Publications
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86 peer reviewed publications from 2007
Mok, K.H., Pettersson, J., Orrenius, S., Svanborg, C., HAMLET, protein folding, and tumor cell death, Biochemical and Biophysical Research Communications, 354, (1), 2007, p1-7
Richard K. Porter, "Regulation of UCP function" , Harden Conference, , Ambelside UK , September , 2007, Guy Brown & Michael Murphy
Richard K. Porter, "Molecular mechanisms in metabolic and oxidative stress - role of mitochondria" , NutriGenomic Organization" (NuGO) Conference, Cork, May, 2007, Michael Gibney
Richard K. Porter, "A Role for Uncoupling Proteins in Thymus Function" , International Society for Oxygen Transport in Tissues" (ISOTT) , Uppsala University, Sweden, September , 2007, ISOTT co-chaired with Britten Chance
Andrew Bowie, Luke O'Neil, Julianne Stack, Geoff Smith, Ismar Haga, 'Orthopoxvirus vectors, genes and products thereof (A46R protein)', EPO, WO2004/031225, 2007
Teeling, J.L., Felton, L.M., Deacon, R.M.J., Cunningham, C., Rawlins, J.N.P., Perry, V.H., Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines, 21, (6), 2007, p836-850
Kochetkov DV, Il'inskaia GV, Komarov PG, Strom E, Agapova LS, Ivanov AV, Budanov AV, Frolova EI, Chumakov PM, Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53, Molecular Biology, 41, (3), 2007, p515 - 523
Elliott, J., Lynch, O.T., Suessmuth, Y., Qian, P., Boyd, C.R., Burrows, J.F., Buick, R., Stevenson, N.J., Touzelet, O., Gadina, M., Power, U.F., Johnston, J.A., Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase, Journal of Virology, 81, (7), 2007, p3428-3436
Kelly AP., Finlay DK., Hinton HJ., Clarke RG., Fiorini E, Radtke F., Cantrell DA, Notch-induced T cell development requires phosphoinositide-dependent kinase 1, EMBO Journal, 26, (14), 2007, p3441 - 3450
Miniaturization and Automation for High-throughput Membrane Protein Crystallization in Lipidic Mesophases. in, editor(s)Chayen. N. , Crystallization Strategies for Structural Genomics, 2007, pp169-194 , [Cherezov, V., Caffrey, M.]
Cherezov, V., Caffrey, M. , Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction. , Faraday Discussions, 136, 2007, p188-205
M. Peddi, A., Muthusubramaniam, L., Zheng, Y. F., Cherezov, V., Caffrey,, High-throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases., IEEE Transactions on Automation Science and Engineering, 4, (2), 2007, p129-140
Caffrey, M., Bernal and the genesis of structural biology. , Journal of Physics: Conference Series, 57, 2007, p17-28
Höfer, N., Kolaj, O., Li, H., Cherezov, V., Gillilan, R., Wall, J., Caffrey, M., Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus., Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 63, (8), 2007, p673-677
Yuan L., Zheng, Y.F., Chen. W., and Caffrey, M. , Automatic Mixing of Bio-Samples Using Micro-Channel and Centrifugation , Proc. IEEE Conference on Automation Science and Engineering,, IEEE Conference on Automation Science and Engineering,, Scottsdale, AZ, September 22-25, IEEE, 2007, pp634-639
A general robotic approach for high-throughput automation in the handling of biosamples. in, editor(s)Eds Zhang, M., Nelson, B., Felder, R., , Life Science Automation - Fundamental and Applications., Norwood, MA. , Artech House, 2007, pp395-409 , [Zheng, Y.F., Peddi, A. Muthusubramaniam, L., Cherezov, V., and Caffrey, M.]
Luan, B., Caffrey, M., Aksimentiev, A., Structural Refinement of the OpcA Adhesin Using Molecular Dynamics., Biophysics Journal, 93, 2007, p3058-3069
Boyle-Roden, E., Hoefer, N., Dey, K. K., Grandinetti, P. J., Caffrey, M., High resolution 1H NMR of a lipid cubic phase using a solution NMR probe, Journal of Magnetic Resonance, 189, 2007, p13-19
Mok KH (Inventor), Mok KH (Assignee), Pharmazeutische Zusammensetzung mit einem Retro-Inverso Isomerpeptid, 2007, Deutsches Patent DE 60308710
Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67
Patrick Guirnalda, Noel B. Murphy, Derek Nolan and Samuel J. Black, Anti-Trypanosoma brucei activity in Cape buffalo serum during the cryptic phase of parasitemia is mediated by antibodies, International Journal for Parasitology, 37, (12), 2007, p1391-1399
Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G. , Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily., Experimental Gerontology, 42, (10), 2007, p995-1002.
Plunkett FJ, Franzese O, Finney HM, Fletcher JM, Belaramani LL, Salmon M, Dokal I, Webster D, Lawson AD, Akbar AN., The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation., Journal of Immunology , 178, (12), 2007, p7710-7719
McDonald A, Tipton K, O'Sullivan J, Olivieri A, Davey GP, Coonan AM, Fu W, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, 2007, p783 - 786
Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297
Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG., Target specific virtual screening: optimization of an estrogen receptor screening platform., Journal of Medicinal Chemistry, 50, (22), 2007, p5301-5310
Khor CC, Chapman SJ, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Sillah J, Sirugo G, Peshu N, Williams TN, Maitland K, Davies RJ, Kwiatkowski DP, Day NP, Yala D, Crook DW, Marsh K, Berkley JA, O'Neill LA, Hill AV., A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis., Nature Genetics, 39, (4), 2007, p523-8
Horgan CP, Oleksy1 A, Alexander V. Zhdanov AV, Lall PY, Ian J. White, Khan AR, Futter CE, McCaffrey JG & McCaffrey MW, Rab11-FIP3 is critical for the structural integrity of the endosomal-recycling compartment., Traffic, 8, (1), 2007, p414-430
Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72
Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26
Golden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR, Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection., Journal of virology, 81, (17), 2007, p9292-9298
Zaman, MB, Leonard, MO, Ryan, EJ, Nolan, NP, Hoti, E, Maguire, D, Mulcahy, H, Traynor, O, Taylor, CT, Hegarty, JE, Geoghegan, JG, O'Farrelly, C, Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?, Transplantation, 84, (10), 2007, p1272-8
Meade, KG, Gormley, E, Doyle, MB, Fitzsimons, T, O'Farrelly, C, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease., BMC genomics, 8, 2007, p400
McDonald, A.G., Boyce, S., Moss, G.P., Dixon, H.B.F. and Tipton, K.F. , ExplorEnz: a MySQL database of the IUBMB enzyme nomenclature, BMC Biochemistry, 27, (8:14), 2007, p1-7
Hernandez-Guillamon, M., Bolea, I., Sole, M., Boada, M., Tipton, K.F. and Unzeta, M., Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro. , Journal of Biochemistry (Tokyo), 142, (5), 2007, p571 - 576
Strolin Benedetti, M., Tipton, K.F. and Whomsley., R. , Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?, Fundamamental and Clinical Pharmacology, 21, (5), 2007, p467 - 480
Ben Ramadan, Z., Wrang, M.L. and Tipton, K.F. , Species Differences in the Selective Inhibition of Monoamine Oxidase (1-methyl-2-phenylethyl)hydrazine and its Potentiation by Cyanide., Neurochemical Research, 32, (10), 2007, p1783 - 1790
Pålsson-McDermott EM, O'Neill LA., The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60
Loane DJ, Deighan, BF, Clarke RM, Lynch AM, Lynch MA, Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiol Aging., 2007
Gubster C, Goodbody R, Ecker A, Brady G, O'Neill LA, Jacobs N, Smith GL., Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus, Journal of General Virology, 88, (6), 2007, p1667-1676
Constantinos Brikos, Robin Wait, Shajna Begum, Luke A. J. O'Neill, and Jeremy Saklatvala,, Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components, Molecular and Cellular Proteomics, 6, 2007, p1551-1559
Carpenter S, O'Neill LA., How important are Toll-like receptors for antimicrobial responses?, Cell Microbiology, 9, (8), 2007, p1891-1901.
Wietek C, O'Neill LA., Diversity and regulation in the NF-kappaB system., Trends Biochem Sci., 32, (7), 2007, p311-319.
Watters TM, Kenny EF, O'Neill, LA., Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins., Immunol Cell Biol., 85, (6), 2007, p411-419.
Nuñez Miguel R, Wong J, Westolll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant, A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins., PLoS ONE, 2, (8), 2007, pe788.
Becker CE, O'Neill LA., Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs., Semin Immunopathol. , 29, (3), 2007, p239-48.
McGettrick AF, O'Neill LA., Toll-like receptors: key activatory of leucocytes and regulator of haematopoiesis, Br J Haematol., 139, (2), 2007, p185-93
Doyle SL, Jefferies CA, Feighery C, O'Neill LA., Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase., Journal of Biological Chemistry, 282, (51), 2007, p36953-36960.
Palsson-McDermott EM, O'Neill LA. , The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60
Palsson-McDermott EM, O'Neill, LA. , Building an immune system from nine domains., Biochem Soc Trans., 35, (6), 2007, p1437-44
O'Neill LA., TAMpering with toll-like receptor signaling., Cell, 131, (6), 2007, p1039-41
Lynch AM, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'Connell F, Lynch MA., Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus., Neurobiology of Aging, 28, (6), 2007, p845 - 855
Marshall-Clarke,S., Downes, J.E., Haga, I.R., Bowie, A.G., Borrow, P., Pennock, J.L. Grencis, R.K. & Rothwell, P, Polyinosic acid is a ligand for Toll-like receptor 3, Journal of Biological Chemistry, 282, (34), 2007, p24759 - 24766
O'Connor GM, Holmes A, Mulcahy F, Gardiner CM. , Natural Killer cells from long-term non-progressor HIV patients are characterized by altered phenotype and function., Clinical Immunology, 124, (3), 2007, p277 - 283
O'Connor GM, Guinan K, Cunningham RT, Middleton D, Parham P and Gardiner CM, Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells., Journal of Immunology, 178, 2007, p235 - 241
McDonald, A.G., Boyce, S., Moss, G.P., Dixon, H.B.F. and Tipton, K.F., ExplorEnz: a MySQL database of the Enzyme Nomenclature, BMC Biochemistry, 8, (14), 2007, p1-7
Keating, S.E., Maloney, G.M., Moran, E.M. & Bowie, A.G, IRAK-2 participates in multiple toll-like receptor signalling pathways to NFkappaB via activation of TRAF6 ubiquitination, The Journal of Biological Chemistry, 282, (46), 2007, p33435 - 33443
Adams, A.E., Hanrahan, O., Nolan, D.N., Voorheis, H.P. Fallon, P. and Porter, R.K., Images of Mitochondrial UCP 1 in Mouse Thymocytes using Confocal Microscopy, Biochimica Biophysica Acta (Bioenergetics), 1777, 2007, p115 - 117
Beck V, Jabùrek M, Demina T, Rupprecht A, Porter RK, Jezek P, Pohl EE., Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers., FASEB J, 21, (4), 2007, p1137-1144
Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA., Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid., Journal of Neurochemistry, 2007
Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313
Meegan, M.J., Barrett, I., Zimmmermann, J., Knox, A.J.S., Zisterer, D.M. & Lloyd, D.G. , Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells. , Journal of Enzyme Inhibition and Medicinal Chemistry, 22, (5), 2007, p655-66
Smith, H.M., Knox, A.S., Zisterer, D.M., Lloyd, D.G., & Meegan, M.J. , Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives., Medicinal Chemistry, 3, (2), 2007, p135 - 155
Innate Immune Signalling Pathways and Viral Recognition: New Perspectives in, editor(s)Gavin McAlpine , Focus on Signal Transduction Research, Nova Science Publishers, 2007, pp173 - 188, [Ismar R Haga & Andrew G Bowie]
G. A. Scalabrino, N. Hogan, K.M.O'Boyle, G.R. Slator, D.J.Gregg, C.M.Fitchett, S.M.Draper, G.W. Bennet, P.M.Hinkle, K.Bauer, Discovery of a Dual Action, First-in-class Peptide that mimics and enhances CNS-mediated actions of Thyrotropin-releasing Hormone , Neuropharmacology, 52, (7), 2007, p1472 - 1481
O'Sullivan, J., Davey, G.P., O'Sullivan, M. I. and Tipton, K.F, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase., Journal of Neural Transmission, 114, (6), 2007, p751 - 756
Olivieri, A., Tipton, K. and O'Sullivan, J., L-lysine as a recognition molecule for the VAP-1 function of SSAO., Journal of Neural Transmission, 114, (6), 2007, p747 - 749
Strolin Benedetti, M., Tipton, K.F., Whomsley, R. and Baltes, E., Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans. , Journal of Neural Transmission, 114, (6), 2007, p787 - 791
Scalabrino, G.A., Hogan, N., O'Boyle, K.M., Slator, G.R., Gregg, D.J., Fitchett, C.M., Draper, S.M., Bennett, G.W., Hinkle, P.M., Bauer, K., Williams, C.H., Tipton, K.F. and Kelly, J.A., Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. , Neuropharmacology, 52, (7), 2007, p1472 - 1481
Healy, J. and Tipton, K.F., Ceruloplasmin and what it might do., Journal of Neural Transmission, 114, (6), 2007, p777 - 781
McDonald, AG., Tipton, K.F., O'Sullivan, J., Olivieri, A., Davey, G. P., Coonan, A.M. and Fu, W., , Modelling the roles of MAO and SSAO in glucose transport., Journal of Neural Transmission, 114, (6), 2007, p783 - 786
Boomsma, F. and Tipton, K.F. , Renalase, a catecholamine-metabolising enzyme? , Journal of Neural Transmission, 114, (6), 2007, p775 - 775
Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377
Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528
Sheedy F. and O'Neill L.A., The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling, Journal of Leukocyte Biology, 82, (2), 2007, p196-203
O'Neill LA and Bowie AG, The family of five: TIR domain containing adapters in TLR signalling, Nat Rev Immunol, 7, 2007, p353-364
Mok KH, Kuhn LT, Goez M, Day IJ, Lin JC, Andersen NH, Hore PJ, A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein, Nature, 447, (7140), 2007, p106 - 109
Mok KH, Pettersson J, Orrenius S, Svanborg C, HAMLET, protein folding, and tumour cell death (Mini review), Biochemical and Biophysical Research Communications, 354, (1), 2007, p1 - 7
J O'Sullivan, G Davey, M O'Sullivan, KF Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, J Neural Transm, 2007
Perry, V.H., Cunningham, C. and Holmes, C, Systemic infections affect chronic neurodegeneration, Nature Reviews Immunology, 7, (2), 2007, p161 - 167
Colm Cunningham, Suzanne Campion, Jessica Teeling, Leigh Felton and V.H.Perry, The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double stranded RNA (Poly I:C)., Brain, Behavior and Immunity, 21, (4), 2007, p490 - 502
Bowie, A.G. & Fitzgerald, K.F. , RIG-I; Tri-ing to discriminate between self and non-self RNA, Trends in Immunology, 28, (4), 2007, p147 - 150
Bowie, A.G., Recent advances in understanding the role of Toll-like receptors in anti-viral immunity, Clinical and Experimental Immunology, 147, (2), 2007, p217 - 226
Lysaght, J., Jarnicki, A. and Mills, K.H.G. , Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumour immunity. , Cancer Immunology and Immunotherapy, Published online Feb, (DOI 10.1007/s00262-0), 2007, p1367 - 1379
Braat, H, McQuirk, P., Ten Kate F.J.W., Huibregtse, I., Dunne, P, Hommes, D.W., Deventer, S and Mills, K. H.G. , Prevention of experimental colitis by parenteral administration of a pathogen derived immunomodulatory molecule. , Gut, 56, 2007, p351 - 357
Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky GA, Shattil SJ. , ADAP is required for normal {alpha}IIb{beta}3 activation by VWF/GP Ib-IX-V and other agonists., Blood , Vol 109, (3), 2007, p1018 - 1025