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Dr. Sinead Cristin Corr
Associate Professor, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Dempsey, E. and Corr, S.C., Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives, Frontiers in Immunology, 13, (840245), 2022 Journal Article, 2022 DOI TARA - Full Text

Iyer, N. and Corr, S.C., Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease, Nutrients, 13, (12), 2021 Journal Article, 2021 DOI

Stiegeler, S. and Mercurio, K. and Iancu, M.A. and Corr, S.C., The impact of micrornas during inflammatory bowel disease: Effects on the mucus layer and intercellular junctions for gut permeability, Cells, 10, (12), 2021 Journal Article, 2021 DOI

Amy A. O'Callaghan and Elaine Dempsey and Namrata Iyer and Sarah Stiegeler and Kevin Mercurio and Siné, Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection, Frontiers in Cellular and Infection Microbiology, 11, 2021 Journal Article, 2021 DOI

Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4 Journal Article, 2020 TARA - Full Text DOI

Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 Journal Article, 2019 TARA - Full Text DOI

Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 12, (7), 2018, p835- Journal Article, 2018 TARA - Full Text DOI

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Masters SL, NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease., Nature communications, 2018 Journal Article, 2018 DOI TARA - Full Text

Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 Journal Article, 2017 TARA - Full Text DOI

Westermann C, Gleinser M, Corr SC, Riedel CU., A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue., Frontiers in microbiology, 7, 2016, p1220 Journal Article, 2016 DOI

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13 Journal Article, 2016 DOI URL

Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.] Book Chapter, 2016 URL

Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016 Conference Paper, 2016

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 TARA - Full Text URL

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 TARA - Full Text DOI

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 TARA - Full Text DOI

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 DOI TARA - Full Text

Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778 Journal Article, 2014 TARA - Full Text DOI

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 DOI TARA - Full Text

Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299 Journal Article, 2012 TARA - Full Text DOI

Gantier, M.P., Stunden, H.J., McCoy, C.E., Behlke, M.A., Wang, D., Kaparakis-Liaskos, M., Sarvestani, S.T., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., A miR-19 regulon that controls NF-"B signaling, Nucleic Acids Research, 40, (16), 2012, p8048-8058 Journal Article, 2012

AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery, LABORATORY INVESTIGATION, 92, NATURE PUBLISHING GROUP, 2012 Conference Paper, 2012

Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012 Journal Article, 2012 TARA - Full Text DOI

Andrea Scharfe Nugent, Sinead Corr, John O'leary, Sean Daly, Luke O'neill, A novel role for free fetal DNA in non-infectious preterm birth, American Journal of Obstetrics & Gynecology, 204, Elsevier, 2011 Conference Paper, 2011

AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, A Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9, LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, 90, NATURE PUBLISHING GROUP, 2010 Conference Paper, 2010

Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S. , The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue. , Gastroenterology, 2009, pp243 Conference Paper, 2009

Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709 Journal Article, 2009 DOI

Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens in, Advances in Food and Nutrition Research, 2009, pp1-15 , [Corr, S.C., Hill, C., Gahan, C.G.M.] Book Chapter, 2009

Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357 Journal Article, 2009 DOI

Corr, S.C., Gahan, C.G. and Hill, C. , M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. , FEMS Immunology & Medical Microbiology, 52, (1), 2008, p2-12 Journal Article, 2008 DOI

Corr, S.C., Li, Y., Riedel, C.U., O'Toole, P.W., Hill, C. and Gahan, C.G. , Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118., Proceedings of the National Academy of Sciences of the USA, 104, (8), 2007, p7617-7621 Journal Article, 2007 DOI

Corr, S.C., Gahan, C.G. and Hill, C., Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response, FEMS Immunology & Medical Microbiology, 50, (3), 2007, p380-388 Journal Article, 2007 DOI

Corr, S.C., O'Hara, A.M., O'Mahony, L., Shanahan, F., Hill, C. and Gahann, C.G. , Induction of CCL20 by Listeria monocytogenes is dependent upon entry to the host cell cytosol., Gastroenterology, 2007, pp132 Conference Paper, 2007

Bron, P.A., Monk, I.R., Corr, S.C., Hill, C. and Gahan, C.G., Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes., Applied and Environmental Microbiology, 72, (4), 2006, p2876-2884 Journal Article, 2006 DOI

Corr, S., Hill, C. and Gahan, C.G., An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells., Microbial Pathogenesis, 41, (6), 2006, p241-250 Journal Article, 2006 DOI

Research Expertise

Keywords

; BACTERIAL INFECTION; EPITHELIAL PERMEABILITY; GUT BARRIER FUNCTION; IBD; Infection and immunity; INFLAMMATION; Intestinal Barrier Function; INTESTINAL EPITHELIAL-CELLS; INTESTINAL INFECTIONS; INTESTINAL INFLAMMATION; MICROBIOTA; miRNA; Molecular basis to inflammation and innate immunity; MOUSE MODELS; Probiotic

Recognition

Awards and Honours

Frontiers for the Future, SFI 2020

Starting Investigator Research Grant, SFI 2011

Crohn's and Colitis Foundation of America, Litwin IBD Pioneer Award 2016

Aurora Leadership Development Programme, Advance HE 2019

Irish Representative, Microbiology Society "Young Microbiologist of the Year" British Isles. 2007

Irish Society of Gastroenterology Spring Meeting, Ireland, Awarded best talk. 2007

Rowett Research Institute-Institut National de la Recherche Agronomique, Gut Microbiology Symposium, Aberdeen, Scotland, Awarded best talk. 2006

Society for General Microbiology, Dublin, Awarded best talk. 2006

Presidents Fund Award, Society for General Microbiology 2004

Travel Award: INRA-Gut Microbiology, France 2004

Travel Award:American Society of Microbiologists & International Union of Microbiological Societies (IUMS) Congresses U.S.A. 2005

Travel Award: Microbiology Society, IUMS Congress, U.S.A. 2005

Travel Award: FEMS, Microbiology Symposium, Spain 2006

Travel Award: INRA-Gut Microbiology, Scotland 2006

Travel Award,, Fundacao Oswaldo Cruz, Rio de Janeiro, Brasil 2013

Travel Award: Microbiology Society Meeting, Dublin 2006

Memberships

Adjunct Faculty Member APC Microbiome Ireland 2017 – Present

Microbiology Society 2002 – Present

Irish Society of Immunology 2008 – Present

Irish Epithelial Physiology Group 2015 – Present

Irish Society of Gastroenterology 2006 – Present

Dublin Academy of Pathogenomics and Infection Biology 2015 – Present

American Gastroenterological Association 2002 – 2014