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Selected scientific collaborations (Past and present)

Title: Molecular definition of the sequences within PATH proteins that are required for aggregation and mammalian cell interaction – a fluorescent assay of invasion
Collaborative Body: Science foundation Ireland
Status: Active
Details:  Fluorescent studies for monitoring invasion of al Escherichia coli into mammalian cells.
Principal investigators: Dr Stephen Smith and Anthony Davies (TCD) 

Title: Study of the Molecular Mechanisms of Cell Migration in circulating t lymphocytes using siRNA.  

Collaborative Body: Marie-Curie Programme (EU)
Status: Active
Details:  To elucidate the mechanisms involved in T lymphocyte migration using genome scale siRNA library and High content Screening platform.  The funding of this project has duration of 5 years and funding for 4 research staff.
Principal investigators: Prof. Dermot Kelleher and Dr Aideen Long (TCD)

Title: The RNAi Global Initiative
Collaborative Interaction: Thermofisher Biosciences (Dharmacon) and IMM Trinity College Dublin.
Status: Active
Details: This ongoing interaction between the RNAi Global Initiative and TCD researchers is in place to share information with other participating members to collectively facilitate the consortiums genome-wide siRNA screening activities.

Title: Cell based assay miniaturisation for siRNA screening
Collaborative Interaction: Labcyte Sunnyvale California and Trinity College Dublin.
Status: Active
Details: We have been working with labcyte and their Acoustic Dispensing instrumentation (the Labcyte Echo 555) with the aim to find a reliable and straight forward means of miniaturising cell based assays for high content screening.  Our main focus is utilising this technology for use within our own siRNA screens.    
Principal Investigator: Anthony Davies (TCD)
Associated Link: http://www.labcyte.com/_fileupload/SBS09_RNAi_Poster.pdf

Title: SFI Research Cluster in Cancer Research
Collaborative Body: Science Foundation Ireland
Status: Active
Details: Target Identification using HCS for focused siRNA and Small molecule Screens.  Elucidating the mechanisms of drug resistance in breast and other cancers.
Principle investigator: Prof. Ken O’Byrne (TCD)
http://www.dcu.ie/news/2009/jun/s0609o.shtml

Title: Assay Miniaturisation for High Content Screening
Collaborative Body: AstraZeneca  and Trinity College Dublin
Status: Active
Details: Development of a Nano scale assay system for drug discovery 
Principle investigator: Dr Anthony Davies (TCD), Dr Peter Simpson (AZ)

Title: The potential of using High Content Screening technology as a primary and secondary screening platform, for the study of bioactivity of marine organism extracts.
Collaborative Body: Marine Biodiscovery/ Biotechnology Research Programme
Status: Completed
Details: The ultimate aim of this project was to determine the feasibility of using High content systems for the screening and assessment of marine organism samples for potential therapeutic efficacy.
Principal Investigators: Prof’s Mark Lawlor and Dermot Kelleher (TCD)  

Title: “Development of a platform and toolkit for understanding interactions between nanoparticles and the living world”.
Collaborative Body: NanoInteract  (European Commission funded research)
Status: Active
Details: Focused on the understanding the interactions between engineered nanoparticles and living systems The NanoInteract consortium consists of 8 academic partners in Europe, 1 US academic partner, 2 European research centres, and 6 industry partners representing the industry base where Nanotechnology will be important in the coming decades.
Principal investigator: Prof. Yuri Volkov (TCD).

Title: Assessing the potential cardiotoxic effects of anti HIV drugs.
Collaborative Interaction: The Data Collection o­n Adverse events of Anti-HIV Drugs (DAD)
Status: Active
Details: We have used HCS to examine the potential cardiotoxic effects of different classes of anti HIV drugs in combinational regimens using a myoblastic cell line.       
Principal Investigators: Dr(s) Paul Spiers, Martina Hennessy and Prof Fiona Mulcahy (TCD)

Title: High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles.
Collaborative Interaction: University of Michigan and Trinity College Dublin
Status: Completed
Details: We have offered a new way of assessing bio-compatibility of nano materials with high-content screening assay technologies.
Principal Investigators: Nick Kotov (University of Michigan), Yuri Gun’ko and Yuri Volkov (Trinity College Dublin).