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Publications

Below is the list of peer and non peer publications from the School of Biochemistry and Immunology.

Show: AllPeer ReviewedNon Peer Reviewed
105 publications from 2012

Kabadi S.V., Stoica B.A., Hanscom M., Loane D.J., Kharebava G., Murray II M.G., Cabatbat R.M., Faden A.I., CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury, Neurotherapeutics, 9, (2), 2012, p405 - 421, p405-421
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Kabadi S.V., Stoica B.A., Byrnes K.R., Hanscom M., Loane D.J., Faden A.I., Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma, Journal of Cerebral Blood Flow and Metabolism, 32, (1), 2012, p137 - 149, p137-149
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Kabadi S.V., Stoica B.A., Loane D.J., Byrnes K.R., Hanscom M., Cabatbat R.M., Tan M.T., Faden A.I., Cyclin D1 gene ablation confers neuroprotection in traumatic brain injury, Journal of Neurotrauma, 29, (5), 2012, p813 - 827, p813-827
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Piao C.-S., Loane D.J., Stoica B.A., Li S., Hanscom M., Cabatbat R., Blomgren K., Faden A.I., Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury, Neurobiology of Disease, 46, (3), 2012, p745 - 758, p745-758
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Wu J., Kharebava G., Piao C., Stoica B.A., Dinizo M., Sabirzhanov B., Hanscom M., Guanciale K., Faden A.I., Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo, PLoS ONE, 7, (7), 2012
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Sabirzhanov B., Stoica B.A., Hanscom M., Piao C.-S., Faden A.I., Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis, Journal of Neurochemistry, 123, (4), 2012, p542 - 554, p542-554
Journal Article; Published; Peer Reviewed; Author Profile: HANSCOMM; DOI

Kelly, O.M. and McNamara, Y.M. and Manzke, L.H. and Meegan, M.J. and Porter, R.K., The preservation of in vivo phosphorylated and activated uncoupling protein 3 (UCP3) in isolated skeletal muscle mitochondria following administration of 3,4-methylenedioxymethamphetamine (MDMA aka ecstasy) to rats/mice, Mitochondrion, 12, (1), 2012, p110-119
Journal Article; Published; Peer Reviewed; Author Profile: RKPORTER; DOI; URL

McCarthy, G., Mills, E., Mill, K, Dunne, A., Osteoarthritis-Associated Basic Calcium Phosphate Crystals Induce IL-1, IL-18 and S100A8 Production in A Tyrosine Kinase Dependent Manner. , Arthritis Rheumatol. , 2012 ACR/ACHP Annual Meeting, Atlanta, 2012, 2012
Conference Paper; Published; Peer Reviewed; Author Profile: AIDUNNE

Lars Manzke, An Investigation of the Physiological and pathological Role of Uncoupling Proteins, Trinity College Dublin, 2012
Thesis; Published; Peer Reviewed; Author Profile: RKPORTER

Martel, M.-A., Ryan, T., Bell, K., Fowler, J., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P., Grant, S., Wyllie, D., Hardingham, G., The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults, 74, (3), 2012, p543-556
Journal Article; Published; Peer Reviewed; Author Profile: TRYAN6

Richard K. Porter, Mitochondrial Uncoupling Protein 1 (UCP1) turnover and function, European Bioenergetics Conference 2012 (EBEC 2012), Freiburg, Germany, , (Sep 2012) , 2012, EBEC
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Richard K. Porter, Regulation of metabolism in Cancer and Immune Cells Symposium in Trinity College Dublin, Irish Area Section of the Biochemical Society (IASBS), Trinity College Dublin, (Nov 2012) , 2012, Richard K. Porter
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

L.H. Manzke, K.J. Clarke, R.K. Porter, Upregulation of mitochondrial glycerol-3-phosphate dehydrogenase abundance in brown adipose tissue mitochondria from UCP1 knock-out mice, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2012 (EBEC 2012), Freiburg, Germany, 15-20 September 2012, (1817), 2012, pps43-
Meeting Abstract; Published; Peer Reviewed; Author Profile: RKPORTER; DOI

Exley, M.A. and Lynch, L. and Nowak, M., NKT cells of cancer patients and how models can inform therapeutic plans, 2012, 129-151pp
Book; Published; Peer Reviewed; Author Profile: LYNCHL3; DOI; URL

Sestrins Link Tumor Suppressors with the AMPK -TOR Signaling Network in, editor(s)Cai Huang , Protein Phosphorylation in Human Health, Nvi Sad, Croatia, InTech, 2012, pp51 - 96, [Andrei V. Budanov]
Book Chapter; Published; Peer Reviewed; Author Profile: BUDANOVA; URL

Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M, Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3., Cell Metabolism, 16, (3), 2012, p311 - 321
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Min S, Meehan J, Sullivan LM, Harte NP, Xie Y, Davey GP, Svanborg C, Brodkorb A, Mok KH, Alternatively folded proteins with unexpected beneficial functions., Biochemical Society transactions, 40, (4), 2012, p746-51
Journal Article; Published; Peer Reviewed; Author Profile: GDAVEY; DOI

McKay, P.B., Fayne, D., Horn, H.W., James, T., Peters, M.B., Carta, G., Caboni, L., Nevin, D.K., Price, T., Bradley, G., Williams, D.C., Rice, J.E., Lloyd, D.G., Consensus computational ligand-based design for the identification of novel modulators of human estrogen receptor alpha, Molecular Informatics, 31, (3-4), 2012, p246-258
Journal Article; Published; Peer Reviewed; Author Profile: FAYNED

Creagh, E.M., Inflammatory caspases during IBD, Broad Medical Research Program 'Advances in Understanding IBD', Los Angeles, USA, 22, 23 February 2012, edited by Prof. Daniel Hollander , 2012
Oral Presentation; Presented; Peer Reviewed; Author Profile: ECREAGH

Greene, LM, O'Boyle, NM, Nolan, DP, Meegan, MJ, Zisterer, DM, The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells, Biochemical Pharmacology, 84, (5), 2012, p612-624
Journal Article; Published; Peer Reviewed; Author Profiles: NIOBOYLE DZISTRER MMEEGAN ; DOI

Diniz, DG, Foro, CAR, Turiel, MCP, Sosthenes, MCK, Demachki, S, Gomes, GF, Rego, CMD, Magalhaes, MC, Pinho, BG, Ramos, JP, Casseb, SMM, Brito, MD, da Silva, EVP, Nunes, MRT, Diniz, JAP, Cunningham, C, Perry, VH, Vasconcelos, PFC, Diniz, CWP, Environmental influences on antibody-enhanced dengue disease outcomes, MEMORIAS DO INSTITUTO OSWALDO CRUZ, 107, (8), 2012, p1021-+
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO

Immunology of Multiple Sclerosis in, The Biology of Multiple Sclerosis, Cambridge University Press, 2012, pp1-146 , [Fletcher JM and Mills KHG]
Book Chapter; Published; Peer Reviewed; Author Profiles: MILLSK FLETCHJ ; URL

Oficjalska, K., Laukens, D. and Creagh, E.M., Investigation of the role of caspases in a DSS-colitis model of IBD, Irish Society of Gastroenterology Winter Meeting, Dublin, Ireland, 23rd-24th Nov. 2012, 2012
Oral Presentation; Presented; Peer Reviewed; Author Profile: ECREAGH

Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, MacLullich AM, Brayne C, Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study., Brain : a journal of neurology, 135, (Pt 9), 2012, p2809-16
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Artemenko, N.V., McDonald, A.G., Davey, G.P., Rudd, P.M., Databases and tools in glycobiology, Methods in Molecular Biology, 899, 2012, p325-350
Journal Article; Published; Peer Reviewed; Author Profile: GDAVEY; DOI

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, , The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation, Nature communications, 3, 2012, p7 - 10
Journal Article; Published; Peer Reviewed; Author Profile: MCGETTRA; URL

Mori, A., Oleszycka, E., Sharp, F.A., Coleman, M., Ozasa, Y., Singh, M., O'Hagan, D.T., Tajber, L., Corrigan, O.I., McNeela, E.A., Lavelle, E.C., The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses, European Journal of Immunology, 42, (10), 2012, p2709-2719
Journal Article; Published; Peer Reviewed; Author Profiles: LAVELLEE OCORRIGN ; DOI

Caboni, L., Kinsella, G. K., Blanco, F., Fayne, D., Jagoe, W. N., Carr, M., Williams, D. C., Meegan, M. J., Lloyd, D. G., "True" Antiandrogens-Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor-Coactivator Interactions: Novel Tools for Prostate Cancer, , J Med Chem,, 55, (4 ), 2012, p1635 - 1644
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED MMEEGAN

Enhancing the Teaching and Learning of Labortatory Sciences through a Virtual Learning Environment. in, editor(s)Marcus-Quinn A, Bruen C, Allen M, Dundon A, Diggins Y , The Digital Learning Revolution in Ireland : Case Studies from the National Learning Resources Service. , Cambridge, UK, Cambridge Scholars Publishing,, 2012, pp181 - 194, [Robinson GA, Nic A' Bháird N, Kelly VP]
Book Chapter; Published; Peer Reviewed; Author Profile: KELLYVP

Campbell*, M, Doyle*, SL, Ozaki, E, Salomon, RG, Mori, A, Kenna, PF, Kiang, AS, Humphries, MM, Lavelle, EC, O'Neill, LAJ, Hollyfield, JG, and Humphries, P, NLRP3 plays a protective role during the development of age related macular degeneration through the induction of IL-18 by drusen components., Nature Medicine, 18, (5), 2012, p791 - 798
Journal Article; Published; Peer Reviewed; Author Profiles: LAVELLEE CAMPBEM2 ; DOI

Bowie, A.G., Innate sensing of bacterial cyclic dinucleotides: More than just STING, Nature Immunology, 13, (12), 2012, p1137-1139
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Keely, NO, Zisterer, DM, Meegan, MJ, Design, Synthesis and Biochemical Evaluation of Estrogen Receptor Ligand Conjugates as Tumour Targeting Agents, LETTERS IN DRUG DESIGN & DISCOVERY, 9, (3), 2012, p295-304
Journal Article; Published; Peer Reviewed; Author Profile: DZISTRER

Li, D., Boland, C., Walsh, K., Caffrey, M., Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases, Journal of Visualised Experiments, 67, 2012, pe4000
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI

Li D, Boland C, Aragao D, Walsh K, Caffrey M, Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography., Journal of visualized experiments : JoVE, (67), 2012, pe4001
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE

Khelashvili, G, Albornoz, PBC, Johner, N, Mondal, S, Caffrey, M, Weinstein, H, Why GPCRs behave differently in cubic and lamellar lipidic mesophases, Journal of the American Chemical Society, 134, (38), 2012, p15858-15868
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI

Aherne, M, Lyons, JA, Caffrey, M, A fast, simple and robust protocol for growing crystals in the lipidic cubic phase, Journal of Applied Crystallography , 45, (6), 2012, p1330-1333
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI

Lyons JA, Aragão D, Slattery O, Pisliakov AV, Soulimane T, Caffrey M, Structural insights into electron transfer in caa3-type cytochrome oxidase., Nature, 487, (7408), 2012, p514-8
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE

Caffrey M, Li D, Dukkipati A, Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes., Biochemistry, 51, (32), 2012, p6266-88
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI

Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL LYNCHL3 ; DOI

Meade KG, O'Gorman GM, Narciandi F, Machugh DE, O'Farrelly C, Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro., Molecular immunology, 50, (1-2), 2012, p108-116
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

Sarwar S, Ryan EJ, Iqbal M, McCormick PA, O'Farrelly C, Hegarty J, Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection., Irish journal of medical science, 181, (1), 2012, p53-58
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C, Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells., Reproductive biomedicine online, 25, (3), 2012, p322-328
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87
Journal Article; Published; Peer Reviewed; Author Profiles: LYNCHL3 OFARRECL ; DOI

Chapwanya A, Meade KG, Foley C, Narciandi F, Evans AC, Doherty ML, Callanan JJ, O'Farrelly C, The postpartum endometrial inflammatory response: a normal physiological event with potential implications for bovine fertility., Reproduction, fertility, and development, 24, (8), 2012, p1028-1039
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ, Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection., Cytokine, 60, (2), 2012, p328-33
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL FEARONU ; DOI

McGovern, R.E., Fernandes, H., Khan, A.R., Power, N.P., Crowley, P.B., Protein camouflage in cytochrome c-calixarene complexes, Nature Chemistry, 4, (7), 2012, p527-533
Journal Article; Published; Peer Reviewed; Author Profile: AMIRRAFK; DOI

Fernandes, H., Franklin, E., Jollivet, F., Bliedtner, K., Khan, A.R., Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1., PloS one, 7, (4), 2012, pe35637
Journal Article; Published; Peer Reviewed; Author Profile: AMIRRAFK; DOI

Porter, R.K., Studies on the function and regulation of mitochondrial uncoupling proteins, Advances in Experimental Medicine and Biology, 748, 2012, p171 - 184
Journal Article; Published; Peer Reviewed; Author Profile: RKPORTER; URL

Clarke, KJ, Adams, AE, Manzke, LH, Pearson, TW, Borchers, CH, Porter, RK, A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1), BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1817, (10), 2012, p1759-1767
Journal Article; Published; Peer Reviewed; Author Profile: RKPORTER; DOI

Greene, LM, O'Boyle, NM, Nolan, DP, Meegan, MJ, Zisterer, DM, The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells, BIOCHEMICAL PHARMACOLOGY, 84, (5), 2012, p612-624
Journal Article; Published; Peer Reviewed; Author Profiles: DENOLAN DZISTRER ; DOI

Sanderson DJ, Rawlins JN, Deacon RM, Cunningham C, Barkus C, Bannerman DM., Hippocampal lesions can enhance discrimination learning despite normal sensitivity to interference from incidental information., Hippocampus, 22, (7), 2012, p1553 - 1566
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS, Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor., Immunity, 36, (4), 2012, p561-571
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Stack J, Bowie AG, Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions., The Journal of biological chemistry, 287, (27), 2012, p22672-22682
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G, Viral immune modulators perturb the human molecular network by common and unique strategies., Nature, 487, (7408), 2012, p486-490
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-ß and in the cortex of aged rats., The Journal of biological chemistry, 287, (41), 2012, p34709-21
Journal Article; Published; Peer Reviewed; Author Profiles: VACMPBLL AGBOWIE ; DOI

Leow-Dyke S, Allen C, Denes A, Nilsson O, Maysami S, Bowie AG, Rothwell NJ, Pinteaux E, Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro., Journal of neuroinflammation, 9, 2012, p230
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

David Tombs, A new covenant?, Sunday Sequence, 30 September 2012, BBC Radio Ulster, 2012
Oral Presentation; Presented; Non Peer Reviewed; Author Profile: RKPORTER

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation., Nature communications, 3, 2012, p707
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL DOYLES8 ; DOI

Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP, Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs., Circulation. Cardiovascular interventions, 5, (2), 2012, p279-287
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Wen H, Ting JP, O'Neill LA, A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?, Nature immunology, 13, (4), 2012, p352-357
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL CORRSC ; DOI

Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798
Journal Article; Published; Peer Reviewed; Author Profiles: LAVELLEE PHUMPHRS GJFARRAR LAONEILL DOYLES8 ; DOI

Netea MG, Wijmenga C, O'Neill LA, Genetic variation in Toll-like receptors and disease susceptibility., Nature immunology, 13, (6), 2012, p535-542
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Foley NH, O'Neill LA, miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes., Journal of leukocyte biology, 92, (3), 2012, p521-527
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Dowling JK, O'Neill LA, Biochemical regulation of the inflammasome., Critical reviews in biochemistry and molecular biology, 47, (5), 2012, p424-443
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Connolly DJ, O'Neill LA, New developments in Toll-like receptor targeted therapeutics., Current opinion in pharmacology, 12, (4), 2012, p510-518
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Ward SG, O'Neill LA, Spurs in the hunt for new immunomodulatory drug targets., Current opinion in pharmacology, 12, (4), 2012, p439-443
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL, Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1ß production., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p3795-9
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

O'Neill LA, "Transflammation": when innate immunity meets induced pluripotency., Cell, 151, (3), 2012, p471-3
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Jones, S.A., Sutton, C.E., Cua, D., Mills, K.H.G., Therapeutic potential of targeting IL-17 , Nature Immunology, 13, (11), 2012, p1022-1025
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK CASUTTON ; DOI

Enzymes: Irreversible Inhibition. in, A.G. McDonald and K.F. Tipton, Keith F. , Encyclopedia of the Life Sciences (eLS)., Chichester., John Wiley & Sons, Ltd, 2012, [A.G. McDonald and K.F. Tipton.]
Book Chapter; Published; Peer Reviewed; Author Profiles: KTIPTON AMCDONLD

Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG, Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows., BMC genomics, 13, (1), 2012, p489
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL KENNYEL ; DOI

Connell S, Meade KG, Allan B, Lloyd AT, Kenny E, Cormican P, Morris DW, Bradley DG, O'Farrelly C, Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing., PloS one, 7, (8), 2012, pe40409
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL DBRADLEY KENNYEL ; DOI

Nevin DK, Peters MB, Carta G, Fayne D, Lloyd DG, Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds., Journal of medicinal chemistry, 55, (11), 2012, p4978-89
Journal Article; Published; Peer Reviewed; Author Profile: FAYNED

Blanco F, Egan B, Caboni L, Elguero J, O'Brien J, McCabe T, Fayne D, Meegan MJ, Lloyd DG, Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists., Journal of chemical information and modeling, 52, (9), 2012, p2387-97
Journal Article; Published; Peer Reviewed; Author Profile: FAYNED

Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M, Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways., Clinical cancer research : an official journal of the American Association for Cancer Research, 18, (2), 2012, p380-91
Journal Article; Published; Peer Reviewed; Author Profile: JMURRAY6

Yuen HF, Abramczyk O, Montgomery G, Chan KK, Huang YH, Sasazuki T, Shirasawa S, Gopesh S, Chan KW, Fennell D, Janne P, El-Tanani M, Murray JT, Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells., Bioscience reports, 32, (4), 2012, p413-22
Journal Article; Published; Peer Reviewed; Author Profile: JMURRAY6

Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092
Journal Article; Published; Peer Reviewed; Author Profiles: TFOSTER GEOGHEJO MCLOUGRM ; DOI

Min, SY, Meehan, J, Sullivan, LM, Harte, NP, Xie, YJ, Davey, GP, Svanborg, C, Brodkorb, A, Mok, KH, Alternatively folded proteins with unexpected beneficial functions, Biochemical Society Transactions, 40, 2012, p746-751
Journal Article; Published; Peer Reviewed; Author Profile: MOK1; DOI

David K. Finlay, Ella Rosenzweig, Linda V. Sinclair, Carmen Feijoo-Carnero, Jens L. Hukelmann, Julia Rolf, Andrey A. Panteleyev, Klaus Okkenhaug, Doreen A. Cantrell, PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells, Journal of Experimental Medicine, 209, (13), 2012, p2441 - 2453
Journal Article; Published; Peer Reviewed; Author Profile: FINLAYD; URL

David K Finlay, Regulation of glucose metabolism in T cells: new insight into the role of phosphoinositide 3-kinases, Frontiers in Immunology, 3, 2012, p247-
Review Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012
Journal Article; Published; Peer Reviewed; Author Profiles: CORRSC CMARTIN3 OLEARYJJ DBRHMSON LAONEILL ; DOI

Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J, Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p4144-4153
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK NICHEAC2 LAVELLEE ; DOI

Sutton CE, Mielke LA, Mills KH, IL-17-producing gamma delta T cells and innate lymphoid cells., European Journal of Immunology, 42, (9), 2012, p2221-2231
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK CASUTTON ; DOI

Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase., Clinical immunology (Orlando, Fla.), 144, (3), 2012, p228-236
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK LAVELLEE AIDUNNE ; DOI

Morine MJ, Toomey S, McGillicuddy FC, Reynolds CM, Power KA, Browne JA, Loscher C, Mills KH, Roche HM, Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice., The Journal of nutritional biochemistry, 2012, p228-236
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI

Higgs R, Higgins SC, Ross PJ, Mills KH, Immunity to the respiratory pathogen Bordetella pertussis., Mucosal immunology, 5, (5), 2012, p485-500
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI

Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM, Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance., Molecular nutrition & food research, 56, (8), 2012, p1212-1222
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK FINUCAOR ; DOI

Allen AC, Kelly S, Basdeo SA, Kinsella K, Mulready KJ, Mills KH, Tubridy N, Walsh C, Brady JJ, Hutchinson M, Fletcher JM, A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers., Multiple sclerosis (Houndmills, Basingstoke, England), 18, (12), 2012, p1797 - 1800
Journal Article; Published; Peer Reviewed; Author Profiles: SBASDEO MILLSK WALSHC FLETCHJ ; DOI

Pindjakova J, Hanley SA, Duffy MM, Sutton CE, Weidhofer GA, Miller MN, Nath KA, Mills KH, Ceredig R, Griffin MD, Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction., Kidney International, 81, (4), 2012, p379-390
Journal Article; Published; Peer Reviewed; Author Profiles: CASUTTON MILLSK ; DOI

Field RH, Gossen A, Cunningham C, Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium., The Journal of Neuroscience, 32, (18), 2012, p6288 - 6294
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI; URL

McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR, Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 42, (3), 2012, p392-404
Journal Article; Published; Peer Reviewed; Author Profile: MCLOUGRM; DOI

Bowie, A.G., The STING in the Tail for Cytosolic DNA-Dependent Activation of IRF3, Science Signalling, 5, 2012, ppe5
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487
Journal Article; Published; Peer Reviewed; Author Profiles: KTIPTON JOSULLI ; DOI

Caboni L, Kinsella GK, Blanco F, Fayne D, Jagoe WN, Carr M, Williams DC, Meegan MJ, Lloyd DG, 'True' antiandrogens - selective non ligand-binding pocket disruptors of androgen receptor-coactivator interactions: Novel Tools for Prostate Cancer., Journal of Medicinal Chemistry, 55, (4), 2012, p1635 - 1644
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED DWILLIMS ; DOI

Conroy H, Galvin KC, Higgins SC, Mills KH, Gene silencing of TGF-ß1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells., Cancer Immunology & Immunotherapy, 61, (3), 2012, p425-431
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI

Jean M Fletcher, Sharee A Basdeo, Aideen C Allen and Padraic J Dunne, Therapeutic use of vitamin D and its analogues in autoimmunity, Recent Patents in Inflammation Allergy Drug Discovery, 6, (1), 2012, p22 - 34
Review Article; Published; Peer Reviewed; Author Profiles: FLETCHJ SBASDEO

Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424
Journal Article; Published; Peer Reviewed; Author Profiles: JOSEPHMK MILLSK MORANBA ; DOI

Marshall NA, Galvin KC, Corcoran AM, Boon L, Higgs R, Mills KH, Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-ã+IL-17+ polyfunctional T-cells that mediate rejection of murine tumors, Cancer Research, 72, (3), 2012, p581-591
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI; URL

Tânia Oliveira, Santosh Panjikar, John B. Carrigan, Muaawia Hamza, Paul C. Engel, Amir R. Khan, Crystal Structure of NAD-dependent Peptoniphilus Asaccharolyticus Glutamate Dehydrogenase Reveals Determinants of Cofactor Specificity, Journal of Structural Biology, 177, (2), 2012, p543-552
Journal Article; Published; Peer Reviewed; Author Profile: AMIRRAFK; DOI; URL

Immunostimulatory properties of biodegradable microparticles in, editor(s)John H. Morrow, Clint Schmidt, Nadeem Sheikh, Huw Davies , Vaccinology: Principles and Practice., Wiley-Blackwell, 2012, [Sharp, F.A. and Lavelle, E.C ]
Book Chapter; In_press; Peer Reviewed; Author Profile: LAVELLEE

Cunningham C, Skelly DT, Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?, Journal of Neuroimmune Pharmacology : The Official Journal of the Society on NeuroImmune Pharmacology, 7, (1), 2012, p60-73
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI; URL

Orlagh M. Kelly, Yvonne M. McNamara, Lars H. Manzke, Mary J. Meegan, Richard K. Porter, The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice, Mitochondrion, 12, (1), 2012, p110-9
Journal Article; Published; Peer Reviewed; Author Profiles: RKPORTER MMEEGAN ; DOI; URL

Carol Murray, David Sanderson, Chris Barkus, R.M.J. Deacon, J.N.P. Rawlins, David Bannerman and Colm Cunningham, Systemic inflammation induces acute working memory deficits in the primed brain; relevance for delirium, Neurobiology of Aging, 33, (3), 2012, p603-616.e3
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI; URL

McNeela, E.A. and Lavelle, E.C. , Recent advances in microparticles and nanoparticles for mucosal vaccination , Current Topics in Microbiology and Immunology, 354, 2012, p75-99
Journal Article; Published; Peer Reviewed; Author Profile: LAVELLEE; DOI