Publications
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27 publications from 2022
Hooftman, A. and O'Neill, L.A.J., Nanoparticle asymmetry shapes an immune response, Nature, 601, (7893), 2022, p323-325
Baldanti, F. and Ganguly, N.K. and Wang, G. and Möckel, M. and Oâ Neill, L.A. and Renz, H. and dos Santos Ferreira, C.E. and Tateda, K. and Van Der Pol, B., Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future, Critical Reviews in Clinical Laboratory Sciences, 2022
Toller-Kawahisa, J.E. and Oâ Neill, L.A.J., Creating ATP via creatine kinase B for NLRP3 activation, Nature Immunology, 2022
Peace, C.G. and Oâ Neill, L.A.J., The role of itaconate in host defense and inflammation, Journal of Clinical Investigation, 132, (2), 2022
Ryan, D.G. and Knatko, E.V. and Casey, A.M. and Hukelmann, J.L. and Dayalan Naidu, S. and Brenes, A.J. and Ekkunagul, T. and Baker, C. and Higgins, M. and Tronci, L. and Nikitopolou, E. and Honda, T. and Hartley, R.C. and O'Neill, L.A.J. and Frezza, C. and Lamond, A.I. and Abramov, A.Y. and Arthur, J.S.C. and Cantrell, D.A. and Murphy, M.P. and Dinkova-Kostova, A.T., Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response, iScience, 25, (2), 2022
Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8
Ryan, T.A.J. and Preston, R.J.S. and Oâ Neill, L.A.J., Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants, Biochemical Journal, 479, (6), 2022, p731-750
Pinkerton, J.W. and Kim, R.Y. and Brown, A.C. and Rae, B.E. and Donovan, C. and Mayall, J.R. and Carroll, O.R. and Khadem Ali, M. and Scott, H.A. and Berthon, B.S. and Baines, K.J. and Starkey, M.R. and Kermani, N.Z. and Guo, Y.-K. and Robertson, A.A.B. and O'Neill, L.A.J. and Adcock, I.M. and Cooper, M.A. and Gibson, P.G. and Wood, L.G. and Hansbro, P.M. and Horvat, J.C., Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma, Journal of Allergy and Clinical Immunology, 149, (4), 2022, p1270-1280
Campiani, G. and Khan, T. and Ulivieri, C. and Staiano, L. and Papulino, C. and Magnano, S. and Nathwani, S. and Ramunno, A. and Lucena-Agell, D. and Relitti, N. and Federico, S. and Pozzetti, L. and Carullo, G. and Casagni, A. and Brogi, S. and Vanni, F. and Galatello, P. and Ghanim, M. and McCabe, N. and Lamponi, S. and Valoti, M. and Ibrahim, O. and O'Sullivan, J. and Turkington, R. and Kelly, V.P. and VanWemmel, R. and DÃaz, J.F. and Gemma, S. and Zisterer, D. and Altucci, L. and De Matteis, A. and Butini, S. and Benedetti, R., Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy, European Journal of Medicinal Chemistry, 235, (114274), 2022
Williams, N.C. and Ryan, D.G. and Costa, A.S.H. and Mills, E.L. and Jedrychowski, M.P. and Cloonan, S.M. and Frezza, C. and O'Neill, L.A., Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages, Journal of Biological Chemistry, 298, (2), 2022
Gibbons, L. and Ozaki, E. and Greene, C. and Trappe, A. and Carty, M. and Coppinger, J.A. and Bowie, A.G. and Campbell, M. and Doyle, S.L., SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration, Frontiers in Neuroscience, 16, (852114), 2022
Wahaab, A. and Mustafa, B.E. and Hameed, M. and Stevenson, N.J. and Anwar, M.N. and Liu, K. and Wei, J. and Qiu, Y. and Ma, Z., Potential role of flavivirus ns2b-ns3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: A review, Viruses, 14, (1), 2022
Zhang, Y. and Gargan, S. and Roche, F.M. and Frieman, M. and Stevenson, N.J., Inhibition of the IFN-α JAK/STAT Pathway by MERS-CoV and SARS-CoV-1 Proteins in Human Epithelial Cells, Viruses, 14, (4), 2022
Mannion JM, McLoughlin RM, Lalor SJ, The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease, Clinical Reviews in Allergy & Immunology,, March 11, 2022
Cooper AJR, Clegg J, Cassidy FC, Hogan AE, McLoughlin RM., Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity., Microorganisms, 10, (1), 2022
Marilena Karavyraki, Richard K. Porter, Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma., Medical Oncology, 2022
Hyesoo Jeon and Jerrard M. Hayes and K. H. Mok, In Silico Analysis of Therapeutic Antibody Aggregation and the Influence of Glycosylation, Glycosylation, 2022, p169--183
Hough, K. and Verschuur, C.A. and Cunningham, C. and Newman, T.A., Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss, GLIA, 70, (2), 2022, p219-238
Gu L, Casserly D, Brady G, Carpenter S, Bracken AP, Fitzgerald KA, Unterholzner L, Bowie AG., Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7., Nature communications, 13, (1), 2022, p14
McElroy AN, Invernizzi R, Laskowska JW, O'Neill A, Doroudian M, Moghoofei M, Mostafaei S, Li F, Przybylski AA, O'Dwyer DN, Bowie AG, Fallon PG, Maher TM, Hogaboam CM, Molyneaux PL, Hirani N, Armstrong ME, Donnelly SC., Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis., American journal of respiratory and critical care medicine, 2022
Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022
McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022
Laura K Finnegan, Naomi Chadderton, Paul F Kenna, Arpad Palfi, Michael Carty, Andrew G Bowie, Sophia Millington-Ward, Gwyneth Jane Farrar, SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration, International Journal of Molecular Sciences, 2022
Ryan, L. and Mills, K.H.G., Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis, European Journal of Immunology, 52, (1), 2022, p24-33
Lynch RI, Lavelle EC., Immuno-modulatory biomaterials as anti-inflammatory therapeutics., Biochemical pharmacology, 197, 2022, p114890
Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy , Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Anthony M. McElligott , Daniela M. Zisterer , A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma , Life Sciences, 290, 2022
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236