Publications
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78 peer reviewed publications from 2006
Richard K. Porter, "A New Look at Mitochondrial Uncoupling Protein 1" , European Bioenergetics Conference (EBEC) , Moscow State University, Russia, July, 2006, Vladimir Schulachev
Keith F Tipton, Gavin Davey, Martha Motherway, Monoamine oxidase assays, Current Protocols in Toxicology, 2006, p4.21.1 - 4.21.42
Taurine, taurine analogues, and mitochondrial function and dysfuntion in, Taurine 6, 2006, pp469 - 479, [M Palmi, G Davey, KF Tipton, A Meini]
Andrew Bowie, Martina Schroeder, Geoff Smith, Stuart Lucas, 'Compositions and methods for modulating an immune response (K7 protein)', EPO, WO 2008/023077 , 2006
Andrew Bowie, Michael Carry, Martina Schroeder, Paul Moynagh, 'Compositions and methods for modulating an immune response (SARM)', IPO, WO 2007/096854, 2006
The Role of the Immune System in Cancer. in, Infection in the cancer patient., Oxford University Press, 2006, pp19 - 41, [Stevenson NJ and Johnston JA. ]
Lloyd DG, Golfis G, Knox AJ, Fayne D, Meegan MJ, Oprea TI, Oncology exploration: charting cancer medicinal chemistry space., Drug discovery today, 11, (3-4), 2006, p149-59
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA, Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis., Arthritis and rheumatism, 54, (5), 2006, p1662-72
Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO, Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection., Antimicrobial agents and chemotherapy, 50, (11), 2006, p3856-60
McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC, CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections., Proceedings of the National Academy of Sciences of the United States of America, 103, (27), 2006, p10408-13
Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL, A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2., The Journal of experimental medicine, 203, (13), 2006, p2853-63
Liu HK, Perrier S, Lipina C, Finlay D, McLauchlan H, Hastie CJ, Hundal HS, Sutherland C, Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226, BMC Molecular Biology, 7, (14), 2006
Finlay D., Ruiz-Alcaraz AJ., Lipina C., Perrier S., Sutherland C, A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression, Journal of Molecular Endocrinology, 37, (2), 2006, p227 - 237
Siegel, D. P., Cherezov, V., Greathouse, D. V., Koeppe II, R. E., Killian, J. A., Caffrey, M. , Transmembrane Peptides Stabilize Inverted Cubic Phases in a Biphasic Length-dependent Manner: Implications for Protein-induced Membrane Fusion., Biophysical Journal, 90, 2006, p200-211
Raman, P., Cherezov, V., Caffrey, M., The Membrane Protein Data Bank., Cellular and Molecular Life Sciences, 63, (1), 2006, p36-51.
Cherezov, V., Clogston, J., Papiz, M., Caffrey, M., Room to move. Crystallizing membrane proteins in swollen lipidic mesophases., Journal of Molecular Biology, 357, 2006, p1605-1618
Cherezov, V., Caffrey, M., Picoliter-scale Crystallization of Membrane Proteins., Journal of Applied Crystallography, 39, (4), 2006, p604-609
Cherezov, V., Yamashita, E., Liu, W., Zhalnina, M., Cramer, W. A., Caffrey, M., In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution. , Journal of Molecular Biology, 364, (4), 2006, p716-734
Liu, W., Caffrey, M. , Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces., Biochemistry , 45, (39), 2006, p11713-11726
Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Reg European Patent No. 1549334 (27 Sep 2006)
Mok KH (Inventor), Mok KH (Assignee), Pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Irish Patent Register No. 1549334 (27 Sep 2006)
Mills, K.H.G., Higgins, S.H and Lavelle, E.C. , Tracheal Cytotoxin/ "Methods and compositions for modulating and immune response, 2006
Lavelle E.C., Evaluation of the binding, uptake and immune responses elicited to orally administered lectins and microparticles, Methods , 38, (2), 2006, p84-89
Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, Masters JE, Rustin MH, Taams LS, Beverley PC, Macallan DC, Akbar AN., Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo., Journal of Clinical Investigation, 116, (9), 2006, p2423-2433.
O'Sullivan J., O'Sullivan M.I., Tipton K.F. and Davey G.P. , Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, 71, 2006, p105 - 112
O'Sullivan J., Hernandez M., Unzeta M., Tipton K.F. and Davey G.P, Inhibition of semicarbazide sensitive sensitive amine oxidase and adhesion function. , Journal of Neural Transmission, 75, 2006, p105 - 112
Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70
Higgs, R, Cormican, P, Cahalane, S, Allan, B, Lloyd, AT, Meade, K, James, T, Lynn, DJ, Babiuk, LA, O'farrelly, C, Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection., Infection and immunity, 74, (3), 2006, p1692-
Canny, G, Drudy, D, Macmathuna, P, O'Farrelly, C, Baird, AW, Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical., Life Sciences, 78, (9), 2006, p920-5
Volkov, Y, Long, A, Freeley, M, Golden-Mason, L, O'Farrelly, C, Murphy, A, Kelleher, D, The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration., Gastroenterology, 130, (2), 2006, p482-92
Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204
Cawood, TJ, Moriarty, P, O'Farrelly, C, O'Shea, D, The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis., European journal of endocrinology / European Federation of Endocrine Societies, 155, (3), 2006, p395-403
Kelly, AM, Golden-Mason, L, Traynor, O, Geoghegan, J, McEntee, G, Hegarty, JE, O'Farrelly, C, Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity., Cytokine, 35, (3-4), 2006, p171-9
Leonard, MO, Kieran, NE, Howell, K, Burne, MJ, Varadarajan, R, Dhakshinamoorthy, S, Porter, AG, O'Farrelly, C, Rabb, H, Taylor, CT, Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006
Lavelle, E.C. and O'Hagan, D.T, Delivery systems and adjuvants for oral vaccines, Expert Opinion on Drug Delivery , 3, (6), 2006, p747 - 762
Lloyd, D.G., Smith, H.M., O'Sullivan, T., Knox, A.S., Zisterer, D.M. & Meegan, M.J. , Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes : Synthesis, Structure-Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists , Medicinal Chemistry, 2, (2), 2006, p147 - 168
O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F. and Davey, G, P., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine., Journal of Neural Transmission (suppl.), 71, 2006, p105 - 112
Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O'Neill LA* and Hertzog P* , Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation, Nature Immunol., 7, (2), 2006, p148 - 155
Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proceedings of the National Academy of Sciences , 103, (16), 2006, p6299 - 6304
McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201
O'Neill LA, Targeting signal transduction as a strategy to treat inflammatory diseases, Nature Rev. Drug Disc, 5, (7), 2006, p549 - 563
Miggin SM and O'Neill LA, New insights into the regulation of TLR signaling, Journal of Leukocyte Biology, 80, (2), 2006, p220 - 226
Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357
O'Neill LA, DisSARMing Toll-like receptor signaling, Nat Immunol., 7, (10), 2006, p1023 - 1025
Doyle, SL and O'Neill LAJ, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol., 72, (9), 2006, p1102 - 1113
Wietek,C, Cleaver, CS, Ludbrook, V, Wilde, J, White, J, Bell, DJ, Lee, M, Dickson, M, Ray, KP and O'Neill, LAJ, IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65, The Journal of Biological Chemistry, 281, (46), 2006, p34973 - 34981
Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL, Resolution of inflammation: state of the art, definitions and terms, The FASEB Journal, 21, (2), 2006, p325 - 332
Goez M, Kuprov I, Mok KH, Hore PJ, Novel pulse sequences for time-resolved photo-CIDNP, Molecular Physics, 104, (10-11), 2006, p1675 - 1686
Shin C, Mok KH, Han JH, Ahn JH, Lim Y, Conformational analysis in solution of gastrin releasing peptide, Biochemical and Biophysical Research Communications, 350, (1), 2006, p120 - 124
Jagoe WN, Lindsay AJ, Read RJ, McCoy AJ, McCaffrey MW & Khan AR, Crystal structure of Rab11 in complex with Rab11 Family Interacting Protein 2, Structure (Cell Press), 14, (8), 2006, p1273 - 1283
Jagoe WN, Jackson SR, Lindsay AJ, McCaffrey MW & Khan AR, Purification, crystallization, and preliminary X-ray diffraction studies of Rab11 in complex with Rab11-FIP2, Acta Crystallogr Sect F Struct Biol Cryst Commun. , 62, (7), 2006, p692 - 694
Delphine Boche, Colm Cunningham*, Fabian Docagne, Helen Scott and V. Hugh Perry , TGFb1 regulates the inflammatory response during chronic neurodegeneration , Neurobiology of Disease, 22, ((3)), 2006, p638-650
Carty, M., Goodbody, R., Schröder, M., Stack, J., Moynagh, P.N. & Bowie, A.G. , The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling, Nature Immunology, 7, (10), 2006, p1074 - 1081
Boughan, P.K., Argent, R.H., Body-Malapel, M., Park, J-H., Ewings, K.E., Bowie, A.G., Ong, S.J., Cook, S.J., Sorensen, O.E., Manzo, B.A., Klein, N.J. Nuñez, G., Atherton, J.C. & Bajaj-Elliott, M., Nucleotide-binding oligomerisation domain-1 (NOD-1) and epidermal growth factor receptor (EGFR): critical regulators of Ò-defensins during Helicobacter Pylori infection, The Journal of Biological Chemistry, 281, (17), 2006, p11637 - 11648
Lipinski, K.S., Pelech, S., Mountain, A., Irvine, A.S., Kraaij, R., Bangma, C.H., Mills, K.H.G. and Todryk S.M, Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity. , Cancer Immunology and Immunotherapy, 55, (3), 2006, p347 - 354
Higgins, S., Jarnicki, A, Lavelle, E.C. and Mills, K.H.G, TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells, The Journal of Immunology, 177, 2006, p7980 - 7989
Brennan, C.M. & Porter R.K., The effects of acute and endurance exercise on UCP 3 protein expression in mouse gastrocnemius, plantaris, soleus and EDL muscles, EBEC Short Reports, EBEC 2006, Moscow, July, edited by V. Borisov , 14, Elsevier/Biochimica Biophysica Acta (Bioenergetics), 2006, pp363-
Porter, R.K., A New Look at Mitochondrial Uncoupling Protein 1, Biochimica Biophysica Acta, 1757, 2006, p446 - 448
Beck, V., Jabùrek, M., Breen, E.P., Porter, R.K., Je ek, P. and Pohl, E.E. , A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1., Biochimica Biophysica Acta (Bioenergetics), 1757, 2006, p474 - 479
Brennan, C.M., Breen, E.P. and Porter, R.K., Cold acclimation and oxygen consumption in the thymus, Biochimica Biophysica Acta (Bioenergetics), 1757, (11), 2006, p1463-1468
Jarnicki, A.G., Lysaght, J, Todryk, S, Mills, K.H.G, Suppression of antitumor immunity by IL-10 and TGF-b-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells., Journal of Immunology, 177, (2), 2006, p896-904
McGrath, LB, Onnis, V, Campiani, G, Williams, DC, Zisterer, DM and McGee, MM, Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn(2+)-dependent acidic endonuclease activity., Apoptosis, 11, (9), 2006, p1473 - 1487
Carta G, Onnis V, Knox AJS, Fayne D, Lloyd DG, Permuting input for more effective sampling of 3D conformer space, Journal of Computer-Aided Molecular Design , 20, (6), 2006, p179 - 190
Arai T, Kelly VP, Minowa O, Noda T, Nishimura S. , The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA , Toxicology , 221, 2006, p179 - 186
Sutton, C., Brereton, C., Keogh, B., Mills, K.H.G. Lavelle, E.C., A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis, The Journal of Experimental Medicine, 203, (7), 2006, p1685 - 1691
Pays E, Vanhollebeke B, Vanhamme L, Patriaux-Hanocq F, Nolan DP, Perez-Morga D, The trypanolytic factor of human serum, Nature Reviews Microbiology, 4, (6), 2006, p477 - 486
Lavelle EC, Lectins and microparticles for enhanced oral vaccination, Methods, 38, (2), 2006, p84 - 89
Youdim, M.B.H., Edmondson, D. and Tipton, K.F., The therapeutic potential of monoamine oxidase inhibitors., Nature Reviews in Neuroscience, 7, (4), 2006, p295 - 309
Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, and Leavitt AD, Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function, Journal of Thrombosis and Haemostasis, 4, 2006, p436 - 442
Stephenson, I., Nicholson, K.G. Rudin, A. Colegate, A., Podda, A. Bugarini, R., del Giudice, G., Minutello, A., Bonnington, S., Holmgren, J., Mills, K.H.G, and Zambon, M.C., Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers, The Journal of Virology, 80, (10), 2006, p4962 - 4970
O'Connor GM, Hart OM and Gardiner CM, Putting the NK cell in its Place, Immunology, 117, (1), 2006, p1 - 10
Soriani A, Moran B, De Virgilio M, Kawakami T, Altman A, Lowell C, Eto K and Shattil SJ, A role for PKCtheta in outside-in alphaIIb,beta3 signaling, Journal of Thrombosis and Haemostasis, 4, 2006, p648 - 655
O'Neill LA, Targetting signal transduction pathways as a strategy for anti-inflammatory drugs, Nature Reviews Drug Discovery, 2006
Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495
O'Neill LA, How Toll-like receptors signal: what we know and what we don't know, Current Opinion in Immunology, 18, (1), 2006, p3 - 9
Mansell A, Toynbee J, Gray P, Doyle S, Hilton D, O'Neill LA and Hertzog P, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation , Nature Immunology, 7, (2), 2006, p148 - 155
Breen, E.P., Gouin, S., Brennan, C.M., Murphy, A.F., Haines, L.R., Pearson, T.W., Murphy, P.V. and Porter, R.K., On the mechanism of mitochondrial uncoupling protein 1 function, Journal of Biological Chemistry, 281, 2006, p2114 - 2119
Lavelle, E.C., Grant, G., Pfuller,U. and O'Hagan, D.T, Type II ribosome-inactivating proteins from mistletoe are effective adjuvants when administered by mucosal and transcutaneous routes, Vaccine , Supplement 2, (S2), 2006