Tim Mantle
Fellow Emeritus, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578 Journal Article, 2013 DOI

McManus, G., Costa, M., Canals A., Coll, M., & Mantle, T.J. , Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked co-operativity, introduces a novel mechansim for ping-pong kinetic behaviour and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione, FEBS Journal, 278, 2011, p273 - 281 Journal Article, 2011

Hayes, J.M. and Mantle, T.J., The effect of pH on the initial rate kinetics of the dimeric biliverdin-IXα reductase from the cyanobacterium Synechocystis PCC6803 , FEBS Journal, 276, 2009, p4414-4425 Journal Article, 2009 DOI

Franklin, E., Browne, S., Horan, A.E., Inomata,K., Hammam, M.A.S., Kinoshita, H., Lamparter,T., Golfis, G. and Mantle, T.J. , The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXα reductase and human biliverdin-IXβ reductase , FEBS Journal, 276, 2009, p4405-4413 Journal Article, 2009 DOI

L. J.Smith, S. Browne, A. J. Mulholland and T. J. Mantle, Computational and experimental studies on the catalytic mechanism of biliverdin IXβ reductase, Biochemical Journal, 411, 2008, p475-484 Journal Article, 2008 DOI

Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67 Journal Article, 2007 TARA - Full Text

Mantle TJ & Noone P., Chromatofocusing, Methods Mol Biol, 244, 2004, p233 - 237 Journal Article, 2004

Tetlow, N., Robinson , A., Mantle, T. & Board, P., Polymorphism of human Mu class glutathione transferases, Pharmacogenetics, 14 , 2004, p359 - 368 Journal Article, 2004

TJ Mantle (ed), The Behaviour of Enzymes in Cells, Biochem. Soc. Trans, 31, 2003, pp711 - 739 Conference Paper, 2003

MANTLE, TJ, HAEM DEGRADATION IN ANIMALS AND PLANTS, BIOCHEMICAL SOCIETY TRANSACTIONS, 30, 2002, p630 - 633 Journal Article, 2002

PEREIRA, PJB, MACEDO-RIBEIRO, S, PARRAGA, A, PEREZ-LUQUE, R, CUNNINGHAM, O, DARCY, K, MANTLE, TJ, COLL, M, STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE, AN EARLY FETAL BILIRUBIN IX BETA PRODUCING ENZYME, NATURE STRUCTURAL BIOLOGY, 8, 2001, p215 - 220 Journal Article, 2001

MANTLE, TJ, ENZYMES: NATURE'S NANOMACHINES, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p331 - 336 Journal Article, 2001

CUNNINGHAM, O, GORE, MG, MANTLE, TJ, INITIAL-RATE KINETICS OF THE FLAVIN REDUCTASE REACTION CATALYSED BY HUMAN BILIVERDIN-IX BETA REDUCTASE (BVR-B), BIOCHEMICAL JOURNAL, 345, 2000, p393 - 399 Journal Article, 2000

CUNNINGHAM, O, DUNNE, A, SABIDO, P, LIGHTNER, D, MANTLE, TJ, STUDIES ON THE SPECIFICITY OF THE TETRAPYRROLE SUBSTRATE FOR HUMAN BILIVERDIN-IX ALPHA REDUCTASE AND BILIVERDIN-IX BETA REDUCTASE - STRUCTURE-ACTIVITY RELATIONSHIPS DEFINE MODELS FOR BOTH ACTIVE SITES, JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 2000, p19009 - 19017 Journal Article, 2000

Spectrophotometric assays in, editor(s)M.G. Gore , Spectrophotomety and spectrofluorimetry, Oxford, Oxford University Press, 2000, pp183 - 208, [Mantle, T.J. & Harris] Book Chapter, 2000

Mantle, T.J., Parraga, A., Vega, M.C., Garcia-Saez, I., Walsh, S.B., Phillips, M. & Coll, M., Studies on the reaction mechanism of mouse liver glutathione S-transferase P1-1, Clin. Chem. & Enzym. Commun., 8, 1999, p223 - 230 Journal Article, 1999

WALSH, SB, FRANKLIN, E, MANTLE, TJ, EVIDENCE FOR MODULATION OF THE INTERACTION BETWEEN CYS-47 AND LYS-54 IN GLUTATHIONE S-TRANSFERASE PI BY THE NATURE OF THE RESIDUE AT POSITION 56, BIOCHEMICAL SOCIETY TRANSACTIONS, 25, 1998, pS614 - S614 Journal Article, 1998

PARRAGA, A, GARCIA-SAEZ, I, WALSH, SB, MANTLE, TJ, COLL, M, THE THREE-DIMENSIONAL STRUCTURE OF A CLASS-PI GLUTATHIONE S-TRANSFERASE COMPLEXED WITH GLUTATHIONE: THE ACTIVE-SITE HYDRATION PROVIDES INSIGHTS INTO THE REACTION MECHANISM, BIOCHEMICAL JOURNAL, 333, 1998, p811 - 816 Journal Article, 1998

CUNNINGHAM, O, MANTLE, TJ, CLONING, OVEREXPRESSION AND PURIFICATION OF BILIVERDIN IX-BETA REDUCTASE., BIOCHEMICAL SOCIETY TRANSACTIONS, 25, 1998, pS613 - S613 Journal Article, 1998

VEGA, MC, WALSH, SB, MANTLE, TJ, COLL, M, THE THREE-DIMENSIONAL STRUCTURE OF CYS-47-MODIFIED MOUSE LIVER GLUTATHIONE S-TRANSFERASE P1-1 - CARBOXYMETHYLATION DRAMATICALLY DECREASES THE AFFINITY FOR GLUTATHIONE AND IS ASSOCIATED WITH A LOSS OF ELECTRON DENSITY IN THE ALPHA B-3(10)B REGION, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, 1998, p2844 - 2850 Journal Article, 1998

Glutathione conjugation in, editor(s)N Gooderham , Drug Metabolism: Towards the Millenium, Amsterdam, IOS Press, 1998, pp101 - 108, [Mantle, T.J.] Book Chapter, 1998

ENNIS, O, MAYTUM, R, MANTLE, TJ, CLONING AND OVEREXPRESSION OF RAT KIDNEY BILIVERDIN IX ALPHA REDUCTASE AS A FUSION PROTEIN WITH GLUTATHIONE S-TRANSFERASE: STEREOCHEMISTRY OF NADH OXIDATION AND EVIDENCE THAT THE PRESENCE OF THE GLUTATHIONE S-TRANSFERASE DOMAIN DOES NOT EFFECT BVR-A ACTIV, BIOCHEMICAL JOURNAL, 328, 1997, p33 - 36 Journal Article, 1997

MURPHY, KC, GRAHAM, M, MANTLE, T, SHELLEY, RK, SCHIZOPHRENIA, LUNG CANCER AND GLUTATHIONE-S-TRANSFERASE-MU, IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE, 13, 1997, p138 - 139 Journal Article, 1997

Cunningham, O. & Mantle, T.J., Cloning, overexpression and purification of biliverdin-IX reductase, Biochem. Soc. Trans., 25, 1997, pS613 - S613 Journal Article, 1997

Walsh, S.B., Franklin, E. & Mantle, T.J., Evidence for modulation of the interaction between cys-47 and lys-54 in glutathione S-transferase Pi by the nature of the residue at position-56, Biochem. Soc. Trans., 25, 1997, pS614 - S614 Journal Article, 1997

OROZCO, M, VEGA, C, PARRAGA, A, GARCIASAEZ, I, COLL, M, WALSH, S, MANTLE, TJ, LUQUE, FJ, ON THE REACTION MECHANISM OF CLASS PI GLUTATHIONE S-TRANSFERASE, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 28, 1997, p530 - 542 Journal Article, 1997

SHALLOE, F, ELLIOTT, G, ENNIS, O, MANTLE, TJ, EVIDENCE THAT BILIVERDIN-IX BETA REDUCTASE AND FLAVIN REDUCTASE ARE IDENTICAL, BIOCHEMICAL JOURNAL, 316, 1996, p385 - 387 Journal Article, 1996

Murphy, K.C., Graham, M., Mantle, T & Shelley R.K., Schizophrenia, lung cancer and glutathione S-transferase Mu, Irish J. Psych. Med, 13, 1996, p138 - 139 Journal Article, 1996

Chromatofocusing in, editor(s)S. Doonan , Protein Purification Protocols, Totowa, New Jersey, Humana Press, 1996, pp249 - 254, [Mantle, T.J. & Noone, P.] Book Chapter, 1996

WALSH, SB, MANTLE, TJ, MODIFICATION OF MOUSE-LIVER GLUTATHIONE-S-TRANSFERASE-PI BY IODOACETIC ACID, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, S485 - S485 Miscellaneous, 1995

MANTLE, TJ, THE GLUTATHIONE-S-TRANSFERASE MULTIGENE FAMILY - A PARADIGM FOR XENOBIOTIC INTERACTIONS, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, p423 - 425 Journal Article, 1995

ENNIS, OM, MANTLE, T, EXPRESSION OF RAT BILIVERDIN REDUCTASE AS A GLUTATHIONE-S-TRANSFERASE FUSION PROTEIN, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, S443 - S443 Miscellaneous, 1995

ELLIOTT, G, MANTLE, TJ, PURIFICATION AND PROPERTIES OF SALMON LIVER BILIVERDIN REDUCTASE, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS389 - S389 Journal Article, 1995

MAHMUD, N, STINSON, J, OCONNELL, MA, MANTLE, TJ, KEELING, PWN, FEELY, J, WEIR, DG, KELLEHER, D, MICROALBUMINURIA IN INFLAMMATORY BOWEL-DISEASE, GUT, 35, 1994, p1599 - 1604 Journal Article, 1994

GARCIASAEZ, I, PARRAGA, A, PHILLIPS, MF, MANTLE, TJ, COLL, M, MOLECULAR-STRUCTURE AT 1-CENTER-DOT-8-ANGSTROM OF MOUSE-LIVER CLASS-PI GLUTATHIONE-S-TRANSFERASE COMPLEXED WITH S-(P-NITROBENZYL)GLUTATHIONE AND OTHER INHIBITORS, JOURNAL OF MOLECULAR BIOLOGY, 237, 1994, p298 - 314 Journal Article, 1994

PHILLIPS, MF, MANTLE, TJ, INACTIVATION OF MOUSE-LIVER GLUTATHIONE-S-TRANSFERASE YFYF (PI CLASS) BY ETHACRYNIC-ACID AND 5,5'-DITHIOBIS-(2-NITROBENZOIC ACID), BIOCHEMICAL JOURNAL, 294, 1993, p57 - 62 Journal Article, 1993

BOYCE, SJ, MANTLE, TJ, EFFECT OF LEAD ACETATE AND CARBON PARTICLES ON THE EXPRESSION OF GLUTATHIONE-S-TRANSFERASE YFYF IN RAT-LIVER, BIOCHEMICAL JOURNAL, 294, 1993, p301 - 304 Journal Article, 1993

KD Tew, CB Pickett, TJ Mantle, B Mannervik & JD Hayes (eds), Structure and Function of Glutathione S-transferases, Ann Arbor, London & Tokyo, CRC Press Boca Raton, 1993 Book, 1993

RYAN, J, MANTLE, T, COSTIGAN, DC, A NORMAL POPULATION STUDY OF HUMAN SALIVARY INSULIN-LIKE GROWTH FACTOR-I (IGF-1) CONCENTRATIONS FROM BIRTH THROUGH PUBERTY, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 74, 1992, p774 - 778 Journal Article, 1992

RYAN, J, MANTLE, T, MCQUAID, S, COSTIGAN, DC, SALIVARY INSULIN-LIKE GROWTH FACTOR-I ORIGINATES FROM LOCAL SYNTHESIS, JOURNAL OF ENDOCRINOLOGY, 135, 1992, p85 - & Journal Article, 1992

RYAN, J, COMPARISON OF TYPE-1 INSULIN-LIKE GROWTH-FACTOR (IGF) RECEPTOR-BINDING IN OVINE TISSUE AND HUMAN PLACENTAL MEMBRANES, Biochem. Soc. Trans, 1991, 19, 1991, ppS63 - S63 Meeting Abstract, 1991

PHILLIPS, MF, MANTLE, TJ, THE INITIAL-RATE KINETICS OF MOUSE GLUTATHIONE-S-TRANSFERASE YFYF - EVIDENCE FOR AN ALLOSTERIC SITE FOR ETHACRYNIC-ACID, BIOCHEMICAL JOURNAL, 275, 1991, p703 - 709 Journal Article, 1991

K.F. Tipton & T.J. Mantle (eds), Amine Oxidases: Structure, Function and Expression, Biochem. Soc. Trans., 19, 1991, pp199 - 233 Conference Paper, 1991

MANTLE, TJ, MCCUSKER, FM, PHILLIPS, M, BOYCE, S, GLUTATHIONE S-TRANSFERASES, BIOCHEMICAL SOCIETY TRANSACTIONS, 18, 1990, p175 - 177 Journal Article, 1990

RYAN, J, ASSOCIATION OF PLASMA INSULIN-LIKE GROWTH FACTOR-I CARRIER PROTEIN INVIVO, Biochem. Soc. Trans., 1990, 18, 1990, pp335 - 336 Meeting Abstract, 1990

Roy, A.B. & Mantle, T.J., The anomalous kinetics of sulphatase A, Biochem. J., 261, 1989, p689 - 697 Journal Article, 1989

MCCUSKER, FMG, BOYCE, SJ, MANTLE, TJ, THE DEVELOPMENT OF GLUTATHIONE S-TRANSFERASE SUBUNITS IN RAT-LIVER - SENSITIVE DETECTION OF THE MAJOR SUBUNIT FORMS OF RAT GLUTATHIONE S-TRANSFERASE BY USING AN ELISA METHOD, BIOCHEMICAL JOURNAL, 262, 1989, p463 - 467 Journal Article, 1989

Contributions of glutathione S-transferase to drug resistance in nature in, editor(s)J.D. Hayes, C.B. Pickett & T.J. Mantle , Glutathione S-transferases and drug resistance, London, Philadelphia and New York, Taylor and Francis, 1989, [Hayes, J.D., Pickett, C.B. & Mantle, T.J.] Book Chapter, 1989

J.D. Hayes, T.J. Mantle & C.B. Pickett (eds), Glutathione S-transferases and Drug Resistance, London, New York and Philadelphia , Taylor and Francis, 1989 Book, 1989

ROY, AB, THE ANOMALOUS KINETICS OF SULFATASE-A, by MANTLE, TJ , BIOCHEMICAL JOURNAL, 261, 1989, p689 - 697 Review, 1989

Some immunocytochemical and other recent studies on rodent glutathione S-transferases in, editor(s)J.D. Hayes, C.B. Pickett & T.J. Mantle , Glutathione S-transferases and drug resistance, London, Philadelphia and New York, Taylor and Francis, 1989, [McCusker, F.M., Phillips, M.F., Boyce, S.J. & Mantle, T.J.] Book Chapter, 1989

RYAN, J, SALIVARY SOMATOMEDIN C INSULIN-LIKE GROWTH FACTOR-I - EVIDENCE OF LOCAL PRODUCTION, Biochem. Soc. Trans., 1989, 17, 1989, pp610 - 610 Meeting Abstract, 1989

RIGNEY, E, MANTLE, TJ, DICKINSON, FM, THE KINETICS OF OX KIDNEY BILIVERDIN REDUCTASE IN THE PRE-STEADY STATE - EVIDENCE THAT THE DISSOCIATION OF BILIRUBIN IS THE RATE-DETERMINING STEP, BIOCHEMICAL JOURNAL, 259, 1989, p709 - 713 Journal Article, 1989

GRAHAM, MN, MANTLE, TJ, PURIFICATION OF A CLASS-C A-TYPE BETA-LACTAMASE FROM A DEREPRESSED STRAIN OF ENTEROBACTER-CLOACAE - COMPARISON OF THE WILD-TYPE AND MUTANT ENZYME WITH THOSE FROM STRAIN-P99, STRAIN-208 AND STRAIN-GN7471, BIOCHEMICAL JOURNAL, 260, 1989, p705 - 710 Journal Article, 1989

RIGNEY, E, MANTLE, TJ, THE REACTION-MECHANISM OF BOVINE KIDNEY BILIVERDIN REDUCTASE, BIOCHIMICA ET BIOPHYSICA ACTA, 957, 1988, p237 - 242 Journal Article, 1988

RIGNEY, EM, CHLORIDE ABOLISHES FLUX THROUGH THE SUBSTRATE-INHIBITION PATHWAY OF BILIVERDIN REDUCTASE, Biochem. Soc. Trans., 1988, 16, I, 1988, pp403 - 404 Meeting Abstract, 1988

GRAHAM, MN, KINETIC-PROPERTIES OF A DEREPRESSED BETA-LACTAMASE FROM ENTEROBACTER-CLOACAE, Biochem. Soc. Trans., 1988, 16, 1988, pp404 - 405 Meeting Abstract, 1988

RIGNEY, EM, PHILLIPS, O, MANTLE, TJ, SOME PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF OX KIDNEY BILIVERDIN REDUCTASE, BIOCHEMICAL JOURNAL, 255, 1988, p431 - 435 Journal Article, 1988

Graham, M.N. & Mantle, T.J., Kinetic properties of a de-repressed -lactamase from Enterobacter cloacae, Biochem. Soc. Trans., 16, 1988, p404 - 405 Journal Article, 1988

BOYCE, SJ, IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUTATHIONE S-TRANSFERASE SUBUNITS IN RAT-BRAIN, Biochem. Soc. Trans., 1988, 16, 1988, pp386 - 387 Meeting Abstract, 1988

Glutathione S-transferase heterogeneity: novel forms or sticky artefacts ? in, editor(s)T.J. Mantle, C.B. Pickett and J.D. Hayes , Glutathione S-transferases and carcinogenesis, London, New York and Philadelphia, Taylor and Francis, 1987, pp65 - 67, [McCusker, F.M. & Mantle, T.J.] Book Chapter, 1987

T.J. Mantle, C.B. Pickett & J.D. Hayes (eds), Glutathione S-transferases and Carcinogenesis, London, New York and Philadelphia , Taylor and Francis, 1987 Book, 1987

Tissue distribution of glutathione S-transferase subunits in rodents: an immunocytochemical study in, editor(s)T.J. Mantle, C.B. Pickett and J.D. Hayes , Glutathione S-transferases and carcinogenesis, London, New York and Philadelphia, Taylor and Francis, 1987, ppDD - DD, [Boyce, S.J., McBennett, S.M., Mantle, T.J. & Hayes, J.D.] Book Chapter, 1987

MCCUSKER, FM, ISOLATION OF GLUTATHIONE S-TRANSFERASE-G FROM RAT-LIVER, Biochem. Soc. Trans., 1987, 15, 1987, pp222 - 222 Meeting Abstract, 1987

HAYES, JD, COULTHWAITE, RE, STOCKMAN, PK, HUSSEY, AJ, MANTLE, TJ, WOLF, CR, GLUTATHIONE-S-TRANSFERASE SUBUNITS IN THE MOUSE AND THEIR CATALYTIC ACTIVITIES TOWARDS REACTIVE ELECTROPHILES, ARCHIVES OF TOXICOLOGY, 1987, p136 - 146 Journal Article, 1987

T.J. Mantle (ed), Roles and Functions of Glutathione, Biochem. Soc. Trans. , 15, 1986, pp717 - 736 Conference Paper, 1986

Worrall, D.M., Daly, A.K. & Mantle, T.J., Kinetic studies on the major form of aldehyde reductase in ox kidney: a general kinetic mechanism to explain substrate dependent mechanisms and the inhibition by anticonvulsants, J. Enz. Inhib., 1, 1986, p163 - 168 Journal Article, 1986

Hayes, J.D. & Mantle, T.J., Use of immuno-blot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Evidence for three immunochemically distinct groups of transferase in the rat, Biochem. J., 233, 1986, p779 - 788 Journal Article, 1986

Hayes, J.D. & Mantle, T.J., Inhibition of hepatic and extrahepatic glutathione S-transferases by primary and secondary bile acids, Biochem. J., 233, 1986, p407 - 415 Journal Article, 1986

HAYES, JD, MANTLE, TJ, ANOMALOUS ELECTROPHORETIC BEHAVIOR OF THE GLUTATHIONE-S-TRANSFERASE YA AND YK SUBUNITS ISOLATED FROM MAN AND RODENTS - A POTENTIAL PITFALL FOR NOMENCLATURE, BIOCHEMICAL JOURNAL, 237, 1986, p731 - 740 Journal Article, 1986

HEYENGA, AG, THE DETERMINATION OF GLUCURONIC AND GULONIC ACID BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY, Biochem. Soc. Trans., 1985, 13, 1985, pp483 - 484 Meeting Abstract, 1985

GRAHAM, MN, PARTIAL-PURIFICATION OF MYOINOSITOL OXYGENASE FROM OX KIDNEY BY USING PHENYL-SEPHAROSE, Biochem. Soc. Trans., 1985, 13, 1985, pp481 - 481 Meeting Abstract, 1985

RIGNEY, EM, NUCLEOTIDE BINDING TO OX KIDNEY BILIVERDIN REDUCTASE, Biochem. Soc. Trans., 1985, 13, 1985, pp502 - 502 Meeting Abstract, 1985

SHEEHAN, D, MANTLE, TJ, EVIDENCE FOR 2 FORMS OF LIGANDIN (YAYA DIMERS OF GLUTATHIONE S-TRANSFERASE) IN RAT-LIVER AND KIDNEY, BIOCHEMICAL JOURNAL, 218, 1984, p893 - 897 Journal Article, 1984

PHILLIPS, O, MANTLE, TJ, TUFFERY, AR, HEYWORTH, CM, WILSON, SR, HOUSLAY, MD, ON THE POSSIBLE ROLE OF BILIVERDIN STIMULATION OF CYCLIC-AMP LEVELS AS A TRIGGER FOR LIVER-REGENERATION IN THE RAT, BIOCHEMICAL PHARMACOLOGY, 33, 1984, p1963 - 1967 Journal Article, 1984

Determination of the relative molecular mass of proteins by gel filtration, density gradient centrifugation, sedimentation equilibrium in the airfuge, radiation inactivation and polyacrylamide electrophoresis in, editor(s)K.F. Tipton , Techniques in the life sciences, Shannon, Ireland, Elsevier Scientific Publishers Ireland Ltd., 1984, pp1 - 26, [Mantle, T.J.] Book Chapter, 1984

BUTLER, BM, THE EFFECT OF PH ON THE SLOW KINETIC TRANSIENTS OF ARYLSULFATASE-A, Biochem. Soc. Trans., 1984, 12, 1984, pp468 - 468 Meeting Abstract, 1984

RYLE, CM, MANTLE, TJ, STUDIES ON THE GLUTATHIONE S-TRANSFERASE ACTIVITY ASSOCIATED WITH RAT-LIVER MITOCHONDRIA, BIOCHEMICAL JOURNAL, 222, 1984, p553 - 556 Journal Article, 1984

SHEEHAN, D, RYLE, CM, MANTLE, TJ, SELECTIVE INDUCTION OF GLUTATHIONE S-TRANSFERASE-D IN RAT TESTIS BY PHENOBARBITAL, BIOCHEMICAL JOURNAL, 219, 1984, p687 - 688 Journal Article, 1984

Tipton, K.F., O'Carroll, A.-M., Mantle, T.J. & Fowler, C.J., Factors involved in the selective inhibition of monoamine oxidase, Mod. Probl. Pharmacopsychtiat., 19, 1983, p15 - 30 Journal Article, 1983

OFAGAIN, C, BUTLER, BM, MANTLE, TJ, THE EFFECT OF PH ON THE KINETICS OF ARYLSULFATASE-A AND ARYLSULFATASE-B, BIOCHEMICAL JOURNAL, 213, 1983, p603 - 607 Journal Article, 1983

Sheehan, D. & Mantle, T.J., Isolation of the major cyanogen bromide cleavage fragment of the a- and c-subunits of glutathione S-transferases AA, B and ligandin, Biochem. Soc. Trans., 11, 1983, p353 - 354 Journal Article, 1983

Sheehan, D. & Mantle, T.J., The nomenclature of the multiple forms of glutathione S-transferase in the rat, Biochem. Soc. Trans., 11, 1983, p353 - 353 Journal Article, 1983

Monoamine oxidase A and B: time for re-evaluation in, editor(s)S. Kalsner , Trends in autonomic pharmacology; vol. 2, Baltimore , Urban & Schwarzenburg, 1982, pp523 - 542, [Mantle, T.J. & Tipton, K.F.] Book Chapter, 1982

FOWLER, CJ, MANTLE, TJ, TIPTON, KF, THE NATURE OF THE INHIBITION OF RAT-LIVER MONOAMINE-OXIDASE TYPE-A AND TYPE-B BY THE ACETYLENIC INHIBITORS CLORGYLINE, L-DEPRENYL AND PARGYLINE, BIOCHEMICAL PHARMACOLOGY, 31, 1982, p3555 - 3561 Journal Article, 1982

Tipton, K.F., Rivett, A.J., Daly, A.K. & Mantle, T.J., Kinetic studies with aldehyde reductases, Prog. Clin. Biol. Res., 114, 1982, p197 - 208 Journal Article, 1982

DALY, AK, MANTLE, TJ, PURIFICATION AND CHARACTERIZATION OF THE MULTIPLE FORMS OF ALDEHYDE REDUCTASE IN OX KIDNEY, BIOCHEMICAL JOURNAL, 205, 1982, p373 - 380 Journal Article, 1982

Kinetic studies with aldehyde reductases in, editor(s)H. Weiner and B. Wermuth , Enzymology of carbonyl metabolism: Aldehyde dehydrogenase and aldo/keto reductase, New York, Alan R. Liss, Inc., 1982, pp197 - 208, [Tipton, K.F., Rivett, A.J., Daly, A.K. & Mantle, T.J.] Book Chapter, 1982

Sheehan, D. & Mantle, T.J., Glutathione S-transferases AA and B possess a common antigenic determinant, Biochem. Soc. Trans., 10, 1982, p113 - 113 Journal Article, 1982

DALY, AK, MANTLE, TJ, THE KINETIC MECHANISM OF THE MAJOR FORM OF OX KIDNEY ALDEHYDE REDUCTASE WITH D-GLUCURONIC ACID, BIOCHEMICAL JOURNAL, 205, 1982, p381 - 388 Journal Article, 1982

OFAGAIN, C, BOND, U, ORSI, BA, MANTLE, TJ, THE SLOW KINETIC TRANSIENTS OF ARYLSULFATASE-A, BIOCHEMICAL JOURNAL, 201, 1982, p345 - 352 Journal Article, 1982

The inhibition of rat liver monoamine oxidase by clorgyline and deprenyl in, editor(s)M.B.H. Youdim and E.S. Paykel , Monoamine oxidase inhibitors - The State of the Art, Chichester, U.K., John Wiley & Sons Ltd., 1981, pp3 - 15, [Tipton, K.F. & Mantle, T.J.] Book Chapter, 1981

Scully, N.C. & Mantle, T.J., The identity of the c-subunits of glutathione S-transferases AA and B, Biochem. Soc. Trans., 1981, p296 - 296 Journal Article, 1981

Phillips, O. & Mantle, T.J., Some kinetic and physical properties of biliverdin reductase, Biochem. Soc. Trans., 9, 1981, p275 - 278 Journal Article, 1981

SCULLY, NC, MANTLE, TJ, TISSUE DISTRIBUTION AND SUBUNIT STRUCTURES OF THE MULTIPLE FORMS OF GLUTATHIONE S-TRANSFERASE IN THE RAT, BIOCHEMICAL JOURNAL, 193, 1981, p367 - 370 Journal Article, 1981

Daly, A.K. & Mantle, T.J., Multiple forms of aldehyde reductase from ox kidney, Biochem. Soc. Trans., 9, 1981, p295 - 295 Journal Article, 1981

T.J. Mantle (ed), Monomeric NAD(P)-linked oxidoreductases, Biochem. Soc. Trans., 9, 1981, pp271 - 282 Conference Paper, 1981

Fowler, C.J., Callingham, B.A., Mantle, T.J. & Tipton, K.F., The effect of lipophilic compounds upon the activity of rat liver monoamine oxidase-A and -B, Biochem. Pharmacol., 29, 1980, p1173 - 1183 Journal Article, 1980

O'Fagain, C., Burke, J. & Mantle, T.J., Inhibition of arylsulphatases A and B by nucleotides and other anions, Biochem. Soc. Trans., 8, 1980, p450 - 451 Journal Article, 1980

Scully, N.C. & Mantle, T.J., Studies on the nature of the multiple forms of the glutathione S-transferases, Biochem. Soc. Trans., 8, 1980, p451 - 452 Journal Article, 1980

Molecular weight determination by gel filtration, density gradient centrifugation, electrophoresis and irradiation inactivation in, Techniques in the Life Sciences, B1/1, Elsevier/North Holland, Biomedical Press, 1979, [Mantle, T.J.] Book Chapter, 1979

Barnard, E.A., Dolly, J.O., Lo, M. & Mantle, T.J., Biochem. Soc. Trans., 6, 1978, p649 - 651 Journal Article, 1978

Callingham, B.A., Fowler, C.J., Mantle, T.J. & Tipton, K.F., Monoamine oxidase A and B; a useful concept ?, Biochem. Pharmacol., 27, 1978, p97 - 101 Journal Article, 1978

Tipton, K.F. & Mantle, T.J., Selective inhibition of monoamine oxidase, Abstracts VI World Congress of Psychiatry, 1977, p64 - 64 Journal Article, 1977

Tipton, K.F., Houslay, M.D. & Mantle, T.J., A kinetic method for the detection of inhibitory contaminants in radioactive substrates, Biochem. Pharmacol., 26, 1977, p1525 - 1527 Journal Article, 1977

Dynamics of monoamine oxidase in, editor(s)E. Usdin, N. Weiner and M.B.H. Youdim , Structure and Function of Monoamine Enzymes, 1977, pp559 - 585, [Tipton, K.F. & Mantle, T.J.] Book Chapter, 1977

Mantle, T.J., Houslay, M.D., Garrett, N.J. & Tipton, K.F., 5-Hydroxy tryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria, J. Pharm. Pharmac., 28, 1976, p667 - 671 Journal Article, 1976

Tipton, K.F., Mantle, T.J. & Houslay, M.D., Some problems concerning the apparent multiplicity of monoamine oxidase, Psychopharmacol. Bull., 1976 Journal Article, 1976

Long, R.F., Mantle, T.J. & Wilson, K., Substrate-selective inhibition of monoamine oxidase by some cyclopropylamino substituted oxadiazoles, Biochem. Pharmacol., 25, 1976, p247 - 252 Journal Article, 1976

Mantle, T.J., Tipton, K.F. & Garrett, N.J., Inhibition of monoamine oxidase by amphetamine and related compounds, Biochem. Pharmacol., 25, 1976, p2073 - 2077 Journal Article, 1976

Mantle, T.J., Garrett, N.J. & Tipton, K.F., The development of monoamine oxidase in rat liver and brain, FEBS Letts., 64, 1975, p227 - 230 Journal Article, 1975

Mantle, T.J., Wilson, K. & Long, R.F., Studies on the selective inhibition of membrane-bound rat liver monoamine oxidase, Biochem. Pharmacol., 24, 1975, p2039 - 2046 Journal Article, 1975

Mantle, T.J., Kinetic studies on rat liver monoamine oxidase, C.N.A.A., 1974 Thesis, 1974

Non-Peer-Reviewed Publications

Mantle, T.J., Enzymes: nature's exquisite nanomachines. A tale of two transients and some floppy bits, Royal Irish Academy, Dublin, 1999 Conference Paper, 1999

Tipton, K.F. & Mantle, T.J., Selective inhibition and the multiplicity of monoamine oxidase, Second World Congress of Biological Psychiatry, Barcelona, 1978 Meeting Abstract, 1978

Tipton, K.F., Houslay, M.D. & Mantle, T.J., The nature and locations of the multiple forms of monoamine oxidase, Ciba Foundation Symposium: "Monoamine oxidase and its inhibition", Excerpta Medica, North Holland, 1976, pp5 - 16 Conference Paper, 1976

Research Expertise

Description

. CURRENT RESEARCH INTERESTS: Research in the Molecular Enzymology Group centres on structural, kinetic and regulatory aspects of a number of enzymes. . BILIVERDIN-IX REDUCTASE AS A PHARMACOLOGICAL TARGET FOR NEONATAL JAUNDICE. . STRUCTURAL AND KINETIC STUDIES ON GST-P1-1. . . BILVERDIN REDUCTASE AND THE ANTIOXIDANT RESPONSE. . THE TRANSIENT KINETICS OF SULPHATASE A. . FINANCIAL SUPPORT: SFI, Enterprise Ireland (Proof of Concept), HRB, IACR, PRTLI . MAJOR COLLABORATORS: Miquel Coll (Barcelona), John Hayes (Dundee), Mike Gore (Southampton), Phil Board (Canberra), Pedro Pereira (Porto).

Projects

  • Funding Agency
    • MRC (UK)
  • Funding Agency
    • Wellcome Trust (UK)
  • Funding Agency
    • NIH (USA)
  • Funding Agency
    • AICR (UK)

Keywords

3-DIMENSIONAL STRUCTURE; ACID; ALBUMIN-BOUND BILIRUBIN; ALPHA REDUCTASE; ANTIOXIDANT; ARYLSULPHATASE A; AUTONOMIC NEUROPATHY; BETA REDUCTASE; BILE-PIGMENTS; BILIRUBIN; BILIRUBIN ANALOGS; BINDING; C57BL/6 MICE; CANCER; CARDIOVASCULAR RISK-FACTORS; CELLS; CHEMICAL HEPATOCARCINOGENESIS; CIGARETTE SMOKING; CLEAVAGE; CROHNS-DISEASE; DISEASE; DNA; ENZYME KINETICS; ENZYME STRUCTURE; ETHACRYNIC-ACID; EXCRETION; EXPRESSION; FACTOR-I; FORMS; GENE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE; GLUTATHIONE-S-TRANSFERASE-MU; GLYCOSAMINOGLYCANS; HEME OXYGENASE; HEPATOCARCINOGENESIS; HIGH CATALYTIC ACTIVITY; HUMAN PLACENTA; HUMAN-SERUM; IGF-I; INACTIVATION; INDEX; INTESTINAL INFLAMMATION; KIDNEY; LEUKOCYTES; LIVER; LUNG CANCER; MARKER; PROTEINS; PURIFICATION; RAT-LIVER; SCHIZOPHRENIA; SMOKING; SOMATOMEDIN-C; ULCERATIVE-COLITIS

Recognition

Representations

Editorial Board of the Biochemical Journal 1993-2000

Elected Secretary of the Molecular and Cellular Pharmacology Group of the Biochemical Society. 1995-1998

Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin 1988-1992

Editorial Adviser: Biochemical Journal; Biochim. Biophys. Acta; Eur. J. Biochem; Diabetologia 1990-

Editor: Glutathione S-transferases and Carcinogenesis, Taylor and Francis 1987

Editor: Glutathione S-transferases and Drug Resistance, Taylor and Francis 1989

Editor: Structure and function of glutathione S-transferases, CRC Press 1993

Awards and Honours

Elected Fellow of Trinity College 1985

Royal Irish Academy's Medal for Biochemistry 1999

Memberships

Nominated to the National Committee for Biochemistry (of the Royal Irish Academy) 1996 – 1999

European Environmental Mutagen Society: Councillor for Ireland 1987 – 1989

Biochemical Society: Editorial Board,Biochemical Journal 1993 – present

Biochemical Society: Elected to the Molecular and Cellular Pharmacology Group 1993 – present

Biochemical Society: Elected to the Molecular Enzymology Group 1988 – 1993

Biochemical Society: Elected to Irish Area Section Committee 1983 – 1988

Biochemical Society (Member) 1974 – present

Director, National Pharmaceutical Biotechnology Centre, Trinity College, Dublin 1988 – 1992