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Publications

Below is the list of peer and non peer publications from the School of Biochemistry and Immunology.

Show: AllPeer ReviewedNon Peer Reviewed
109 publications from 2015

He X., Lakkaraju S.K., Hanscom M., Zhao Z., Wu J., Stoica B., Mackerell A.D., Faden A.I., Xue F., Acyl-2-aminobenzimidazoles: A novel class of neuroprotective agents targeting mGluR5, Bioorganic and Medicinal Chemistry, 23, (9), 2015, p2211 - 2220, p2211-2220
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Lakkaraju S.K., Mbatia H., Hanscom M., Zhao Z., Wu J., Stoica B., MacKerell A.D., Faden A.I., Xue F., Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5, Bioorganic and Medicinal Chemistry Letters, 25, (11), 2015, p2275 - 2279, p2275-2279
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Lecca D, Nevin DK, Mulas G, Casu MA, Diana A, Rossi D, Sacchetti G, Fayne, Carta AR, Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPAR" agonist in vitro and in MPTP-treated mice., Neuroscience, 2015
Journal Article; Published; Peer Reviewed; Author Profile: FAYNED

David K Finlay, Food fight, Immune cells vs Cancer, Trinity Biomedical Frontiers Series, Trinity Biomedical Sciences Institute, 2015, School of Biochemistry and Immunology
Invited Talk; Presented; Non Peer Reviewed; Author Profile: FINLAYD

Ryan, T.J. and Roy, D.S. and Pignatelli, M. and Arons, A. and Tonegawa, S., Engram cells retain memory under retrograde amnesia, Science, 348, (6238), 2015, p1007-1013
Journal Article; Published; Peer Reviewed; Author Profile: TRYAN6; DOI; URL

McCarthy, G., Cunningham, C., Corr, E., Dunne, A., Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ -induced Anti-Osteoclastogenic Signaling in human osteoclast precursors. , Arthritis Rheumatol. , 2015 ACR/ACHP Annual Meeting, San Francisco, 2015, 67 (suppl 10), 2015
Conference Paper; Published; Peer Reviewed; Author Profile: AIDUNNE

Aisling Dunne and Kingston Mills, 'TLR2 agonists and vaccines and uses thereof', European Patent Office, WO/2015/140234, 2015
Patent; Submitted; Peer Reviewed; Author Profile: AIDUNNE; URL

Fintan Geoghegan, Cancer Cell Bioenergetics in response to Anti-cancer Agents, Trinity College Dublin, 2015
Thesis; Published; Peer Reviewed; Author Profile: RKPORTER

Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S., Memory. Engram cells retain memory under retrograde amnesia., Science (New York, N.Y.), 348, (6238), 2015, p1007-1013
Journal Article; Published; Peer Reviewed; Author Profile: TRYAN6; DOI

Tonegawa S, Pignatelli M, Roy DS, Ryan TJ., Memory engram storage and retrieval., Current opinion in neurobiology, 35, 2015, p101-109
Journal Article; Published; Peer Reviewed; Author Profile: TRYAN6; DOI

Richard K. Porter, Thymocyte/T-cell function and mitochondrial uncoupling proteins, Ireland China Partnership, Guangzhou Medical Centre, Mainland China, , (Mar 2015) , 2015
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER; URL

Richard K. Porter, Energy Metabolism in Immune cells , Joint Weizmann-TBSI Immunology Meeting, Weizmann Institute, Israel, (Jun 2015), 2015
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Richard K. Porter, The Role of Mitochondrial Uncoupling Proteins (UCP's) in Thymocyte/T-Cell Development and Function, Visiting Professor, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University in Poznań, Poland , (Oct 2015) , 2015, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University in Poznań, Poland
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms, Journal of Biological Chemistry, 290, (47), 2015, p28343 - 28352
Journal Article; Published; Peer Reviewed; Author Profiles: MOK1 GDAVEY MROWAN ; URL

Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter, MSTN GENOTYPE VARIATION EFFECTS SKELETAL MUSCLE MITOCHONDRIAL ABUNDANCE IN UNTRAINED THOROUGHBRED HORSES., International Biochemistry of Exercise Conference (IBEC), Sao Paulo, Brazil, 07-09 Sep 2015 , 2015
Meeting Abstract; Published; Peer Reviewed; Author Profile: RKPORTER

Kim, E.Y. and Lynch, L. and Brennan, P.J. and Cohen, N.R. and Brenner, M.B., The transcriptional programs of iNKT cells, Seminars in Immunology, 27, (1), 2015, p26-32
Journal Article; Published; Peer Reviewed; Author Profile: LYNCHL3; DOI; URL

Kohlgruber, A. and Lynch, L., Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes, Current Diabetes Reports, 15, (11), 2015
Journal Article; Published; Peer Reviewed; Author Profile: LYNCHL3; DOI; URL

Lynch, L. and Michelet, X. and Zhang, S. and Brennan, P.J. and Moseman, A. and Lester, C. and Besra, G. and Vomhof-Dekrey, E.E. and Tighe, M. and Koay, H.-F. and Godfrey, D.I. and Leadbetter, E.A. and Sant'Angelo, D.B. and Von Andrian, U. and Brenner, M.B., Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T reg cells and macrophages in adipose tissue, Nature Immunology, 16, (1), 2015, p85-95
Journal Article; Published; Peer Reviewed; Author Profile: LYNCHL3; DOI; URL

Colm Cunningham, British Association for Psychopharmacology Conference, Bristol, August, 2015, BAP
Invited Talk; Presented; Non Peer Reviewed; Author Profile: CUNNINCO

Colm Cunningham, Keynote lecture, European Delirium Associaton/British Geriatric Society Meeting, London, September, 2015, BGS/EDA
Invited Talk; Presented; Non Peer Reviewed; Author Profile: CUNNINCO

AGS/NIA Delirium Conference Writing Group, Planning Committee and Faculty., The American Geriatrics Society/National Institute on Aging Bedside-to-Bench Conference: Research Agenda on Delirium in Older Adults., Journal of the American Geriatrics Society, 63, (5), 2015, p843-852
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Zhao, B; Shah, P ; Budanov, A ; Qiang, L ; Ming, M ; Aplin, A ; Sims, D ; He, Y, Sestrin2 positively regulates AKT signaling and survival in human squamous cell carcinoma and melanoma cells, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Annual Meeting of the Society-for-Investigative-Dermatology, Atlanta, GA, MAY 06-09, 135, NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA, 2015, ppS18 - S18
Conference Paper; Published; Peer Reviewed; Author Profile: BUDANOVA; URL

Ding B, Parmigiani A, Yang C, Budanov AV, Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation., Cell Cycle, 14, (20), 2015, p3231 - 3241
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Budanov AV, SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR., Molecular & Cellular Oncology, 2, (3), 2015, p3
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J, Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart., FASEB Journal, 29, (2), 2015, p408 - 417
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Li D, Stansfeld P.J, Sansom M.S.P, Keogh A, Vogeley L, Howe N, Lyons J.A, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin N.A, Cherezov V, Liu W, Bandaru S, English N.J, Gati C, Barty A, Yefanov O, Chapman H.N, Diederichs K, Messerschmidt M, Boutet S, Williams G.J, Seibert M.M, Caffrey M, Ternary structure reveals mechanism of a membrane diacylglycerol kinase, Nature Communications, 6, 2015, p10140-
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Thiruchelvam U, Wingfield M, O'Farrelly C, Natural Killer Cells: Key Players in Endometriosis, American Journal of Reproductive Immunology, 74, (4), 2015, 291-301
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; URL

Foley C, Chapwanya A, Callanan J.J, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer W.G, Lynn D.J, O'Farrelly C, Meade K.G, Erratum to: 'Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis'[BMC Genomics. 2015;16:811.], 2015, -
Miscellaneous; Published; Peer Reviewed; Author Profile: OFARRECL; DOI; URL

Sheedy, F.J., Turning 21: Induction of miR-21 as a key switch in the inflammatory response, Frontiers in Immunology, 6, (JAN), 2015
Journal Article; Published; Peer Reviewed; Author Profile: FSHEEDY

Ouimet, M., Ediriweera, H.N., Mahesh Gundra, U., Sheedy, F.J., Ramkhelawon, B., Hutchison, S.B., Rinehold, K., Van Solingen, C., Fullerton, M.D., Cecchini, K., Rayner, K.J., Steinberg, G.R., Zamore, P.D., Fisher, E.A., Loke, P., Moore, K.J., MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis, Journal of Clinical Investigation, 125, (12), 2015, p4334-4348
Journal Article; Published; Peer Reviewed; Author Profile: FSHEEDY

David Finlay, Glucose and glycolysis are anti-inflammatory in Dendritic cells , 111th International Titisee Conference, Titisee, Germany, April, 2015
Invited Talk; Presented; Non Peer Reviewed; Author Profile: FINLAYD

David Finlay, Metabolic regulation of Natural Killer Cells , American Association of Immunology (AAI), New Orleans, 9 May, 2015
Invited Talk; Presented; Non Peer Reviewed; Author Profile: FINLAYD

David Finlay, Nutrients control immune responses , Irish Society of Immunology, Trinity College Dublin, September , 2015
Invited Talk; Presented; Non Peer Reviewed; Author Profile: FINLAYD

Kelly B, O'Neill L.A.J, Metabolic reprogramming in macrophages and dendritic cells in innate immunity, Cell Research, 25, (7), 2015, p771 - 784
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Finucane O.M, Lyons C.L, Murphy A.M, Reynolds C.M, Klinger R, Healy N.P, Cooke A.A, Coll R.C, Mcallan L, Nilaweera K.N, O'Reilly M.E, Tierney A.C, Morine M.J, Alcala-Diaz J.F, Lopez-Miranda J, O'Connor D.P, O'Neill L.A, Mcgillicuddy F.C, Roche H.M, Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity, Diabetes, 64, (6), 2015, p2116 - 2128
Journal Article; Published; Peer Reviewed; Author Profiles: FINUCAOR LAONEILL ; DOI; URL

Kelly B, Tannahill G.M, Murphy M.P, O'Neill L.A.J, Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages, Journal of Biological Chemistry, 290, (33), 2015, p20348 - 20359
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Norata G.D, Caligiuri G, Chavakis T, Matarese G, Netea M.G, Nicoletti A, O'Neill L.A.J, Marelli-Berg F.M, The Cellular and Molecular Basis of Translational Immunometabolism, Immunity, 43, (3), 2015, p421 - 434
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

O'Neill L.A.J, How Low Cholesterol Is Good for Anti-viral Immunity, Cell, 163, (7), 2015, p1572 - 1574
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Murphy A.G, O'Keeffe K.M, Lalor S.J, Maher B.M, Mills K.H.G, McLoughlin R.M, Staphylococcus aureus infection of mice expands a population of memory γΎ T cells that are protective against subsequent infection (Journal of Immunology (2014) 192 (3697-3708)), Journal of Immunology, 194, (9), 2015, p4588-
Journal Article; Published; Peer Reviewed; Author Profiles: MCLOUGRM LALORST MILLSK ; DOI; URL

Edwards S.C, McGinley A.M, McGuinness N.C, Mills K.H.G, γÎ" T cells and NK cells - distinct pathogenic roles as innate-like immune cells in CNS autoimmunity, Frontiers in Immunology, 6, (SEP), 2015, p1-
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI; URL

Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK LAONEILL ; DOI; URL

Investigating inflammasome activation under conditions of cellular stress and injury in, Stress Responses: Methods and Protocols, 2015, pp105-113 , [Cunningham C.C, Corr E.M, Cox D.J, Dunne A]
Book Chapter; Published; Peer Reviewed; Author Profiles: DOCOX AIDUNNE ; DOI; URL

Foley C, Chapwanya A, Callanan JJ, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer WG, Lynn DJ, O' Farrelly C, Meade KG, Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis., BMC genomics, 16, 2015, p811
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352
Journal Article; Published; Peer Reviewed; Author Profiles: MROWAN JBOLAND GDAVEY ; DOI

Diez-Cecilia E, Carson R, Kelly B, van Schaeybroeck S, Murray JT, Rozas I, Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway., Bioorganic & medicinal chemistry letters, 25, (19), 2015, p4287-92
Journal Article; Published; Peer Reviewed; Author Profiles: JMURRAY6 ROZASI ; DOI

Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune-Stimulating Complexes (ISCOMs) in, Mucosal Immunology, 2015, pp1211-1231 , [McEntee, C., Lavelle, E.C., O'Hagan, D.T.]
Book Chapter; Published; Peer Reviewed; Author Profile: LAVELLEE; DOI

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL MILLSK ECREAGH CORRSC ; DOI

Gardiner CM, NK cell function and receptor diversity in the context of HCV infection., Frontiers in microbiology, 6, 2015, p1061
Journal Article; Published; Peer Reviewed; Author Profile: GARDINEC; DOI

Dunphy SE, Sweeney CM, Kelly G, Tobin AM, Kirby B, Gardiner CM, Natural killer cells from psoriasis vulgaris patients have reduced levels of cytotoxicity associated degranulation and cytokine production., Clinical immunology (Orlando, Fla.), 2015
Journal Article; Published; Peer Reviewed; Author Profiles: ATOBIN GARDINEC

Keating SE, Ní Chorcora C, Dring MM, Stallings RL, O'Meara A, Gardiner CM, Increased frequencies of the killer immunoglobulin-like receptor genes KIR2DL2 and KIR2DS2 are associated with neuroblastoma., Tissue antigens, 86, (3), 2015, p172-7
Journal Article; Published; Peer Reviewed; Author Profile: GARDINEC

Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM, 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells., Genes and immunity, 16, (5), 2015, p301-10
Journal Article; Published; Peer Reviewed; Author Profile: GARDINEC

Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, Collu G, Loddo R, Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents., European journal of medicinal chemistry, 102, 2015, p648-60
Journal Article; Published; Peer Reviewed; Author Profiles: DZISTRER DWILLIMS ; DOI

Greene LM, Meegan MJ, Zisterer DM, Combretastatins: More Than Just Vascular Targeting Agents?, The Journal of pharmacology and experimental therapeutics, 355, (2), 2015, p212-27
Journal Article; Published; Peer Reviewed; Author Profile: DZISTRER

The importance of cell mediated immunity for bacterial vaccines in, Vaccine Design: Innovative Approaches and Novel Strategies, Caister Academic Press, 2015, pp220 - 249, [Alison G.Murphy & Rachel M. McLoughlin]
Book Chapter; Published; Peer Reviewed; Author Profile: MCLOUGRM; DOI

Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, Nolan DP, Yamaryo-Botté Y, Botté C, Kremer A, Burkard GS, Rassow J, Roditi I, Pérez-Morga D, Pays E.(, Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1., Nature Communications, 6, 2015, p8078 - 8088
Journal Article; Published; Peer Reviewed; Author Profile: DENOLAN; URL

Renata Reis, Edel Hennessy, Caoimhe Murray, Éadaoin W. Griffin and Colm Cunningham, At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. , Neuropathology and Applied Neurobiology, 41 , (6), 2015, p780 - 797
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Hennessy, E; Griffin E; Cunningham C, Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL-1β and TNF-α, Journal of Neuroscience, 35, (22), 2015, p8411 - 8422
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; URL

Edwards SC, McGinley AM, McGuinness NC, Mills KH, γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity., Frontiers in immunology, 6, 2015, p455
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI

Brummelman J, Wilk MM, Han WG, van Els CA, Mills KH, Roads to the development of improved pertussis vaccines paved by immunology., Pathogens and disease, 73, (8), 2015, pftv067
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI

Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM, Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity., Journal of immunology (Baltimore, Md. : 1950), 195, (2), 2015, p528-40
Journal Article; Published; Peer Reviewed; Author Profiles: SBASDEO MILLSK FEARONU ; DOI

Dempsey A, Bowie AG, Innate immune recognition of DNA: A recent history., Virology, 479-480, 2015, p146-52
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG, Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation., Journal of virology, 89, (16), 2015, p8406-15
Journal Article; Published; Peer Reviewed; Author Profiles: AGBOWIE BRADYG1 ; DOI

Wang, H., El Maadidi, S., Fischer, J., Grabski, E., Dickhöfer, S., Klimosch, S., Flannery, S.M., Filomena, A., Wolz, O-O., Schneiderhan-Marra, N., Löffler, M.W., Wiese, M., Pichulik, T., Müllhaupt, B., Semela, D., Dufour, J-F., the East-German and Swiss Hepatitis C Virus Study Groups, Bochud, P-Y., Bowie, A.G., Kalinke, U., Berg, T., Weber, A.N.R. , A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance, Hepatology, 62, 2015, p1375 - 1387
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226
Journal Article; Published; Peer Reviewed; Author Profiles: ROGERSTR TFOSTER GEOGHEJO LAVELLEE MCLOUGRM MACAOGAM LALORST JFENNELL ; DOI

David Finlay, Metabolic regulation of natural killer cells, Biochemical Society Transactions, 43, (4), 2015, p758 - 762.
Review Article; Published; Non Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Murray C1, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C., Brain, Behaviour and Immunity,, 48, 2015, p274 - 286
Journal Article; Published; Peer Reviewed; Author Profile: STEVENNJ; URL

Lui PY, Jin DY, Stevenson NJ., MicroRNA: master controllers of intracellular signaling pathways., Cellular and Molecular Life Sciences, 72, (18), 2015, p3531 - 3542
Review Article; Published; Peer Reviewed; Author Profile: STEVENNJ; URL

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA, Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1., Proceedings of the National Academy of Sciences of the United States of America, 112, (23), 2015, p7231-6
Journal Article; Published; Peer Reviewed; Author Profiles: ACURTIS LAONEILL KAHOKAMP ; DOI

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505
Journal Article; Published; Peer Reviewed; Author Profiles: DWILLIMS GUNNLAUT NULL-25DD5D6F8D3B8B68 DENOLAN ; DOI

David Finlay, Starved human T lymphocytes keep fighting., European Journal of Immunology, 2015
Review Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

David Finlay, Glucose, glycolysis and lymphocyte responses., Molecular Immunology, 2015
Review Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Lall, P., Lindsay, A.J., Hanscom, S., (...), McCaffrey, M.W., Khan, A.R., Structure-function analyses of the interactions between Rab11 and Rab14 small GTPases with their shared effector Rab coupling protein (RCP), Journal of Biological Chemistry, 290, (30), 2015, 18817-18832
Journal Article; Published; Peer Reviewed; Author Profiles: AMIRRAFK UBOND ; DOI

Fergus, C., Barnes, D., Alqasem, M.A., Kelly, V.P, The queuine micronutrient: Charting a course from microbe to man , Nutrients, 7, (4), 2015, p2897-2929
Journal Article; Published; Peer Reviewed; Author Profile: KELLYVP; DOI

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota A.E, Surana P, Kottur J, Nair D.T, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang B.-C, Steinmetz M.O, Caffrey M, Wang M, Fast native-SAD phasing for routine macromolecular structure determination, Nature Methods, 12, (2), 2015, p131 - 133
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Huang C.-Y, Olieric V, Ma P, Panepucci E, Diederichs K, Wang M, Caffrey M, In meso in situ serial X-ray crystallography of soluble and membrane proteins, Acta Crystallographica Section D: Biological Crystallography, 71, 2015, p1238 - 1256
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota A.E, Surana P, Kottur J, Nair D.T, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang B.-C, Steinmetz M.O, Caffrey M, Wang M, Erratum: Fast native-SAD phasing for routine macromolecular structure determination (Nature Methods (2015) 12 (131-133)), Nature Methods, 12, (7), 2015, p692-
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Fowler P.W, Orwick-Rydmark M, Radestock S, Solcan N, Dijkman P.M, Lyons J.A, Kwok J, Caffrey M, Watts A, Forrest L.R, Newstead S, Gating topology of the proton-coupled oligopeptide symporters, Structure, 23, (2), 2015, p290 - 301
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Stansfeld P.J, Goose J.E, Caffrey M, Carpenter E.P, Parker J.L, Newstead S, Sansom M.S.P, MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes, Structure, 23, (7), 2015, p1350 - 1361
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Kang Y, Zhou X.E, Gao X, He Y, Liu W, Ishchenko A, Barty A, White T.A, Yefanov O, Han G.W, Xu Q, De Waal P.W, Ke J, Tan M.H.E, Zhang C, Moeller A, West G.M, Pascal B.D, Van Eps N, Caro L.N, Vishnivetskiy S.A, Lee R.J, Suino-Powell K.M, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams G.J, Messerschmidt M, Gati C, Zatsepin N.A, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad C.E, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter C.S, Carragher B, Caffrey M, Jiang H, Chapman H.N, Spence J.C.H, Fromme P, Weierstall U, Ernst O.P, Katritch V, Gurevich V.V, Griffin P.R, Hubbell W.L, Stevens R.C, Cherezov V, Melcher K, Xu H.E, Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, Nature, 523, (7562), 2015, p561 - 567
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

O'Neill L.A.J, A Broken Krebs Cycle in Macrophages, Immunity, 42, (3), 2015, p393 - 394
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Menon D, Coll R, O'Neill L.A.J, Board P.G, GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway, Journal of Cell Science, 128, (10), 2015, p1982 - 1990
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Haneklaus M, O'Neill L.A.J, NLRP3 at the interface of metabolism and inflammation, Immunological Reviews, 265, (1), 2015, p53 - 62
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Edwards S.C, Higgins S.C, Mills K.H.G, Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction, Brain, Behavior, and Immunity, 50, 2015, p41 - 46
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI; URL

Basdeo, S.A., Moran, B., Cluxton, D., (...), Fearon, U., Fletcher, J.M., Polyfunctional, pathogenic CD161+ Th17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity, Journal of Immunology, 195, (2), 2015, p528-540
Journal Article; Published; Peer Reviewed; Author Profile: FLETCHJ; DOI

Cloonan S.M, Elmes R.B.P, Erby M, Bright S.A, Poynton F.E, Nolan D.E, Quinn S.J, Gunnlaugsson T, Williams D.C, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells, Journal of Medicinal Chemistry, 58, (11), 2015, p4494 - 4505
Journal Article; Published; Peer Reviewed; Author Profiles: GUNNLAUT DENOLAN ; DOI; URL

McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560
Journal Article; Published; Peer Reviewed; Author Profiles: LYNCHMA MILLSK ; DOI; URL

O'Brien EC, Abdulahad WH, Rutgers A, Huitema MG, O'Reilly VP, Coughlan AM, Harrington M, Heeringa P, Little MA, Hickey FB, Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1ß secretion in response to anti-MPO antibodies., Scientific reports, 5, 2015, p11888 -
Journal Article; Published; Peer Reviewed; Author Profiles: MLITTLE OBRIEE33 ; DOI; URL

Davitt, C.J.H., Lavelle, E.C., Delivery strategies to enhance oral vaccination against enteric infections, Advanced Drug Delivery Reviews, 2015
Journal Article; In_press; Peer Reviewed; Author Profile: LAVELLEE; DOI

Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780
Journal Article; Published; Peer Reviewed; Author Profiles: DOHERTDE LYNCHL3 ; DOI; URL

O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54
Journal Article; Published; Peer Reviewed; Author Profiles: JOSULLI DWILLIMS DZISTRER ; DOI

Murray, C., Griffin, E.W., O'Loughlin, E., (...), Harkin, A., Cunningham, C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I: C, Brain, Behavior, and Immunity, 48, 2015, 274-286
Journal Article; Published; Peer Reviewed; Author Profiles: CUNNINCO AHARKIN

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445-
Journal Article; Published; Peer Reviewed; Author Profiles: TFOSTER GEOGHEJO MCLOUGRM ; DOI

Li, D. Pye, V.E. Caffrey, M., Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method, Acta Crystallographica Section D Biological Crystallography, 71, 2015, p104 - 122
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Caffrey, M., A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes, Acta Crystallographica Section F Structural Biology Communications, 71, 2015, p3 - 18
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Murphy, T.M. O'Donovan, A. Mullins, N. O'Farrelly, C. McCann, A. Malone, K., Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes, Psychiatric Genetics, 25, (2), 2015, p71 - 78
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI; URL

Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL MILLSK ; DOI; URL

Colm Cunningham and Edel Hennessy , Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research , Alzheimer's Research & Therapy, 7, 2015, p33-
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347
Miscellaneous; Published; Peer Reviewed; Author Profiles: ACURTIS JOSEPHMK PALSSONE LAONEILL ; DOI

Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F., TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei., Nucleic Acids Research, 43, 2015, p637 - 644
Journal Article; Published; Peer Reviewed; Author Profile: DENOLAN

Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK ECREAGH ; DOI

Clarke, K.J., Carroll, A.M., O'Brien, G., Porter, R.K. , Detection of UCP1 protein and measurements of dependent GDP-sensitive proton leak in non- phosphorylating thymus mitochondria, Methods in Molecular Biology, 1241, 2015, p123-135
Journal Article; Published; Peer Reviewed; Author Profile: RKPORTER; DOI

Kearney CJ, Cullen SP, Tynan GA, Henry CM, Clancy D, Lavelle EC, Martin SJ, Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production., Cell death and differentiation, 22, 2015, p1313-1327
Journal Article; Published; Peer Reviewed; Author Profiles: LAVELLEE MARTINSJ ; DOI

Cox, D. J., Field, R. H., Williams, D. G., Baran, M., Bowie, A. G., Cunningham, C. and Dunne, A. , DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease, GLIA, 63, (5), 2015, p812-825
Journal Article; Published; Peer Reviewed; Author Profiles: AGBOWIE AIDUNNE CUNNINCO DOCOX ; DOI

Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH, A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine., Mucosal immunology, 8, (3), 2015, p607-617
Journal Article; Published; Peer Reviewed; Author Profiles: AIDUNNE CASUTTON MILLSK ; DOI

Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992
Journal Article; Published; Peer Reviewed; Author Profiles: COFINLAY LAONEILL MILLSK ; DOI

Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK LAONEILL ECREAGH ; DOI

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80
Journal Article; Published; Peer Reviewed; Author Profiles: JOSEPHMK LAONEILL FSHEEDY PALSSONE ; DOI

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203
Journal Article; Published; Peer Reviewed; Author Profiles: SMOMARA HARDIMAO OGOBBO KTIPTON KELLYJA WALSHC CAMPBEM2 ; DOI

Davis DH, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, Brayne C, Rahkonen T, Sulkava R, Sanderson DJ, Rawlins JN, Bannerman DM, MacLullich AM, Cunningham C, Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium., The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 23, (4), 2015, 403-415
Journal Article; Published; Peer Reviewed; Author Profiles: CUNNINCO MURRAYC7 ; DOI