, (10), 2017, p1584-1797
Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 -
Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017
Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923-
Tobin, Laura M and Mavinkurve, Meenal and Carolan, Eirin and Kinlen, David and O'Brien, Eoin C and Little, Mark A and Finlay, David K and Cody, Declan and Hogan, Andrew E and O'Shea, Donal, NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient, JCI insight, 2, (24), 2017, pe94939
Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells, Journal of Immunology, 2017
Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17 -
Lebre, F., Sridharan, R., Sawkins, M.J., Kelly, D.J., O'Brien, F.J. and Lavelle, E.C., The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation, Scientific Reports, 7, (1), 2017, p2922 -
N Willis-Fox, A. Gutacker, M.P. Browne, A.R. Khan, M.E.G.Lyons, U. Scherf, R.C. Evans, Selective recohnition of biologically important anions using a diblock polyfluorene-polythiophene conjugated polyelectrolyte, Polymer Chemistry, 8, 2017, p7151 - 7159
Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 18, (11), 2017, p1197 - 1206
Malebari, AM, Greene, LM, Nathwani, SM, Fayne, D, O'Boyle, NM, Wang, S, Twamley, B, Zisterer, DM, Meegan, MJ, Beta-lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285
Cunniffe G.M, DÃaz-Payno P.J, Ramey J.S, Mahon O.R, Dunne A, Thompson E.M, O'Brien F.J, Kelly D.J, Growth plate extracellular matrix-derived scaffolds for large bone defect healing, European Cells and Materials, 33, 2017, p130 - 142
Corr E.M, Cunningham C.C, Helbert L, McCarthy G.M, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Research and Therapy, 19, (1), 2017, p23-
Nounamo B, Li Y, O'Byrne P, Kearney A.M, Khan A, Liu J, An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function, Virology, 503, 2017, p94 - 102
Mulvaney E.P, O'Meara F, Khan A.R, O'Connell D.J, Kinsella B.T, Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor, Biochimica et Biophysica Acta - Molecular Cell Research, 1864, (10), 2017, p1819 - 1832
Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201
Terry K. Smith, Frédéric Bringaud, Derek P. Nolan, Luisa M. Figueiredo, Metabolic reprogramming during the Trypanosoma brucei life cycle, F1000Research, 2017, p683-
Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J.C, Tye H, Biette K, Jedlicka P, Brodsky K.S, Gerich M.E, Mack M, Robertson A.A.B, Cooper M.A, Furuta G.T, Dinarello C.A, O'Neill L.A, Eltzschig H.K, Masters S.L, McNamee E.N, Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome, Journal of Experimental Medicine, 214, (6), 2017, p1737 - 1752
Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S., CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression., Journal of immunology (Baltimore, Md. : 1950), 198, (11), 2017, p4490-4501
Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243
McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12
Gu, X.-X., Plotkin, S.A., Edwards, K.M., (...), Lu, K.T., Taylor, C.E. , Waning immunity and microbial vaccines-workshop of the National Institute of Allergy and infectious diseases, Clinical and Vaccine Immunology, 24, (7), 2017, pe00034-17
Nascimento, I.P., Rodriguez, D., Santos, C.C., (...), Rappuoli, R., Leite, L.C.C. , Recombinant BCG expressing LTAK63 adjuvant induces superior protection against Mycobacterium tuberculosis , Scientific Reports, 7, (1), 2017, p2109
Dyck, L., Mills, K.H.G. , Immune checkpoints and their inhibition in cancer and infectious diseases, European Journal of Immunology, 47, (5), 2017, p765-779
Pinkerton J.W, Kim R.Y, Robertson A.A.B, Hirota J.A, Wood L.G, Knight D.A, Cooper M.A, O'Neill L.A.J, Horvat J.C, Hansbro P.M, Inflammasomes in the lung, Molecular Immunology, 86, 2017, p44-55
Hughes M.M, Mcgettrick A.F, O'Neill L.A.J, Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages, Microbiology Spectrum, 5, (1), 2017, p0044-
Van den Bossche J, O'Neill L.A, Menon D, Macrophage Immunometabolism: Where Are We (Going)?, Trends in Immunology, 38, (6), 2017, p395-406
O'Neill L.A.J, The Hunger Games: Salmonella, Anorexia, and NLRP3, Cell Metabolism, 25, (2), 2017, p225 - 226
O'Neill L, Immunometabolism and the land of milk and honey, Nature Reviews Immunology, 17, (4), 2017, p217-
Mills E.L, Kelly B, O'Neill L.A.J, Mitochondria are the powerhouses of immunity, Nature Immunology, 18, (5), 2017, p488 - 498
Haneklaus M, O'Neil J.D, Clark A.R, Masters S.L, O'Neill L.A.J, The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome, Journal of Biological Chemistry, 292, (17), 2017, p6869 - 6881
ZasÅ'ona Z, Palsson-McDermott E.M, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran S.E, Peters-Golden M, O'Neill L.A.J, The induction of Pro-IL-1β by lipopolysaccharide requires endogenous prostaglandin E
Brady, G., Haas, D.A., Farrell, P.F., Pichlmair, A. and Bowie, A.G. , Molluscum Contagiosum Virus protein MC005 inhibits NFκB activation by targeting NEMO-regulated IKK activation, The Journal of Virology, 91, (15), 2017, p00545-17
Almine J., Almine J., O'Hare C., O'Hare C., Dunphy G., Dunphy G., Haga I., Naik R., Atrih A., Connolly D., Taylor J., Kelsall I., Bowie A., Beard P., Beard P., Unterholzner L., Unterholzner L., IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes, Nature Communications, 8, 2017, p14392
Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, (14), 2017, p2525-2535
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764
Davis DH, Muniz-Terrera G, Keage HA, Stephan BC, Fleming J, Ince PG, Matthews FE, Cunningham C, Ely EW, MacLullich AM, Brayne C, Epidemiological Clinicopathological Studies in Europe (EClipSE) Collaborative Members., Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies., JAMA Psychiatry, 74, (3), 2017, p244-251
Zaslona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LA., The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma., American Journal of Physiology Lung Cellular and Molecular Physiology, 2017, pL855-L860
Moore C., Movia D., Smith R., Hanlon D., Lebre F., Lavelle E., Byrne H., Coleman J., Volkov Y., McIntyre J., Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation, 2D Materials, 4, (2), 2017
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay, Glucose represses dendritic cell-induced T cell responses, Nature Communications, (8), 2017, p15620-
Clair M. Gardiner and David K. Finlay, What Fuels Natural Killers? Metabolism and NK Cell Responses, Frontiers in Immunolobgy, 8, 2017
Hackett, E.E., Sheedy, F.J., MiR-21 alters circulating Treg function in vascular disease-hope for restoring immunoregulatory responses in atherosclerosis?, Annals of Translational Medicine, 5, (1), 2017
Leech JM, Lacey KA, Mulcahy ME, Medina E, McLoughlin RM, IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections., 198, (6), 2017, p2352-2365
Zhao B, Shah P, Qiang L, He TC, Budanov A, He YY, Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes., Photochemistry and photobiology, 93, (1), 2017, p375 - 381
Martinez VG, Crown J, Porter RK, O'Driscoll L., Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer, International Journal of Cancer, 140, (12), 2017, p2771 - 2784
McGarry T 1 , Biniecka M 1 , Gao W 1 , Cluxton D 2 , Canavan M 1 , Wade S 3 , Wade S 1 , Gallagher L 1 , Orr C 1 , Veale DJ 1 , Fearon U , Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis, Science Reports, 7, (22), 2017, p43165-
Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells., J immunology, 198 , (2), 2017, p2249 - 2259
Ghachi M.E, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez J.-C, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F, Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis, Cellular and Molecular Life Sciences, 74, (12), 2017, p2319-2332
Stojkovic B, Mullen M.P, Donofrio G, McLoughlin R.M, Meade K.G, Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle, Veterinary Immunology and Immunopathology, 184, 2017, p18 - 28
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039
Misiak A, Wilk M.M, Raverdeau M, Mills K.H.G, IL-17-producing innate and pathogen-specific tissue resident memory γΎ T cells expand in the lungs of Bordetella pertussis-infected mice, Journal of Immunology, 198, (1), 2017, p363 - 374
Doherty W, Adler N, Knox A, Nolan D, McGouran J, Nikalje A.P, Lokwani D, Sarkate A, Evans P, Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents, European Journal of Organic Chemistry, 2017, (1), 2017, p175 - 185
Hennessy E, Gormley S, Lopez-Rodriguez A.B, Murray C, Murray C, Cunningham C, Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration, Brain, Behavior, and Immunity, 59, 2017, p233 - 244
C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316
Meegan MJ, Nathwani S, Twamley B, Zisterer DM, O'Boyle NM., Piperlongumine (piplartine) and analogues: Antiproliferative microtubule-destabilising agents., European Journal of Medicinal Chemistry, 125, 2017, p453 - 463
Tivnan, A., Heilinger, T., Lavelle, E.C. and Prehn, J.H.M. , Advances in immunotherapy for the treatment of glioblastoma., Journal of Neuro-Oncology, 131, (1), 2017, p1-9