Publications
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131 peer reviewed publications from 2014
Bourke, J., Brereton, C.F., Gordon, S.V., Lavelle, E.C., Scanlan, E.M., The synthesis and biological evaluation of mycobacterial p-hydroxybenzoic acid derivatives (p-HBADs), Organic and Biomolecular Chemistry, 12, (7), 2014, p1114-1123
Oleszycka, E., Lavelle, E.C., Immunomodulatory properties of the vaccine adjuvant alum, Current Opinion in Immunology, 28, (1), 2014, p1-5
Canavan, M., McCarthy, C., Larbi, N.B., Dowling, J.K., Collins, L., O'Sullivan, F., Hurley, G., Murphy, C., Quinlan, A., Moloney, G., Darby, T., Macsharry, J., Kagechika, H., Moynagh, P., Melgar, S., Loscher, C.E., Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-"Bp50, Innate Immunity, 20, (7), 2014, p675-687
Gangemi, G. and Gazzerro, P. and Fiore, D. and Chiara Proto, M. and Butini, S. and Gemma, S. and Casagni, A. and Laezza, C. and Vitale, M. and Ligresti, A. and Dimarzo, V. and Zisterer, D.M. and Nathwani, S. and Clive Williams, D. and Campiani, G. and Bifulco, M., Erratum: PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines (European Journal of Pharmacology (2013) 714:1-3 (379-387)), European Journal of Pharmacology, 728, (1), 2014, p190
Kehoe, J.J., Lišková, K., Mok, K.H., O'Brien, N., Kelly, A.L., Brodkorb, A., Formation of cytotoxic "-lactalbumin / sodium oleate complexes: Concentration and temperature effects, International Dairy Journal, 38, (1), 2014, p65-73
Sullivan, L.M., Kehoe, J.J., Barry, L., Buckley, M.J.M., Shanahan, F., Mok, K.H., Brodkorb, A., Gastric digestion of "-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling, British Journal of Nutrition, 112, (4), 2014, p638-646
Korean Immigrant Experiences in America and in Ireland: Breaking the Vicious Circle of Ethnic Patterns in, editor(s)Bertoni R , Quaderni di cultura, Volume 11, Turin, Italy, Trinity College Dublin and Trauben Edizioni, 2014, pp107 - 121, [Mok KH]
Richard K. Porter, Mitochondrial Efficiency and Basal Metabolic rate in Mammals, University of Warwick, UK, , (Jan 2014) , 2014
Richard K. Porter, Mitochondrial Uncoupling Protein 1 and Immune Cell Function, 48th Annual Scientific Meeting of the European Society for Clinical Investigation, , Utrecht, The Netherlands,, (May 2014), 2014, European Society for Clinical Investigation,
Richard K. Porter, Energy Metabolism in Immune cells , Taichung University Taiwan, , (Oct 2014) , 2014, Lee-Feng Chien
Hogan, A.E. and Gaoatswe, G. and Lynch, L. and Corrigan, M.A. and Woods, C. and O'Connell, J. and O'Shea, D., Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus, Diabetologia, 57, (4), 2014, p781-784
Exley, M.A. and Hand, L. and O'Shea, D. and Lynch, L., Interplay between the immune system and adipose tissue in obesity, Journal of Endocrinology, 223, (2), 2014, pR41-R48
Lynch, L., Adipose invariant natural killer T cells, Immunology, 142, (3), 2014, p337-346
O'Boyle NM, Pollock JK, Carr M, Knox AJ, Nathwani SM, Wang S, Caboni L, Zisterer DM, Meegan MJ., β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., Journal of medicinal chemistry, 57, (22), 2014, p9370-9382
Andrew Bowie, Barry Harrington, Tatyana Lysakova, Brian Keogh, 'Vaccinia virus protein A46 peptide and use thereof', EPO, US Patent No. 8,722,052, 2014
Viral Infections and the DNA Sensing Pathway: Lessons from Herpesviruses and Beyond in, editor(s)Ishii, K.J. and Tang, J.C.T. , Biological DNA Sensor: the Impact of Nucleic Acids on Diseases and Vaccinology, Elsevier, 2014, pp171 - 203, [Paludan, S.R. & Bowie, A.G. ]
Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls in, editor(s)Kusnecov and Anisman , Psychoneuroimmunology, Oxford, UK, 2014, pp347--364 , [Colm Cunningham]
Fernandez-Hernando C, Moore KJ, Rayner KJ, Sheedy FJ, Suarez Y, 'miR-33 inhibitors and uses thereof to decrease inflammation', US Patent and Trading Office, PCT/US2012/035855 , 2014
Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A, Sims DM, He YY, Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells., Journal of Biological Chemistry, 289, (52), 2014, p35806 - 3514
The role of tumor suppressor p53 in the antioxidant defense and metabolism. in, editor(s)Swati Palit Deb and Sumitra Deb , Mutant p53 and MDM2 in Cancer, Netherlands, Springer, 2014, pp337 - 358, [Budanov AV]
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV, Sestrins inhibit mTORC1 kinase activation through the GATOR complex., Cell Reports, 9, (4), 2014, p1281 - 1291
Caffrey M, Li D, Howe N, Shah S.T.A, 'Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase, Philosophical Transactions of the Royal Society B: Biological Sciences, 369, (1647), 2014
Fitzmaurice K, Hurst J, Dring M, Rauch A, McLaren P.J, GÌnthard H.F, Gardiner C, Klenerman P, Courtney G, Crosbie O, Crowe J, Fanning L, Hegarty J, Kelleher D, Lawlor E, Lee J, McKiernan S, Murray F, Norris S, O'Farrelly C, Thornton L, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H.C, Burton-Jeangros C, Calmy A, Cavassini M, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux C.A, Gorgievski M, Haerry D, Hasse B, Hirsch H.H, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Ledergerber B, Martinetti G, Martinez De Tejada B, Metzner K, MÌller N, Nadal D, Pantaleo G, Regenass S, Rickenbach M, Rudin C, Schöni-Affolter F, Schmid P, Schultze D, SchÌpbach J, Speck R, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection, Gut, 64, (5), 2014, p813 - 819
Ramkhelawon, B., Hennessy, E.J., Ménager, M., Ray, T.D., Sheedy, F.J., Hutchison, S., Wanschel, A., Oldebeken, S., Geoffrion, M., Spiro, W., Miller, G., McPherson, R., Rayner, K.J., Moore, K.J., Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity, Nature Medicine, 20, (4), 2014, p377-384
Mawhinney L, Armstrong ME, O' Reilly C, Bucala R, Leng L, Fingerle-Rowson G, Fayne D, Keane MP, Tynan A, Maher L, Cooke G, Lloyd D, Conroy H, Donnelly SC, Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer., Molecular medicine, 20, (1), 2014, p729 - 735
Caboni, L., Gálvez-Llompart, M., Gálvez, J., Blanco, F., Rubio-Martinez, J., Fayne, D., Lloyd, D.G., Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2 h -pyrrole-5-one as a non-ligand-binding-pocket antiandrogen, Journal of Chemical Information and Modeling, 54, (10), 2014, p2953-2966
Kesel, A.J., Huang, Z., Murray, M.G., Prichard, M.N., Caboni, L., Nevin, D.K., Fayne, D., Lloyd, D.G., Detorio, M.A., Schinazi, R.F., Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire, Antiviral Chemistry and Chemotherapy, 23, (5), 2014, p197-215
Arancibia, S., Espinoza, C., Salazar, F., Del Campo, M., Tampe, R., Zhong, T.-Y., De Ioannes, P., Moltedo, B., Ferreira, J., Lavelle, E.C., Manubens, A., De Ioannes, A.E., Becker, M.I., A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma, PLoS ONE, 9, (1), 2014, pe94703-
Mothiram U, Brennan PC, Lewis SJ, Moran B, Robinson J, Digital radiography exposure indices: A review., Journal of medical radiation sciences, 61, (2), 2014, p112-8
Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA, The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10., The Journal of biological chemistry, 289, (7), 2014, p4316-25
Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA, Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation., The Journal of biological chemistry, 289, (10), 2014, p6429-37
Greenhill CJ, Jones GW, Nowell MA, Newton Z, Harvey AK, Moideen AN, Collins FL, Bloom AC, Coll RC, Robertson AA, Cooper MA, Rosas M, Taylor PR, O'Neill LA, Humphreys IR, Williams AS, Jones SA, Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction., Arthritis research & therapy, 16, (4), 2014, p419
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, mTOR- and HIF-1"-mediated aerobic glycolysis as metabolic basis for trained immunity., Science (New York, N.Y.), 345, (6204), 2014, p1250684
van den Bosch MW, Palsson-Mcdermott E, Johnson DS, O'Neill LA, LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production., The Journal of biological chemistry, 289, (33), 2014, p22980-90
Donnelly RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK, mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function., Journal of immunology (Baltimore, Md. : 1950), 193, (9), 2014, p4477-84
Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA, Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells., PloS one, 9, (9), 2014, pe106710
Galván-Peña S, O'Neill LA, Metabolic reprograming in macrophage polarization., Frontiers in immunology, 5, 2014, p420
Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A, The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4., Journal of leukocyte biology, 96, (3), 2014, p427-36
Bowie AG, Rad50 and CARD9, missing links in cytosolic DNA-stimulated inflammation., Nature immunology, 15, (6), 2014, p534-6
Wang H, Flannery SM, Dickhöfer S, Huhn S, George J, Kubarenko AV, Lascorz J, Bevier M, Willemsen J, Pichulik T, Schafmayer C, Binder M, Manoury B, Paludan SR, Alarcon-Riquelme M, Bowie AG, Försti A, Weber AN, A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival., The Journal of biological chemistry, 289, (33), 2014, p23123-31
Gürtler C, Carty M, Kearney J, Schattgen SA, Ding A, Fitzgerald KA, Bowie AG, SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter., Journal of immunology (Baltimore, Md. : 1950), 192, (10), 2014, p4821-32
Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, TRAM is required for TLR2 endosomal signaling to type I IFN induction., Journal of immunology (Baltimore, Md. : 1950), 193, (12), 2014, p6090-102
Cape, E. Hall, R.J. van Munster, B.C. de Vries, A. Howie, S.E.M. Pearson, A. Middleton, S.D. Gillies, F. Armstrong, I.R. White, T.O. Cunningham, C. de Rooij, S.E. MacLullich, A.M.J., Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1ß in delirium after hip fracture, Journal of Psychosomatic Research, 77, (3), 2014, p219 - 225
Sanders, R.D. Coburn, M. Cunningham, C. Pandharipande, P., Risk factors for postoperative delirium, The Lancet Psychiatry, 1, (6), 2014, p404 - 406
Boustani, M. Rudolph, J. Shaughnessy, M. Gruber-Baldini, A. Alici, Y. Arora, R.C. Campbell, N. Flaherty, J. Gordon, S. Kamholz, B. Maldonado, J.R. Pandharipande, P. Parks, J. Waszynski, C. Khan, B. Neufeld, K. Olofsson, B. Thomas, C. Young, J. Davis, D. Laurila, J. Page, V. Teodorczuk, A. Agar, M. Meagher, D. Spiller, J. Schieveld, J. Milisen, K. de Rooij, S. van Munster, B. Kreisel, S. Cerejeira, J. Hasemann, W. Wilson, D. Cunningham, C. Morandi, A. Slooter, A. Detroyer, E. Caraceni, A. MacLullich, A., The DSM-5 criteria, level of arousal and delirium diagnosis: Inclusiveness is safer, BMC Medicine, 12, (1), 2014, p141-
Caffrey, M., Li, D., Howe, N., Shah, S.T.A., Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase, Philosophical Transactions of the Royal Society B: Biological Sciences, 369, (1647), 2014, 20130621-
Tan, J. Rouse, S.L. Li, D. Pye, V.E. Vogeley, L. Brinth, A.R. El Arnaout, T. Whitney, J.C. Howell, P.L. Sansom, M.S.P. Caffrey, M., A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa, Acta Crystallographica Section D Biological Crystallography, 70, (8), 2014, p2054 - 2068
Nji, E. Li, D. Doyle, D.A. Caffrey, M., Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa, Acta Crystallographica Section F Structural Biology Communications, 70, 2014, p1362 - 1367
Lyons, J.A. Parker, J.L. Solcan, N. Brinth, A. Li, D. Shah, S.T. Caffrey, M. Newstead, S., Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters, EMBO Reports, 15, (8), 2014, p886 - 893
Caffrey, M. Eifert, R. Li, D. Howe, N., The lipid cubic phase or in meso method for crystallizing proteins. Bushings for better manual dispensing, Journal of Applied Crystallography, 47, (5), 2014, p1804 - 1806
Boland, C. Li, D. Shah, S.T.A. Haberstock, S. Dötsch, V. Bernhard, F. Caffrey, M., Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination, Cellular and molecular life sciences : CMLS71, 24, 2014, p4895-4910
Li, D. Caffrey, M., Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic, Scientific Reports, 4, 2014, p5806-
Takeda, H. Hattori, M. Nishizawa, T. Yamashita, K. Shah, S.T.A. Caffrey, M. Maturana, A.D. Ishitani, R. Nureki, O., Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE, Nature Communications, 5, 2014, p5374-
Donnelly, R.P., Loftus, R.M., Keating, S.E., (...), Gardiner, C.M., Finlay, D.K., MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function, Journal of Immunology, 193, (9), 2014, p4477-4484
Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263
Lawless, N. Vegh, P. O'Farrelly, C. Lynn, D.J., The role of microRNAs in bovine infection and immunity, Front. Immunol., 5, (NOV), 2014, p611-
Petrasca A, Doherty DG, Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells, Frontiers in Immunology, 2014, 650-
Diez-Cecilia, E. Kelly, B. Perez, C. Zisterer, D.M. Nevin, D.K. Lloyd, D.G. Rozas, I., Guanidinium-based derivatives: Searching for new kinase inhibitors, European Journal of Medicinal Chemistry, 81, 2014, p427 - 441
Creagh, E.M., The role of inflammatory caspases during intestinal immunity, Biochemistry lecture series, Maynooth University, Ireland, 11 February, 2014
Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer, Living with Cancer in the 21st Century, Trinity College Dublin, September 2014, 2014
Donnelly R, Loftus R, Keating S, Gardiner CM and Finlay DK. , mTORC1-dependent metabolic reprogramming is a prerequisite for Natural Killer cell effector function. , Journal of Immunology, 193, (9), 2014, p4477 - 4484
Lecordier L, Uzureau1 P, Tebabi1 P, Pérez-Morga1 D, Nolan DP , Schumann Burkard G, Roditi I and Epays E , Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum. , Molecular Microbiology, 94, 2014, p625 - 636
Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer , Irish Society of Gastroenterology Winter Proceedings, Dublin, Ireland, 21, 22nd November, 2014
Oficjalska, K., Creagh, E.M., A Protective Role for Caspase-11 during Acute Experimental Colitis, British Society of Immunology Annual Meeting, Brighton, UK, 2-4th December 2014, 2014
Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM, Glycosylation and Fc receptors., Current topics in microbiology and immunology, 382, 2014, p165-99
Hayes JM, Frostell A, Cosgrave EF, Struwe WB, Potter O, Davey GP, Karlsson R, Anneren C and Rudd PM , Fc gamma receptor glycosylation modulates the binding of IgG Glycoforms - a requirement for stable antibody interactions. , Journal of Proteome Research , (13), 2014, p5471 - 5485
Creagh, E.M., A protective role for caspase-11 during acute experimental murine colitis, Faculty of Medicine and Health Sciences Research Seminar Series, Ghent University, Belgium , 16th December, 2014
Creagh E.M., Caspase crosstalk: integration of apoptotic and innate immune signalling pathways., Trends in Immunology, 35, (12), 2014, p631 - 640
Misstear, K., Mcneela, E.A., Murphy, A.G., (...), Mcloughlin, R.M., Lavelle, E.C. , Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus, Journal of Infectious Diseases, 209, (9), 2014, p1479-1484
Stack, J., Doyle, S.L., Connolly, D.J., (...), Paludan, S.R., Bowie, A.G. , TRAM is required for TLR2 endosomal signaling to type I IFN induction, Journal of Immunology, 193, (12), 2014, p6090-6102
Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919
Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907
Pollock, JK, Verma,NK, O'Boyle, NM, Carr, MG, Meegan, MJ, Zisterer, DM, Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway, Biochemical Pharmacology, 92, (4), 2014, p544-557
O'Boyle, NM, Pollock, JK, Carr, M, Knox, AJS, Nathwani, SM, Wang, S, Caboni, L, Zisterer, DM, Meegan, MJ, Beta-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand, Journal of Medicinal Chemistry, 57, (22), 2014, p9370 - 9382
McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026
McLoughlin KE, Nalpas NC, Rue-Albrecht K, Browne JA, Magee DA, Killick KE, Park SD, Hokamp K, Meade KG, O'Farrelly C, Gormley E, Gordon SV, MacHugh DE, RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis., Frontiers in immunology, 5, 2014, p396
Connolly DJ, Bowie AG, The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease., Biochemical pharmacology, 2014
Brady, Gareth Bowie, Andrew G., Innate immune activation of NFκB and its antagonism by poxviruses, Cytokine & Growth Factor Reviews, 2014
Doherty W, James J, Evans P, Martin L, Adler N, Nolan D, Knox A. , Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones., Organic & Biomolecular Chemistry, 12, (38), 2014, p12(38):756 - 7571
Abautret-Daly AE, Davitt CJ, Lavelle EC, Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections., Biochemical pharmacology, 92, (2), 2014, p173-83
Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus colonization: modulation of host immune response and impact on vaccine design, Frontiers in Immunology, 4, 2014, p507-
Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708
Draper E, DeCourcey J, Higgins SC, Canavan M, McEvoy F, Lynch M, Keogh B, Reynolds C, Roche HM, Mills KH, Loscher CE, Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses., The Journal of nutritional biochemistry, 25, (7), 2014, p741-9
Allen AC, Mills KH, Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity., Expert review of vaccines, 13, (10), 2014, p1253-1264
Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17
Adkins I, Kamanova J, Kocourkova A, Svedova M, Tomala J, Janova H, Masin J, Chladkova B, Bumba L, Kovar M, Ross PJ, Tuckova L, Spisek R, Mills KH, Sebo P, Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells., PloS one, 9, (8), 2014, pe104064
Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M, IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration., Science translational medicine, 6, (230), 2014, p230ra44
Meade, K.G., Cormican, P., Narciandi, F., Lloyd, A., O'Farrelly, C., Bovine β-defensin gene family: Opportunities to improve animal health?, Physiological Genomics, 46, (1), 2014, p17-28
Kelly, A, Fahey, R, Fletcher, JM, Keogh, C, Carroll, AG, Siddachari, R, Geoghegan, J, Hegarty, JE, Ryan, EJ, O'Farrelly, C, CD141(+) myeloid dendritic cells are enriched in healthy human liver, JOURNAL OF HEPATOLOGY, 60, (1), 2014, p135-142
Lawless, N., Reinhardt, T.A., Bryan, K., (...), Lippolis, J., Lynn, D.J., Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model, G3: Genes, Genomes, Genetics, 4, (6), 2014, p957-971
Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050
Whelehan, CJ, Barry-Reidy, A, Meade, KG, Eckersall, PD, Chapwanya, A, Narciandi, F, Lloyd, AT, O'Farrelly, C, Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue, BMC GENOMICS, 15, 2014, p128-
Morrison, M.H., Keane, C., Quinn, L.M., (...), Bergin, C., Gardiner, C.M., IFNL cytokines do not modulate human or murine NK cell functions, Human Immunology, 75, (9), 2014, 996-1000
Mockler MB, Conroy MJ, Lysaght J, Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment., Frontiers in oncology, 4, 2014, p107
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816-
HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments, OMICS group, 2014, [Napoletano S, Bannan C, Bergin C and Stevenson NJ]
Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230-
Weierstall, U., James, D., Wang, C., (...), Caffrey, M., Cherezov, V., Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography, Nature Communications, 5, 2014, p3309-
Johner, N, Mondal, S, Morra, G, Caffrey, M, Weinstein, H, Khelashvili, G, Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, (8), 2014, p3271-3284
Li, DF, Howe, N, Dukkipati, A, Shah, STA, Bax, BD, Edge, C, Bridges, A, Hardwicke, P, Singh, OMP, Giblin, G, Pautsch, A, Pfau, R, Schnapp, G, Wang, MT, Olieric, V, Caffrey, M, Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy, CRYSTAL GROWTH & DESIGN, 14, (4), 2014, p2034-2047
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-
Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050
Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells., Biochemical pharmacology, 87, (4), 2014, p611-24
Gürtler, C., Carty, M., Kearney, J., Schattgen, S.A., Ding, A., Fitzgerald, K.A. and Bowie, A.G. , SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter, Journal of Immunology, 192, 2014, p4821 - 4832
Raverdeau M, Mills KH, Modulation of T cell and innate immune responses by retinoic Acid., Journal of immunology (Baltimore, Md. : 1950), 192, (7), 2014, p2953-8
Finlay CM, Walsh KP, Mills KH, Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases., Immunological reviews, 259, (1), 2014, p206-30
O'Neill, L.A.J., Glycolytic reprogramming by TLRs in dendritic cells, Nature Immunology, 15, (4), 2014, p314-315
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437
Draper, Eve DeCourcey, Joseph Higgins, Sarah C. Canavan, Mary McEvoy, Fiona Lynch, Mark Keogh, Brian Reynolds, Clare Roche, Helen M. Mills, Kingston H. G. Loscher, Christine E., Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses, The Journal of Nutritional Biochemistry, 25, (7), 2014, p741-9
Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA, Interleukin-6 signaling drives fibrosis in unresolved inflammation., Immunity, 40, (1), 2014, p40-50
Ismail M. Meraza, Claire H.A Hearnden, Xuewu Liua, Marie Yang, Laura Williams, Jianhua Gua, Jessica R. Rhudy, Kenji Yokoi, Ed C. Lavelle and Rita E. Serda , Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization increasing the anti-tumor efficacy of doxorubicin nanoliposomes, PLoS One, 2014, p0094703-
Mills KH, Gerdts V, Mouse and Pig Models for Studies of Natural and Vaccine-Induced Immunity to Bordetella pertussis., The Journal of infectious diseases, 209 Suppl 1, 2014, pS16-9
Mills KH, Ross PJ, Allen AC, Wilk MM, Do we need a new vaccine to control the re-emergence of pertussis?, Trends in microbiology, 22, (2), 2014, p49-52
Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63
Kelly, A., Fahey, R., Fletcher, J.M., Keogh, C., Carroll, A.G., Siddachari, R., Geoghegan, J., Hegarty, J.E., Ryan, E.J., O'Farrelly, C., CD141+ myeloid dendritic cells are enriched in healthy human liver, Journal of Hepatology, 60, (1), 2014, p135-142
Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi & Luke A.J. O'Neill , Circadian Clock Proteins and Immunity, Immunity, Volume 40, (2), 2014, 178-186
Kelly, Aoife Ryan, Elizabeth J. O'Farrelly, Cliona, Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems", Journal of Hepatology, 60, (5), 2014, p1098-1099
Svärd J, Blanco F, Nevin D, Fayne D, Mulcahy F, Hennessy M, Spiers JP, Differential interactions of antiretroviral agents with LXR, ER and GR nuclear receptors: potential contributing factors to adverse events., British journal of pharmacology, 171, (2), 2014, p480-97
Kennedy A, Petrasca A, Doherty DG, Hennessy M, Spiers JP, HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or V"9V"2 T lymphocytes., AIDS (London, England), 28, (1), 2014, p131-3
Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA., The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10., The Journel of Biological Chemistry, 289, (9), 2014, p4316-4325
Bourke J, Brereton CF, Gordon SV, Lavelle EC and Scanlan EM, The Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs), Organic & Biomolecular Chemistry, 12, (7), 2014, p1114-1123
Arancibia, S., Espinoza, C., Salazar, F., Del Campo, M., Tampe, R., Zhong, T-Y., De Ioannes, P., Moltedo, B., Ferreira, J., Lavelle, E.C., Manubens, A., De Ioannes, A.E. and Becker, M.I., A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata exhibits outstanding anti-tumor activity in melanoma., PLoS One, 9, (1), 2014, pe87240
Oleszycka, E. and Lavelle, E.C, The immunomodulatory properties of the vaccine adjuvant alum., Current Opinion in Immunology, 28C, 2014, p1 - 5
Mills KH, Prior Exposure to Bacteria Attenuates Viral Disease of the Respiratory Tract: A Role for IL-17 and Innate Immune Memory?, American journal of respiratory and critical care medicine, 189, (2), 2014, p126-8
Carty M, Reinert L, Paludan SR, Bowie AG, Innate antiviral signalling in the central nervous system., Trends in immunology, 35, (2), 2014, 79-87
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67
Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design., Frontiers in immunology, 4, 2014, p507
Andrew G. McDonald and Keith F. Tipton, The effects of tyramine and 4-aminophenol on the oscillating peroxidase-oxidase reaction, The Journal of Physical Chemistry B, 118, (1), 2014, p18 - 25
David Finlay, IRF4 links antigen affinity to CD8(+) T-cell metabolism., Journal of Immunology and Cell Biology , 92, 2014, p6 - 7
Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484
McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121