Publications
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132 publications from 2016
Keely, N.O. and Carr, M. and Yassin, B. and Ana, G. and Lloyd, D.G. and Zisterer, D. and Meegan, M.J., Design, synthesis and biochemical evaluation of novel selective estrogen receptor ligand conjugates incorporating an endoxifen-combretastatin hybrid scaffold, Biomedicines, 4, (3), 2016
Immune Response to Staphylococcus aureus in, Staphylococcus: Genetics and Physiology., Caister Academic Press , 2016, pp335--388 , [Aisling F. Brown, Rachel M. McLoughlin]
Ryan, T.J. and Tonegawa, S., Erratum: Rehebbilitating Memory (Neuropsychopharmacology (2016) 41 (370-371) DOI: 10.1038/npp.2015.264), Neuropsychopharmacology, 41, (5), 2016, p1437
Lecca, D., Nevin, D.K., Mulas, G., Casu, M.A., Diana, A., Rossi, D., Sacchetti, G., Fayne, D., Carta, A.R., Erratum: Corrigendum to "Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPAR" agonist in vitro and in MPTP-treated mice" (Neuroscience (2015) 302 (23"35)(S030645221500367X)(10.1016/j.neuroscience.2015.04.026)), Neuroscience, 339, 2016
Innate immune receptors in, editor(s)Pablo Pelegrin and Francesco Di Virgilio , Nod Like Receptors, Springer, 2016, pp1-43 , [Muñoz-Wolf, N and Lavelle, E.C. ]
Cunningham, C., Corr, E., McCarthy, G., Dunne, A, Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid. , Arthritis Rheumatol. , 2016 ACR/ACHP Annual Meeting, Washington, 68 (suppl 10)., 2016
Cunningham, C., Corr, E.M., McCarthy, G.M. and Dunne A, Intra-articular Basic Calcium Phosphate and Monosodium Urate Crystals Inhibit anti-osteoclastogenic Cytokine Signalling, Osteoarthritis and Cartilage, 24, 2016, p2141 - 2152
Frank RA, Komiyama NH, Ryan TJ, Zhu F, O'Dell TJ, Grant SG., NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation., Nature communications, 7, 2016, p11264
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C., What is memory? The present state of the engram., BMC biology, 14, 2016, p40
Ryan TJ, Tonegawa S., Rehebbilitating Memory., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41, (1), 2016, p370-371
Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S., Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease., Nature, 531, (7595), 2016, p508-512
Svanborg C, Mok KH, Trulsson M, Mossberg A-K, Storm P, Ho CS, 'Biologically active complex and its preparation', European Patent Office, EP 2 643 010 B1, 2016, HAMLET Pharma AB
McGettrick AF, Corcoran SE, Barry PJG, McFarland J, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LAJ, Nolan DP, The Trypanosoma brucei metabolite indolepyruvate decreases HIF-1 and glycolysis in macrophages as a mechanism of innate immune evasion, Proceedings of the National Academy of Sciences, U.S.A., 113, (48), 2016, pE7778 - E7787
Kim KH, Yun S, Mok KH, Lee EK, Thermodynamic analysis of ANS binding to partially unfolded α-lactalbumin: correlation of endothermic to exothermic changeover with formation of authentic molten globules, Journal of Molecular Recognition, 29, 2016, p446 - 451
Abbas SN, Mok KH, Rashid N, Xie Y, Ruether M, O'Brien J, Akhtar M, NMR studies on mechanism of isomerisation of fructose 6-phosphate to glucose 6-phosphate catalysed by phosphoglucose isomerase from Thermococcus kodakarensis, Bioorganic Chemistry, 66, 2016, p41 - 45
Richard K. Porter, The Role of Mitochondrial Uncoupling Proteins in Thymus and Immune Cell Function, Visiting Professor, University of St. Andrews, Scotland, , April 2016, 2016
C.McKenna R.K.Porter, S.Waters and D.Kenny, Mitochondrial abundance and respiratory chain activities in muscle of cattle divergent in residual feed intake, European Federation of Animal Science (EAAP), Belfast UK, 29 Aug - 2 Sept 2016, Wageningen Academic Publisher, 2016
C.McKenna R.K.Porter, S.Waters and D.Kenny, Mitochondrial abundance and respiratory chain activities in muscle of cattle divergent in residual feed intake, EAAP, Belfast UK, 29 Aug - 2 Sept 2016, Wageningen Academic Publisher, 2016
Emma B. O ' Connor , Richard K. Porter , Patrick T. Walsh , A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2016 (EBEC 2016), Riva del garda, July 2-7, 2016, edited by Paolo Bernardi , Elsevier, 2016, pppe98-
Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter , MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses,, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2016 (EBEC 2016), Riva del garda, July 2-7, 2016, edited by Paolo Bernardi , Volume 1857, 2016, ppp44-
Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia, Irish Society of Gastroenterology, Summer Proceedings, Irish Society of Gastroenterology, Summer Meeting, Galway, Ireland., June 2016, edited by Michael Dineen, ISG , 2016
Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia , 'Innovation in Diagnosis & Treatment of Colorectal Neoplasia', Centre for Colorectal Disease, St. Vincent's Hospital, 9th September, 2016, Prof. K Sheahan
Narciandi, F. and Fernandez-Fuertes, B. and Khairulzaman, I. and Jahns, H. and King, D. and Finlay, E.K. and Mok, K.H. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract, Biology of Reproduction, 95, (6), 2016, p1-9
Fernandez-Fuertes, B. and Narciandi, F. and O'Farrelly, C. and Kelly, A.K. and Fair, S. and Meade, K.G. and Lonergan, P., Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle, Biology of Reproduction, 95, (6), 2016, p1-12
Lynch, L. and Hogan, A.E. and Duquette, D. and Lester, C. and Banks, A. and LeClair, K. and Cohen, D.E. and Ghosh, A. and Lu, B. and Corrigan, M. and Stevanovic, D. and Maratos-Flier, E. and Drucker, D.J. and O'Shea, D. and Brenner, M., iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy, Cell Metabolism, 24, (3), 2016, p510-519
Kohlgruber, A.C. and LaMarche, N.M. and Lynch, L., Adipose tissue at the nexus of systemic and cellular immunometabolism, Seminars in Immunology, 28, (5), 2016, p431-440
Khalid, H. and Mukherjee, S.P. and O'Neill, L. and Byrne, H.J., Structural dependence of in vitro cytotoxicity, oxidative stress and uptake mechanisms of poly(propylene imine) dendritic nanoparticles, Journal of Applied Toxicology, 36, (3), 2016, p464-473
Lavelle, E.C. and Tomar, J., Mucosal vaccines, adjuvants and delivery 2016 - A meetings management conference, Drugs of the Future, 41, (11), 2016, p689-695
The Role of Inflammasomes in Adjuvant-Driven Humoral and Cellular Immune Responses in, editor(s)Virgil Schijns and Derek O'Hagan , Immunopotentiators in Modern Vaccines , 2016, pp23-42 , [Munoz-Wolf, N., McCluskey, S. and Lavelle, E.C.]
Medzhitov R, Belkaid Y, Davis M.M, Glimcher L, O'Neill L.A.J, Sallusto F, Immunology Gets out of the Box, Cell, 165, (4), 2016, p763 - 764
O'Neill L.A.J, Kishton R.J, Rathmell J, A guide to immunometabolism for immunologists, Nature Reviews Immunology, 16, (9), 2016, p553 - 565
Corcoran S.E, O'Neill L.A.J, HIF1α and metabolic reprogramming in inflammation, Journal of Clinical Investigation, 126, (10), 2016, p3699 - 3707
Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13
O'Neill L.A.J, A Metabolic Roadblock in Inflammatory Macrophages, Cell Reports, 17, (3), 2016, p625 - 626
Brady G, Boggan L, Bowie A, O'Neill L.A.J, Erratum: Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1 (The Journal of Biological Chemistry (2005) 280 (30723-30734) DOI: 10.1074/jbc.M500435200), Journal of Biological Chemistry, 291, (48), 2016, p25278-
Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240-
Arts R.J.W, Novakovic B, ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng S.-C, Wang S.-Y, Habibi E, Gonçalves L.G, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk F.L, Williams D.L, van der Meer J.W.M, Logie C, O'Neill L.A, Dinarello C.A, Riksen N.P, van Crevel R, Clish C, Notebaart R.A, Joosten L.A.B, Stunnenberg H.G, Xavier R.J, Netea M.G, Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity, Cell Metabolism, 24, (6), 2016, p807 - 819
Basiorka A.A, McGraw K.L, Eksioglu E.A, Chen X, Johnson J, Zhang L, Zhang Q, Irvine B.A, Cluzeau T, Sallman D.A, Padron E, Komrokji R, Sokol L, Coll R.C, Robertson A.A.B, Cooper M.A, Cleveland J.L, O'Neill L.A, Wei S, List A.F, The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype, Blood, 128, (25), 2016, p2960 - 2975
Colm Cunningham, Neurosciences in Intensive Care Symposium, Pasteur institute, Paris, June, 2016
Colm Cunningham, Immunology research series, University of Cambridge, October, 2016
Colm Cunningham, American Delirium Society Annual Meeting, Nashville, June, 2016
Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun O, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM, Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults, J Nutr, 146, (9), 2016, p1801 - 1806
Fischer J, Weber AN, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner CM, O'Farrelly C, Berg T., Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection., Gut, 2016, pdoi: 10.1136/gutjnl-2015-31023
David Finlay, Glucose represses Dendritic Cell-induced T cell responses, Institute Seminar, Medical University of Vienna, Institute of Medical GeneticsUniversity of , 6th December, 2016, Thomas Weichhart, PhD
Gleeson, L.E., Sheedy, F.J., Metabolic reprogramming & inflammation: Fuelling the host response to pathogens, Seminars in Immunology, 28, (5), 2016, p450-468
Sensing the Environment Through Sestrins: Implications for Cellular Metabolism. in, editor(s)Kwan W. Jeon and Lorenzo Galluzzi , International Review of Cell and Molecular Biology, Elsevier, 2016, pp1 - 24, [Parmigiani A, Budanov AV]
Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV, Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death., Scientific Reports, 6, (22538), 2016, p14
Tsilioni I, Filippidis AS, Kerenidi T, Budanov AV, Zarogiannis SG, Gourgoulianis KI, Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells., Clinical Biochemistry, 49, (9), 2016, p726 - 728
Fearon U, Canavan M, Biniecka M, Veale DJ, Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis., 2016
Olieric V, Weinert T, Finke A.D, Anders C, Li D, Olieric N, Borca C.N, Steinmetz M.O, Caffrey M, Jinek M, Wang M, Data-collection strategy for challenging native SAD phasing, Acta Crystallographica Section D: Structural Biology, 72, (3), 2016, p421 - 429
Huang C.Y, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M, In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures, Acta crystallographica. Section D, Structural biology, 72, 2016, p93 - 112
Wojdyla J.A, Panepucci E, Martiel I, Ebner S, Huang C.-Y, Caffrey M, Bunk O, Wang M, Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals, Journal of Applied Crystallography, 49, 2016, p944 - 952
Vogeley L, El Arnaout T, Bailey J, Stansfeld P.J, Boland C, Caffrey M, Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin, Science, 351, (6275), 2016, p876 - 880
Zhou X.E, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White T.A, Yefanov O, Han G.W, Xu Q, De Waal P.W, Suino-Powell K.M, Boutet S, Williams G.J, Wang M, Li D, Caffrey M, Chapman H.N, Spence J.C.H, Fromme P, Weierstall U, Stevens R.C, Cherezov V, Melcher K, Xu H.E, X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, Scientific Data, 3, 2016, p21-
Rues R.-B, Henrich E, Boland C, Caffrey M, Bernhard F, Cell-free production of membrane proteins in escherichia coli lysates for functional and structural studies, Protocol Heterologous Expression of Membrane Proteins, 1432, 2016, p1-21
Conroy M.J, Fitzgerald V, Doyle S.L, Channon S, Useckaite Z, Gilmartin N, Oâ Farrelly C, Ravi N, Reynolds J.V, Lysaght J, The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function, Journal of Leukocyte Biology, 100, (6), 2016, p1435 - 1442
Mulcahy M.E, McLoughlin R.M, Staphylococcus aureus and influenza a virus: Partners in coinfection, mBio, 7, (6), 2016, e02068-16
Lalor S.J, McLoughlin R.M, Memory γÎ" T Cellsâ"Newly Appreciated Protagonists in Infection and Immunity, Trends in Immunology, 37, (10), 2016, p690 - 702
Mulcahy M.E, McLoughlin R.M, Hostâ"Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization, Trends in Microbiology, 24, (11), 2016, p872 - 886
Stojkovic B, McLoughlin R.M, Meade K.G, In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves, Veterinary Immunology and Immunopathology, 182, 2016, p1 - 10
Williams JM, Bezak T, Das M, Ning Z, Lucking EF, Kelly VP, Harrison P, Young P, O'Connell MJ, Dockery P, O'Halloran KD, Moore T , Psg22 null mouse embryos develop normally under normoxic and hypoxic conditions of pregnancy., Science Matters, 10, (19185), 2016
Exley M.A, Tsokos G.C, Mills K.H.G, Elewaut D, Mulhearn B, What rheumatologists need to know about innate lymphocytes, Nature Reviews Rheumatology, 12, (11), 2016, 2016 Nov;12(11):658-668. doi:
Hayes J.M, Wormald M.R, Rudd P.M, Davey G.P, Fc gamma receptors: Glycobiology and therapeutic prospects, Journal of Inflammation Research, 9, 2016, p209 - 219
Pandiyan P, Lavelle E.C, Editorial: Immune cells in the mucosa, Frontiers in Immunology, 7, (DEC), 2016, p00657-
Al-Ani B, Fitzpatrick M, Al-Nuaimi H, Coughlan A.M, Hickey F.B, Pusey C.D, Savage C, Benton C.M, O'Brien E.C, O'Toole D, Mok K.H, Young S.P, Little M.A, Changes in urinary metabolomic profile during relapsing renal vasculitis, Scientific Reports, 6, 2016, 38074 -
Greene L.M, Butini S, Campiani G, Williams D.C, Zisterer D.M, Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines, Journal of Cancer, 7, (15), 2016, p2367 - 2377
Johnson G.P, Lloyd A.T, O'Farrelly C, Meade K.G, Fair S, Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract, Reproduction, Fertility and Development, 28, (10), 2016, p1499 - 1508
Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan D.D, Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?, American Journal of Transplantation, 16, (3), 2016, p751 - 757
Coughlan A.M, Harmon C, Whelan S, O'Brien E.C, O'Reilly V.P, Crotty P, Kelly P, Ryan M, Hickey F.B, O'Farrelly C, Little M.A, Myeloid engraftment in humanized mice: Impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain, Stem Cells and Development, 25, (7), 2016, p530 - 541
Thiruchelvam U, Wingfield M, O'Farrelly C, Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor, American Journal of Reproductive Immunology, 75, (4), 2016, p493 - 502
Fischer J, Weber A.N.R, Bohm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-MÃ"ller E, Malinverni R, Bochud P.-Y, Gardiner C, O'Farrelly C, Berg T, Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection, Gut, 2016
Robinson M.W, Harmon C, O'Farrelly C, Liver immunology and its role in inflammation and homeostasis, Cellular and Molecular Immunology, 13, (3), 2016, p267 - 276
Conroy M.J, Galvin K.C, Kavanagh M.E, Mongan A.M, Doyle S.L, Gilmartin N, O'Farrelly C, Reynolds J.V, Lysaght J, CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer, Immunology and Cell Biology, 94, (6), 2016, p531 - 537
Harmon C, Robinson M.W, Fahey R, Whelan S, Houlihan D.D, Geoghegan J, O'Farrelly C, Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver, European Journal of Immunology, 46, (9), 2016, p2111 - 2120
Doherty R, Whiston R, Cormican P, Finlay E.K, Couldrey C, Brady C, O'Farrelly C, Meade K.G, The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle, Scientific Reports, 6, 2016, p31014
Rush G, O'Donovan A, Nagle L, Conway C, McCrohan A, O'Farrelly C, Lucey J.V, Malone K.M, Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy, Journal of Affective Disorders, 205, 2016, p60 - 68
Kelly A, Robinson M.W, Roche G, Biron C.A, O'Farrelly C, Ryan E.J, Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway, Journal of Interferon and Cytokine Research, 36, (12), 2016, p671 - 680
Shirey, K.A, Lai, W., Pletneva, L.M., Patel, M., Pang, C., Kurt-Jones, E., Lipsky, M., Roger, T., Calandra, T., Tracey, K., Al Abed, Y., Bowie, A.G., Fasano, A., Dinarello, C., Gusovsky, F., Blanco, J.C.G., and Vogel S.N., Novel Strategies for Targeting Innate Immune Responses to Influenza , Mucosal Immunology , 9, 2016, p1173 - 1182
Dyck L, Wilk M.M, Raverdeau M, Misiak A, Boon L, Mills K.H.G, Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model, Cancer Immunol Immunother , 65, 2016, p1491-
Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441
Saadatian-Elahi M, Plotkin S, Mills K.H.G, Halperin S.A, McIntyre P.B, Picot V, Louis J, Johnson D.R, Pertussis: Biology, epidemiology and prevention, Vaccine, 34, (48), 2016, p5819 - 5826
Ouimet, M., Koster, S., Sakowski, E., Ramkhelawon, B., Van Solingen, C., Oldebeken, S., Karunakaran, D., Portal-Celhay, C., Sheedy, F.J., Ray, T.D., Cecchini, K., Zamore, P.D., Rayner, K.J., Marcel, Y.L., Philips, J.A., Moore, K.J., Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism, Nature Immunology, 17, (6), 2016, p677-686
Greene LM, Nathwani SM, Zisterer DM., Inhibition of γ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5., Oncology Letters, 12, (4), 2016, p2900 - 2905
Carr M, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ., Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells., Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 2016, p117-130
Flood B, Oficjalska K, Fay J, O'Grady A, Ryan EJ, Doherty GA, Kay E and Creagh EM. , Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients. , Gasteroenterology, Digestive Diseases Week (DDW), San Diego, CA, 19-24 May 2016, 150, (4), American Gastroenterology Association (AGA), 2016, ppS616-S617
Brindisi M, Maramai S, Brogi S, Fanigliulo E, Butini S, Guarino E, Casagni A, Lamponi S, Bonechi C, Nathwani SM, Finetti F, Ragonese F, Arcidiacono P, Campiglia P, Valenti S, Novellino E, Spaccapelo R, Morbidelli L, Zisterer DM, Williams CD, Donati A, Baldari C, Campiani G, Ulivieri C, Gemma S., Development of novel cyclic peptides as pro-apoptotic agents., European Journal of Medicinal Chemistry, 117, 2016, p301 - 320
Greene TF, Wang S, Greene LM, Nathwani SM, Pollock JK, Malebari AM, McCabe T, Twamley B, O'Boyle NM, Zisterer DM, Meegan MJ, Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents., Journal of Medicinal Chemistry, 59, (1), 2016, p90 - 113
Neuroinflammatory Disorders in, editor(s)Orla Hardiman, Colin P. Doherty, Marwa Elami, Peter Bede , Neurodegenerative Disorders, Springer International Publishing, 2016, pp269 - 287, [Costelloe C, Fletcher JM, Fitzgerald D. Neuroinflammatory Disorders. (In Neurodegenerative Disorders).]
Basdeo SA, Kelly S, O'Connell K, Tubridy N, McGuigan C, Fletcher JM, Increased expression of Tbet in CD4+ T cells from clinically isolated syndrome patients at high risk of conversion to clinically definite MS. , Springer Plus, 5, 2016, p779-
Dunne M, Ryan C, Tosetto M, Nolan B, Geraghty R, Winter DC, O'Connell R, Hyland J, Doherty GA, Sheahan K, Ryan EJ, Fletcher JM., Enrichment of inflammatory IL-17 and TNF-α secreting CD4+ T cells within colorectal tumours despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1., Frontiers in Oncology, 6, 2016, p50-
Muñoz-Wolf N, Lavelle EC., Innate Immune Receptors., Methods Mol Biol., 1417, 2016, p1 - 43
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787
Davitt, C.J.H., McNeela, E.A., Longet, S., Tobias, J., Aversa, V., McEntee, C.P., Rosa, M., Coulter, I.S., Holmgren, J., Lavelle, E.C., A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal pathogens, Journal of Controlled Release, 233, 2016, p162-173
Hughes, C.S., Colhoun, L.M., Bains, B.K., Kilgour, J.D., Burden, R.E., Burrows, J.F., Lavelle, E.C., Gilmore, B.F., Scott, C.J., Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages, Particle and Fibre Toxicology, 13, (1), 2016, p19-
Schwartz, C., O'Grady, K., Lavelle, E.C., Fallon, P.G., Interleukin 33: An innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer, European Journal of Immunology, 46, (5), 2016, p1091-1100
Lebre, F., Hearnden, C.H., Lavelle, E.C., Modulation of Immune Responses by Particulate Materials, Advanced Materials, 2016, 5525-5541
Carroll, E.C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H.B.T., Mansouri, S., McEntee, C.P., Lambe, E., Agger, E.M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K.A., Bowie, A.G., Lavelle, E.C., The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons, Immunity, 44, (3), 2016, p597 - 608
Oleszycka, E., Moran, H.B.T., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J. and Lavelle, E.C. , IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination. , FEBS Journal, 283, (1), 2016, p9 - 24
Walls J, Sinclair L, Finlay D, Nutrient sensing, signal transduction and immune responses., Seminars in Immunology, 28, (5), 2016, p396-407
Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM., Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells., Journal of Immunology, 196, (6), 2016, p2552 - 2560
Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T, TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway., Science Signalling, 9, 2016, pra19-
Assmann N, Finlay DK., Metabolic regulation of immune responses: therapeutic opportunities., Journal of Clinical Investigation, 126, (6), 2016, p2031 - 2039
Mahony R, Ahmed S, Diskin C, Stevenson NJ, SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?, Cellular and Molecular Life Sciences, 73, (17), 2016, p3323 - 3336
Kahvedzic -Seljubac A, Nathwani S.-M, Zisterer D.M, Rozas I, Isouronium and N-hydroxyguanidinium derivatives as Cell growth inhibitors: A comparative study, European Journal of Medicinal Chemistry, 117, 2016, p269 - 282
Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM, The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL"induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells., International journal of oncology, 49, (1), 2016, p74-88
Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells., Investigational new drugs, 34, (5), 2016, p663-76
Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ, Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles., Bioorganic & medicinal chemistry, 24, (18), 2016, p4075-99
Mills E.L, O'Neill L.A, Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal, European Journal of Immunology, 46, (1), 2016, p13 - 21
O'Neill L.A.J, Pearce E.J, Immunometabolism governs dendritic cell and macrophage function, Journal of Experimental Medicine, 213, (1), 2016, p15 - 23
Joosten L.A.B, Abdollahi-Roodsaz S, Dinarello C.A, O'Neill L, Netea M.G, Toll-like receptors and chronic inflammation in rheumatic diseases: New developments, Nature Reviews Rheumatology, 12, (6), 2016, p344 - 357
Arbore G, West E.E, Spolski R, Robertson A.A.B, Klos A, Rheinheimer C, Dutow P, Woodruff T.M, Yu Z.X, O'Neill L.A, Coll R.C, Sher A, Leonard W.J, Köhl J, Monk P, Cooper M.A, Arno M, Afzali B, Lachmann H.J, Cope A.P, Mayer-Barber K.D, Kemper C, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells, Science, 352, (6292), 2016
Gardiner C.M, Mills K.H.G, The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases, Seminars in Immunology, 28, (4), 2016, p343-350
Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427-
Lee J.P.W, Foote A, Fan H, Peral de Castro C, Lang T, Jones S.A, Gavrilescu N, Mills K.H.G, Leech M, Morand E.F, Harris J, Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages, Autophagy, 12, (6), 2016, p907 - 916
Raverdeau M, Breen C.J, Misiak A, Mills K.H.G, Retinoic acid suppresses IL-17 production and pathogenic activity of γΎ T cells in CNS autoimmunity, Immunology and Cell Biology, 94, (8), 2016, p763 - 773
McDonald AG, Hayes JM, Davey GP, Metabolic flux control in glycosylation., Current opinion in structural biology, 40, 2016, p97-103
Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2
Corr E.M, Cunningham C.C, Dunne A, Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 251, 2016, p197 - 205
Oliveira T, Sharkey M.A, Engel P.C, Khan A.R, Crystal structure of a chimaeric bacterial glutamate dehydrogenase, Acta Crystallographica Section:F Structural Biology Communications, 72, 2016, p462 - 466
McDonald, A.G, Tipton, K.F. and Davey, G.P. , A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts, PLOS Computational Biology, 12, (4), 2016, pe1004844-
McIntyre J, Verma N.K, Smith R.J, Moore C, Nerl H, McEvoy N, Berner N, McGovern I, Khan U, Lyons P, O'Neill L, Nicolosi V, Duesberg G.S, Byrne H.J, Coleman J, Volkov Y, A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene, RSC Advances, 6, (70), 2016, p65299 - 65310
McDonald AG, Tipton KF, Davey GP, A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts., PLoS computational biology, 12, (4), 2016, pe1004844
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885
Martin DS, Leonard S, Devine R, Redondo C, Kinsella GK, Breen CJ, McEneaney V, Rooney MF, Munsey TS, Porter RK, Sivaprasadarao A, Stephens JC, Findlay JB., Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice., J Mol Endocrinol , 56, (3), 2016, p261 - 271
Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200
Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15., Investigational new drugs, 34, (2), 2016, 159-167
Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22-
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449
Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714
Loftus RM, Finlay DK, Immunometabolism; cellular metabolism turns immune regulator., Journal of Biological Chemistry, 291, (1), 2016, p1 - 10
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M, Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells., Cancer biology & therapy, 17, (8), 2016, p849 - 858