Publications
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128 peer reviewed publications from 2013
Finlay, D.K., MTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB, Biochemical Society Transactions, 41, (2), 2013, p681-686
Ryan, T.J. and Kopanitsa, M.V. and Indersmitten, T. and Nithianantharajah, J. and Afinowi, N.O. and Pettit, C. and Stanford, L.E. and Sprengel, R. and Saksida, L.M. and Bussey, T.J. and O'dell, T.J. and Grant, S.G.N. and Komiyama, N.H., Erratum: Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior (Nature Neuroscience (2013) 16 (25-32)), Nature Neuroscience, 16, (12), 2013, p1908
Orlagh Kelly, Investigations into the physiological function mitochondrial uncoupling protein 3, Trinity College Dublin, 2013
Ryan, T.J., Kopanitsa, M.V., Indersmitten, T., Nithianantharajah, J., Afinowi, N.O., Pettit, C., Stanford, L.E., Sprengel, R., Saksida, L.M., Bussey, T.J., O'Dell, T.J., Grant, S.G.N., Komiyama, N.H., Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior, 16, (1), 2013, p25-32
Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R.L., Ryan, T.J., Tonegawa, S., Creating a false memory in the hippocampus, 341, (6144), 2013, p387-391
Richard K. Porter, Efficiency of Mitochondrial Function in Mammals, University of Umeå, Sweden., (Nov 2013) , 2013
Viana, L.C., Lima, C.M., Oliveira, M.A., Borges, R.P., Cardoso, T.T., Almeida, I.N.F., Diniz, D.G., Bento-Torres, J., Pereira, A., Batista-de-Oliveira, M., Lopes, A.A.C., Silva, R.F.M., Abadie-Guedes, R., Amâncio dos Santos, A., Lima, D.S.C., Vasconcelos, P.F.C., Cunningham, C., Guedes, R.C.A., Picanço-Diniz, C.W., Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: Stereological analysis and three dimensional morphometry, 238, 2013, p280-296
Experimental models of cognitive dysfunction in infection and critical illness in, editor(s)Stevens, Sharshar and Ely , Brain Disorders in Critical Illness, Cambridge, 2013, pp97 - 107, [Colm Cunningham, Robert D. Stevens, Tarek Sharshar, E. Wesley Ely]
Morrison-Nozik, A ; Tong, C ; Lee, JH ; Budanov, A ; Karin, M ; Li, J , Sestrin2 is cardioprotective against ischemia/reperfusion injury by promoting LKB1-mediated AMPK activation, FASEB JOURNAL, Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Boston, MA, APR 20-24, 27, FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA, 2013, pp1
Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F, Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death., Cell Death and Differentiation, 20, (4), 2013, p611 - 619
Lee JH, Budanov AV, Karin M, Sestrins orchestrate cellular metabolism to attenuate aging., Cell Metabolism, 18, (6), 2013, p792 - 801
Moore, K.J., Sheedy, F.J., Fisher, E.A., Macrophages in atherosclerosis: A dynamic balance, Nature Reviews Immunology, 13, (10), 2013, p709-721
Sheedy, F.J., Moore, K.J., IL-1 signaling in atherosclerosis: Sibling rivalry, Nature Immunology, 14, (10), 2013, p1030-1032
Sheedy, F.J., Grebe, A., Rayner, K.J., Kalantari, P., Ramkhelawon, B., Carpenter, S.B., Becker, C.E., Ediriweera, H.N., Mullick, A.E., Golenbock, D.T., Stuart, L.M., Latz, E., Fitzgerald, K.A., Moore, K.J., CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation, Nature Immunology, 14, (8), 2013, p812-820
Ligand-Based Molecular Design Using Pseudoreceptors in, editor(s)Gisbert Schneider , De novo Molecular Design, Weinheim, Wiley-VCH Verlag GmbH & Co., 2013, [Darren Fayne]
Fayne, D., De-peptidising protein-protein interactions - Big jobs for small molecules, Drug Discovery Today: Technologies, 10, (4), 2013
James Fogarty, Innovations in Irish Research, Medical Independent, March, 2013
Greene, LM, Wang, S, O'Boyle, NM, Bright, SA, Reid, JEA, Kelly, PJ, Meegan, MJ, Zisterer, DM, Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer, Oncology Reports, 29, (6), 2013, p2451-2458
Murray CL, Obiang P, Bannerman D, Cunningham C, Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice., PloS one, 8, (10), 2013, pe78385
O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, (5), 2013, p610-2
Murphy N, Petrasca A, Murphy NM, Reilly VO, Evans P, Doherty DG, Zhu XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377
Hilton, KJ, Cunningham, C, Reynolds, RA, Perry, VH, Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease, PLOS ONE, 8, (6), 2013, e68062-
Diniz, D.G., Foro, C.A.R., Sosthenes, M.C.K., (...), Vasconcelos, P.F.C., Diniz, C.W.P., Aging and environmental enrichment exacerbate inflammatory response on antibody-enhanced dengue disease in immunocompetent murine model, European Journal of Inflammation, 11, (3), 2013, 719-731
Killick, K.E., Ní Cheallaigh, C., O'Farrelly, C., (...), Machugh, D.E., Harris, J., Receptor-mediated recognition of mycobacterial pathogens, Cellular Microbiology, 15, (9), 2013, p1484-1495
Stack, J., Hurst, T.P., Flannery, S.M., (...), Khan, A.R., Bowie, A.G. , Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitment, Journal of Biological Chemistry, 288, (47), 2013, p33642-33653
Li, DF, Shah, STA, Caffrey, M, Host Lipid and Temperature as Important Screening Variables for Crystallizing Integral Membrane Proteins in Lipidic Mesophases. Trials with Diacylglycerol Kinase, CRYSTAL GROWTH & DESIGN, 13, (7), 2013, p2846-2857
Hopper, JTS, Yu, YTC, Li, DF, Raymond, A, Bostock, M, Liko, I, Mikhailov, V, Laganowsky, A, Benesch, JLP, Caffrey, M, Nietlispach, D, Robinson, CV, Detergent-free mass spectrometry of membrane protein complexes, NATURE METHODS, 10, (12), 2013, p1206-+
Liu, W., Wacker, D., Gati, C., (...), Stevens, R.C., Cherezov, V., Serial femtosecond crystallography of G protein-coupled receptors, Science, 342, (6165), 2013, p1521-1524
Connell, S, Meade, KG, Allan, B, Lloyd, AT, Downing, T, O'Farrelly, C, Bradley, DG, Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene, G3-GENES GENOMES GENETICS, 3, (5), 2013, p881-890
Rehman, S, Ikram, M, Khan, A, Min, S, Azad, E, Hofer, TS, Mok, KH, Baker, RJ, Blake, AJ, Rehman, SU, New dicoumarol sodium compound: crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, 2013, p110-
Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, (7), 2013, pe69090
Lawless N, Foroushani AB, McCabe MS, O'Farrelly C, Lynn DJ, Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection., PloS one, 8, (3), 2013, pe57543
Breen EP, Pilgrim W, Clarke KJ, Yssel C, Farrell M, Zhou J, Murphy PV, Porter RK. , Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths., Journal of Chemical Biology, 6, (3), 2013, p121 - 133
Ofijalska, K. and Creagh, E.M., Role of caspase-11 in a DSS-colitis model of IBD, The innate immune response in the pathogenesis of infectious disease, Minas Gerais, Brazil, 10-15 May 2013, 2013
Maclullich AM, Anand A, Davis DH, Jackson T, Barugh AJ, Hall RJ, Ferguson KJ, Meagher DJ, Cunningham C, New horizons in the pathogenesis, assessment and management of delirium., Age and ageing, 42, (6), 2013, p667-74
Dunny E, Doherty W, Evans P, Malthouse JP, Nolan D, Knox AJ., Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation., Journal of Medicinal Chemistry, 56, (17), 2013, p6638 - 6650
Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090
Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP in, 2013, pp9-18 , [Westwell-Roper, C., Dunne, A., Kim, M.L., Verchere, C.B., Masters, S.L.]
Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J., Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104), Proceedings of the National Academy of Sciences of the United States of America, 110, (43), 2013, p17600
Davey, G.P., Bolaños, J.P., Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: Impact on Parkinson's disease, Journal of Neurochemistry, 125, (3), 2013, p332-333
Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578
Xie, Y., Min, S., Harte, N.P., Kirk, H., O'Brien, J.E., Voorheis, H.P., Svanborg, C., Hun Mok, K., Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications, Proteins: Structure, Function and Bioinformatics, 81, (1), 2013, p1-17
Rehman, S., Ikram, M., Baker, R.J., Zubair, M., Azad, E., Min, S., Riaz, K., Mok, K.H., Rehman, S.-U., Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives, Chemistry Central Journal, 7, (1), 2013, p68-
Sullivan, L.M., Mok, K.H., Brodkorb, A., The formation of an anti-cancer complex under simulated gastric conditions, Food Digestion, 4, (1), 2013, p7-18
Ho, J.C.S., Storm, P., Rydström, A., Bowen, B., Alsin, F., Sullivan, L., Ambite, I., Mok, K.H., Northen, T., Svanborg, C., Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): Unique and shared effects on signaling and death, Journal of Biological Chemistry, 288, (24), 2013, p17460-17471
Rehman, S., Ikram, M., Khan, A., Min, S., Azad, E., Hofer, T.S., Mok, K.H., Baker, R.J., Blake, A.J., Rehman, S.U., New dicoumarol sodium compound: Crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, (1), 2013, p110-
Fletcher, J., Hutchinson, M., Tubridy, N., Response to comment on the article by Allen et al. 'A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers', Multiple Sclerosis , 19, (4), 2013, p509
Keane, C., O'Shea, D., Reiberger, T., Peck-Radosavljevic, M., Farrell, G., Bergin, C., Gardiner, C.M., Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection, PLoS ONE, 8, (6), 2013, pe66831-
Uzureau, P., Uzureau, S., Lecordier, L., Fontaine, F., Tebabi, P., Homblé, F., Grélard, A., Zhendre, V., Nolan, D.P., Lins, L., Crowet, J.-M., Pays, A., Felu, C., Poelvoorde, P., Vanhollebeke, B., Moestrup, S.K., LyngsÃ", J., Pedersen, J.S., Mottram, J.C., Dufourc, E.J., Pérez-Morga, D., Pays, E., Mechanism of Trypanosoma brucei gambiense resistance to human serum, Nature, 501, (7467), 2013, p430-434
Greene, L.M., Nolan, D.P., Regan-Komito, D., Campiani, G., Williams, D.C., Zisterer, D.M., Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells, International Journal of Oncology, 43, (3), 2013, p927-935
Connolly DJ, O'Neill LA, McGettrick AF., The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling, Journal of Biological Chemistry, 288, (8), 2013, p5616 - 5623
O'Connell K, Kelly S, Kinsella K, Jordan S, Kenny O, Murphy D, Heffernan E, O'Laoide R, O'Shea D, McKenna C, Cassidy L, Fletcher J, Walsh C, Brady J, McGuigan C, Tubridy N, Hutchinson M, Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial., Trials, 14, 2013, p272
Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15., J. Biol. Chem., 288, (35), 2013, p25066 - 25075
Khan, A.R., Ménétrey, J., Structural biology of arf and rab GTPases' effector recruitment and specificity, Structure , 21, (8), 2013, p1284-1297
Khan AR, Oligomerization of rab/effector complexes in the regulation of vesicle trafficking., Progress in molecular biology and translational science, 117, 2013, p579-614
Sharkey MA, Oliveira TF, Engel PC, Khan AR, Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases., The FEBS journal, 280, (18), 2013, p4681-92
Lall, P., Horgan, C.P., Oda, S., (...), McCaffrey, M.W., Khan, A.R., Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase, Biochimica et Biophysica Acta - Proteins and Proteomics , 1834, (12), 2013, p2679-2690
Paludan, S.R., Bowie, A.G., Horan, K.A., Fitzgerald, K.A., Recognition of herpesviruses by the innate immune system, Nature Reviews Immunology, 13, 2013, p614
Ruane, DT., Brane, L., Reis, B., Cheong, C., Poles, J., Do, Y., Zhu, H., Velinzon, K., Choi, J-H., Studt, N., Mayer, L., Lavelle, E.C., Steinman, R., Mucida, D and Mehandru, S. , Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract., The Journal of Experimental Medicine, 210, (9), 2013, p1871-1888
Adjuvant Strategies in Vaccines. in, editor(s)Prendergast/Jaffee , Cancer Immunotherapy: Immune Suppression and Tumor Growth, Academic Press, 2013, pp333-349 , [Hearnden, C and Lavelle, E.C.]
Yang, M., Flavin, K., Kopf, I., Radics, G., Hearnden, C.H.A., McManus, G.J., Moran, B., Villalta-Cerdas, A., Echegoyen, L.A., Giordani, S. and Lavelle, E.C. , Chemical surface functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation, Small, 9, (24), 2013, p4194 - 4206
Caboni, L. Egan, B., Kelly, B.,Blanco, F., Fayne, D., Meegan, M. J., Lloyd, D. G, Structure-Activity Relationships in Non-Ligand Binding Pocket (Non-LBP) Diarylhydrazide Antiandrogens,, J Chem Inf Model, 53, (8), 2013, p2116 - 2130
Butt AQ, Mills KH, Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines., Oncogene, 2013
Bowie AG, Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1., Immunity, 39, (3), 2013, p423-5
Stack J, Hurst TP, Flannery SM, Brennan K, Rupp S, Oda S, Khan AR, Bowie AG, Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor ß-activated kinase 1 (TAK1) recruitment., The Journal of biological chemistry, 288, (47), 2013, p33642-53
Adamik, J., Wang, K.Z.Q., Unlu, S., Su, A.-J.A., Tannahill, G.M., Galson, D.L., O'Neill, L.A., Auron, P.E., Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α, PLoS One, 8, (8), 2013, pe70622
Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA, A long noncoding RNA mediates both activation and repression of immune response genes., Science (New York, N.Y.), 341, (6147), 2013, p789-92
McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, (32), 2013, 22893-22898
Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J. , Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104) (Erratum), 2013, - 17600
Kenny, E.F., Quinn, S.R., Doyle, S.L., Vink, P.M., van Eenennaam, H., O'Neill, L.A.J., Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin, PLoS ONE, 8, (8), 2013, part. no. e74103
Mcgettrick, A.F., O'Neill, L.A.J., NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases, Diabetes, Obesity and Metabolism , 15, (S3), 2013, p19-25
Bernard, N.J., O'Neill, L.A, Mal, more than a bridge to MyD88, IUBMB Life , 65, (9), 2013, p777-786
Palsson-Mcdermott, E.M., O'Neill, L.A.J., The Warburg effect then and now: From cancer to inflammatory diseases, BioEssays, 35, (11), 2013, p965-973
Mills, E., O'Neill, L.A.J., Succinate: a metabolic signal in inflammation, Trends in Cell Biology, 2013
Andrew G. McDonald and Keith F. Tipton, Fifty-five years of Enzyme classification: advances and difficulties, FEBS Journal, 2013
Moran B, Blanco-Fernández A, Gardner R, Tigges J, Toxavidis V, Daley JF, Remote access technology offers tremendous possibilities to the cytometry community., Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83, (12), 2013, p1062-5
Narciandi F, Lloyd A, Meade KG, O'Farrelly C, A novel subclass of bovine ?-defensins links reproduction and immunology., Reproduction, fertility, and development, 2013
Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489
Griffin EW, Skelly DT, Murray CL, Cunningham C, Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction., The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, (38), 2013, p15248-58
Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH, Retinoic acid expression associates with enhanced IL-22 production by "" T cells and innate lymphoid cells and attenuation of intestinal inflammation., The Journal of experimental medicine, 210, (6), 2013, p1117-24
McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM, Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice., American journal of physiology. Endocrinology and metabolism, 305, (2), 2013, pE834-E844
Walsh, K.P., Mills, K.H.G., Dendritic cells and other innate determinants of T helper cell polarisation, Trends in Immunology, 34, (11), 2013, p521-530
Wetterling, Mok, McGoldrick, Basu, Non-Destructive Investigation of Glass Fiber Reinforced Composites via Magnetic Resonance Imaging, Key Engineering Materials, 569-570, 2013, p126 - 131
Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M, PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines., European journal of pharmacology, 2013
Skelly DT, Hennessy E, Dansereau MA, Cunningham C, A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1beta, TNF-alpha and IL-6 Challenges in C57BL/6 Mice., PloS one, 8, (7), 2013, pe69123
Gürtler, C., Bowie, A.G., Innate immune detection of microbial nucleic acids, Trends in Microbiology, 21, (8), 2013, p413-420
Paludan, S., Bowie, A., Immune Sensing of DNA, Immunity , 38, (5), 2013, p870-880
Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM, Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells., International journal of oncology, 2013
Lysaght, J, Verma, NK, Maginn, EN, Ryan, JM, Campiani, G, Zisterer, DM, Williams, DC, Browne, PV, Lawler, MP, McElligott, AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 42, (1), 2013, p239-246
Kahvedzic, A, Nathwani, SM, Zisterer, DM, Rozas, I, Aromatic Bis-N-hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations, Journal of Medicinal Chemistry, 56, (2), 2013, p451-459
Nathwani, SM, Hughes, L, Greene, LM, Carr, M, O'Boyle, NM, McDonnell, S, Meegan, MJ, Zisterer, DM, Novel cis-restricted beta-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro, ONCOLOGY REPORTS, 29, (2), 2013, p585-594
O'Boyle, NM, Greene, LM, Keely, NO, Wang, S, Cotter, TS, Zisterer, DM, Meegan, MJ, Synthesis and biochemical activities of antiproliferative amino acid and phosphate derivatives of microtubule-disrupting beta-lactam combretastatins, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62, 2013, p705-721
O'Neill, L.A.J., Golenbock, D., Bowie, A.G., The history of Toll-like receptors-redefining innate immunity, Nature Reviews Immunology, 13, (6), 2013, p453-460
Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066
Haneklaus, M., Gerlic, M., O'Neill, L.A.J., Masters, S.L., miR-223: Infection, inflammation and cancer, Journal of Internal Medicine, 274, (3), 2013, p215-226
Li, DF, Lyons, JA, Pye, VE, Vogeley, L, Aragao, D, Kenyon, CP, Shah, STA, Doherty, C, Aherne, M, Caffrey, M, Crystal structure of the integral membrane diacylglycerol kinase, Nature, 497, (7450), 2013, p521-524
Crystallizing membrane proteins for structure-function studies using lipidic mesophases in, editor(s)Randy,Urzhumtsev A.G.,Alexandre A.G.,Lunin V.Y. , NATO Science for Peace and Security Series A: Chemistry and Biology, 2013, pp33-46 , [Caffrey, M.]
Klintmalm, G., O'Farrelly, C., Taking the rap: Multiple effects of blocking mammalian target of rapamycin, Hepatology, 57, (1), 2013, p1-3
Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. coli stimulation, Veterinary Immunology and Immunopathology , 151, (1-2), 2013, p157-162
Lawless, N., Foroushani, A.B.K., McCabe, M.S., O'Farrelly, C., Lynn, D.J., Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection, PLoS ONE, 8, (3), 2013, part. no. e57543
O'Donovan, A., Rush, G., Hoatam, G., Hughes, B.M., McCrohan, A., Kelleher, C., O'Farrelly, C., Malone, K.M., Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder, Depression and Anxiety , 30, (4), 2013, p307-314
Doherty, R., O'Farrelly, C., Meade, K.G., Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC), Veterinary Immunology and Immunopathology, 154, (3-4), 2013, p102-110
Franklin, E., Khan, A.R., Poxvirus antagonism of innate immunity by Bcl-2 fold proteins, Journal of Structural Biology, 181, (1), 2013, p1-10
Mills, K.H.G., Dungan, L.S., Jones, S.A., Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses, Journal of Leukocyte Biology, 93, (4), 2013, p489-497
Morine, M.J., Toomey, S., McGillicuddy, F.C., Reynolds, C.M., Power, K.A., Browne, J.A., Loscher, C., (...), Roche, H.M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice, Journal of Nutritional Biochemistry, 24, (5), 2013, p788-795
Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282
Clarke, KJ, Porter, RK, Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 45, (1), 2013, p81-89
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+
Woods, K, a'Bhaird, NN, Dooley, C, Perez-Morga, D, Nolan, DP, Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei, PLOS ONE, 8, (1), 2013, e52846-
Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264
Greene LM, Wang S, O'Boyle NM, Bright SA, Reid JE, Kelly P, Meegan MJ, Zisterer DM, Combretazet-3 a novel synthetic cis-stable combretastatin A-4-azetidinone hybrid with enhanced stability and therapeutic efficacy in colon cancer., Oncology reports, 29, (6), 2013, p2451-8
Cunningham C, Microglia and neurodegeneration: The role of systemic inflammation, GLIA, 61, 2013, p71 - 90
Cunningham C, MacLullich AM, At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response, Brain, Behavior and Immunity, 28, 2013, p1 - 13
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578
Mansur DS, Maluquer de Motes C, Unterholzner L, Sumner RP, Ferguson BJ, Ren H, Strnadova P, Bowie AG, Smith GL, Poxvirus Targeting of E3 Ligase ß-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-"B Activation and Promote Immune Evasion and Virulence., PLoS pathogens, 9, (2), 2013, pe1003183
Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR, Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2311-9
Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80
Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928
Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45
Connolly DJ, O'Neill LA, McGettrick AF, The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling., The Journal of biological chemistry, 288, (8), 2013, p5616-5623
O'Neill LA, Hardie DG, Metabolism of inflammation limited by AMPK and pseudo-starvation., Nature, 493, (7432), 2013, p346-355
O'Neill LA, Immunology. Sensing the dark side of DNA., Science (New York, N.Y.), 339, (6121), 2013, p763-764
Jones SA, Mills KH, Harris J., Autophagy and inflammatory diseases., Immunology and Cell Biology, 91, (3), 2013, p250-258
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, p1-15
Monitoring extracellular amino acid neurotransmitters and hROS by in vivo microdialysis in rats: a practical approach. in, G Giovanni & V. Di Matteo , Microdialysis Techniques in Neuroscience, Neuromethods, New York, USA, Humana Press, 2013, pp225-248 , [M.A. Colivicchi, C. Stefanini, W. Freinbichler, C. Ballini, L. Bianchi, K.F. Tipton and L. Della Corte.]
Kearney CJ, Sheridan C, Cullen SP, Tynan GA, Logue SE, Afonina IS, Vucic D, Lavelle EC, Martin SJ, Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production., The Journal of biological chemistry, 288, (7), 2013, p4878-4890
Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51
Rolf J, Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA., AMPKα1: A glucose sensor that controls CD8 T-cell memory., European Journal of Immunology, 43, (4), 2013, p889-96