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School of Biochemistry and Immunology

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Dr. Howard Voorheis
Fellow Emeritus, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Hanrahan O, Webb H, O'Byrne R, Brabazon E, Treumann A, Sunter JD, Carrington M, Voorheis HP, The glycosylphosphatidylinositol-PLC in Trypanosoma brucei forms a linear array on the exterior of the flagellar membrane before and after activation., PLoS Pathogens, 5, (6), 2009, pe1000468 Journal Article, 2009 DOI TARA - Full Text

Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117 Journal Article, 2008 TARA - Full Text DOI

Bridges DJ, Pitt AR, Hanrahan O, Brennan K, Voorheis HP, Herzyk P, de Koning HP, Burchmore RJ, Characterisation of the plasma membrane subproteome of bloodstream form Trypanosoma brucei., Proteomics, 8, (1), 2008, p83-99 Journal Article, 2008 DOI

Nolan, D.P., Jackson, D.G., Biggs, M.J., Brabazon, E.D., Pays, A., Van Laethem, F., Paturiaux-Hanocq, F., (...), Pays, E., Erratum: Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma, brucei (Journal of Biological Chemistry (2000) 275 (4072-4080)) , 2005, - 31340 Miscellaneous, 2005

O'Beirne, C., & Voorheis, H. P., Single-cycle, real-time, fluorescence characterization of the cycle of endocytosis - exocytosis of surface immune complexes in bloodstream forms of Trypanosoma brucei, Biochemistry, 2005 Journal Article, 2005

O'Beirne, C. & Voorheis, H. P., Progression of Surface Immune Complexes to the Flagellar Pocket and through the Endosomal System of T. brucei assessed by Confocal Laser Scanning Fluorescence Microscopy, J. Cell Sci., 2005 Journal Article, 2005

O'Beirne, C. & Voorheis, H. P., The fate of IgM and IgG anti-VSG antibodies following binding to the surface coat of Trypanosoma brucei', J. Biol. Chem., 2005 Journal Article, 2005

Chattopadhyay, A., Jones, N. G., Nietlispach, D., Nielsen, P. R., Voorheis, H. P., Mott, H. R. & Carrington, M., Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat 1.2, Journal of Biological Chemistry, 280, (8), 2005, p7228 - 7235 Journal Article, 2005 DOI

Smith, G. A. & Voorheis, H. P., European Patent Office, Patent for Submission, Fluorescent pH Probes, 2004 Patent, 2004

Voorheis, H. P. & Smith, G. A., European Patent Office, Patent Pending, Phospholipid Derivatives, 2004 Patent, 2004

Nolan, D. & Voorheis, H. P., Hydrogen ion gradients across the mitochondrial, endosomal and plasma membranes in bloodstream forms of Trypanosoma brucei - Solving the three-compartment problem, European Journal of Biochemistry, 267, (15), 2000, p4601 - 4614 Journal Article, 2000 DOI

Nolan, D.P., Jackson, D.G., Biggs, M.J., Brabazon, E.D., Pays, A., Van Laethem, F., Paturiaux-Hanocq, F., (...), Pays, E., Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma brucei , Journal of Biological Chemistry, 275, (6), 2000, p4072 - 4080 Journal Article, 2000 DOI

Nolan, D. & Voorheis, H. P., Factors that determine the plasma membrane potential in bloodstream forms of Trypanosoma brucei, European Journal of Biochemistry, 267, (15), 2000, p4615 - 4623 Journal Article, 2000 DOI

Redpath MB, Windle H, Nolan D, Pays E, Voorheis HP, Carrington M, ESAG11, a new VSG expression site-associated gene from Trypanosoma brucei., Molecular and biochemical parasitology, 111, (1), 2000, p223-228 Journal Article, 2000 DOI

Zintl, A., Poole, W. R., Voorheis, H. P. & Holland, C. V., Cryptobia infections in brown trout, Salmo trutta L., caught as by catch in the Burrishoole catchment, County Mayo, Western Ireland, Journal of Fish Diseases, 22, (4), 1999, p325 - 329 Journal Article, 1999 DOI

O'Beirne,C. Lowry, C. M. & Voorheis, H. P., Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite, Molecular and Biochemical Parasitology, 91, (1), 1998, p165 - 193 Journal Article, 1998 DOI

Zintl, A., Poole, W. R., Voorheis, H. P. & Holland, C. V., Naturally occurring Trypanosoma granulosum infections in the European eel, Anguilla anguilla from County Mayo, Western Ireland, Journal of Fish Diseases, 20, (5), 1997, p333 - 341 Journal Article, 1997 DOI

Nolan, D., Jackson, D. G., Windle, H. J., Pays, A., Geuskens, M., Michel, A., Voorheis, H. P. and Pays, E., Characterization of a novel, stage-specific, invariant surface protein in Trypanosoma brucei containing an internal, serine-rich, repetitive motif, Journal of Biological Chemistry, 272, (46), 1997, p29212 - 29221 Journal Article, 1997 DOI

Voorheis, H. P., United States Patent, Diagnostic method for Alzheimer's Disease by Screening for tau-peptides in the blood of a patient, 1996, 5, 492, 812 Patent, 1996

Rolin, S., Hanocq-Quertier, J., Paturiaux-Hanocq, F., Nolan, D., Salmon, D., Webb, H., Carrington, M., Voorheis, P. & Pays, E., Simultaneous but independent activation of adenylate cyclase and glycosylphosphatidylinositol-phospholipase C under stress conditions in Trypanosoma brucei, Journal of Biological Chemistry, 271, 1996, p10844 - 10852 Journal Article, 1996 DOI

Jackson, D. J., Windle, H. J. & Voorheis, H. P., The Identification, Purification and Characterization of Two Invariant Surface Glycoproteins Located beneath the Surface Coat Barrier of Bloodstream Forms of T. brucei, Journal of Biological Chemistry, 268, (11), 1993, p8085 - 8095 Journal Article, 1993 URL

Doherty, M. L., Windle, H. J., Voorheis, H. P., Larkin, H., Casey, M., Clery, D. & Murray, M., Clinical disease associated with Trypanosoma theileri infection in a calf in Ireland, Veterinary Record , 132, (26), 1993, p653 - 656 Journal Article, 1993

Nolan, D. P. & Voorheis, H. P., The mitochondrion in bloodstream forms ofTrypanosoma brucei is energized by the electrogenic pumping of protons catalysed by the F1F0 ATPase, European Journal of Biochemistry , 209, (1), 1992, p207 - 216 Journal Article, 1992 DOI

Offer, J. L., Voorheis, H. P., Metcalfe, J. C. & Smith, G. A., The synthesis and tritium radiolabelling of fluorinated analogues of myo-inositol, Journal of the Chemical Society, Perkin Transactions 1, 8, 1992, p935 - 960 Journal Article, 1992 DOI

Nolan, D. P. & Voorheis, H. P., The distribution of permeant ions demonstrates the presence of at least two distinct electrical gradients in bloodstream forms of Trypanosoma brucei, European Journal of Biochemistry, 202, (2), 1991, p411 - 420 Journal Article, 1991 DOI

Jackson, D. J. & Voorheis, H. P., Changes in the Pattern of Cell Surface Proteins During Transformation of Bloodstream Forms of Trypanosoma brucei in vitro, Biochemical Society Transactions , 18, (5), 1990, p1032 - 1033 Journal Article, 1990

Nolan, D. P. & Voorheis, H. P., Bioenergetic Studies of Bloodstream Forms of Trypanosoma brucei: Electrical and H+ Gradients, Biochemical Society Transactions , 18, (5), 1990, p735 - 739 Journal Article, 1990

Cronin, C. N., Nolan, D. P. & Voorheis, H. P., The Enzymes of the Classical Pentose Phosphate Pathway Display Differential Activities in Procyclic and Bloodstream Forms of Trypanosoma brucei, FEBS Letters, 244, (1), 1989, p26 - 30 Journal Article, 1989 DOI

Reid, I.M., Monson, J.R.T., Keane, F.B.V., Tanner, W.A., Darzi, A., O'Morain, C., Taner, W.A., Voorheis, H.P. (...), Given, H.F., Royal Academy of Medicine in Ireland Section of Sugery - Proceedings of the registrars' prize meeting held at the Royal College of Surgeons in Ireland on Friday 14th April 1989 , Irish Journal of Medical Science , 158, (9), 1989, p234-238 Journal Article, 1989 DOI

Transformation of Trypanosoma brucei from its Bloodstream Form into its Procyclic Form is Accompanied by a Change in the Ionic Conductance of the Plasma Membrane in, editor(s)Keeling, D. & Benham, C. , Ion Transport, 1989, pp355 , [Nolan, D. P. & Voorheis, H. P.] Book Chapter, 1989

The Energization of Amino Acid Transport by Trypanosoma brucei in, editor(s)Keeling, D. & Benham, C. , Ion Transport, 1989, pp373 , [Cleary, P. M. & Voorheis, H. P.] Book Chapter, 1989

Dolan, M. T. Reid, C. G. & Voorheis, H. P., Calcium Ions Initiate the Selective Depolymerization of the Pellicular Microtubules in Bloodstream Forms of Trypanosoma brucei, Journal of Cell Science, 80, 1986, p123 - 140 Journal Article, 1986

Jackson, D. J. & Voorheis, H. P., Release of the Variant Surface Glycoprotein from Trypanosoma brucei occurs via cleavage of a Phosphodiester Linkage, Biochemical Society Transactions, 13, 1985, p493 - 493 Journal Article, 1985

Dolan, M. T. & Voorheis, H. P., The Specific Release of Tubulin from the Pellicular Microtubules of Trypanosoma brucei is initiated by Ca2+, Biochemical Society Transactions , 13, 1985, p775 - 775 Journal Article, 1985

Jackson, D. J. & Voorheis, H. P., Release of the Variable Surface Coat Glycoprotein from Trypanosoma brucei Requires the Cleavage of a Phosphate Ester, Journal of Biological Chemistry , 260, (8), 1985, p5179 - 5183 Journal Article, 1985 URL

Jackson, D. J. & Voorheis, H. P., Release of the Varient Surface Glycoprotein from Trypanosoma brucei is Stimulated by the Local Anaesthetic, Benzyl Alcohol, Biochemical Society Transactions , 13, 1985, p494 - 495 Journal Article, 1985

Jackson, D. J. & Voorheis, H. P., Rapid Purification of the Membrane-Bound and Released Forms of the Variant Surface Glycoprotein from Trypanosoma brucei, Biochemical Society Transactions , 13, 1985, p493 - 494 Journal Article, 1985

JACKSON, DG, RELEASE OF THE VARIANT SURFACE GLYCOPROTEIN FROM TRYPANOSOMA-BRUCEI IS STIMULATED BY THE LOCAL-ANESTHETIC, BENZYL ALCOHOL, unknown, 1985, 13, ISI Web of Science, 1985, pp494 - 495 Meeting Abstract, 1985

JACKSON, DG, RAPID PURIFICATION OF THE MEMBRANE-BOUND AND RELEASED FORMS OF THE VARIANT SURFACE GLYCOPROTEIN FROM TRYPANOSOMA-BRUCEI, unknown, 1985, 13, ISI Web of Science, 1985, pp493 - 494 Meeting Abstract, 1985

Jackson, D. J., Owen, M. J. & Voorheis, H. P., A New Method for the Rapid Purification of both the Membrane-Bound and Released Forms of the Varient Surface Glycoprotein from Trypanosoma brucei, Biochemical Journal, 230, (1), 1985, p195 - 202 Journal Article, 1985

Voorheis, H. P. & Bowles, D. J. and Smith, G. A., Characteristics of the Release of the Surface Coat Protein from Bloodstream Forms of Trypanosoma brucei, Journal of Biological Chemistry , 257, (5), 1982, p2300 - 2304 Journal Article, 1982 URL

Voorheis, H. P. & Martin, B. R., Local Anaesthetics including Benzyl Alcohol Activate the Adenylate Cyclase in Trypanosoma brucei by a Calcium-Dependent Mechanism, European Journal of Biochemistry , 123, (2), 1982, p371 - 376 Journal Article, 1982 DOI

Voorheis, H. P. & Martin, B. R., Characteristics of the Calcium-Mediated Mechanism Activating Adenylate Cyclase in Trypanosoma brucei, European Journal of Biochemistry , 116, (3), 1981, p471 - 477 Journal Article, 1981 DOI

Voorheis, H. P., Energized Amino Acid Transport by Trypanosoma brucei Requires a Glycolytic Intermediate, Biochemical Society Transactions , 8, (3), 1980, p273 - 275 Journal Article, 1980

Voorheis, H. P., Fatty Acid Uptake by Bloodstream Forms of Trypanosoma brucei and Other Species of the Kinetoplastida, Molecular and Biochemical Parasitology , 1, (3), 1980, p177 - 186 Journal Article, 1980 DOI

Voorheis, H. P. & Martin, B. R., Swell-Dialysis Demonstrates that Adenylate Cyclase in Trypanosoma brucei is Regulated by Calcium Ions, European Journal of Biochemistry , 113, (1), 1980, p223 - 227 Journal Article, 1980

Bowles, D. J. & Voorheis, H.P., Release of the Surface Coat from the Plasma Membrane of Bloodstream Forms of Trypanosoma brucei Requires Calcium Ions, FEBS Letters, 139, (1), 1980, p17 - 21 Journal Article, 1980 DOI

Brett, C. T. & Voorheis, H. P., Glycoprotein Biosynthesis in Trypanosoma brucei: The Glycosylation of Glycoproteins Located in and Attached to the Plasma Membrane, European Journal of Biochemistry , 109, (1), 1980, p139 - 150 Journal Article, 1980 DOI

Voorheis, H. P., Gale, J. S., Owen, M. J. & Edwards, W., The Isolation and Partial Characterization of the Plasma Membrane from Trypanosoma brucei, Biochemistry Journal, 180, (1), 1979, p11-20 Journal Article, 1979 URL

Martin, B. R., Voorheis, H. P. & Kennedy, E. L., Adenylate Cyclase in Bloodstream Forms of Trypanosoma (Trypanozoon) brucei sp., Biochemical Journal , 175, (1), 1978, p207 - 212 Journal Article, 1978

Martin, B. R. & Voorheis, H. P., A simple enzymic method for the synthesis of adenosine 5' [α 32P]triphosphate on a preparative scale , Biochemical Journal, 161, (3), 1977, p555 - 559 Journal Article, 1977

Voorheis, H. P., Changes in the Kinetic Behavior of Threonine Transport into Trypanosoma brucei Elicited by Variation in Hydrogen Ion Concentration, Biochemical Journal , 164, (1), 1977, p15 - 25 Journal Article, 1977

Owen, M. J. & Voorheis, H. P., Active-Site Directed Inhibition of the Plasma Membrane Carrier Transporting Short-Chain, Neutral Amino Acids into Trypanosoma brucei, European Journal of Biochemistry , 62, (3), 1976, p619 - 624 Journal Article, 1976 DOI

Voorheis, H. P., Studies on the Active Site of the N1 Amino Acid Transport Carrier of T. brucei, Transactions of the Royal Society of Tropical Medicine and Hygiene , 67, (2), 1973, p256 - 257 Journal Article, 1973 DOI

Voorheis, H. P., An Amino Group at the Binding Site of the N1 Amino Acid Transport Carrier of Trypanosoma brucei', Abstr. Commun. Meet. Fed. Eur. Biochem. Soc., 8, 1972, p96 - 96 Journal Article, 1972

Voorheis, H. P., Amino Acid Transport in Trypanosoma brucei, Trans. Roy. Soc. Trop. Med. Hyg., 65, 1971, p241 - 243 Journal Article, 1971

Hubbard, R. W., Voorheis, H. P. & Therriault, D. G., The Incorporation of Glycerol into the Glyceride-Glycerol of Fat Cells Isolated from Chronically Cold-Exposed Rats, Lipids, 5, (1), 1970, p114 - 120 Journal Article, 1970 DOI

Hubbard, R. W., Therriault, D. G. & Voorheis, H. P., The Turnover of Lipid Esters in Adipose Tissue from Cold-Exposed Rats, Bull. N. J. Acad. Sci. Special Symp. Issue, 1969, p52 - 58 Journal Article, 1969

Voorheis, H. P., The Effect of T. brucei (S-42) on Host Carbohydrate Metabolism: Liver Production and Peripheral Tissue Utilization, Transactions of the Royal Society of Tropical Medicine and Hygiene , 63, (1), 1969, p122 - 123 Journal Article, 1969 DOI

Jaffe, J. J., Voorheis, H .P. & McCormack Jr., J. J., Comparative Effects of Diverse Mamallian Sera on the Uptake and Protein Incorporation of 14C-labelled Amino Acids by Bloodstream Forms of T. brucei and T. rhodesiense in vitro, Transactions of the Royal Society of Tropical Medicine and Hygiene , 63, (1), 1969, p118 - 119 Journal Article, 1969 DOI

Non-Peer-Reviewed Publications

O'Conor, K., Voorheis, H. P. and O'Sullivan, C. , Visualisation of Confocal Fluorescence Microscopy Data, Proceedings of the fifth Irish Workshop on Computer Graphics, 2004, pp1-6 Conference Paper, 2004

Research Expertise

Description

The main thrust of my research work has been the study of membrane processes in Trypanosomes. SIGNIFICANT MILESTONES IN THIS WORK: A. First studies of amino acid transport in trypanosomes, (refs 1-2, 5-8, 10 & 14) B. Development of the current method used for the commercial production of [32P]ATP (ref 9) C. First production of isolated plasma membranes in trypanosomes (ref 12) D. Development of a mild method for selectively and reversibly permeablizing plasma membranes to small molecules while leaving other cellular membranes unaffected, (ref 16) E. First series of studies characterizing the adenylate cyclase in bloodstream form trypanosomal plasma membranes and discovery of the regulation of this enzyme by Ca2+, (ref 11, 16-17, 20 & 38) F. First study of glycoprotein biosythesis in trypanosomes, (ref 15) G. Discovery of the phosphodiester linkage of the variant surface glycoprotein to the lipid anchor and its cleavage during release from the cell surface, (ref 18-19, 21, 23 & 25) H. First series of studies of the bioenergetics of bloodstream form trypanosomes, (refs 31,33,35, 44-45) I. Discovery and characterization of invariant surface glycoproteins on the surface of bloodstream form trypanosomes and demonstration of their life cycle specificity, (ref 40, 43 & 47) J. Discovery of the ability of bloodstream stage trypanosomes to defend themselves against antibody without cell damage, (ref 41 & 49) K. First 3-D structure of the C-terminal folding domain of the variant surface glycoprotein (VSG) in trypanosomes (ref. 48) L. Development of a new continuous, pre-steady state, single turn-over fluorescence assay for the endocytotic-exocytotic cycle and its use to characterize the endocytosis of surface immune complexes and nutritional factors, (refs 49-50) M. Development of Specific Fluorescent Phospholipid Probes for the Plasma Membrane of all Eukaryotic Cells (Patent Pending, European Patent Office, submitted 2004) N. Development of a new class of Fluorescent Probes (PHRODO) that can be linked to proteins and respond with increased fluorescence as pH drops (Patent Pending, European Patent Office, submitted 2004)

Projects

  • Title
    • The bioenergetics of parasite (Trypanosoma brucei) adaption to life in an insect vector (Tsetse fly)
  • Funding Agency
    • Enterprise Ireland Basic Research Grant
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • Development of 3-D displays of confocal images & Modelling the movement & docking of membrane proteins
  • Funding Agency
    • ITAC-2
  • Date From
    • 2002
  • Date To
    • 2007
  • Title
    • Development of a mathematical model for fitting integrated rate equations to fluorescence data from a pre-steady state, single turn-over assay of the endocytotic - exocytotic cycle
  • Funding Agency
    • ITAC-1
  • Date From
    • 1997
  • Date To
    • 2002
  • Title
    • Confocal laser scanning fluorescence microscopic localization of invariant stage-specific surface glycoproteins in Trypanosoma brucei as part of the effort to develop an anti-trypanosomal vaccine
  • Funding Agency
    • NPBC
  • Date From
    • 1998
  • Date To
    • 2003
  • Title
    • The role of a new phosphotransferase in generating ATP anaerobically in Trypanosoma brucei
  • Funding Agency
    • The Health Research Board Project Grant
  • Date From
    • 1998
  • Date To
    • 2001
  • Title
    • Phosphorylation of a unique site in human tau protein and formation of paired-helical-filaments
  • Funding Agency
    • Forbairt Basic research Grant
  • Date From
    • 1997
  • Date To
    • 1999
  • Title
    • Development of the CDL genetic element for analysing gene expression and pathogenicity in Leishmania
  • Summary
    • (fixed price - expenditure not time limited)
  • Funding Agency
    • EU Contract CI1*-CT93-0020
  • Date From
    • 1997
  • Date To
    • 2000
  • Title
    • Immunization against the pathogenic factors of T. evansi. Its application to camels, swine and water buffaloes
  • Funding Agency
    • EU Contract TS3*CT94-0293
  • Date From
    • 1994
  • Date To
    • 1997
  • Title
    • Studies of the vaccine potential of recombinant invariant surface membrane proteins of the medically important African trypanosomes from the Surface of T. brucei
  • Funding Agency
    • EEC Contract T53-CT92-0075
  • Date From
    • 1992
  • Date To
    • 1995
  • Title
    • Diagnostic Tests for Circulating Antigens and Antibodies in Trypanosomiasis using Stage-Specific Invarient Surface Antigens: Phase 2
  • Funding Agency
    • World Health Organization
  • Date From
    • 1992
  • Date To
    • 1995
  • Title
    • Development of a diagnostic test for Alzheimer's disease based on circulating tau protein fragments
  • Funding Agency
    • American Biogenetic Sciences, Inc.
  • Date From
    • 1991
  • Date To
    • 1994
  • Title
    • Assay of circulating Anti-ISG70 Antibodies in Patients with African Trypanosomiasis
  • Funding Agency
    • Bioresearch Ireland Ltd.
  • Date From
    • 1990
  • Date To
    • 1991
  • Title
    • Diagnostic Tests in Trypanosomiasis using Stage-Specific Invarient Surface Antigens
  • Funding Agency
    • World Health Organization
  • Date From
    • 1990
  • Date To
    • 1991
  • Title
    • IgM-Dependent Clearance of Ig-VSG Complexes from the Surface of Trypanosoma brucei
  • Funding Agency
    • EEC Contract TS2*0303-IRL (EDB)
  • Date From
    • 1990
  • Date To
    • 1992
  • Title
    • Studies on the Phosphoketolase Pathway, A Recently Discovered Pathway for the Metabolism of Glucose
  • Funding Agency
    • Medical Research Board (Ireland)
  • Date From
    • 1987
  • Date To
    • 1989
  • Title
    • Studies on the L-Pentose Phosphoketolase Pathway
  • Funding Agency
    • The Welcome Trust
  • Date From
    • 1987
  • Date To
    • 1988
  • Title
    • Antibiotics acting via the L-glycerol-3-phosphate transport system of T.brucei
  • Funding Agency
    • Medical Research Council of Ireland
  • Date From
    • 1986
  • Date To
    • 1987
  • Title
    • Mechanisms Controlling Cell Differentiation in T. brucei. Targets for Chemotherapy
  • Funding Agency
    • EEC Contract TSD-M-046-IRL(H)
  • Date From
    • 1984
  • Date To
    • 1986
  • Title
    • Identification of Proteins Mediating Cell - Cell Contact in Normal and Transformed Cells
  • Funding Agency
    • Irish Cancer Society
  • Date From
    • 1983
  • Date To
    • 1986
  • Title
    • Role of Ca2+ in Surface Antigen Switching
  • Funding Agency
    • Medical Research Council of Ireland
  • Date From
    • 1983
  • Date To
    • 1986
  • Title
    • Role of cAMP in Surface Coat Switching
  • Funding Agency
    • Trinity College Research Development Fund
  • Date From
    • 1983
  • Date To
    • 1986
  • Title
    • Cytoskeleton - Plasma Membrane Interaction
  • Funding Agency
    • Trinity College Research Development Fund
  • Date From
    • 1982
  • Date To
    • 1985
  • Title
    • Isolation of the N1 Amino Acid Carrier
  • Funding Agency
    • Medical Research Council of Ireland
  • Date From
    • 1979
  • Date To
    • 1982
  • Title
    • Energy Coupling to Amino Acid Transport
  • Funding Agency
    • Medical Research Council (UK)
  • Date From
    • 1976
  • Date To
    • 1979
  • Title
    • Amino Acid Transport Carriers in T. brucei
  • Funding Agency
    • Ministry (UK) for Overseas Development
  • Date From
    • 1972
  • Date To
    • 1975
  • Title
    • Lipids in Trypanosomes
  • Funding Agency
    • Ministry (UK) for Overseas Development
  • Date From
    • 1969
  • Date To
    • 1972
  • Title
    • Amino Acid Transport in Trypanosomes
  • Funding Agency
    • Ministry (UK) for Overseas Development
  • Date From
    • 1968
  • Date To
    • 1969

Keywords

ACIDIC REPETITIVE PROTEIN; AFRICAN TRYPANOSOMES; AGGREGATION; ANEMIA; ANTIBODIES; BLOOD; BLOOD-STREAM; BLOOD-STREAM FORMS; BOVINE; CARASSIUS-AURATUS; CATTLE; CELL-SURFACE; CONCANAVALIN-A; CRYPTOBIA-SALMOSITICA; CYCLIC-AMP; CYCLICAMP; DANILEWSKYI; DIFFERENTIATION; DISAGGREGATION; DISTINCT; ENDOSOME; EXPRESSION SITE; FISHES; GAIRDNERI; GOLDFISH; GUANYLATE-CYCLASE; HEMOFLAGELLATE; IMMUNITY; IMMUNOGLOBULIN-A; INOSITOL-ACYLATION; LAVERAN; LIPOPHILIC CATION; MEMBRANE; MEMBRANE-POTENTIAL CHANGES; MESNIL; MITOGENIC STIMULATION; NA+/H+ EXCHANGE; NEURO-BLASTOMA; ONCORHYNCHUS; PH GRADIENTS; PHORBOL ESTER; PLASMA-MEMBRANE; PROCYCLIC FORMS; PROTEIN KINASE; PROTEIN-KINASE-C; PROTEOLYSIS; PROTON PUMP; PROTON-MOTIVE FORCE; RAINBOW-TROUT; SACCHAROMYCES-CEREVISIAE; SALMOSITICA KATZ; STREPTOCOCCUS-LACTIS; TRYPANOSOMA BRUCEI; VARIANT SURFACE GLYCOPROTEIN

Recognition

Awards and Honours

Fellow of Trinity College, Dublin, Ireland 1979

US Army Commendation Medal 1967

Distinguished Service Citation, Kyong Sang Puk Do Provincial Government, Taegu, Korea 1966

Victor Vaughn Honory Medical Society, Ann Arbor, Michigan, USA 1964

National Honor Society, Detroit, Michigan, USA 1957