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Dr. James Murray
External Examiner, Biochemistry


James Murray's research group has a long-term interest in understanding cell signalling and how genetic mutations or cellular stress alters cell physiology to cause disease. In particular, his lab is working on the role of reversible phosphorylation in the control of cell growth and autophagy. Publications from his lab have recently described novel signalling mechanisms in cancer that control the autophagy pathway. Other work from his lab has reported the role of protein kinases in Alzheimer's disease and diabetes. Current work in his lab has turned its attention to how autophagy is regulated in new pathologies, including nephropathic cystinosis (funded in part by Cystinosis Ireland). Funding in his laboratory is provided by the IRC and HRB, with historical support from the BBSRC, Wellcome Trust, BHF and industry. James reviews papers Nature Communications, EMBO J, Biochem J, Cancer Research, PNAS and others, and he is a grant reviewer for national and international agencies. His recent seminars and invited talks have included the TRANSAUTOPHAGY conference in Oct 2016, and talks at the Universities of Paris, Descartes, Tubingen and Cardiff. James is also Chair for the European Commission funded TRANSAUTOPHAGY COST action (CA15138).

He obtained his Bachelors degree in Molecular Biology from Queen's University, Belfast and a PhD in Molecular Immunology on a scholarship programme at the Yamanouchi Research Institute, Oxford. He has also had postdoctoral training at the Albert Einstein College of Medicine, New York and at the MRC Protein Phosphorylation Unit, University of Dundee. In 2002, he won a prestigious Juvenile Diabetes Research Foundation of America Fellowship and a second Fellowship, in 2005, from the British Heart Foundation. Prior to joining Trinity College Dublin, James was a group leader in the Centre for Cancer Research and Cell Biology, Queen's University Belfast.

Publications and Further Research Outputs

Peer-Reviewed Publications

Rad E, Murray JT, Tee AR., Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression., Cancers, 10, (1), 2018 Journal Article, 2018 DOI

McCaig C, Ataliotis P, Shtaya A, Omar AS, Green AR, Kind CN, Pereira AC, Naray-Fejes-Toth A, Fejes-Toth G, Yáñez-Muñoz RJ, Murray JT, Hainsworth AH., Induction of the cell survival kinase Sgk1: A possible novel mechanism for "-phenyl-N-tert-butyl nitrone in experimental stroke., Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, p271678X17746980 Journal Article, 2017 DOI

Lane JD, Korolchuk VI, Murray JT., Signalling mechanisms in autophagy: an introduction to the issue., Essays in biochemistry, 61, (6), 2017, p561-563 Journal Article, 2017 DOI

Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay, Glucose represses dendritic cell-induced T cell responses, Nature Communications, (8), 2017, p15620- Journal Article, 2017 URL DOI TARA - Full Text

Chintapalli R, Murray MJ, Murray JT, Heat Inactivation of Garlic (Allium sativum) Extract Abrogates Growth Inhibition of HeLa Cells., Nutrition and cancer, 2016, p1-9 Journal Article, 2016 DOI

Klionsky et al, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)., Autophagy, 12, (1), 2016, p1 - 122 Journal Article, 2016 DOI

Diez-Cecilia E, Carson R, Kelly B, van Schaeybroeck S, Murray JT, Rozas I, Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway., Bioorganic & medicinal chemistry letters, 25, (19), 2015, p4287-92 Journal Article, 2015 DOI

D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB, TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities., Oncotarget, 5, (6), 2014, p1609-20 Journal Article, 2014

Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR, FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation., Autophagy, 10, (10), 2014, p1749-60 Journal Article, 2014 DOI TARA - Full Text

Huang YH, Al-Aidaroos AQ, Yuen HF, Zhang SD, Shen HM, Rozycka E, McCrudden CM, Tergaonkar V, Gupta A, Lin YB, Thiery JP, Murray JT, Zeng Q, A role of autophagy in PTP4A3-driven cancer progression., Autophagy, 10, (10), 2014, p1787-800 Journal Article, 2014 DOI TARA - Full Text

Matchett KB, McFarlane S, Hamilton SE, Eltuhamy YS, Davidson MA, Murray JT, Faheem AM, El-Tanani M, Ran GTPase in nuclear envelope formation and cancer metastasis., Advances in experimental medicine and biology, 773, 2014, p323-51 Journal Article, 2014

Pike, L.R.G., Singleton, D.C., Buffa, F., Abramczyk, O., Phadwal, K., Li, J.-L., Simon, A.K., Murray, J.T., Harris, A.L., Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival, Biochemical Journal, 449, (2), 2013, p389-400 Journal Article, 2013 DOI TARA - Full Text

Pike LR, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li JL, Simon AK, Murray JT, Harris AL, Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival., The Biochemical journal, 449, (2), 2013, p389-400 Journal Article, 2013 DOI

Rundqvist HC, Lilja MR, Rooyackers O, Odrzywol K, Murray JT, Esbjörnsson M, Jansson E., Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise., Physiological Reports, 1, (5), 2013, pe00076 Journal Article, 2013 TARA - Full Text DOI

Sahin P, McCaig C, Jeevahan J, Murray JT, Hainsworth AH, The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain., Neuropathology and applied neurobiology, 39, (6), 2013, p623-33 Journal Article, 2013 DOI

Vanbergen A & Insect Pollinators Initiative, Threats to an ecosystem service: pressures on pollinators, Frontiers in Ecology and the Environment, 11, (5), 2013, p251-259 Journal Article, 2013 DOI

Yuen HF, Abramczyk O, Montgomery G, Chan KK, Huang YH, Sasazuki T, Shirasawa S, Gopesh S, Chan KW, Fennell D, Janne P, El-Tanani M, Murray JT, Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells., Bioscience reports, 32, (4), 2012, p413-22 Journal Article, 2012

Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M, Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways., Clinical cancer research : an official journal of the American Association for Cancer Research, 18, (2), 2012, p380-91 Journal Article, 2012

McCaig C, Potter L, Abramczyk O, Murray JT, Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle., Biochemical and biophysical research communications, 411, (2), 2011, p227-34 Journal Article, 2011

McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, O'Hagan B, Odrzywol K, Murray J, Longley D, McKerr G, Fennell DA, Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK., Cell death & disease, 1, 2010, pe108 Journal Article, 2010

MacKenzie MG, Hamilton DL, Murray JT, Taylor PM, Baar K, mVps34 is activated following high-resistance contractions., The Journal of physiology, 587, (Pt 1), 2009, p253-60 Journal Article, 2009

Mackenzie MG, Hamilton DL, Murray JT, Baar K, mVps34 is activated by an acute bout of resistance exercise., Biochemical Society transactions, 35, (Pt 5), 2007, p1314-6 Journal Article, 2007

Byfield MP, Murray JT, Backer JM, hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase., The Journal of biological chemistry, 280, (38), 2005, p33076-82 Journal Article, 2005

Rixon HW, Brown G, Murray JT, Sugrue RJ, The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection., The Journal of general virology, 86, (Pt 2), 2005, p375-84 Journal Article, 2005

Murray JT, Cummings LA, Bloomberg GB, Cohen P, Identification of different specificity requirements between SGK1 and PKBalpha., FEBS letters, 579, (5), 2005, p991-4 Journal Article, 2005

Analysis of hVps34/hVps15 interactions with Rab5 in vivo and in vitro. in, 2005, pp789-99 , [Murray JT, Backer JM] Book Chapter, 2005

Murray JT, Campbell DG, Peggie M, Mora A, Alfonso M, Cohen P, Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL., The Biochemical journal, 384, (Pt 3), 2004, p489-94 Journal Article, 2004 DOI TARA - Full Text

Murray JT, Campbell DG, Morrice N, Auld GC, Shpiro N, Marquez R, Peggie M, Bain J, Bloomberg GB, Grahammer F, Lang F, Wulff P, Kuhl D, Cohen P, Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3., The Biochemical journal, 384, (Pt 3), 2004, p477-88 Journal Article, 2004 DOI TARA - Full Text

Murray JT, Panaretou C, Stenmark H, Miaczynska M, Backer JM, Role of Rab5 in the recruitment of hVps34/p150 to the early endosome., Traffic (Copenhagen, Denmark), 3, (6), 2002, p416-27 Journal Article, 2002

Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM, Chen YG, Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis., The Journal of biological chemistry, 277, (33), 2002, p29363-8 Journal Article, 2002

Murray J, Wilson L, Kellie S, Phosphatidylinositol-3' kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor., Journal of cell science, 113 Pt 2, 2000, p337-48 Journal Article, 2000

Hill K, Welti S, Yu J, Murray JT, Yip SC, Condeelis JS, Segall JE, Backer JM, Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells., The Journal of biological chemistry, 275, (6), 2000, p3741-4 Journal Article, 2000

Murray JT, Craggs G, Wilson L, Kellie S, Mechanism of phosphatidylinositol 3-kinase-dependent increases in BAC1.2F5 macrophage-like cell density in response to M-CSF: phosphatidylinositol 3-kinase inhibitors increase the rate of apoptosis rather than inhibit DNA synthesis., Inflammation research : official journal of the European Histamine Research Society ... [et al.], 49, (11), 2000, p610-8 Journal Article, 2000

Research Expertise


Autophagy; Drug Discovery; KINASE; kinase inhibitors; lipid phosphorylation; metabolism; mitophagy; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOINOSITIDE 3-KINASE; PHOSPHORYLATION; protein phosphorylation; reversible phosphorylation; Signal Transduction; xenophagy