Publications
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93 publications from 2003
Koh, D., Yang, H., Kim, K., Lee, S., Mok, K.H., Lim, Y., Stereochemical Elucidation of Norbornene Derivatives Synthesized as Leukotriene D4 Receptor Antagonists, Spectroscopy Letters, 36, (5-6), 2003, p407-418
Oliver J. P. Joyce, Factors Effecting Mitochondrial Efficiency, Trinity College Dublin, 2003
Ravelli, R.B.G. and Leiros, H.-K.S. and Pan, B. and Caffrey, M. and McSweeney, S., Specific radiation damage can be used to solve macromolecular crystal structures, Structure, 11, (2), 2003, p217-224
García-Salcedo, J.A., Gijón, P., Nolan, D.P., Tebabi, P., Pays, E., A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei, EMBO Journal, 22, (21), 2003, p5851-5862
Andrew Bowie, Luke O'Neill, Mary Harte, Geoff Smith, Ismar Haga, Geraldine Maloney , 'Orthopoxvirus vectors, genes and products thereof (A52R protein). ', EPO, WO 2004/022762, 2003
Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, Gudkov AV, Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells., Cancer Research, 63, (11), 2003, p2905 - 2912
Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21
Mortier S, De Vriese AS, McLoughlin RM, Topley N, Schaub TP, Passlick-Deetjen J, Lameire NH, Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane., Journal of the American Society of Nephrology : JASN, 14, (5), 2003, p1296-306
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N, Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation., The Journal of clinical investigation, 112, (4), 2003, p598-607
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4., The Journal of biological chemistry, 278, (28), 2003, p26258-64
Caffrey, M., Membrane Protein Crystallization, Journal of Structural Biology, 142, (1), 2003, p108-132
Cherezov, V., D. P. Siegel, W. Shaw, S. W. Burgess and M. Caffrey. , The kinetics of non-lamellar phase formation in dope-me: relevance to biomembrane fusion., Journal of Membrane, 195, (3), 2003, p165-182
Cherezov, V., Caffrey, M., Nano-volume Plates with Excellent Optical Properties for Fast, Inexpensive Crystallization Screening of Membrane Proteins., Journal of Applied Crystallography, 36, 2003, p1372-1377
Misquitta, Y., Caffrey, M., Detergents Destabilize the Cubic Phase of Monoolein. Implications for Membrane Protein Crystallization., Biophysical Journal, 85, (5), 2003, p3084-3096
Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.]
Mills, K.H.G., Boyd, A.P., Ross, P.J. and Lavelle, EC., , CyaA in the prophylaxis/treatment of inflammatory and immune-mediated disorders., 2003
Lantto J, Fletcher JM, Ohlin M., Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus, Virology., 305, (1), 2003, p201-209
D. Brady, N. Lowe, S. Gaines L. Fenelon, J. McPartlin, C. O'Farrelly, Inhibition of S. mutans growth by hen egg derived fatty acids., J Food Sci, 68, (4), 2003, p1433-1437
Lynn, DJ, Lloyd, AT, O'Farrelly, C, Bioinformatics: implications for medical research and clinical practice., Clinical and investigative medicine. Médecine clinique et experimentale, 26, (2), 2003, p70-4
Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8
Gaines, S, James, TC, Folan, M, Baird, AW, O'Farrelly, C, A novel spectrofluorometric microassay for Streptococcus mutans adherence to hydroxylapatite., Journal of microbiological methods, 54, (3), 2003, p315-23
Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50
Lynn, DJ, Lloyd, AT, O'Farrelly, C, In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)., Veterinary immunology and immunopathology, 93, (3-4), 2003, p177-84
Smith, F, Golden-Mason, L, Deignan, T, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, J, O'Farrelly, C, Localization of T and B lymphocytes in histologically normal adult human donor liver., Hepato-gastroenterology, 50, (53), 2003, p1311-5
Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535
Hayden, PJ, O'Brien, M, Collins, B, O'Farrelly, C, Murphy, K, Inherited thrombotic tendency in a pedigree with antithrombin La Rochelle (N405K) and factor V Leiden., Clinical and laboratory haematology, 25, (3), 2003, p191 - 193
Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779
Holmes, C., El-Oki, M., Williams, A.L., Cunningham, C., Wilcockson, D. and Perry, V.H. , Systemic infection, interleukin-1b and cognitive decline in Alzheimer's disease., Journal of Neurology Neurosurgery and Psychiatry , 74, 2003, p788-789.
Cunningham, C., Deacon, R.M.J., Wells, H., Boche, D., Waters, S., Picano Diniz, C., Scott, H., Rawlins, J.N.P. and Perry V.H., Synaptic changes characterise early behavioural signs in the ME7 model of murine prion disease, European Journal of Neuroscience , 17, 2003, p2147-2155
Boche, D., Cunningham, C., Gauldie, J. and Perry, V.H., Transforming Growth Factor-b1-mediated Neuroprotection Against Excitotoxic injury in Vivo, Journal of Cerebral Blood Flow and Metabolism, 23, 2003, p1174-1182
Perry V.H., Newman, T.A. Cunningham, C, The impact of systemic infection on neurodegenerative disease, Nature reviews Neuroscience, 4, (February), 2003, p103 - 112
Mok KH, Nagashima T, Day IJ, Jones JA, Jones CJV, Dobson CM, Hore PJ, Rapid Sample-Mixing Technique for Transient NMR and Photo-CIDNP Spectroscopy: Applications to Real-Time Protein Folding, Journal of the American Chemical Society, 125, (41), 2003, p12484 - 12492
Arai T, Kelly VP, Komoro K, Minowa O, Noda T, Nishimura S., Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA, Cancer Research, 63, 2003, p4287 - 4292
O'Sullivan J, O'Sullivan M, Tipton KF, Unzeta M, Del Mar Hernandez M, Davey GP, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, Biochim Biophys Acta., 1647, (1-2), 2003, p367 - 371
Pando MJ, Gardiner CM, Gleimer M, McQueen KL and Parham P, The protein made from a common allele of KIR3DL1 (3DL1*004) is poorly expressed at the cell surface due to substitutions at positions 86 in Ig domain 0 and 182 in Ig domain 1, Journal of Immunology, 171, 2003, p6640 - 6649
Mulligan J.M., Campiani G., Ramunno A., Nacci V., Zisterer D.M. , Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by pyrrolo-1,5-benzoxazepine, PBOX-21., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1639, (1), 2003, p43 - 52
Vanhamme, L, Paturiaux-Hanocq F., Poelvoorde, P., Nolan, DP, Lins, L, Van den Abbeele, J, Pays, A, Tebabi, P., Xong, HV, Jacquet, A, Moguilevsky, N, Dieu, M, Kane, JP, De Baetselier, P., Brasseur R & Pays, Apolipoprotein L-I is the trypanosome lytic factor of human serum, Nature, 422, 2003, p83 - 87
García-Salcedo J.A., Gijón P., Nolan, D.P., Tebabi, P. and Pays, E., The histone ADP-ribosyl transferase activity of a trypanosomal SIR2 homologue plays a role in DNA repair, EMBO J., 22, 2003, p5851 - 5862
Communication in trypanosomatids in, editor(s)Maudlin, I., Holmes, P.H. and Miles M.A. , Trypanosomiasis and Leishmaniasis, biology and control, Oxford, CAB International, 2003, pp59 - 75, [Nolan, D.P., Garcia Salcedo, J.-A., Vanhamme, L., and Pays, E.]
Novel approaches for vaccine development against trypanosomiasis in Africa in, editor(s)Serageldin I. And Persley, G.J. , "Biotechonologyand sustainable development: voices of the south and north" Biotechnologyin agriculture series No 26, Oxford, CABInternational, 2003, pp173 - 185, [Murphy, N.B., Nolan, D. and Black, S.J.]
Tipton KF, O'Sullivan MI, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochem Soc Trans, 31, 2003, p711 - 715
TJ Mantle (ed), The Behaviour of Enzymes in Cells, Biochem. Soc. Trans, 31, 2003, pp711 - 739
O'NEILL LA et al., PCT application - "A52R - Orthopoxvirus, genes and products thereof", 2003
O'NEILL LA et al., PCT application - "A46R - Orthopoxvirus, genes and products thereof"., 2003
Cadenas, S., Jekabsons, M.B., Carroll, A.M., Porter, R.K. & Brand, M.D., Rat muscle mitochondria treated with Dowex are GDP insensitive, 674th Biochemical Society Meeting, 29, 2003, pp123
Brennan, C.M., McElligott, A.M., Warmington, S.A. & Porter, R.K., Skeletal muscle uncoupling protein 3 expression following endurance swimming training in mice, 674th Biochemical Society Meeting, 29, 2003, pp120
Joyce, O.J.P., Farmer, M.K. Tipton, K.F. & Porter, R.K., Oxidative Phosphorylation by in situ Synaptosomal Mitochondria from Whole Brain of Young and Old Rats, J. Neurochem., 86, 2003, p1032 - 1041
Cunningham, O., McElligott, A.M., Carroll, A.M., Breen, E., Reguenga, C., Oliveira, M.E.M, Azevedo, J.E. & Porter, R.K., Selective Detection of UCP 3 Expression in Skeletal Muscle: Effect of Thyroid Status and Temperature Acclimation, Biochim. Biophys. Acta, 1604, 2003, p170 - 179
L. A. O'Neill, K. A. Fitzgerald and A. G. Bowie, The Toll-IL-1 receptor adaptor family grows to five members, Trends in immunology, 24, (6), 2003, p286-90
P. J. Hertzog, L. A. O'Neill and J. A. Hamilton, The interferon in TLR signaling: more than just antiviral, Trends in Immunology, 24, (10), 2003, p534-539
A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3
L. A. O'Neill, Z. Brown and S. G. Ward, Toll-like receptors in the spotlight, Nature immunology, 4, (4), 2003, p299
L. A. O'Neill, SIGIRR puts the brakes on Toll-like receptors., Nature immunology, 4, (9), 2003, p823-824
S. G. Ward and L. A. O'Neill, Spotlight on new anti-inflammatory drug targets in the immune system, Current opinion in pharmacology, 3, (4), 2003, p391-5
L. A. O'Neill, Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases, Current opinion in pharmacology, 3, (4), 2003, p396-403
E. F. Dunn, N. J. Gay, A. F. Bristow, D. P. Gearing, L. A. O'Neill and X. Y. Pei, High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity, Biochemistry, 42, (37), 2003, p10938-10944
L. A. O'Neill, The role of MyD88-like adapters in Toll-like receptor signal transduction, Biochemical Society Transactions, 31, (Pt 3), 2003, p643-637
L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9
C. A. Jefferies, S. Doyle, C. Brunner, A. Dunne, E. Brint, C. Wietek, E. Walch, T. Wirth and L. A. O'Neill, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4, The Journal of Biological Chemistry, 278, (28), 2003, p26258-64
A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451
C. Wietek, S. M. Miggin, C. A. Jefferies and L. A. O'Neill, Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, The Journal of Biological Chemistry, 278, (51), 2003, p50923-50931
Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11
Brennan, C.M., McElligott, A.M., Warmington, S.A. and Porter, R.K., Skeletal muscle uncoupling protein 3 expression following endurance swimming training in mice, Proceedings of the 674th Biochemical Society Meeting, Trinity College Dublin, July, 2003
Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11
Mills, H.H.G., McGuirk, P., Keogh, B., FHA in the prophylaxis of immune mediated disorders., 2003, 2003/076
Mills, K.H.G. and Brady, M., Hepatitis C virus (HCV) proteins., 2003, 2003/0279
Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562
Brady, M. MacDonald, A., Rowan, A. and Mills K.H.G., Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes, EUROPEAN JOURNAL OF IMMUNOLOGY, 33, (12), 2003, p3448 - 3457
Higgins, S., Lavelle, E., McCann, C., Keogh, B., McNeela, E, Byrne, P., O'Gorman, B., Jarnicki, A., McGuirk, P. and Mills, K.H.G., Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology, Journal of Immunology, 171, (6), 2003, p3119 - 3127
Lavelle, E., McNeela, E., Armstrong, M., Leavy, O., Higgins, S.C. and Mills K.H.G., Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation, The Journal of Immunology, 171, 2003, p2384 - 2392
Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190
Kelly, A., Vereker, E., Brady, M., Brooks, C., Loscher, C, Mills, K.H.G. and Lynch, M.A., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta induced inhibition of long term potentation in the rat dentate gyrus, J. Biol Chem., 278, (21), 2003, p19453 - 19462
Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124
Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33
Mills, K.H.G., Cosgrove, C., McNeela E.A., Sexton, A., Giemza, R., Jabbal-Gill, I., Church, A., Lin, W., Illum, L., Podda, A., Rappuoli, R., Pizza, M. Griffin, G.E. and Lewis, D.J.M., Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a, Infection and Immunity, 71, (2), 2003, p726 - 732
Induction and detection of T cell responses in, editor(s)A. Robinson, M.J. Hudson, and M. P. Cranage , Methods in Molecular Medicine. Vol 87: Vaccine protocols, 2nd Edition, NJ, USA, Humana Press Inc., 2003, pp255 - 278, [Mills, K.H.G.]
Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin]
Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562
Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190
O'Neill LA , Antisense modulation of TLR-4 expression, Expert Opinion on Therapeutic Patents, 13, (12), 2003, p1887 - 1889
Harte, MT, Haga, I, Maloney, G, Gray, P, Reading, PC, Bartlett, N, Smith, GL, Bowie, AG and O'Neill, LAJ , The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence, Journal of Experimental Medicine, 197, (3), 2003, p343 - 351
O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD
Tipton, K. F., O'Sullivan, M. P., Davey, G. P. and O'Sullivan, J. , It can be a complicated life being an enzyme, Biochem. Soc. Trans, 31, 2003, p711 - 715
Kinetics of Catalyzed Reactions ' Biological in, editor(s)I.T. Horváth , Encyclopedia of Catalysis , John Wiley & Sons, Inc, 2003, pp395 - 471 , [McDonald, A. G. and Tipton, K. F.]
Seymour, C. B., Mothersill, C., Mooney, R., Moriarty, M. and Tipton, K. F., Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity, BRITISH JOURNAL OF CANCER, 89, (10), 2003, p1979 - 1986
Joyce, O. J. P., Farmer, M. K., Tipton, K. F. and Porter, R. K., Oxidative phosphorylation by in situ synaptosomal mitochondria from whole brain of young and old rats, JOURNAL OF NEUROCHEMISTRY, 86, (4), 2003, p1032 - 1041
Dalfo, E., Hernandez, M., Lizcano, J. M., Tipton, K. F. and Unzeta, M., Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma. , BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1638, (3), 2003, p278 - 286
O'Sullivan, J., O'Sullivan, M., Tipton, K. F., Unzeta, M., Del Mar Hernandez, M. and Davey, G. P., The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p367 - 371
O'Sullivan, M., MacDougall, M. B., Unzeta, M., Lizcano J. M. and Tipton K. F., Semicarbazide-sensitive amine oxidases in pig dental pulp, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p333 - 336
Modulation of Toll-like receptor signalling by viruses in, editor(s)C.D O'Connor and D.G.E Smith , SGM symposium 62: Microbial subversion of host cells, Cambridge, Cambridge University Press, 2003, pp109 - 128, [Bowie, A. ]
Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33
Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124
Kelly Á, Vereker E, Brady M. Barry C, Loscher C, Mills KHG, Lynch MA., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462