Dr. Sinead Cristin Corr
Associate Professor, Microbiology
Biography
Dr Sinéad Corr qualified with a BSc Microbiology in 2002 and in 2007 with a PhD in Molecular Microbiology from the Dept. of Microbiology and Alimentary Pharmabiotic Centre (APC), University College Cork (UCC). This was followed by postdoctorate work as part of a collaboration between GlaxoSmithKline and APC (2006-2008), and subsequently with Prof. Luke O'Neill's Inflammation Research Group, at the School of Biochemistry and Immunology, Trinity College Dublin (TCD) (2008-2015). In 2015, Sinéad obtained an academic position in the Dept. of Microbiology, TCD, where she established the Microbiome & Mucosal Immunity research group. Dr Corr is also Faculty member and Funded Investigator with APC Microbiome Ireland, Cork.
Publications and Further Research Outputs
Peer-Reviewed Publications
Iyer N, Williams MA, O'Callaghan AA, Dempsey E, Cabrera-Rubio R, Raverdeau M, Crispie F, Cotter PD, Corr SC. , Lactobacillus salivarius UCC118" Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model. Microorganisms. , Microorganisms, 2022
Sheehan, K., Sheridan, H., Corr, S.C., Characterising the Potential Therapeutic Effects of Indane Dimers against Chronic Gut Inflammation", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022
Stiegeler, S, Corr S.C., , Investigating the protective impact of the miR-21 depleted microbiome on the intestinal barrier", MUCIN2022 conference, Utrecht, Netherlands, 27-29 Jul , 2022
Mercurio, K., Corr, S.C.,, The mechanistic impact of miR-21 on intercellular junctions and susceptibility to intestinal inflammation", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022
Iyer, N. and Williams, M.A. and Oâ Callaghan, A.A. and Dempsey, E. and Cabrera-Rubio, R. and Raverdeau, M. and Crispie, F. and Cotter, P.D. and Corr, S.C., Lactobacillus salivarius UCC118â"¢ Dampens Inflammation and Promotes Microbiota Recovery to Provide Therapeutic Benefit in a DSS-Induced Colitis Model, Microorganisms, 10, (7), 2022
Wang J, Dempsey E, Corr SC, Kukula-Koch W, Sasse A, Sheridan H., The Traditional Chinese Medicine Houttuynia cordata Thunb decoction alters intestinal barrier function via an EGFR dependent MAPK (ERK1/2) signalling pathway, Phytomedicine , 105, 2022, p154353-
Sheehan, K., Sheridan, H., Corr, S.C. , Characterising the Potential Therapeutic Effects of Indane Dimers against Chronic Gut Inflammation", Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential, Trinity College Dublin, 27-28 Oct , 2022
Stiegeler. S., Corr S.C., , miR-21 negatively impacts the mucus barrier, gut microbiome and subsequent inflammation, Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential, Trinity College Dublin, 27-28 Oct , 2022
John R. Kelly, Gerard Clarke, Andrew Harkin, Sinead C. Corr, Stephen Galvin, Vishnu Pradeep, John F. Cryan, Veronica O'Keane, Timothy G. Dinan, Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis, International Journal of Clinical and Health Psychology, 2022
Stiegeler, S., Corr, S.C., Investigating the protective impact of the miR-21 depleted microbiome on the intestinal barrier", Irish Society of Immunology, Annual meeting,, Maynooth, Ireland, 01-02 Sep, 2022
Mercurio, K., Corr, S.C., , The mechanistic impact of miR-21 on intercellular junctions and susceptibility to intestinal inflammation", Microbiology Society UK, Focussed Meeting Microbiome and Mucosa-associated infectious disease: Mining for antimicrobial and postbiotics with therapeutic potential,, Trinity College Dublin, 27-28 Oct , 2022
Dempsey E, Corr SC. , Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives, Frontiers in Immunology, 13, (840245), 2022
O'Callaghan AA, Dempsey E, Iyer N, Stiegeler S, Mercurio K, Corr SC., Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection, Frontiers in Cellular and Infection Microbiology, 11, 2021
Dempsey, E., Corr, S.C., Sheedy, F.S., , Immunomodulatory Properties of a Naturally-Derived Macrofungal ß-Glucan in Gastrointestinal Inflammation", Host-Pathogen Communication, Ireland-Israel-Denmark Meeting, Trinity College Dublin, 10-11 Nov, 2021
AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, 'Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery', LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, 2021
Jinfan Wang, Sinead Corr, Astrid Sasse, Helen Sheridan, Scientific evaluation of traditional chinese medicine (TCD) Houttuynia cordata Thunb (Yu xing Tao) A case study., Planta Medica, 69th Internatinal Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Bonn, Germany, Sept. 6-8 2021, Thieme, 2021
Iyer, N. and Corr, S.C., Gut microbial metabolite-mediated regulation of the intestinal barrier in the pathogenesis of inflammatory bowel disease, Nutrients, 13, (12), 2021
Stiegeler S, Mercurio K, Iancu MA, Corr SC. , The impact of micrornas during inflammatory bowel disease: Effects on the mucus layer and intercellular junctions for gut permeability, Cells, 10, (12), 2021
Iyer, N., McLoughlin, R., Corr, S.C., , Free microbial metabolites from healthy and dysbiotic gut microbiota differentially regulate intestinal immune response", Host-Pathogen Communication, Ireland-Israel-Denmark Meeting, Trinity College Dublin, 10-11 Nov, 2021
Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4
O'Callaghan AA, Corr SC, , Modulation of the Antibacterial Activities of Macrophages by Gut Metabolites, rish Society of Immunology, Annual Meeting, Royal College of Surgeons Ireland, 19-20 Sep , 2019
Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5
O'Callaghan AA, Corr SC, Intestinal Metabolites Enhance Intestinal Barrier Defences Against Inflammation & Infection", The 8th Exploring Human Host-Microbiome Interactions in Health and Disease meeting, , Wellcome Genome Campus, UK, 23"25 October, 2019
Williams MA, Corr SC, Probiotic modulation of inflammatory microRNA-21 in a mouse model of colitis, 8th Meeting of the Dublin Academy of Pathogenomics & Infection Biology, Trinity College Dublin, 12th Jan, 2018
Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Masters SL, NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease., Nature communications, 2018
Williams MA, Corr SC, Probiotic modulation of intestinal immunity, Microbiology Society Focussed Meeting: Microbes and Mucosal Surfaces, University College Dublin, 21st June , 2018
Williams MA, Corr SC,, Modulation of Intestinal Immunity by Lactobacillus salivarius, Irish Society of Immunology, Annual Meeting, Trinity College Dublin, 30-31 Aug, 2018
Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 12, (7), 2018, p835-
Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201
Johnston, D., O"Neill, L.A., Corr SC, Loss of microRNA-21 protects against inflammation in a mouse model of colitis, 7th Meeting of the Dublin Academy of Pathogenomics & Infection Biology, University College Dublin, 2017, 2017
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379
Johnston, D., O"Neill, L.A., Corr SC, Loss of microRNA-21 protects against inflammation in a mouse model of colitis, Joint Meeting of the Irish Society for Immunology and The Society for General Microbiology, Cork, 1-2 Sept 2016, 2016
Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787
Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016
Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.]
Westermann, C. and Gleinser, M. and Corr, S.C. and Riedel, C.U., A critical evaluation of bifidobacterial adhesion to the host tissue, Frontiers in Microbiology, 7, (AUG), 2016
Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60
Johnston DGW, O'Neill LAJ, Corr SC, MicroRNA-21 regulates phagocytic responses during infection with Listeria, Irish Society of Immunology, Annual Meeting, Trinity College Dublin, 14-15 Sep. 2015, 2015
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437
Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+
Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299
AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery, LABORATORY INVESTIGATION, 92, NATURE PUBLISHING GROUP, 2012
Gantier, M.P., Stunden, H.J., McCoy, C.E., Behlke, M.A., Wang, D., Kaparakis-Liaskos, M., Sarvestani, S.T., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., A miR-19 regulon that controls NF-"B signaling, Nucleic Acids Research, 40, (16), 2012, p8048-8058
Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012
Andrea Scharfe Nugent, Sinead Corr, John O'leary, Sean Daly, Luke O'neill, A novel role for free fetal DNA in non-infectious preterm birth, American Journal of Obstetrics & Gynecology, 204, Elsevier, 2011
AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9., LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP , 2010
AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, A Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9, LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, 90, NATURE PUBLISHING GROUP, 2010
Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S. , The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue. , Gastroenterology, 2009, pp243
Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709
Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S, 'The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue, Gastroenterology, 2009
Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens in, Advances in Food and Nutrition Research, 2009, pp1-15 , [Corr, S.C., Hill, C., Gahan, C.G.M.]
Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357
Corr, S.C., Gahan, C.G. and Hill, C. , M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. , FEMS Immunology & Medical Microbiology, 52, (1), 2008, p2-12
Corr, S.C., O'Hara, A.M., O'Mahony, L., Shanahan, F., Hill, C. and Gahann, C.G. , Induction of CCL20 by Listeria monocytogenes is dependent upon entry to the host cell cytosol., Gastroenterology, 2007, pp132
Corr, S.C., Li, Y., Riedel, C.U., O'Toole, P.W., Hill, C. and Gahan, C.G. , Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118., Proceedings of the National Academy of Sciences of the USA, 104, (8), 2007, p7617-7621
Corr, S.C., Gahan, C.G. and Hill, C., Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response, FEMS Immunology & Medical Microbiology, 50, (3), 2007, p380-388
Corr, S., Hill, C. and Gahan, C.G., An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells., Microbial Pathogenesis, 41, (6), 2006, p241-250
Bron, P.A., Monk, I.R., Corr, S.C., Hill, C. and Gahan, C.G., Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes., Applied and Environmental Microbiology, 72, (4), 2006, p2876-2884
Non-Peer-Reviewed Publications
Sinead Corr, "Unravelling interactions between the gut microbiome & the immune system to decipher mechanisms of disease, APC Microbiome Ireland Research Symposium, University College Cork, 2020
Corr, S.C., Decoding the dialogue between the microbiota and gut immunity in health & disease, Irish College of Opthamologists, Annual Conference, Galway, 15-17 May 2019 , 2019
Corr, S.C., Novel regulators of barrier function, the gut microbiota and intestinal health, Microbes in Medicine, Microbiology Society, Trinity College Dublin, 24-25 Oct 2019, 2019
Corr, S.C., Gut Microbiome-Immune system crosstalk in health & disease, PharmTox Society Public Symposium Microbiome-Management and Manipulation, University College Dublin, 2018, 2018
Sinead Corr, The contribution of the microbiome to IBD susceptibility, AMNCH, Tallaght University Hospital, 2018
Corr, S.C., Ireland at the cutting edge of gut health research, "Beneficial Bacteria: Positioning Ireland as a centre for excellence and innovation in gut health nutrition", Public Forum hosted by Purefiber Ltd, Science Gallery, Dublin, 2018, 2018
Research Expertise
Description
Using in vitro and in vivo based models and analysis of clinical samples combined with Next-Generation Sequencing my research explores specific hypotheses about the host-microbiome relationship, assessing the impact of the gut microbiome on health and deciphering the mechanisms underlying disease associations. Of interest, gastroenteritis, including bacterial infectious diseases, are a major cause of morbidity and mortality worldwide, while inflammatory bowel diseases affect over 2 million people in Europe. Our research has a key focus on IBD and we target Microbiome, Metabolome, cytokine and microRNA networks to understand how healthy immune responses are maintained at the intestinal mucosal barrier and what processes over-ride this during disease or infection. This research has a strong translational focus maintained by active collaboration with clinician colleagues and industrial biopharma partners, with the aim of identifying therapeutic strategies including novel dietary interventions, postbiotics and naturally-sourced bio-actives to manipulate intestinal immunity and enhance the beneficial aspects of the gut microbiome, with the ultimate goal of boosting health. Core Research Strands: Regulation of the intestinal epithelial barrier & immunity: Implications for infectious disease and inflammation Novel regulators of innate immunity and the Microbiome: MicroRNAs Exploring the functional attributes of the microbiome (including pathogenic and non-pathogenic bacteria) and its metabolites Pathogenesis of bacterial infection and identification of novel antimicrobials Therapeutic Manipulation of the Microbiome, Intestinal Immunity and Health: Dietary Interventions and functional foods; microbiome-based strategies including probiotics and postbiotic; Naturally-sourced bio-actives; novel antimicrobials;Recognition
Memberships
Committee member of the Prokaryotic Division, Microbiology Society UK & Ireland
Member of Core Knowledge Creating Team (Life & Health: Food) CharmEU Initiative
Faculty, APC Microbiome Ireland, Cork
Scientific Advisor on the Animal Welfare Body, Trinity College Dublin
Microbiology Society UK & Ireland
Irish Society of Immunology
Irish Epithelial Physiology Group
Irish Society of Gastroenterology
Dublin Academy of Pathogenomics and Infection Biology
American Gastroenterological Association