Publications
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70 publications from 2019
Kufer, T.A., Creagh, E.M. & Bryant C., Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense, Trends in Immunology, in press, 2019
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenso, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744
Pignatelli, M. and Ryan, T.J. and Roy, D.S. and Lovett, C. and Smith, L.M. and Muralidhar, S. and Tonegawa, S., Engram Cell Excitability State Determines the Efficacy of Memory Retrieval, Neuron, 101, (2), 2019, p274-284.e5
Bowie, A.G., Harnessing poxviral know-how for anti-cytokine therapies, Journal of Biological Chemistry, 294, (13), 2019, p5228-5229
Silveira, A.A.A. and Mahon, O.R. and Cunningham, C.C. and Corr, E.M. and Mendonça, R. and Saad, S.T.O. and Costa, F.F. and Dunne, A. and Conran, N., S100A8 acts as an autocrine priming signal for heme-induced human MÏ. pro-inflammatory responses in hemolytic inflammation, Journal of Leukocyte Biology, 106, (1), 2019, p35-43
Geiger, S.S. and Curtis, A.M. and O'Neill, L.A.J. and Siegel, R.M., Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production, Immunology, 157, (2), 2019, p122-136
Ketelhuth, D.F.J. and Lutgens, E. and BÀck, M. and Binder, C.J. and Van den Bossche, J. and Daniel, C. and Dumitriu, I.E. and Hoefer, I. and Libby, P. and O'Neill, L. and Weber, C. and Evans, P.C., Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology, Cardiovascular research, 115, (9), 2019, p1385-1392
Hooftman, A. and O'Neill, L.A.J., The Immunomodulatory Potential of the Metabolite Itaconate, Trends in Immunology, 40, (8), 2019, p687-698
WaschbÃŒsch, D. and HÃŒbel, N. and Ossendorf, E. and Lobbestael, E. and Baekelandt, V. and Lindsay, A.J. and McCaffrey, M.W. and Khan, A.R. and Barnekow, A., Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking, PLoS ONE, 14, (1), 2019
Garg, R.R. and Jackson, C.B. and Rahman, M.M. and Khan, A.R. and Lewin, A.S. and McFadden, G., Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs, Journal of Biological Chemistry, 294, (21), 2019, p8480-8489
Campbell, N.K. and Fitzgerald, H.K. and Fletcher, J.M. and Dunne, A., Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1, Frontiers in Immunology, 10, (MAR), 2019, p00345-
Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019
Jiménez, J.M. and Salazar, M.L. and Arancibia, S. and Villar, J. and Salazar, F. and Brown, G.D. and Lavelle, E.C. and MartÃnez-Pomares, L. and Ortiz-Quintero, J. and Lavandero, S. and Manubens, A. and Becker, M.I., TLR4, but neither dectin-1 nor dectin-2, participates in the mollusk hemocyanin-induced proinflammatory effects in antigen-presenting cells from mammals, Frontiers in Immunology, 10, (MAY), 2019
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019
Liddicoat, A.M. and Lavelle, E.C., Modulation of innate immunity by cyclosporine A, Biochemical Pharmacology, 163, 2019, p472-480
Lebre, F. and Lavelle, E.C. and Borges, O., Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies, Journal of Pharmacy and Pharmacology, 71, (6), 2019, p920-928
Davitt, C.J.H. and Longet, S. and Albutti, A. and Aversa, V. and Nordqvist, S. and Hackett, B. and McEntee, C.P. and Rosa, M. and Coulter, I.S. and Lebens, M. and Tobias, J. and Holmgren, J. and Lavelle, E.C., Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines, Mucosal Immunology, 12, (4), 2019, p1055-1064
O'Boyle, N.M. and Ana, G. and Kelly, P.M. and Nathwani, S.M. and Noorani, S. and Fayne, D. and Bright, S.A. and Twamley, B. and Zisterer, D.M. and Meegan, M.J., Synthesis and evaluation of antiproliferative microtubule-destabilising combretastatin A-4 piperazine conjugates, Organic and Biomolecular Chemistry, 17, (25), 2019, p6184-6200
Coyle, R. and Slattery, K. and Ennis, L. and O'Sullivan, M.J. and Zisterer, D.M. , The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway, International Journal of Oncology, 55, (1), 2019, p191-202
Wang, S. and Malebari, A.M. and Greene, T.F. and Oâ Boyle, N.M. and Fayne, D. and Nathwani, S.M. and Twamley, B. and McCabe, T. and Keely, N.O. and Zisterer, D.M. and Meegan, M.J., 3-Vinylazetidin-2-Ones: Synthesis, antiproliferative and tubulin destabilizing activity in MCF-7 and MDA-MB-231 Breast Cancer Cells, Pharmaceuticals, 12, (2), 2019
Browe, D.C. and Mahon, O.R. and DÃaz-Payno, P.J. and Cassidy, N. and Dudurych, I. and Dunne, A. and Buckley, C.T. and Kelly, D.J., Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering, Journal of Biomedical Materials Research - Part A, 2019
Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÌrtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6
Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, (FEB), 2019, p1--
Meade, K.G. and O'Farrelly, C., Î'-Defensins: Farming the microbiome for homeostasis and health, Frontiers in Immunology, 10, (JAN), 2019
Galván-Peña, S., Carroll, R.G., Newman, C., (...), Modis, L.K., O'Neill, L.A., Malonylation of GAPDH is an inflammatory signal in macrophages, Nature Communications, 10, (1), 2019, p338-
Qasim Warraich M, Ghion A, Perdisatt L, Oâ Neill L, Casey A, Oâ Connor C, In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line, Drug and Chemical Toxicology, 2019
Gul S.-E, Oâ neill L, Cassidy J, Naydenova I, Modified surface relief layer created by holographic lithography: Application to selective sodium and potassium sensing, Sensors (Switzerland), 19, (5), 2019
Oâ Neill L.A.J, Artyomov M.N, Itaconate: the poster child of metabolic reprogramming in macrophage function, Nature Reviews Immunology, 19, (5), 2019, p273 - 281
Finlay, D.K., N-myristoylation of AMPK controls T cell inflammatory function, Nature Immunology, 20, (3), 2019, p252-254
Saraswati AP, Relitti N, Brindisi M, Gemma S, Zisterer D, Butini S & Campiani G, Raising the bar in anticancer therapy:recent advances in, and perspectives on, telomerase inhibitors, Drug Discovery Today, 2019
Jones N, Vincent EE, Cronin JG, Panetti S, Chambers M, Holm SR, Owens SE, Francis NJ, Finlay DK, Thornton CA, Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation, Nature Communications, 10, (1), 2019, p2042-
O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D Hogan AE, Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses, Journal of Immunology, 202, (12), 2019, p3404 - 3411
Neher J.J, Cunningham C, Priming Microglia for Innate Immune Memory in the Brain, Trends in Immunology, 40, (4), 2019, p358 - 374
Skelly D.T, Griffin à .W, Murray C.L, Harney S, Oâ Boyle C, Hennessy E, Dansereau M.-A, Nazmi A, Tortorelli L, Rawlins J.N, Bannerman D.M, Cunningham C, Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms (Molecular Psychiatry, (2018), 10.1038/s41380-018-0075-8), Molecular Psychiatry, 2019
Connolly R, Denton M.D, Humphreys H, McLoughlin R.M, Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?, Kidney International, 95, (3), 2019, p518 - 525
O'Brien E.C, McLoughlin R.M, Considering the â~Alternativesâ for Next-Generation Anti-Staphylococcus aureus Vaccine Development, Trends in Molecular Medicine, 25, (3), 2019, p171 - 184
Lacey K.A, Mulcahy M.E, Towell A.M, Geoghegan J.A, McLoughlin R.M, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLoS pathogens, 15, (4), 2019, pe1007713-
Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346
Kohlgruber A.C, Gal-Oz S.T, LaMarche N.M, Shimazaki M, Duquette D, Koay H.-F, Nguyen H.N, Mina A.I, Paras T, Tavakkoli A, von Andrian U, Uldrich A.P, Godfrey D.I, Banks A.S, Shay T, Brenner M.B, Lynch L, Erratum to: γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (Nature Immunology, (2018), 19, 5, (464-474), 10.1038/s41590-018-0094-2), Nature Immunology, 20, (3), 2019, p373-
Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, Oâ Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1--
Wilk M.M, Borkner L, Misiak A, Curham L, Allen A.C, Mills K.H.G, Immunization with whole cell but not acellular pertussis vaccines primes CD4 T
Quinn S.M, Raverdeau M, McGinley A.M, Mills K.H.G, Helminths products directly modulate TÂ cells that mediate experimental autoimmune encephalomyelitis, European Journal of Immunology, 2019
Raverdeau M, Christofi M, Malara A, Wilk M.M, Misiak A, Kuffova L, Yu T, McGinley A.M, Quinn S.M, Massilamany C, Reddy J, Forrester J.V, Mills K.H.G, Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity, EMBO Reports, 20, (5), 2019
Clowry, J., Irvine, A.D., McLoughlin, R.M., Next-generation anti"Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?, Journal of Allergy and Clinical Immunology, 143, (1), 2019, p78-81
Müller M, Legrand C, Tuorto F, Kelly VP, Atlasi Y, Lyko F, Ehrenhofer-Murray AE., Queuine links translational control in eukaryotes to a micronutrient from bacteria., Nucleic acids research, 2019
Vincent P. Kelly, The queuine micronutrient pathway as a therapeutic target in autoimmune disease, Translational Medicine Research Program, The Hospital for Sick Children, Toronto Canada, 14th Jan 2019, 2019, Dr. Colin McKerlie
Cluxton D, Petrasca A, Moran B, Fletcher JM, Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis, Frontiers in Immunology, 10, 2019, p115-
Carty M, Bowie AG., SARM: from immune regulator to cell executioner., Biochemical pharmacology, 2019
Mary F Rooney, Emmeline W Hill, Vincent Kelly and Richard K Porter, Genotype variation at the MSTN locus is associated with skeletal muscle Coenzyme Q level in untrained Thoroughbred horses., Cell Symposium: Exercise Metabolism, Sitges, Barcelona, Spain, May, 2019
Richard K. Porter, Oxygen Consumption as a measure of Cellular Energy Metabolism, Institute of Genomics and Integrative Biology, New Delhi, India, February, 2019
Richard K. Porter, Oxygen Consumption as a measure of Cellular Energy Metabolism, Indian Institute of Science, Bangalore, India, February, 2019
Emma O'Connor, Richard K. Porter, Patrick T. Walsh, The Role of Mitochondrial Uncoupling Protein 3 in T Cell Function, Frontiers in Immunology, 2019, p3788
Nazmi, A., Field, R.H., Griffin, E.W., Haugh, O., Hennessy, E., Cox, D., Reis, R., Tortorelli, L., Murray, C.L., Lopez-Rodriguez, A.B., Lavelle, E.C., Dunne, A. and Cunningham,C. , Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression, Glia, 67, 2019, p1254 - 1276
O'Grady, K., Hearnden, C.C.H., Bento, D., Oleszycka, E., Andersen, P., Muñoz-Wolf, N. and Lavelle, E.C. , IL-33 is a negative regulator of vaccine-induced antigen-specific cellular immunity, The Journal of Immunology, 2019
Chang Y.-H., Nishimura S., Oishi H., Kelly V.P., Kuno A., Takahashi S., TRMT2A is a novel cell cycle regulator that suppresses cell proliferation, Biochemical and Biophysical Research Communications, 508, (2), 2019, p410 - 415, p410-415
David Finlay, Metabolic Regulation of NK cell responses, Immunometabolism: Fundamentals to Prospective New Therapies , Boston, 25th June, 2019, Abcam, Prof Luke O'Neill
David Finlay, NK cell metabolism; Implications for anti-tumour responses, Seminar, Imperial College London, 13th May, 2019, Prof Adam Byrne
David Finlay, Metabolic regulation of NK cell responses, Fuelling the immune response: UK immunometabolism meeting 2019, Newcastle, 14th March, 2019, British Society for Immunology's Immunometabolism Affinity Group
Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674
David Finlay, Metabolic regulation of Natural Killer cell anti-tumour responses, Seminar, Newcastle University, 13th March, 2019, Dr Kevin Marchbank
David Finlay, Metabolic regulation of NK cell responses, IACR annual conference, Belfast, 21st Feburary, 2019
David Finlay, Metabolic regulation of NK cell responses, Seminar, University of Dundee, 8th Feburary, 2019, Prof Doreen Cantrell
Katie O'Brien and David. K Finlay, Immunometabolism and Natural Killer cell responses, Nature Reviews Immunology, 19, (5), 2019, p282 - 290
Nidhi Kedia-Mehta and David. K Finlay, Competition for nutrients; an emerging role in controlling immune responses, Nature Communications, 10, (1), 2019, p2123-
Díaz-Payno, P., Cunniffe G.M., Sheehy, E.J., Critchley, S., Almeida, H., Pitacco, P., Carroll, S., Mahon, O., Dunne, A., Levingstone, T., Moran, C., Brady, R., O'Brien, F.J., Brama, P. and Kelly, D.J., Layering of tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials, 188, 2019, p63 - 73
Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma,Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Maria Rosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Sullivan, Lucia Morbidelli, Roberta Spaccapelo, Cosima Baldari, Stefania Butini, Ettore Novellino, Giuseppe Campiani, Lucia Altucci, Michel Steinmetz, Simone Brogi, Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, p290-320
Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ, Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials. , 188, 2019, p63-73
Sadhbh O'Neill, Richard K. Porter, Vanesa G. Martinez, Lorraine, O'Driscoll , 2-Deoxy-D-Glucose preferentially inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype , Scientific Reports, 9, (1), 2019, p3788 - 3798
McKenna C, Porter RK, Waters SM, Cormican P, McGee M, Kelly AK and Kenny D, An examination of the transcriptional control of energetic efficiency in skeletal muscle and hepatic tissue from beef cattle divergent for residual feed intake, 2019