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Publications

Below is the list of peer and non peer publications from the School of Biochemistry and Immunology.

Show: AllPeer ReviewedNon Peer Reviewed
109 publications from 2010

AndreaDlasková, Kieran J.Clarke, Richard K.Porter, UCP1 ablation increases the production of reactive oxygen species by mitochondria isolated from brown adipose tissue, BBA Bioenergetics, European Bioenergetics Conference 2010, Warsaw, Poland, 1797, 2010, pp85 - 85
Meeting Abstract; Published; Peer Reviewed; Author Profile: RKPORTER; URL

Alison E. Adams, Absence of mitochondrial uncoupling protein 1 affects apoptosis and T-cell profile in mice, BBA Bioenergetics, European Bioenergetics Conference 2010, Warsaw, Poland, 1797, 2010, pp85 - 85
Meeting Abstract; Published; Peer Reviewed; Author Profile: RKPORTER; URL

Richard K. Porter & Kieran J. Clarke, Regulation of H2O2 generation by uncoupling protein 1 in thymus mitochondria, European Bioenergetics Conference 2010, Warsaw, Poland, 1797 Supplement, 2010, pp86 - 86
Meeting Abstract; Published; Peer Reviewed; Author Profile: RKPORTER; URL

Richard K. Porter, "Mitochondrial Uncoupling Protein Regulation", International Congress on Obesity, Sockholm, Sweden, July, 2010, International Congress on Obesity
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Richard K. Porter, "Mitochondrial Uncoupling Protein Regulation" , European Bioenergetics Conference (EBEC) , Warsaw, Poland, July 2010, 2010, European Bioenergetics Conference (EBEC)
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Richard K. Porter, "Investigation into the role of uncoupling protein 3 in the thymus and spleen", COST meeting Coimbra University, Portugal, September 2010, Universiy of Coimbra, Portugal, September 2010, 2010, COST Mitofood
Invited Talk; Published; Peer Reviewed; Author Profile: RKPORTER

Nowak, M. and Lynch, L. and Yue, S. and Ohta, A. and Sitkovsky, M. and Balk, S.P. and Exley, M.A., The A2aR adenosine receptor controls cytokine production in iNKT cells, European Journal of Immunology, 40, (3), 2010, p682-687
Journal Article; Published; Peer Reviewed; Author Profile: LYNCHL3; DOI; URL

Reprogramming human dermal fibroblasts for the generation of pluripotent stem cells. in, editor(s)Freshney, R.I. , Culture of Animal Cells, a Manual of Basic Technique and Specialized Applications, John Wiley & Sons , 2010, [Sullivan S, Davey GP ]
Book Chapter; Published; Non Peer Reviewed; Author Profile: GDAVEY

Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M, Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies., Science, 327, ( 5970), 2010, p1223 - 1228
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Budanov AV, Lee JH, Karin M, Stressin' Sestrins take an aging fight., EMBO Molecular Medicine, 2, (10), 2010, p388 - 400
Journal Article; Published; Peer Reviewed; Author Profile: BUDANOVA; DOI

Weidenmaier C, McLoughlin R.M, Lee J.C, The Zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism, PLoS ONE, 5, (10), 2010
Journal Article; Published; Peer Reviewed; Author Profile: MCLOUGRM; DOI; URL

Greene,. L.M., Nathwani, S.M., Bright, S.A., Fayne, D., Croke, A., Gagliardi,M., McElligott, A.M., O'Connor, L.M., Carr, M.G., Keely, N.O., O'Boyle, N.M., Carroll, P.V., Sarkadi, B., Conneally, E.C., Lloyd,D.G., Lawler, M.P., Meegan, M.J., Zisterer, D.M., The vascular targeting agent combretastatin-A4 and a novel cis-restricted beta-lactam analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance, Journal of Pharmacology and Experimental Therapeutics, 335, (2), 2010, p302-313
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED DZISTRER NIOBOYLE MMEEGAN ; DOI

Barrett, I., Carr, M.G., O'Boyle, N.M., Greene, L.M., Knox, A., Lloyd, D.G., Zisterer, D.M., Meegan, M.J., Lead identification of conformationally restricted benzoxepin type combretastatin analogs: Synthesis, antiproliferative activity, and tubulin effects, Journal of Enzyme Inhibition and Medicinal Chemistry, 25, (2), 2010, p180-194
Journal Article; Published; Peer Reviewed; Author Profiles: MMEEGAN DZISTRER NIOBOYLE ; DOI

Yang,Y., Carta,G., Peters, M.B., Price, T.T., O'Boyle, N.M., Knox, A.J.S., Fayne, D., Williams, D.C., Meegan, M.J., Lloyd, D.G., 'TieredScreen' - Layered virtual screening tool for the identification of novel estrogen receptor alpha modulators, Molecular Informatics, 29, (5), 2010, p421-430
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED NIOBOYLE ; DOI

Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA, Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß in type 2 diabetes., Nature immunology, 11, (10), 2010, p897-904
Journal Article; Published; Peer Reviewed; Author Profile: MOK1

Telford, J.E., Kilbride, S.M., Davey, G.P., Decylubiquinone increases mitochondrial function in synaptosomes, Journal of Biological Chemistry, 285, (12), 2010, p8639-8645
Journal Article; Published; Peer Reviewed; Author Profile: GDAVEY; DOI

Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832
Journal Article; Published; Peer Reviewed; Author Profile: STEVENNJ; DOI

Carty M, Bowie AG, Recent insights into the role of Toll-like receptors in viral infection., Clinical and experimental immunology, 161, (3), 2010, p397-406
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Chapwanya, A., Meade, K.G., Narciandi, F., Stanley, P., Mee, J.F., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial biopsy: a valuable clinical and research tool in bovine reproduction, Theriogenology, 73, (7), 2010, p988-994
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL LYNCHL3 ; DOI

O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997
Journal Article; Published; Peer Reviewed; Author Profiles: LYNCHL3 OFARRECL ; DOI

O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL LYNCHL3 ; DOI

Tajuddin, T., Ryan, E.J., Norris, S., Hegarty, J.E., O'Farrelly, C., Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist, Journal of Gastroenterology and Hepatology, 25, (12), 2010, p1883-1890
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI

Oliveira, T.F., Carrigan, J.B., Hamza, M.A., Sharkey, M.A., Engel, P.C., Khan, A.R., Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticus, Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, (5), 2010, p523-526
Journal Article; Published; Peer Reviewed; Author Profile: AMIRRAFK; DOI

Downing, T., O'Farrelly, C., Bhuiyan, A.K., Silva, P., Naqvi, A.N., Sanfo, R., Sow, R.-S., (...), Bradley, D.G.., Variation in chicken populations may affect the enzymatic activity of lysozyme, Animal Genetics, 41, (2), 2010, p213-217
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL DBRADLEY ; DOI

Cloonan SM, Drozgowska A, Fayne D, Williams DC, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leukemia & lymphoma, 51, (3), 2010, p523-39
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED CLOONAS

McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, O'Hagan B, Odrzywol K, Murray J, Longley D, McKerr G, Fennell DA, Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK., Cell death & disease, 1, 2010, pe108
Journal Article; Published; Peer Reviewed; Author Profile: JMURRAY6

Lysakova-Devine, T., Keogh, B., Harrington, B., Nagpal, K., Halle, A., Golenbock, D.T., Monie, T. & Bowie, A.G. , Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule, The Journal of Immunology, 185, 2010, p4261 - 4271
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

O'Boyle NM, Carr M, Greene LM, Bergin O, Nathwani SM, McCabe T, Lloyd DG, Zisterer DM, Meegan MJ, Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents, Journal of Medicinal Chemistry, 53, (24), 2010, p8569-8584
Journal Article; Published; Peer Reviewed; Author Profiles: MMEEGAN NIOBOYLE DZISTRER ; DOI; URL

McDonald, AG, Tipton, KF, Computer-Controlled System for the Study of Oxidase Reactions: Application to the Peroxidase-Oxidase Oscillator, JOURNAL OF PHYSICAL CHEMISTRY B, 114, 2010
Journal Article; Published; Peer Reviewed; Author Profile: AMCDONLD

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2010, Registered Republic of Korea Patent No. 2003-32468
Patent; Published; Peer Reviewed; Author Profile: MOK1

Mossberg A, Mok KH, Morozova-Roche LA, Svanborg C, Structure and function of human α-lactalbumin made lethal to tumour cells (HAMLET)-type complexes, FEBS Journal, 277, (22), 2010, p4614 - 4625
Journal Article; Published; Peer Reviewed; Author Profile: MOK1; DOI

Masters, S.L., Mielke, L.A. Cornish, A.L., Sutton, C.E., Cengia, L., Roberts, A.W., Wicks, I.P. Mills, K.H.G. and Croker, B.A. , Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production , EMBO Reports, 11, (8), 2010, p640 - 646
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK CASUTTON ; DOI

Ni J, McLoughlin RM, Brodovitch A, Moulin P, Brouckaert P, Casadei B, Feron O, Topley N, Balligand JL, Devuyst O, Nitric oxide synthase isoforms play distinct roles during acute peritonitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25, (1), 2010, p86-96
Journal Article; Published; Peer Reviewed; Author Profile: MCLOUGRM

Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA, Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells., Journal of immunology (Baltimore, Md. : 1950), 184, (4), 2010, p2130-9
Journal Article; Published; Peer Reviewed; Author Profile: MCLOUGRM

Lee JC, Greenwich JL, Zhanel GG, Han X, Cumming A, Saward L, McLoughlin RM, Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection., Infection and immunity, 78, (10), 2010, p4176-86
Journal Article; Published; Peer Reviewed; Author Profile: MCLOUGRM

Finlay DK, Cantrell DA, Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration., Annals of the New York Academy of Sciences, 1183, 2010, p149-57
Review Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Tamás P, Macintyre A, Finlay D, Clarke R, Feijoo-Carnero C, Ashworth A, Cantrell D, LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells, European Journal of Immunology, 40, (1), 2010, p242 - 253
Journal Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA, Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Vα14 iNKT cells, regulatory T cells and conventional T cells, Journal of Immunology, 185, (10), 2010, p5973 - 5982
Journal Article; Published; Peer Reviewed; Author Profile: FINLAYD; DOI; URL

Downing T, Lloyd AT, O'Farrelly C, Bradley DG, The differential evolutionary dynamics of avian cytokine and TLR gene classes., Journal of immunology (Baltimore, Md. : 1950), 184, (12), 2010, p6993-7000
Journal Article; Published; Peer Reviewed; Author Profiles: DBRADLEY OFARRECL ; DOI

Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH, Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis., Journal of Immunology , 185, (3), 2010, p1711-9
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK CASUTTON AIDUNNE ; DOI; URL

McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191
Journal Article; Published; Peer Reviewed; Author Profiles: MCLOUGRM LAVELLEE MORANBA ; DOI; URL

Nagle PS, Quinn SJ, Kelly JM, O'Donovan DH, Khan AR, Rodriguez F, Nguyen B, Wilson WD, Rozas I, Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives., Organic & Biomolecular chemistry, 8, (24), 2010, p5558-67
Journal Article; Published; Peer Reviewed; Author Profiles: JMKELLY AMIRRAFK ROZASI ; DOI; URL

Apweiler, R. Armstrong, R., Bairoch, A., Cornish-Bowden, A., Halling, P.J. Hofmeyr, J.H., Kettner, C... Leyh, T.S., Rohwer J., D. Schomburg, D. Steinbeck C., K. Tipton K., A large-scale protein-function database., Nature Chemical Biology, 6, 2010, p785 - 785
Journal Article; Published; Peer Reviewed; Author Profile: KTIPTON

McDonald, A.G., Tipton, K.F., Stroop, C.J., Davey G.P., GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources., BMC Research Notes, 18, (3), 2010, p1-7
Journal Article; Published; Peer Reviewed; Author Profiles: AMCDONLD GDAVEY KTIPTON ; DOI; URL

McDonald AG, Tipton KF, Computer-controlled system for the study of oxidase reactions: application to the peroxidase-oxidase oscillator., The Journal of Physical Chemistry. B, 114, (49), 2010, p16244-52
Journal Article; Published; Peer Reviewed; Author Profiles: KTIPTON AMCDONLD ; DOI

Smith, KJ, Norris, S, O'Dwyer, AM & O'Mara, SM. , Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha., Neuropsychiatric Disease and Treatment, 2010, p1-18
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL SMOMARA

Höfer N, Aragão D, Caffrey M, Crystallizing Transmembrane Peptides in Lipidic Mesophases, Biophysical Journal, 99, (3), 2010, pL23-L25
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Coleman MM, Keane J, Mills KH., Tregs and BCG--dangerous liaisons in TB., Journal of Leukocyte Biology, 88, (6), 2010, p1067 - 1069
Journal Article; Published; Peer Reviewed; Author Profiles: JOSEPHMK MILLSK ; DOI

Hoare M, Gelson WT, Das A, Fletcher JM, Davies SE, Curran MD, Vowler SL, Maini MK, Akbar AN, Alexander GJ., CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection., Journal of Hepatology, 53, (2), 2010, p252 - 260
Journal Article; Published; Peer Reviewed; Author Profile: FLETCHJ; DOI; URL

O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL FLETCHJ MILLSK ; DOI

Zhang, X., Shephard, F., Kim, H.B., Palmer, I.R., McHarg, S., Fowler, G.J.S., O'Neill, L.A.J., (...), Qwarnstrom, E.E., TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-κB, Journal of Biological Chemistry, 285, (10), 2010, p7222-7232
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

O'Neill, L.A.J., Hennessy, E.J., Parker, A.E, Targeting Toll-like receptors: Emerging therapeutics?, Nature Reviews Drug Discovery, 9, (4), 2010, p293-307
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

O'Neill, L.A.J, Stopping sepsis by targeting sphingosine kinase 1, Science Translational Medicine, 2, (36), 2010, p36ps29
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Coll, R.C., O'Neill, L.A.J., New insights into the regulation of signalling by toll-like receptors and nod-like receptors, Journal of Innate Immunity, 2, (5), 2010, p406-421
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK LAONEILL LAVELLEE AIDUNNE ; DOI

Unterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M., (...), Bowie, A.G., IFI16 is an innate immune sensor for intracellular DNA, Nature Immunology, 11, 2010, p997-1004
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Toll-like receptor 3 in, editor(s)Hansel T.T., Barnes P.J. , Progress in Respiratory Research, Karger, 2010, pp73-79 , [Carty, M., Bowie, A.]
Book Chapter; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Bowie, A.G, TRAF3: Uncovering the Real but Restricted Role in Human, Immunity, 33, (3), 2010, p293-295
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Carty, M., Bowie, A.G, Activation of host pattern recognition receptors by viruses, Clinical and Experimental Immunology, 161, (3), 2010, p397-406
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Brennan, K., Bowie, A.G., Activation of host pattern recognition receptors by viruses, Current Opinion in Microbiology, 13, (4), 2010, p503-507
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

O'Neill, L.A.J., Bowie, A.G., Sensing and Signaling in Antiviral Innate Immunity , Current Biology , 20, (7), 2010, pR328-R333
Journal Article; Published; Peer Reviewed; Author Profiles: AGBOWIE LAONEILL ; DOI

Mulhern, O., Bowie, A.G., Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways , European Journal of Immunology, 40, (4), 2010, p933-935
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI

Higgins, S.C., Mills, K.H.G, TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants, Current Infectious Disease Reports, 12, (1), 2010, p4-12
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI; URL

McGuirk, P., Higgins, S.C., Mills, K.H.G, The role of regulatory T cells in respiratory infections and allergy and asthma, Current Allergy and Asthma Reports, 10, (1), 2010, p21-28
Journal Article; Published; Peer Reviewed; Author Profile: MILLSK; DOI; URL

Fletcher, J.M., Lalor, S.J., Sweeney, C.M., Tubridy, N., Mills, K.H.G, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis , Clinical and Experimental Immunology, 162, (1), 2010, p1-11
Review Article; Published; Peer Reviewed; Author Profiles: MILLSK FLETCHJ LALORST ; DOI; URL

Höfer N, Aragão D, Caffrey M, Crystallizing membrane proteins for structure determination using lipidic mesophases. , Journal of Visualized Experiments, 45, 2010, p1712-
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI; URL

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474
Journal Article; Published; Peer Reviewed; Author Profiles: OFARRECL LONGAI STEVENNJ ; DOI; URL

Miriam Carr, Lisa M. Greene, Andrew J.S. Knox, David G Lloyd, Daniela M. Zisterer and Mary J. Meegan, Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects, European Journal of Medicinal Chemistry, 45, (12), 2010, p5752-5766
Journal Article; Published; Peer Reviewed; Author Profiles: MMEEGAN DZISTRER ; DOI; URL

Diana Spitznagel, John F. O'Rourke, Neal Leddy, Orla Hanrahan, Derek P. Nolan, Identification and Characterization of an Unusual Class I Myosin Involved in Vesicle Traffic in Trypanosoma brucei, PLoS ONE, 5, (8), 2010, pe12282
Journal Article; Published; Peer Reviewed; Author Profile: DENOLAN; DOI; URL

Robert Field, Suzanne Campion, Colleen Warren, Carol Murray and Colm Cunningham, Activation of the systemic anti-viral response by poly I:C exacerbates chronic neurodegeneration: microglial priming and amplified IFNβ and IL-1β responses , Brain Behavior and Immunity , 24, (6), 2010, p996-1007
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO

Martina M. Hughes, Robert H. Field, V. Hugh Perry, Carol L Murray and Colm Cunningham. , Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation , GLIA, 58, 2010, p2017 - 2030
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gargliardi M, Mc Elligott AM, O'Connor L, Carr M, Keely NO, O'Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ, Zisterer DM, The vascular targeting agent Combretastatin-A4 and a novel cis-restricted {beta}-lactam analogue CA-432 induce apoptosis in human chronic myeloid leukemia cells and in ex vivo patient samples including those displaying multidrug resistance., The Journal of Pharmacology and Experimental Therapeutics, 335, (2), 2010, p302 - 313
Journal Article; Published; Peer Reviewed; Author Profiles: FAYNED MPLAWLER MMEEGAN MCELLIGA DZISTRER ; DOI

Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507
Journal Article; Published; Peer Reviewed; Author Profiles: CLOONAS DWILLIMS DZISTRER MPLAWLER ; DOI

Sinead Flannery and Andrew G. Bowie, The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling, Biochemical Pharmacology, 80, (12), 2010, p1981-1991
Journal Article; Published; Peer Reviewed; Author Profile: AGBOWIE; DOI; URL

Yang Y, Carta G, Peters MB, Price T, O'Boyle N, Knox AJ, Fayne D, Williams DC, Meegan MJ, Lloyd DG , 'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha, Molecular Informatics, 29, 2010, p421 - 430
Journal Article; Published; Peer Reviewed; Author Profiles: MMEEGAN DWILLIMS FAYNED ; DOI

Madden SF, Carpenter SB, Jeffery IB, Bjorkbacka H, Fitzgerald KA, O'Neill LA, Higgins DG, Detecting microRNA activity from gene expression data., BMC Bioinformatics, 11, (1), 2010, p257
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty and Cliona O'Farrelly, A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832
Journal Article; Published; Peer Reviewed; Author Profile: OFARRECL; DOI; URL

McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, (27), 2010, p20492-20498
Journal Article; Published; Peer Reviewed; Author Profiles: DOYLES8 FSHEEDY LAONEILL ; DOI; URL

S A Bright, A M McElligott, J W O'Connell, L O'Connor, P Carroll, G Campiani, M W Deininger, E Conneally, M Lawler, D C Williams, and D.M Zisterer, Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo , British Journal of Cancer, 102, 2010, p1474 - 1482
Journal Article; Published; Peer Reviewed; Author Profiles: MCELLIGA DWILLIMS DZISTRER ; DOI; URL

Luan B, Carr R, Caffrey M, Aksimentiev A, The effect of calcium on the conformation of cobalamin transporter BtuB., Proteins, 78, (5), 2010, p1153-62
Journal Article; Published; Peer Reviewed; Author Profile: MCAFFRE; DOI

Alison E. Adams, Orlagh M. Kelly, Richard K.Porter, R. K., Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number, Biochimica et Biophysica Acta (BBA) - Bioenergetics, 16th European Bioenergetics Conference, Warsaw, 17-22 July, edited by L. Wojtczak and K. Zabłocki , 1797, (6-7), Elsevier, 2010, pp807-816
Conference Paper; Published; Peer Reviewed; Author Profile: RKPORTER; DOI; URL

Andrea Dlaskovà, Kieran J. Clarke, Richard K. Porter, R.K. , The role of UCP 1 in the production of reactive oxygen species by mitochondria isolated from brown adipose tissue, Biochimica Biophysica Acta (Bioenergetics), 1797, (8), 2010, p1470 - 1476
Journal Article; Published; Peer Reviewed; Author Profile: RKPORTER; DOI; URL

Rakovich A, Rakovich T, Kelly VP, Lesnyak V, Eychmüller A, Rakovich YP, Donegan JF, Photosensitizer methylene blue-semiconductor nanocrystals hybrid system for photodynamic therapy., Journal of nanoscience and nanotechnology, 10, (4), 2010, p2656-2662
Journal Article; Published; Peer Reviewed; Author Profiles: JDONEGAN KELLYVP ; DOI

Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment , Biochemical Pharmacology, 80, 2010, p31 - 38
Journal Article; Published; Peer Reviewed; Author Profiles: DWILLIMS MPLAWLER DZISTRER ; DOI

Yoon JW, Wilson SP, Mok KH, A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra, Journal of Machine Learning Research, Workshop & Conference Proceedings, 13th International Conference on Artificial Intelligence and Statistics (AISTATS), Chia Laguna Resort, Sardinia, Italy, 13-15 May 2010, edited by Yee Whye Teh, Mike Titterington , 9, 2010, pp940 - 947
Conference Paper; Published; Peer Reviewed; Author Profiles: SWILSON MOK1 ; URL

Barrett I, Carr M, O'Boyle N, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ, Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects., Journal of enzyme inhibition and medicinal chemistry, 25, (2), 2010, p180-94
Journal Article; Published; Peer Reviewed; Author Profiles: MMEEGAN DZISTRER ; DOI

YanMei Liang, Jeremy Hetzel, Ansu Noronha, Daniel Onguru, Susan Carpenter, Melanie Mott, Sherman Biogornia, Caroline Apovian, Noyan Gokce, Jennifer Coukos, Dennis Kasper, Luke O'Neill, Pauline Mwinzi, Francis Farraye, Marie McDonnell, Lisa Ganley-Leal., Systemic Toll-like receptor ligands modify B cell responses in human chronic inflammatory disease., Journal of Clinical Investigation., 2010, p1-10
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI

Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL AIDUNNE ; DOI

Onnis, Valeria; Kinsella, Gemma; Carta, Giorgio; Jagoe, William; Price, Trevor; Williams, Clive; Fayne, Darren; Lloyd, David, Virtual Screening for the identification of novel non-steroidal Glucocorticoid Modulators, Journal of Medicinal Chemistry, 53, 2010, p3065 - 3074
Journal Article; Published; Peer Reviewed; Author Profiles: DWILLIMS FAYNED ; DOI

J.L. Teeling, C. Cunningham. T.A. Newman and V.H. Perry, The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1, Brain, Behavior and Immunity, 24, (3), 2010, p409-19
Journal Article; Published; Peer Reviewed; Author Profile: CUNNINCO; DOI

McGettrick AF, O'Neill LA, Localisation and trafficking of Toll-like receptors: an important mode of regulation. , Current Opinion in Immunology, 22, (1), 2010, p20-27
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL MCGETTRA ; DOI

Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP., Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. , Circulation., 121, (1), 2010, p80-90
Journal Article; Published; Peer Reviewed; Author Profile: LAONEILL; DOI; URL

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147
Journal Article; Published; Peer Reviewed; Author Profiles: OLEARYJJ CMARTIN3 FSHEEDY PALSSONE LAONEILL ; DOI

Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH., Response: Characteristics of IL-17-Producing gammadelta T Cells., Immunity, 32, (1), 2010, p3 - 4
Journal Article; Published; Peer Reviewed; Author Profiles: LAVELLEE LALORST MILLSK ; DOI

Harris, J., Sharp, F.A. and Lavelle, E.C, The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants , European Journal of Immunology , 40, (3), 2010, p634-638
Journal Article; Published; Peer Reviewed; Author Profile: LAVELLEE; DOI

Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28
Journal Article; Published; Peer Reviewed; Author Profiles: LAONEILL ECREAGH LAVELLEE ; DOI; URL

Chen Yi-C, Kelly VP, Stachura SV, Garcia GA. , Characterization of the human tRNA-guanine transglycosylase: confirmation of the heteromeric subunit structure, RNA, 16, (5), 2010, p958-968
Journal Article; Published; Peer Reviewed; Author Profile: KELLYVP; DOI

Rakovich A, Savateeva D, Rakovich T, Donegan JF, Rakovich YP, Kelly VP, Lesnyak V, Eychmuller A , CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy, Nanoscale Research Letters, 1931, 2010, p7573 - 7585
Journal Article; Published; Peer Reviewed; Author Profiles: JDONEGAN KELLYVP ; DOI

MacLeod AK, Kelly VP, Higgins LG, Kelleher MO, Price SA, Bigley AL, Betton GR, Hayes JD., Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants., Drug Metabolism & Disposition, 38, (2), 2010, p341 - 346
Journal Article; Published; Peer Reviewed; Author Profile: KELLYVP; DOI

Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947
Journal Article; Published; Peer Reviewed; Author Profiles: JOSULLI KTIPTON ; DOI

Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607
Journal Article; Published; Peer Reviewed; Author Profiles: LALORST LYNCHMA MILLSK ; DOI; URL

Guinan KJ, Cunningham RT, Meenagh A, Gonzalez A, Dring MM, McGuinness BW, Middleton D and Gardiner CM , Signatures of natural selection and co-evolution between Killer cell immunoglobulin-like receptors (KIR) and HLA class I genes. , Genes and Immunity, 11, (6), 2010, p467-478
Journal Article; Published; Peer Reviewed; Author Profile: GARDINEC; DOI

Nathwani,SM, Butler, S, Fayne,D, McGovern,NN, Sarkardi,B, Meegan,MJ, Lloyd,DG, Campiani,G, Lawler,M, Williams,DC, and Zisterer, DM, Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 66, (3), 2010, p585 - 596
Journal Article; Published; Peer Reviewed; Author Profiles: DZISTRER FAYNED DWILLIMS ; DOI; URL

Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947
Journal Article; Published; Peer Reviewed; Author Profiles: JOSULLI KTIPTON ; DOI; URL

Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607
Journal Article; Published; Peer Reviewed; Author Profiles: MILLSK LYNCHMA ; DOI; URL

Guinan KJ, Cunningham RT, Meenagh A, Dring M, Middleton D and Gardiner CM, Receptor systems controlling natural killer cell function are genetically stratified in Europe, Genes and Immunity, 11, (1), 2010, p67 - 78
Journal Article; Published; Peer Reviewed; Author Profile: GARDINEC

Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300
Journal Article; Published; Peer Reviewed; Author Profiles: DWILLIMS DZISTRER MMEEGAN MPLAWLER ; DOI; URL

Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128
Journal Article; Published; Peer Reviewed; Author Profiles: LYNCHMA MILLSK ; DOI; URL