Patrick Walsh
PIYRA/Ussher Assistant Prof, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG., Research Article, Journal Of Immunology, 2017 Journal Article, 2017 DOI

Cheryl M. Sweeney, Shane E. Russell, Anna Malara, Genevieve Kelly, Rosalind Hughes, Anne-Marie Tobin, Karoline Adamzik, Patrick T. Walsh, Brian Kirby, Human β-Defensin 3 and Its Mouse Ortholog Murine β-Defensin 14 Activate Langerhans Cells and Exacerbate Psoriasis-Like Skin Inflammation in Mice, Journal of Investigative Dermatology, 136, (3), 2016, p723-727 Journal Article, 2016 DOI TARA - Full Text

Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT., IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation., Mucosal Immunology, (Jan 27), 2016, p1193-1204 Journal Article, 2016 DOI

Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714 Journal Article, 2016 DOI

Patrick T. Walsh, Padraic G. Fallon, The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases, Ann N Y Acad Sci, 2016 Journal Article, 2016 DOI

Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ., Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury., Blood, 126, (7), 2015, p915 - 919 Journal Article, 2015 DOI

Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by "" T Cells., Journal of immunology (Baltimore, Md. : 1950), 191, (6), 2013, p3337-3346 Journal Article, 2013 TARA - Full Text DOI

Podolin PL, Foley JP, Carpenter DC, Bolognese BJ, Logan GA, Long E 3rd, Harrison OJ, Walsh PT., T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice., Am J Physiol Lung Cell Mol Physiol., 304, (5), 2013, pL312-L323 Journal Article, 2013 DOI

Russell, SE and Walsh, PT, Sterile inflammation - do innate lymphoid cell subsets play a role?, Frontiers in Immunology, 3, 2012, p246- Journal Article, 2012 TARA - Full Text

Russell SE, Moore AC, Fallon PG, Walsh PT, Soluble IL-2R" (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice., PloS one, 7, (10), 2012, pe47748 Journal Article, 2012 DOI TARA - Full Text

Carey,JB, Pearson,FE, Vrdoljak A, McGrath MG, Crean AM, Walsh, PT, Doody, T, O'Mahony, C, Hill, AVS, Moore, AC., Microneedle Array Design Determines the Induction of Protective Memory CD8+ T Cell Responses Induced by a Recombinant Live Malaria Vaccine in Mice, Plos One, 6, (7), 2011, pe22442- Journal Article, 2011 TARA - Full Text

Masters S.L. & Walsh P.T., Release of the mitochondrial endosymbiont helps explain sterile inflammation. , Proc Natl Acad Sci (USA) , 107, (10), 2010 Journal Article, 2010

Stefanska, A. and Walsh, P.T. *, Chronic Obstructive Pulmonary Disease: evidence for and autoimmune component., Cellular & Molecular Immunology, 6, (2), 2009, p81-86 Journal Article, 2009 URL TARA - Full Text

Tregs and Transplantation Tolerance in, editor(s)A.R. Marks , Science in Medicine: the JCI text book of molecular medicine, USA, American Society for Clinical Investigation, 2008, pp221 - 226, [Walsh P.T., Taylor D.K. and Turka L.A.] Book Chapter, 2008

Porrett, P.M., Yuan, X, LaRosa, D.F., Walsh, P.T. et al., Mechanisms underlying blockade of allograft acceptance by TLR ligands., Journal of Immunology , 181, 2008, p1692 -1699 Journal Article, 2008 URL

Harrison, O., Foley J., Bolognese, B.J., Long, E., Podolin, P.L., and Walsh, P.T. *, Pulmonary infiltration of CD4+CCR6+Th17 type cells associated with chronic cigarette smoke induced airspace enlargement., Immunology Letters, 121, (1), 2008, p13-21 Journal Article, 2008 DOI

Turka, L.A. and Walsh, P.T. , IL-2 receptor signaling in CD4+CD25+Foxp3+ regulatory T cells., Frontiers in Bioscience., 13, 2008, p1440-1446 Journal Article, 2008 DOI

La Rosa, D., Gelman, A.E., Zhang, J., Turka, L.A., Walsh P.T. , CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88 dependent costimulation of effector CD4+ T cells., Immunology Letters, 108, (2), 2007, p183 Journal Article, 2007 DOI

Walsh, P.T., * Benoit, B.M., Wysocka, M., Turka, L.A., Rook, A.H., A role for regulatory T cells in Cutaneous T cell lymphoma: Induction of a CD4+CD25+Foxp3+ phenotype associated with HTLV-1 infection., Journal of Investigative Dermatology, 126, (3), 2006, p690-692 Journal Article, 2006 DOI

Walsh, P.T., Buckler,J.L., Zhang, J., Gelman, A.E., Dalton, N.M., Taylor, D.K., Bensinger, S.J. and Turka L.A., PTEN regulates IL-2 receptor responsiveness of CD4+CD25+ regulatory T cells., Journal of Clinical Investigation, 116, (9), 2006, p2521-2531 Journal Article, 2006 TARA - Full Text DOI

Turka, L., Walsh, P. and Bensinger, S. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; CENTER FOR TECHNOLOGY TRANSFER, SUITE 200, 3160 Chestnut Street, Philadelphia, PA 19104-6283 (US) (All Except US). TURKA, Laurence, A. [US/US]; (US) (US Only). BENSINGER, Steven, J. [US/US]; (US) (US Only). WALSH, Patrick [IE/US]; (US) (US Only)., Manipulation of PTEN in T cells as a strategy to modulate Immune responses., 2006, WO/2006/130560 Patent, 2006

Gelman, A.E., LaRosa, D.F., Zhang, J., Walsh, P.T., Choi, Y., Sunyer, O., Turka, L.A., A single tyrosine in MyD88 initiates PI-3 kinase signals that are essential for CpG DNA mediated proliferation but not survival in CD4+ T cells., Immunity, 25, (5), 2006, p783 Journal Article, 2006 DOI

Buckler, J.L., Walsh, P.T., Porret, P.M., Choi, Y., Turka, L.A., T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN., Journal of Immunology, 177, (7), 2006, p4262 Journal Article, 2006 URL

Taylor, D.K., Walsh, P.T., LaRosa, D., Zhang, J., Burchill, M.A., Farrar, M.A., Turka, L.A., Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady state homeostasis., Journal of Immunology, 177, (4), 2006, p2216-2223 Journal Article, 2006 URL

King, C.G., Kobayashi, T., Kim, T. Yoon, K., Kim, G.K., Chiffoleau, E., Hickman, S.P., Walsh, P.T., Turka, L.A., and Y. Choi. , TRAF6 is a T Cell Intrinsic Negative Regulator Required for the Maintenance of Immune Homeostasis., Nature Medicine, 12, (9), 2006, p1088-1092 Journal Article, 2006 DOI

Walsh, P.T., Strom, T.B. and Turka, L.A., Routes to transplant tolerance versus rejection: the role of cytokines., Immunity, 20, (2), 2004, p121-131 Journal Article, 2004 DOI

Walsh, P.T., Taylor, D.K. and Turka, L.A. , Tregs and transplantation tolerance, Journal of Clinical Investigation, 114, (10), 2004, p1398-1403 Journal Article, 2004 TARA - Full Text DOI

Bensinger, S.J.,* Walsh, P.T.,* Zhang, J., Carroll, M., Parsons, R., Rathmell, J.C., Thompson, C.B., Burchill, M.A., Farrar, M.A. and Turka, L.A., Distinct IL-2 receptor signalling in CD4+CD25+ regulatory T cells., Journal of Immunology, 172, (9), 2004, p5287-5296 Journal Article, 2004 URL

Smith, L.M., Walsh, P.T., Rudiger, T., Cotter, T.G., McCarthy, T.V., Marx, A. and O'Connor, R., EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion., Experimental Cell Research, 292, (2), 2004, p295-303 Journal Article, 2004 DOI

Chiffoleau, E.*, Walsh, P.T.* and Turka, L.A. , Apoptosis and Transplantation tolerance., Immunological Reviews, 193, (1), 2003, p124-145 Journal Article, 2003 DOI

Chiffoleau, E., Kobayashi, T., Walsh, M.C., King, C.G., Walsh, P.T., Hancock, W.W., Choi, Y. and Turka, L.A., Traf6 deficiency during hematopoiesis induces Th2 polarized inflammatory disease. , Journal of Immunology, 171, (11), 2003, p5751-5759 Journal Article, 2003 URL

Kobayashi, T., Walsh, P.T., Walsh, M.C., Speirs, K.M., Chiffoleau, E., King, C.G., Hancock, W.W., Caamano, J.H., Hunter, C.A., Scott, P., Turka, L.A. and Choi, Y., Traf6 is a critical factor for dendritic cell maturation and development., Immunity, 19, (3), 2003, p353-363 Journal Article, 2003 DOI

Walsh, P.T., Smith, L.M. and O'Connor, R., Insulin like growth factor-I activates Akt and Jun N-terminal kinases in promoting the survival of T lymphocytes., Immunology, 107, (4), 2002, p461-471 Journal Article, 2002 DOI

Walsh, P.T. and O'Connor, R. , The insulin-like growth factor receptor is regulated by CD28 and protects activated T cells from apoptosis. , European Journal of Immunology, 30, (4), 2000, p1010-1018 Journal Article, 2000 DOI

Research Expertise

Keywords

Immunology, Immunotherapy; Medicine

Recognition

Awards and Honours

President of Ireland Young Researcher Award SFI 2011-16

Faculty member F1000 Biology 2011

Recipient of GlaxoSmithKline, R&D Exceptional Science Award 2008

Marie Curie Fellow 2009-2013

American Society Of Transplantation Council's Fellowship 2004-2006,

Irish Refining PLC Full University Scholarship, 1997

Memberships

Faculty member of F1000 Biology 2012

Irish Society of Immunology 2008

British Society of Immunology 2008