Dr. Patrick Walsh
Associate Professor, Clinical Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
Narros-Fernández P, O'Donnell A, Sheehy C, Basavarajappa SC, Hernandez Santana YE, Kinlen D, Cody D, Hogan AE, Walsh PT., Serum IL-36ß levels are associated with Insulin sensitivity in paediatric patients with obesity., International journal of obesity (2005), 2024
Rehill AM, Leon G, McCluskey S, Schoen I, Hernandez-Santana Y, Annett S, Klavina P, Robson T, Curtis AM, Renné T, Hussey S, O'Donnell JS, Walsh PT, Preston RJS., Glycolytic reprogramming fuels myeloid cell-driven hypercoagulability., Journal of thrombosis and haemostasis : JTH, 2023, pS1538-7836(23)00774-2
Narros-Fernández P, Chomanahalli Basavarajappa S, Walsh PT., Interleukin-1 family cytokines at the crossroads of microbiome regulation in barrier health and disease., The FEBS journal, 2023
Brennan, K, Craven, S., Cheung, M, Kane, D., Noone, E., O'Callaghan, J., Molloy, E.J., Walsh, P.T., McAuliffe, F.,Doyle, S.L. , Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines., Journal of Leukocyte Biology, 2022
Matarazzo, L. and Hernandez Santana, Y.E. and Walsh, P.T. and Fallon, P.G., The IL-1 cytokine family as custodians of barrier immunity, Cytokine, 154, (155890), 2022
Hernandez Santana YE, Irwin N, Walsh PT., IL-36: a therapeutic target for ulcerative colitis?, Expert opinion on therapeutic targets, 26, (6), 2022, p507-512
Leon, G. Hernandez-Santana, Y.E., Irwin, N., Giannoudaki, E., O'Neill, S., Czismadia, I., Gogarty, M., Lee, T.J., Ruane, D., Long, A., Fallon, P.G., Hussey, S. Walsh, P.T. , IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells., Mucosal Immunology, 2022
Bone R, Fennell BJ, Tam A, Sheldon R, Nocka K, Varghese S, Chang CS, Hawerkamp HC, Yeow A, Saunders SP, Hams E, Walsh PT, Cunningham O, Fallon PG, Discovery and multi-parametric optimization of a high-affinity antibody against Interleukin-25 with neutralizing activity in a mouse model of skin inflammation. , Antibody Therapeutics, 29, 2022, p258 - 267
Sullivan, G.P. and Davidovich, P. and Muñoz-Wolf, N. and Ward, R.W. and Hernandez Santana, Y.E. and Clancy, D.M. and Gorman, A. and Najda, Z. and Turk, B. and Walsh, P.T. and Lavelle, E.C. and Martin, S.J., Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement, Science immunology, 7, (78), 2022, peade5728
Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT., SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin, Journal of Immunology, 207, (2), 2021, p651 - 660
Saiz-Gonzalo G, Hanrahan N, Rossini V, Singh R, Ahern M, Kelleher M, Hill S, O'Sullivan R, Fanning A, Walsh PT, Hussey S, Shanahan F, Nally K, O'Driscoll CM, Melgar S., Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis, Frontiers in Immunology, 12, (655960), 2021
Giannoudaki E, Gargan S, Hussey S, Long A, Walsh PT., Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease., Frontiers in pediatrics, 9, 2021, p640497
Giannoudaki, E. and Stefanska, A.M. and Lawler, H. and Leon, G. and Hernandez Santana, Y.E. and Hassan, N. and Russell, S.E. and Horan, R. and Sweeney, C. and Preston, R.S. and Mantovani, A. and Garlanda, C. and Fallon, P.G. and Walsh, P.T., Erratum: SIGIRR Negatively Regulates IL-36 Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin (Journal of Immunology (2021) 207 (651-660) DOI: 10.4049/jimmunol.2100237), Journal of Immunology, 207, (11), 2021, p2895
Leon G, Hussey S, Walsh PT., The Diverse Roles of the IL-36 Family in Gastrointestinal Inflammation and Resolution., Inflammatory bowel diseases, 27, (3), 2021, p440-450
Emma B. O'Connor, Natalia Muñoz-Wolf, Gemma Leon, Ed C. Lavelle, Kingston H. G. Mills, Patrick T. Walsh and Richard K. Porter, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation, PLoS ONE, 15, (11), 2020, pe02-
Interleukin-1 in, editor(s)Offermmans S and Rosenthal W , Encyclopedia of Molecular Pharmacology, Springer Reference, 2020, [Lucitt MB and Walsh PT]
Hernández-Santana YE, Leon G, St Leger D, Fallon PG, Walsh PT., Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice., Life Sci Alliance, 3, (4), 2020
Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, Oâ Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1--
Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT., Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction., Nature communications, 10, (1), 2019, p4003
Hernandez-Santana YE, Taylor DK, Humbles A, Walsh PT., Advancing the therapeutic potential of the IL-1 family in inflammatory diseases - Meeting report., European journal of immunology, 49, (1), 2019, p8-10
Hernandez-Santana YE, Giannoudaki E, Leon G, Lucitt MB, Walsh PT., Current perspectives on the interleukin-1 family as targets for inflammatory disease., European journal of immunology, 2019
Boland AJ, Gangadharan N, Kavanagh P, Hemeryck L, Kieran J, Barry M, Walsh PT, Lucitt M., Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals., J Cardiovasc Pharmacol Ther., 2018
Mcdonnell, C.J. and Soule, E.E. and Walsh, P.T. and O'donnell, J.S. and Preston, R.J.S., The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease, Seminars in Thrombosis and Hemostasis, 2018, p167 - 175
Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG., IL-17 receptor a maintains and protects the skin barrier to prevent allergic skin inflammation, Journal Of Immunology, 199, (2), 2017, p707-717
Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714
Patrick T. Walsh, Padraic G. Fallon, The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases, Ann N Y Acad Sci, 2016
Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT., IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation., Mucosal Immunology, (Jan 27), 2016, p1193-1204
Cheryl M. Sweeney, Shane E. Russell, Anna Malara, Genevieve Kelly, Rosalind Hughes, Anne-Marie Tobin, Karoline Adamzik, Patrick T. Walsh, Brian Kirby, Human β-Defensin 3 and Its Mouse Ortholog Murine β-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice, Journal of Investigative Dermatology, 136, (3), 2016, p723-727
Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ., Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury., Blood, 126, (7), 2015, p915 - 919
Podolin PL, Foley JP, Carpenter DC, Bolognese BJ, Logan GA, Long E 3rd, Harrison OJ, Walsh PT., T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice., Am J Physiol Lung Cell Mol Physiol., 304, (5), 2013, pL312-L323
Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by "" T Cells., Journal of immunology (Baltimore, Md. : 1950), 191, (6), 2013, p3337-3346
Russell, SE and Walsh, PT, Sterile inflammation - do innate lymphoid cell subsets play a role?, Frontiers in Immunology, 3, 2012, p246-
Russell SE, Moore AC, Fallon PG, Walsh PT, Soluble IL-2R" (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice., PloS one, 7, (10), 2012, pe47748
Carey,JB, Pearson,FE, Vrdoljak A, McGrath MG, Crean AM, Walsh, PT, Doody, T, O'Mahony, C, Hill, AVS, Moore, AC., Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice, Plos One, 6, (7), 2011, pe22442-
Masters S.L. & Walsh P.T., Release of the mitochondrial endosymbiont helps explain sterile inflammation. , Proc Natl Acad Sci (USA) , 107, (10), 2010
Stefanska, A. and Walsh, P.T. *, Chronic Obstructive Pulmonary Disease: evidence for and autoimmune component., Cellular & Molecular Immunology, 6, (2), 2009, p81-86
Harrison, O.J. and Foley, J. and Bolognese, B.J. and Long III, E. and Podolin, P.L. and Walsh, P.T., Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement, Immunology Letters, 121, (1), 2008, p13-21
Tregs and Transplantation Tolerance in, editor(s)A.R. Marks , Science in Medicine: the JCI text book of molecular medicine, USA, American Society for Clinical Investigation, 2008, pp221 - 226, [Walsh P.T., Taylor D.K. and Turka L.A.]
Turka, L.A. and Walsh, P.T. , IL-2 receptor signaling in CD4+CD25+Foxp3+ regulatory T cells., Frontiers in Bioscience., 13, 2008, p1440-1446
Porrett, P.M., Yuan, X, LaRosa, D.F., Walsh, P.T. et al., Mechanisms underlying blockade of allograft acceptance by TLR ligands., Journal of Immunology , 181, 2008, p1692 -1699
La Rosa, D., Gelman, A.E., Zhang, J., Turka, L.A., Walsh P.T. , CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88 dependent costimulation of effector CD4+ T cells., Immunology Letters, 108, (2), 2007, p183
Buckler, J.L. and Walsh, P.T. and Porrett, P.M. and Choi, Y. and Turka, L.A., Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN, Journal of Immunology, 177, (7), 2006, p4262-4266
Walsh, P.T., * Benoit, B.M., Wysocka, M., Turka, L.A., Rook, A.H., A role for regulatory T cells in Cutaneous T cell lymphoma: Induction of a CD4+CD25+Foxp3+ phenotype associated with HTLV-1 infection., Journal of Investigative Dermatology, 126, (3), 2006, p690-692
Gelman, A.E. and LaRosa, D.F. and Zhang, J. and Walsh, P.T. and Choi, Y. and Sunyer, J. . and Turka, L.A., The Adaptor Molecule MyD88 Activates PI-3 Kinase Signaling in CD4+ T Cells and Enables CpG Oligodeoxynucleotide-Mediated Costimulation, Immunity, 25, (5), 2006, p783-793
Walsh, P.T., Buckler,J.L., Zhang, J., Gelman, A.E., Dalton, N.M., Taylor, D.K., Bensinger, S.J. and Turka L.A., PTEN regulates IL-2 receptor responsiveness of CD4+CD25+ regulatory T cells., Journal of Clinical Investigation, 116, (9), 2006, p2521-2531
Walsh, P.T. and Buckler, J.L. and Zhang, J. and Gelman, A.E. and Dalton, N.M. and Taylor, D.K. and Bensinger, S.J. and Hancock, W.W. and Turka, L.A., PTEN inhibits IL-2 receptor-mediated expansion of CD4+CD25 + Tregs, Journal of Clinical Investigation, 116, (9), 2006, p2521-2531
Turka, L., Walsh, P. and Bensinger, S. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; CENTER FOR TECHNOLOGY TRANSFER, SUITE 200, 3160 Chestnut Street, Philadelphia, PA 19104-6283 (US) (All Except US). TURKA, Laurence, A. [US/US]; (US) (US Only). BENSINGER, Steven, J. [US/US]; (US) (US Only). WALSH, Patrick [IE/US]; (US) (US Only)., Manipulation of PTEN in T cells as a strategy to modulate Immune responses., 2006, WO/2006/130560
Taylor, D.K., Walsh, P.T., LaRosa, D., Zhang, J., Burchill, M.A., Farrar, M.A., Turka, L.A., Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady state homeostasis., Journal of Immunology, 177, (4), 2006, p2216-2223
King, C.G., Kobayashi, T., Kim, T. Yoon, K., Kim, G.K., Chiffoleau, E., Hickman, S.P., Walsh, P.T., Turka, L.A., and Y. Choi. , TRAF6 is a T Cell Intrinsic Negative Regulator Required for the Maintenance of Immune Homeostasis., Nature Medicine, 12, (9), 2006, p1088-1092
Smith, L.M., Walsh, P.T., Rudiger, T., Cotter, T.G., McCarthy, T.V., Marx, A. and O'Connor, R., EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion., Experimental Cell Research, 292, (2), 2004, p295-303
Bensinger, S.J.,* Walsh, P.T.,* Zhang, J., Carroll, M., Parsons, R., Rathmell, J.C., Thompson, C.B., Burchill, M.A., Farrar, M.A. and Turka, L.A., Distinct IL-2 receptor signalling in CD4+CD25+ regulatory T cells., Journal of Immunology, 172, (9), 2004, p5287-5296
Walsh, P.T., Strom, T.B. and Turka, L.A., Routes to transplant tolerance versus rejection: the role of cytokines., Immunity, 20, (2), 2004, p121-131
Walsh, P.T., Taylor, D.K. and Turka, L.A. , Tregs and transplantation tolerance, Journal of Clinical Investigation, 114, (10), 2004, p1398-1403
Chiffoleau, E. and Kobayashi, T. and Walsh, M.C. and King, C.G. and Walsh, P.T. and Hancock, W.W. and Choi, Y. and Turka, L.A., TNF Receptor-Associated Factor 6 Deficiency during Hemopoiesis Induces Th2-Polarized Inflammatory Disease, Journal of Immunology, 171, (11), 2003, p5751-5759
Kobayashi, T. and Walsh, P.T. and Walsh, M.C. and Speirs, K.M. and Chiffoleau, E. and King, C.G. and Hancock, W.W. and Caamano, J.H. and Hunter, C.A. and Scott, P. and Turka, L.A. and Choi, Y., TRAF6 is a critical factor for dendritic cell maturation and development, Immunity, 19, (3), 2003, p353-363
Chiffoleau, E.*, Walsh, P.T.* and Turka, L.A. , Apoptosis and Transplantation tolerance., Immunological Reviews, 193, (1), 2003, p124-145
Walsh, P.T., Smith, L.M. and O'Connor, R., Insulin like growth factor-I activates Akt and Jun N-terminal kinases in promoting the survival of T lymphocytes., Immunology, 107, (4), 2002, p461-471
Darren Krause , Anthony Lyons , Patrick Walsh , Rosemary O'Connor , Stress-Activated Protein Kinases (SAPKs) in IGF-I Mediated Cell Survival, Scientific World Journal, 1, (94), 2001
Walsh, P.T. and O'Connor, R. , The insulin-like growth factor receptor is regulated by CD28 and protects activated T cells from apoptosis. , European Journal of Immunology, 30, (4), 2000, p1010-1018
Non-Peer-Reviewed Publications
Patrick Walsh, The role of the IL-1 family of cytokines as mediators of Inflammatory Disease, 2019, TCD and Royal Irish Academy, (1), 49, European Journal of Immunology, 8-10
Research Expertise
Recognition
Awards and Honours
President of Ireland Young Researcher Award SFI
Faculty member F1000 Biology
Recipient of GlaxoSmithKline, R&D Exceptional Science Award
Marie Curie Fellow
American Society Of Transplantation Council's Fellowship
Irish Refining PLC Full University Scholarship,
Memberships
International Cytokine Society
Faculty member of F1000 Biology
Irish Society of Immunology
British Society of Immunology