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Dr. Sinead Cristin Corr
Associate Professor, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Stiegeler, S., Corr, S.C., Investigating the protective impact of the miR-21 depleted microbiome on the intestinal barrier", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022 Poster, 2022

Stiegeler. S., Corr S.C., , miR-21 negatively impacts the mucus barrier, gut microbiome and subsequent inflammation, Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential, Trinity College Dublin, 27-28 Oct , 2022 Oral Presentation, 2022

Iyer N, Williams MA, O'Callaghan AA, Dempsey E, Cabrera-Rubio R, Raverdeau M, Crispie F, Cotter PD, Corr SC. , Lactobacillus salivarius UCC118" Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model. Microorganisms. , Microorganisms, 2022 Journal Article, 2022 URL

Sheehan, K., Sheridan, H., Corr, S.C., Characterising the Potential Therapeutic Effects of Indane Dimers against Chronic Gut Inflammation", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022 Poster, 2022

McKiernan, I., Corr, S.C, Screening for novel postbiotics with anti-inflammatory potential in macrophages, Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential, Trinity College Dublin, 27-28 Oct , 2022 Poster, 2022

Mercurio, K., Corr, S.C.,, The mechanistic impact of miR-21 on intercellular junctions and susceptibility to intestinal inflammation", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022 Poster, 2022

Mercurio, K., Corr, S.C., , The mechanistic impact of miR-21 on intercellular junctions and susceptibility to intestinal inflammation", Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential,, Trinity College Dublin, 27-28 Oct , 2022 Poster, 2022

Stiegeler, S, Corr S.C., , Investigating the protective impact of the miR-21 depleted microbiome on the intestinal barrier", MUCIN2022 conference, Utrecht, Netherlands, 27-29 Jul , 2022 Poster, 2022

Iyer, N. and Williams, M.A. and O†Callaghan, A.A. and Dempsey, E. and Cabrera-Rubio, R. and Raverdeau, M. and Crispie, F. and Cotter, P.D. and Corr, S.C., Lactobacillus salivarius UCC118â"¢ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model, Microorganisms, 10, (7), 2022 Journal Article, 2022 DOI

Sheehan, K., Sheridan, H., Corr, S.C. , Characterising the Potential Therapeutic Effects of Indane Dimers against Chronic Gut Inflammation", Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential, Trinity College Dublin, 27-28 Oct , 2022 Poster, 2022

Wang J, Dempsey E, Corr SC, Kukula-Koch W, Sasse A, Sheridan H., The Traditional Chinese Medicine Houttuynia cordata Thunb decoction alters intestinal barrier function via an EGFR dependent MAPK (ERK1/2) signalling pathway, Phytomedicine , 2022 Journal Article, 2022

Dempsey E, Corr SC. , Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives, Frontiers in Immunology, 13, (840245), 2022 Journal Article, 2022 TARA - Full Text DOI

Iyer, N. and Corr, S.C., Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease, Nutrients, 13, (12), 2021 Journal Article, 2021 DOI

Iyer, N., McLoughlin, R., Corr, S.C., , Free microbial metabolites from healthy and dysbiotic gut microbiota differentially regulate intestinal immune response", Host-Pathogen Communication, Ireland-Israel-Denmark Meeting, Trinity College Dublin, 10-11 Nov, 2021 Poster, 2021

Dempsey, E., Corr, S.C., Sheedy, F.S., , Immunomodulatory Properties of a Naturally-Derived Macrofungal ß-Glucan in Gastrointestinal Inflammation", Host-Pathogen Communication, Ireland-Israel-Denmark Meeting, Trinity College Dublin, 10-11 Nov, 2021 Poster, 2021

Stiegeler S, Mercurio K, Iancu MA, Corr SC. , The impact of micrornas during inflammatory bowel disease: Effects on the mucus layer and intercellular junctions for gut permeability, Cells, 10, (12), 2021 Journal Article, 2021 DOI

O'Callaghan AA, Dempsey E, Iyer N, Stiegeler S, Mercurio K, Corr SC., Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection, Frontiers in Cellular and Infection Microbiology, 11, 2021 Journal Article, 2021 DOI

AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, 'Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery', LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, 2021 Conference Paper, 2021

Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4 Journal Article, 2020 TARA - Full Text DOI

O'Callaghan AA, Corr SC, Intestinal Metabolites Enhance Intestinal Barrier Defences Against Inflammation & Infection", The 8th Exploring Human Host-Microbiome Interactions in Health and Disease meeting, , Wellcome Genome Campus, UK, 23"25 October, 2019 Oral Presentation, 2019

Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 Journal Article, 2019 DOI TARA - Full Text

O'Callaghan AA, Corr SC, , Modulation of the Antibacterial Activities of Macrophages by Gut Metabolites, rish Society of Immunology, Annual Meeting, Royal College of Surgeons Ireland, 19-20 Sep , 2019 Poster, 2019

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Masters SL, NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease., Nature communications, 2018 Journal Article, 2018 DOI TARA - Full Text

Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 12, (7), 2018, p835- Journal Article, 2018 TARA - Full Text DOI

Williams MA, Corr SC,, Modulation of Intestinal Immunity by Lactobacillus salivarius, Irish Society of Immunology, Annual Meeting, Trinity College Dublin, 30-31 Aug, 2018 Poster, 2018

Williams MA, Corr SC, Probiotic modulation of intestinal immunity, Microbiology Society Focussed Meeting: Microbes and Mucosal Surfaces, University College Dublin, 21st June , 2018 Oral Presentation, 2018

Williams MA, Corr SC, Probiotic modulation of inflammatory microRNA-21 in a mouse model of colitis, 8th Meeting of the Dublin Academy of Pathogenomics & Infection Biology, Trinity College Dublin, 12th Jan, 2018 Oral Presentation, 2018

Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 Journal Article, 2017 TARA - Full Text DOI

Johnston, D., O"Neill, L.A., Corr SC, Loss of microRNA-21 protects against inflammation in a mouse model of colitis, 7th Meeting of the Dublin Academy of Pathogenomics & Infection Biology, University College Dublin, 2017, 2017 Poster, 2017

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 URL TARA - Full Text

Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13 Journal Article, 2016 URL DOI

Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.] Book Chapter, 2016 URL

Westermann, C. and Gleinser, M. and Corr, S.C. and Riedel, C.U., A critical evaluation of bifidobacterial adhesion to the host tissue, Frontiers in Microbiology, 7, (AUG), 2016 Journal Article, 2016 DOI

Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016 Conference Paper, 2016

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Westermann C, Gleinser M, Corr SC, Riedel CU., A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue., Frontiers in microbiology, 7, 2016, p1220 Journal Article, 2016 DOI

Johnston, D., O"Neill, L.A., Corr SC, Loss of microRNA-21 protects against inflammation in a mouse model of colitis, Joint Meeting of the Irish Society for Immunology and The Society for General Microbiology, Cork, 1-2 Sept 2016, 2016 Poster, 2016

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 DOI TARA - Full Text

Johnston DGW, O'Neill LAJ, Corr SC, MicroRNA-21 regulates phagocytic responses during infection with Listeria, Irish Society of Immunology, Annual Meeting, Trinity College Dublin, 14-15 Sep. 2015, 2015 Poster, 2015

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 DOI TARA - Full Text

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 TARA - Full Text DOI

Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778 Journal Article, 2014 TARA - Full Text DOI

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 DOI TARA - Full Text

Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012 Journal Article, 2012 TARA - Full Text DOI

Gantier, M.P., Stunden, H.J., McCoy, C.E., Behlke, M.A., Wang, D., Kaparakis-Liaskos, M., Sarvestani, S.T., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., A miR-19 regulon that controls NF-"B signaling, Nucleic Acids Research, 40, (16), 2012, p8048-8058 Journal Article, 2012

Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299 Journal Article, 2012 DOI TARA - Full Text

AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery, LABORATORY INVESTIGATION, 92, NATURE PUBLISHING GROUP, 2012 Conference Paper, 2012

Andrea Scharfe Nugent, Sinead Corr, John O'leary, Sean Daly, Luke O'neill, A novel role for free fetal DNA in non-infectious preterm birth, American Journal of Obstetrics & Gynecology, 204, Elsevier, 2011 Conference Paper, 2011

AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9., LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP , 2010 Conference Paper, 2010

AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, A Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9, LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, 90, NATURE PUBLISHING GROUP, 2010 Conference Paper, 2010

Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709 Journal Article, 2009 DOI

Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357 Journal Article, 2009 DOI

Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S. , The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue. , Gastroenterology, 2009, pp243 Conference Paper, 2009

Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S, 'The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue, Gastroenterology, 2009 Conference Paper, 2009

Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens in, Advances in Food and Nutrition Research, 2009, pp1-15 , [Corr, S.C., Hill, C., Gahan, C.G.M.] Book Chapter, 2009

Corr, S.C., Gahan, C.G. and Hill, C. , M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. , FEMS Immunology & Medical Microbiology, 52, (1), 2008, p2-12 Journal Article, 2008 DOI

Corr, S.C., Li, Y., Riedel, C.U., O'Toole, P.W., Hill, C. and Gahan, C.G. , Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118., Proceedings of the National Academy of Sciences of the USA, 104, (8), 2007, p7617-7621 Journal Article, 2007 DOI

Corr, S.C., Gahan, C.G. and Hill, C., Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response, FEMS Immunology & Medical Microbiology, 50, (3), 2007, p380-388 Journal Article, 2007 DOI

Corr, S.C., O'Hara, A.M., O'Mahony, L., Shanahan, F., Hill, C. and Gahann, C.G. , Induction of CCL20 by Listeria monocytogenes is dependent upon entry to the host cell cytosol., Gastroenterology, 2007, pp132 Conference Paper, 2007

Bron, P.A., Monk, I.R., Corr, S.C., Hill, C. and Gahan, C.G., Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes., Applied and Environmental Microbiology, 72, (4), 2006, p2876-2884 Journal Article, 2006 DOI

Corr, S., Hill, C. and Gahan, C.G., An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells., Microbial Pathogenesis, 41, (6), 2006, p241-250 Journal Article, 2006 DOI

Non-Peer-Reviewed Publications

Corr, S.C., Microbiome and Mucosal Immunity, APC Microbiome Ireland, Annual Symposium, University College Cork, 07 Oct 2022, 2022 Invited Talk, 2022

Corr, S.C., Exploring the host-microbiome relationship in health/disease & therapeutic opportunities, DU MicroSoc-Yakult Focused Meeting Microbiomes and Human Health, Trinity College Dublin, 13th June 2022 , 2022 Invited Talk, 2022

Corr, S.C., The gut microbiome & mucosal immunity, Advances in Infection Biology, University College Dublin, 07 Mar 2022, 2022 Invited Talk, 2022

Sinead Corr, "Unravelling interactions between the gut microbiome & the immune system to decipher mechanisms of disease, APC Microbiome Ireland Research Symposium, University College Cork, 2020 Invited Talk, 2020

Corr, S.C., Decoding the dialogue between the microbiota and gut immunity in health & disease, Irish College of Opthamologists, Annual Conference, Galway, 15-17 May 2019 , 2019 Invited Talk, 2019

Corr, S.C., Novel regulators of barrier function, the gut microbiota and intestinal health, Microbes in Medicine, Microbiology Society, Trinity College Dublin, 24-25 Oct 2019, 2019 Invited Talk, 2019

Corr, S.C., Gut Microbiome-Immune system crosstalk in health & disease, PharmTox Society Public Symposium Microbiome-Management and Manipulation, University College Dublin, 2018, 2018 Invited Talk, 2018

Sinead Corr, The contribution of the microbiome to IBD susceptibility, AMNCH, Tallaght University Hospital, 2018 Invited Talk, 2018

Corr, S.C., Ireland at the cutting edge of gut health research, "Beneficial Bacteria: Positioning Ireland as a centre for excellence and innovation in gut health nutrition", Public Forum hosted by Purefiber Ltd, Science Gallery, Dublin, 2018, 2018 Invited Talk, 2018

Research Expertise

Description

Research in the Corr group focusses primarily on the host-microbe interface within the gastrointestinal (GI) tract. Using in vivo based methods combined with Next-Generation Sequencing we explore specific hypotheses about the host-microbiome relationship, assessing the impact of the gut microbiome on health and deciphering the mechanisms underlying disease associations. Of particular interest, gastroenteritis, including bacterial infectious diseases, are a major cause of morbidity and mortality worldwide, while inflammatory bowel diseases (IBDs) affect over 2 million people in Europe. Our research has a key focus on IBD and we target Microbiome, Metabolome, cytokine and microRNA networks to understand how healthy immune responses are maintained at the intestinal mucosal barrier and what processes over-ride this during disease or in response to infection. This research has a strong translational focus with the aim of identifying therapeutic strategies including novel dietary interventions, postbiotics and naturally-sourced bio-actives to manipulate intestinal immunity and enhance the beneficial aspects of the gut microbiome, with the ultimate goal of boosting health.

Projects

  • Title
    • Resist-AMR Antimicrobial Resistance: Engineering Natural, One- Health, Systems Thinking Solutions to a Manmade Global Disaster
  • Funding Agency
    • Trinity College Dublin Alumni
  • Date From
    • 2023
  • Date To
    • 2027
  • Title
    • Exploring miR-21 in the dialogue between the microbiome and immunity to decipher mechanisms of disease
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2020
  • Date To
    • 2024
  • Title
    • Mushroom digestion as a model to re-define gut-immune system cross-talk via Innate Immune Training.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2020
  • Date To
    • 2022
  • Title
    • Investigating the anti-inflammatory properties of mushrooms
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2022
  • Date To
    • 2024
  • Title
    • The Role of Aquamin in gut microbiome-host interaction
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2022
  • Date To
    • 2024
  • Title
    • Immuno-modulatory potential of Free Microbial metabolites: Leveraging metabolomics to identify bioactive compounds that promote immune homeostasis in the gut
  • Funding Agency
    • Marie Sklodowska-Curie actions
  • Date From
    • 2020
  • Date To
    • 2022
  • Title
    • Exploration of the role of microRNA(miR)-21 in gut homeostasis and disease
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2012
  • Date To
    • 2020
  • Title
    • The Potential therapeutic effects of indane dimers against chronic gut inflammation
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2022
  • Date To
    • 2025
  • Title
    • Unravelling the relationship between host miRNAs and the gut microbiome in IBD
  • Funding Agency
    • Trinity College Dublin
  • Date From
    • 2020
  • Date To
    • 2024
  • Title
    • Investigating the role of the metabolic intermediate succinate in IBD.
  • Funding Agency
    • Crohns and Colitis Foundation America
  • Date From
    • 2016
  • Date To
    • 2017

Keywords

; BACTERIAL INFECTION; BIOACTIVE PEPTIDES; EPITHELIAL PERMEABILITY; Functional Food; GUT BARRIER FUNCTION; IBD; Infection and immunity; INFLAMMATION; Intestinal Barrier Function; INTESTINAL EPITHELIAL-CELLS; INTESTINAL INFECTIONS; INTESTINAL INFLAMMATION; microbiome; MICROBIOTA; miRNA; Molecular basis to inflammation and innate immunity; MOUSE MODELS; Prebiotic; Probiotic

Recognition

Representations

Director of Equality Diversity and Inclusion, School of Genetics & Microbiology, Trinity College Dublin 2020

Prokaryotic Division Committee Member, Microbiology Society UK/Irl 2020

CHARM-EU Master"s in Global Challenges for Sustainability, core Knowledge Creating Team (Food) 2020

Faculty and Funded Investigator, APC Microbiome Ireland, Cork 2017

FEMS Microbiology Letters, Handling Editor 2020

Animal Welfare Body, Trinity College Dublin: Scientific Advisor Since 2015

Review Editor for, Frontiers in Pharmacology, Gastrointestinal and Hepatic Pharmacology 2016

Champion, Microbiology Society (UK/Ireland). Since 2016

Member of the Microbiology Society UK/Irl - SFI Focus Group 2019

Member, Microbiome Stakeholder workshop, Microbiology Society UK/Irl, Dublin. 2016

Awards and Honours

Science Foundation Ireland Frontiers for the Future, Project Award 2020

Science Foundation Ireland, Starting Investigator Research Grant 2011

Crohn's and Colitis Foundation of America, Litwin IBD Pioneer Award 2016

Aurora Leadership Development Programme, Advance HE 2019

Irish Representative, Microbiology Society Young Microbiologist of the Year, British Isles. 2007

Irish Society of Gastroenterology Spring Meeting, Ireland, Awarded best talk. 2007

Rowett Research Institute-Institut National de la Recherche Agronomique, Gut Microbiology Symposium, Aberdeen, Scotland, Awarded best talk. 2006

Society for General Microbiology, Dublin, Awarded best talk. 2006

Travel Award:American Society of Microbiologists & International Union of Microbiological Societies (IUMS) Congresses U.S.A. 2005

Presidents Fund Award, Society for General Microbiology 2004

Travel Award: INRA-Gut Microbiology, France 2004

Travel Award: Microbiology Society, IUMS Congress, U.S.A. 2005

Travel Award: FEMS, Microbiology Symposium, Spain 2006

Travel Award: INRA-Gut Microbiology, Scotland 2006

Travel Award,, Fundacao Oswaldo Cruz, Rio de Janeiro, Brasil 2013

Travel Award: Microbiology Society Meeting, Dublin 2006

Memberships

Microbiology Society UK/Irl Present – 2002

Irish Society of Immunology 2008 – Present

Irish Epithelial Physiology Group 2015 – Present

Irish Society of Gastroenterology 2006 – Present

Dublin Academy of Pathogenomics and Infection Biology 2015 – Present

American Gastroenterological Association 2002 – 2014