Daniela Tropea
Assistant Professor, Psychiatry

Publications and Further Research Outputs

Peer-Reviewed Publications

Wrigley S, Arafa D, Tropea D, Insulin-like growth factor 1: At the crossroads of brain development and aging, Frontiers in Cellular Neuroscience, 11, 2017 Journal Article, 2017 DOI URL

Pizzo R, Gurgone A, Castroflorio E, Amendola E, Gross C, SassoÚ-Pognetto M, Giustetto M, Wang H, Tropea D, Maffei A, Katz D.M, Fagiolini M, Lack of Cdkl5 disrupts the organization of excitatory and inhibitory synapses and parvalbumin interneurons in the primary visual cortex, Frontiers in Cellular Neuroscience, 10, (NOV2016), 2016 Journal Article, 2016 DOI URL

Vahdatpour C, Dyer A.H, Tropea D, Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders, Frontiers in Neuroscience, 10, (SEP), 2016 Journal Article, 2016 URL DOI

1. G. Pini, L. Congiu, A. Benincasa, P. Di Marco, S. Bigoni, A. Dyer, N. Mortimer, A. Della Chiesa, S. O'Leary, R. McNamara, K. J. Mitchell, M. Gill and D. Tropea, Illness Severity, Social & Cognitive Ability and EEG Analysis of Ten Patients with Rett Syndrome Treated with Mecasermin (recombinant human IGF-1): A Clinical Study , Autism Research and treatment, 2016, 2016 Journal Article, 2016 DOI

Pini G, Bigoni S, Congiu L, Romanelli A.M, Scusa M.F, Di Marco P, Benincasa A, Morescalchi P, Ferlini A, Bianchi F, Tropea D, Zappella M, Rett syndrome: a wide clinical and autonomic picture, Orphanet Journal of Rare Diseases, 11, (1), 2016, p1 - 16 Journal Article, 2016 URL DOI

D.Tropea, I. Molinos, S. Bellini, E. Petit, C. O'Toutaigh, I. Nagakura, K. Mitchell, M. Sur, M. Gill, J. Waddington, A. Corvin, Disrupted in schizophrenia 1 (DISC1) mutants have impaired activity-dependent plasticity in vitro and in vivo, Translational Psychiatry, 6, 2016, p712- Journal Article, 2016 TARA - Full Text URL

Tropea D, Mortimer N, Bellini S, Molinos I, Sanfeliu A, Shovlin S, McAllister D, Gill M, Mitchell K, Corvin A, Expression of nuclear Methyl-CpG binding protein 2 (Mecp2) is dependent on neuronal stimulation and application of Insulin-like growth factor 1, Neuroscience Letters, 621, 2016, p111 - 116 Journal Article, 2016 DOI URL

Dyer A.H, Vahdatpour C, Sanfeliu A, Tropea D, The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity, Neuroscience, 325, 2016, p89 - 99 Journal Article, 2016 DOI

Rose EJ, Hargreaves A, Morris D, Fahey C, Tropea D, Cummings E, Caltagirone C, Bossù P, Chiapponi C, Piras F, Spalletta G, Gill M, Corvin A, Donohoe G, Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style., The British journal of psychiatry : the journal of mental science, 204, (2), 2014, p115-121 Journal Article, 2014 DOI TARA - Full Text

Ajetunmobi,A. A., Prina-Mello,Adriele A., Volkov,Yuri Y., Corvin,Aiden P. A.P., Tropea,Daniela D., Nanotechnologies for the study of the central nervous system, Progress in Neurobiology, 123, 2014, p18-36 Journal Article, 2014 TARA - Full Text DOI

Kenny EM, Cormican P, Furlong S, Heron E, Kenny G, Fahey C, Kelleher E, Ennis S, Tropea D, Anney R, Corvin AP, Donohoe G, Gallagher L, Gill M, Morris DW, Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders., Molecular psychiatry, 19, 2014, p872-879 Journal Article, 2014 DOI TARA - Full Text

Ajetunmobi A, Prina-Mello A, Volkov Y, Corvin A, Tropea D, Nanotechnologies for the study of the central nervous system., Progress in neurobiology, 123, 2014, p18-36 Journal Article, 2014

Castro J, Garcia R.I, Kwok S, Banerjee A, Petravicz J, Woodson J, Mellios N, Tropea D, Sur M, Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome, Proceedings of the National Academy of Sciences of the United States of America, 111, (27), 2014, p9941 - 9946 Journal Article, 2014 URL DOI

Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Perreault LP, Giannoulatou E, Tropea D, Maher BS, Wormley B, Kelleher E, Fahey C, Molinos I, Bellini S, Pirinen M, Strange A, Freeman C, Thiselton DL, Elves RL, Regan R, Ennis S, Dinan TG, McDonald C, Murphy KC, O'Callaghan E, Waddington JL, Walsh D, O'Donovan M, Grozeva D, Craddock N, Stone J, Scolnick E, Purcell S, Sklar P, Coe B, Eichler EE, Ophoff R, Buizer J, Szatkiewicz J, Hultman C, Sullivan P, Gurling H, McQuillin A, St Clair D, Rees E, Kirov G, Walters J, Blackwood D, Johnstone M, Donohoe G, O'Neill FA, Kendler KS, Gill M, Riley BP, Spencer CC, Corvin A, An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis., Human molecular genetics, 23, (12), 2014, p3316-26 Journal Article, 2014 TARA - Full Text DOI

D. Tropea, American College Neuropharmachology Annual Meeting, FL, USA, December, 2012 Invited Talk, 2012

G. Pini, M.F. Scusa, B. Felloni, L. Congiu, A. Benincasa, R. Frati, I. Bottiglioni, P. Di Marco, P. Borelli, U. Bonuccelli, A. Della-Chiesa, A. Prina-Mello, D. Tropea, Safety assessment of IGF-1 treatment: study on six Rett patients., Autism research and treatment, 2012 Journal Article, 2012

Corvin AP, Molinos I, Little G, Donohoe G, Gill M, Morris DW, Tropea D, Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms., Neuroscience letters, 520, (1), 2012, p51-56 Journal Article, 2012 DOI

Rose EJ, Morris DW, Fahey C, Robertson IH, Greene C, O'Doherty J, Newell FN, Garavan H, McGrath J, Bokde A, Tropea D, Gill M, Corvin AP, Donohoe G., The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function., Twin Research and Human Genetics, 15, (3), 2012, p296 - 303 Journal Article, 2012 TARA - Full Text DOI

O'Donoghue T, Morris DW, Fahey C, Da Costa A, Foxe JJ, Hoerold D, Tropea D, Gill M, Corvin A, Donohoe G, A NOS1 variant implicated in cognitive performance influences evoked neural responses during a high density EEG study of early visual perception., Human brain mapping, 33, (5), 2012, p1202-11 Journal Article, 2012

Rose EJ, Morris DW, Fahey C, Robertson IH, Greene C, O'Doherty J, Newell FN, Garavan H, McGrath J, Bokde A, Tropea D, Gill M, Corvin AP, Donohoe G, The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function., Twin research and human genetics : the official journal of the International Society for Twin Studies, 15, (3), 2012, p296-303 Journal Article, 2012 DOI

Strange A, Riley BP, Spencer CA, Morris DW, Pirinen M, O'Dushlaine CT, Su Z, Maher BS, Freeman C, Cormican P, Bellenguez C, Kenny EM, Band G, Wormley B, Donohoe G, Dilthey A, Moutsianas L,Quinn E, Edkins S, Judge R, Coleman K, Hunt S, Tropea D, Roche S, Cummings L, Kelleher E, McKeon P, Dinan T, McDonald C, Murphy KC, O'Callaghan E, O'Neill FA, Waddington JL, Walsh D, Giannoulatou E, Langford C, Deloukas P, Gray E, Dronov S, Potter S, Pearson R, Vukcevic D, Tashakkori-Ghanbaria A, Blackwell JM,15, Bramon E, Brown MA, Casas JP, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CNA, Plomin RP, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Stone J, Scolnick E, Purcell S, Sklar P, SGENE+ Consortium, Ripke S, Walters J, Owen MJ, O'Donovan MC, Schizophrenia Working Group of the Psychiatric GWAS Consortium, Peltonen L, McVean G, Kendler KS, Gill M, Donnelly P, Corvin A for Irish Schizophrenia Genomics Consortium and the Wellcome Trust Case Control Consortium 2, Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia., Biological Psychiatry, 72, (8), 2012, p620-628 Journal Article, 2012 DOI TARA - Full Text

D. Tropea, Annual Symposium IRSF , VA, USA, June, 2011 Invited Talk, 2011

D. Tropea, Ohio State University, OH, USA, January, 2011 Invited Talk, 2011

Mellios N, Sugihara H, Castro J, Banerjee A, Le C, Kumar A, Crawford B, Strathmann J, Tropea D, Levine SS, Edbauer D, Sur M, miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity., Nature neuroscience, 14, (10), 2011, p1240-2 Journal Article, 2011

Tropea D, Sur M, Majewska AK, Experience-dependent plasticity in visual cortex: Dendritic spines and visual responsiveness., Communicative & Integrative Biology, 4, (2), 2011, p216-9 Journal Article, 2011 DOI TARA - Full Text

D. Tropea, Mount Sinai School of Medicine , NY, USA, February, 2011 Invited Talk, 2011

Tropea D, Majewska AK, Garcia R, Sur M, Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex., The Journal of neuroscience : the official journal of the Society for Neuroscience, 30, (33), 2010, p11086-95 Journal Article, 2010

D. Tropea, World Congress Psychiatric Genetics, Athens, Greece, October , 2010 Invited Talk, 2010

D. Tropea, Symposium on rare genetic diseases , Viareggio, Italy, February, 2010 Invited Talk, 2010

D. Tropea, Kings College London , UK, December, 2010 Invited Talk, 2010

Tropea D, Van Wart A, Sur M, Molecular mechanisms of experience-dependent plasticity in visual cortex., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364, (1515), 2009, p341-55 Journal Article, 2009

D. Tropea, Stony Brook University, NY, April , 2009 Invited Talk, 2009

D. Tropea, European Conference on Rett Syndrome, Milan, Italy, June , 2009 Invited Talk, 2009

D. Tropea, World Congress Psychiatric Genetics, San Diego, CA, November, 2009 Invited Talk, 2009

Tropea D, Giacometti E, Wilson NR, Beard C, McCurry C, Fu DD, Flannery R, Jaenisch R, Sur M, Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice., Proceedings of the National Academy of Sciences of the United States of America, 106, (6), 2009, p2029-34 Journal Article, 2009

Caleo M, Tropea D, Rossi C, Gianfranceschi L, Maffei L, Environmental enrichment promotes fiber sprouting after deafferentation of the superior colliculus in the adult rat brain., Experimental neurology, 216, (2), 2009, p515-9 Journal Article, 2009

D. Tropea, Ecole Normale Superieure , Paris, April , 2008 Invited Talk, 2008

Lyckman, S. Horng, C. Leamey, D. Tropea, A. Watakabe, A. Van Wart, C. McCurry, T. Yamamori and M. Sur , Transcriptional regulation during the critical period of ocular dominance plasticity: prominent expression of actin-binding and myelination factors. , PNAS, 105, (27), 2008, p9409 - 9414 Journal Article, 2008

D. Tropea, University of Chicago, IL , February , 2008 Invited Talk, 2008

D. Tropea, Stanford University , CA, September , 2008 Invited Talk, 2008

D. Tropea, Rutgers University, NJ, December , 2008 Invited Talk, 2008

D. Tropea, Center for Brain Repair Cambridge, UK, February 2008 , 2008 Invited Talk, 2008

D. Tropea, A. Van Wart and M Sur (, Molecular mechanisms of experience-dependent plasticity in visual cortex., Philos .Trans. R. Soc. Lond B Biol Sci., 2008 Journal Article, 2008

D. Tropea, University of California Santa Barbara, CA, April , 2007 Invited Talk, 2007

D. Tropea, G. Kreiman, A. Lyckman, S. Mukherjee, H. Yu, S. Horng and M. Sur , Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex, Nature Neuroscience,, 9, (5), 2006, p660 - 668 Journal Article, 2006

D. Tropea, University of Rochester, NY, August 2006, 2006 Invited Talk, 2006

Pattabiraman PP, Tropea D, Chiaruttini C, Tongiorgi E, Cattaneo A, Domenici L, Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo., Molecular and cellular neurosciences, 28, (3), 2005, p556-70 Journal Article, 2005

Tropea D, Caleo M, Maffei L, Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats., The Journal of neuroscience : the official journal of the Society for Neuroscience, 23, (18), 2003, p7034-44 Journal Article, 2003

Tropea D, Capsoni S, Covaceuszach S, Domenici L, Cattaneo A, Rat visual cortical neurones express TrkA NGF receptor., Neuroreport, 13, (10), 2002, p1369-73 Journal Article, 2002

Tropea D, Capsoni S, Tongiorgi E, Giannotta S, Cattaneo A, Domenici L, Mismatch between BDNF mRNA and protein expression in the developing visual cortex: the role of visual experience., The European journal of neuroscience, 13, (4), 2001, p709-21 Journal Article, 2001

Tropea D, Domenici L, Expression of TrkB receptors in developing visual cortex is not regulated by light., Cellular and molecular neurobiology, 21, (5), 2001, p545-52 Journal Article, 2001

Sermasi E, Tropea D, Domenici L, A new form of synaptic plasticity is transiently expressed in the developing rat visual cortex: a modulatory role for visual experience and brain-derived neurotrophic factor., Neuroscience, 91, (1), 1999, p163-73 Journal Article, 1999

Sermasi E, Tropea D, Domenici L, Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience., Brain research. Developmental brain research, 113, (1-2), 1999, p61-5 Journal Article, 1999

D. Tropea, E. Sermasi, L. Domenici,, Long term potentiation of feedback horizontal connections in rat primary visual cortex., Dev. Brain Res., 118, 1999, p61 - 67 Journal Article, 1999

Bell I, Campbell KB, Deacon-Elliott D, Noldy NE, A peak detector program for event-related potentials., International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 6, (2), 1988, p151-60 Journal Article, 1988

Meryon SD, Tobias RS, Jakeman KJ, Smear removal agents: a quantitative study in vivo and in vitro., The Journal of prosthetic dentistry, 57, (2), 1987, p174-9 Journal Article, 1987

Recognition

Representations

INVITED TALKS Trinity College Institute of Neuroscience Annual Meeting (Ireland) November 2013 Irish Rett Syndrome Association (Athlone, Ireland) September 2013 American College Neuropharmachology Annual Meeting (FL, USA) December 2012 Imperial College London (UK) October 2012 Annual Symposium IRSF (VA, USA) June 2011

Mount Sinai School of Medicine (NY, USA) February 2011 Ohio State University (OH, USA) January 2011 Kings College London (UK) December 2010 World Congress Psychiatric Genetics (Athens, Greece) October 2010 Symposium on rare genetic diseases (Viareggio, Italy) February 2010 World Congress Psychiatric Genetics (San Diego, CA) November 2009 European Conference on Rett Syndrome (Milan, Italy) June 2009

Stony Brook University (NY) April 2009 Rutgers University (NJ) December 2008 Stanford University (CA) September 2008 Ecole Normale Superieure (Paris) April 2008 University of Chicago (IL) February 2008 Center for Brain Repair Cambridge (UK) February 2008 University of California Santa Barbara (CA) April 2007 University of Rochester (NY) August 2006

Awards and Honours

Travel grant for SfN. Boston Area Neuroscience Group (BANG) 2006

Innovative treatment for rare diseases_TIAMO foundation June 2014