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Dr. Marie Hanscom
Research Fellow, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Kunrong Cheng,* Shannon M. Larabee,* Mazen Tolaymat,* Marie Hanscom, Aaron C. Shang, Alyssa Schledwitz, Shien Hu, Cinthia B. Drachenberg, Min Zhan, Ahmed Chahdi, and Jean-Pierre Raufman, Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice, American Journal of Physiology-Gastrointestinal and Liver Physiology, 320, (4), 2021, p10.1152/ajpgi.00415 Journal Article, 2021

Hanscom M., Loane D.J., Aubretch T., Leser J., Molesworth K., Hedgekar N., Ritzel R.M., Abulwerdi G., Shea-Donohue T., Faden A.I., Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits, Journal of Neuroinflammation, 18, (1), 2021 Journal Article, 2021 DOI

Elise L. Ma, David J. Loane, Marie Hanscom, Bogdan A. Stoica, Alan Faden, Terez Shea-Donohue, Mechanisms Involved in the Long-Term Effects of Traumatic Brain Injury on Colonic Homeostasis, Gastroenterology, 152, (5), 2017, pS731 Journal Article, 2017 DOI

Ma E.L., Smith A.D., Desai N., Cheung L., Hanscom M., Stoica B.A., Loane D.J., Shea-Donohue T., Faden A.I., Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice, Brain, Behavior, and Immunity, 66, 2017, p56 - 69, p56-69 Journal Article, 2017 DOI

Skovira J.W., Wu J., Matyas J.J., Kumar A., Hanscom M., Kabadi S.V., Fang R., Faden A.I., Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury, Journal of Neuroinflammation, 13, (1), 2016 Journal Article, 2016 DOI

Waddell J., Hanscom M., Shalon Edwards N., McKenna M.C., McCarthy M.M., Sex differences in cell genesis, hippocampal volume and behavioral outcomes in a rat model of neonatal HI, Experimental Neurology, 275, 2016, p285 - 295, p285-295 Journal Article, 2016 DOI

Lakkaraju S.K., Mbatia H., Hanscom M., Zhao Z., Wu J., Stoica B., MacKerell A.D., Faden A.I., Xue F., Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5, Bioorganic and Medicinal Chemistry Letters, 25, (11), 2015, p2275 - 2279, p2275-2279 Journal Article, 2015 DOI

He X., Lakkaraju S.K., Hanscom M., Zhao Z., Wu J., Stoica B., Mackerell A.D., Faden A.I., Xue F., Acyl-2-aminobenzimidazoles: A novel class of neuroprotective agents targeting mGluR5, Bioorganic and Medicinal Chemistry, 23, (9), 2015, p2211 - 2220, p2211-2220 Journal Article, 2015 DOI

Xue F., Stoica B.A., Hanscom M., Kabadi S.V., Faden A.I., Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation, CNS and Neurological Disorders - Drug Targets, 13, (4), 2014, p558 - 566, p558-566 Journal Article, 2014 DOI

Stoica B.A., Loane D.J., Zhao Z., Kabadi S.V., Hanscom M., Byrnes K.R., Faden A.I., PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury, Journal of Neurotrauma, 31, (8), 2014, p758 - 772, p758-772 Journal Article, 2014 DOI

Luo T., Wu J., Kabadi S.V., Sabirzhanov B., Guanciale K., Hanscom M., Faden J., Cardiff K., Bengson C.J., Faden A.I., Propofol limits microglial activation after experimental brain trauma through inhibition of nicotinamide adenine dinucleotide phosphate oxidase., Anesthesiology, 119, (6), 2013, p1370 - 1388, p1370-1388 Journal Article, 2013 DOI

Piao C.-S., Loane D.J., Stoica B.A., Li S., Hanscom M., Cabatbat R., Blomgren K., Faden A.I., Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury, Neurobiology of Disease, 46, (3), 2012, p745 - 758, p745-758 Journal Article, 2012 DOI

Sabirzhanov B., Stoica B.A., Hanscom M., Piao C.-S., Faden A.I., Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis, Journal of Neurochemistry, 123, (4), 2012, p542 - 554, p542-554 Journal Article, 2012 DOI

Kabadi S.V., Stoica B.A., Loane D.J., Byrnes K.R., Hanscom M., Cabatbat R.M., Tan M.T., Faden A.I., Cyclin D1 gene ablation confers neuroprotection in traumatic brain injury, Journal of Neurotrauma, 29, (5), 2012, p813 - 827, p813-827 Journal Article, 2012 DOI

Kabadi S.V., Stoica B.A., Hanscom M., Loane D.J., Kharebava G., Murray II M.G., Cabatbat R.M., Faden A.I., CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury, Neurotherapeutics, 9, (2), 2012, p405 - 421, p405-421 Journal Article, 2012 DOI

Kabadi S.V., Stoica B.A., Byrnes K.R., Hanscom M., Loane D.J., Faden A.I., Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma, Journal of Cerebral Blood Flow and Metabolism, 32, (1), 2012, p137 - 149, p137-149 Journal Article, 2012 DOI

Wu J., Kharebava G., Piao C., Stoica B.A., Dinizo M., Sabirzhanov B., Hanscom M., Guanciale K., Faden A.I., Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo, PLoS ONE, 7, (7), 2012 Journal Article, 2012 DOI

Rafiq K., Hanscom M., Valerie K., Steinberg S.F., Sabri A., Novel mode for neutrophil protease cathepsin G-mediated signaling: Membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis, Circulation Research, 102, (1), 2008, p32 - 41, p32-41 Journal Article, 2008 DOI

Khadija Rafiq, Marie Hanscom, Kristoffer Valerie, Susan F. Steinberg, Abdelkarim Sabri, Novel Mode for Neutrophil Protease Cathepsin G"Mediated Signaling, Circulation Research, 102, (1), 2008, p32--41 Journal Article, 2008 DOI

Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID, Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis., Clinical cancer research : an official journal of the American Association for Cancer Research, 2005 Journal Article, 2005

Zhao R., Hanscom M., Goldman I.D., The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells, Biochimica et Biophysica Acta - Biomembranes, 1715, (1), 2005, p57 - 64, p57-64 Journal Article, 2005 DOI

Rongbao Zhao, Feng Gao, Marie Hanscom, I. David Goldman, A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors, Clinical Cancer Research, 10, (2), 2004, p718--727 Journal Article, 2004 DOI

Zhao R., Hanscom M., Chattopadhyay S., Goldman I.D., Selective Preservation of Pemetrexed Pharmacological Activity in HeLa Cells Lacking the Reduced Folate Carrier: Association with the Presence of a Secondary Transport Pathway, Cancer Research, 64, (9), 2004, p3313 - 3319, p3313-3319 Journal Article, 2004 DOI

Zhao R., Gao F., Hanscom M., Goldman I.D., A Prominent Low-pH Methotrexate Transport Activity in Human Solid Tumors: Contribution to the Preservation of Methotrexate Pharmacologic Activity in HeLa Cells Lacking the Reduced Folate Carrier, Clinical Cancer Research, 10, (2), 2004, p718 - 727, p718-727 Journal Article, 2004 DOI

Rongbao Zhao, Marie Hanscom, Shrikanta Chattopadhyay, I. David Goldman, Selective Preservation of Pemetrexed Pharmacological Activity in HeLa Cells Lacking the Reduced Folate Carrier, Cancer Research, 64, (9), 2004, p3313--3319 Journal Article, 2004 DOI

Zhao R., Chattopadhyay S., Hanscom M., Goldman I.D., Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier, Clinical Cancer Research, 10, (24), 2004, p8735 - 8742, p8735-8742 Journal Article, 2004 DOI

Research Expertise

Keywords

brain-gut axis; brain-systemic interactions; CHRONIC NEUROINFLAMMATION; INFLAMMATORY BOWEL DISEASE; NEURODEGENERATION; TRAUMATIC BRAIN INJURY

Recognition

Awards and Honours

Trainee, T32 Research Training in Gastroenterology 2017-2020

Dissertation Award, Brain Injury Association of America 2020

MBF Stereology Workshop Scholarship 2020

Young Investigator Forum, American Neurogastroenterology and Motility Society 2019

Travel Award, Graduate Student Association, University of Maryland, Baltimore 2019

Poster Award, 1st place, Frontiers in Traumatic Brain Injury 2020

Memberships

National Neurotrauma Society 2014 – Current

Society of Neurosciencee 2014 – Current

American Neurogastroenterology and Motility Society 2019 – Current

American Physiological Society 2017 – Current