Paul Smyth
Senior Medical Scientist, Histopathology
Senior Medical Scientist, Molecular Medicine Ireland

Publications and Further Research Outputs

Peer-Reviewed Publications

Aherne ST, Smyth P, Freeley M, Smith L, Spillane C, O'Leary J, Sheils O, Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression., International journal of molecular medicine, 38, (2), 2016, p433-45 Journal Article, 2016 DOI

Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 Journal Article, 2016 DOI

Dorris ER, Blackshields G, Sommerville G, Alhashemi M, Dias A, McEneaney V, Smyth P, O'Leary JJ, Sheils O, Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines., Cancer biology & therapy, 2016, p0 Journal Article, 2016

Gallagher MF, Salley Y, Spillane CD, Ffrench B, El Baruni S, Blacksheilds G, Smyth P, Martin C, Sheils O, Watson W, O'Leary JJ, Enhanced regulation of cell cycle and suppression of osteoblast differentiation molecular signatures by prostate cancer stem-like holoclones., Journal of clinical pathology, 68, (9), 2015, p692-702 Journal Article, 2015 DOI

Sheane BJ, Smyth P, Scott K, Aziz R, Buckley M, Lodge E, Kiely N, Kingston M, McGovern E, Healy M, Walsh JB, Sheils O, Cunnane G, An Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease., MicroRNA (Sha"riqah, United Arab Emirates), 4, (1), 2015, p57-63 Journal Article, 2015

Sadlier C, Rowley D, Morley D, Surah S, O'Dea S, Delamere S, O'Leary J, Smyth P, Clarke S, Sheils O, Bergin C, Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act., HIV medicine, 15, (8), 2014, p499-504 Journal Article, 2014 DOI TARA - Full Text

d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ, The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer., PloS one, 9, (6), 2014, pe100816 Journal Article, 2014 TARA - Full Text DOI

Smyth CM, Akasheh N, Woods S, Kay E, Morgan RK, Thornton MA, O'Grady A, Cummins R, Sheils O, Smyth P, Gleich GJ, Murray FM, Costello RW, Activated eosinophils in association with enteric nerves in inflammatory bowel disease., PloS one, 8, (5), 2013, pe64216 Journal Article, 2013

Dorris ER, Smyth P, O'Leary JJ, Sheils O, MIR141 Expression Differentiates Hashimoto Thyroiditis from PTC and Benign Thyrocytes in Irish Archival Thyroid Tissues., Frontiers in endocrinology, 3, 2012, p102 Journal Article, 2012

Gallagher MF, Heffron CC, Laios A, O'Toole SA, Ffrench B, Smyth PC, Flavin RJ, Elbaruni SA, Spillane CD, Martin CM, Sheils OM, O'Leary JJ, Suppression of cancer stemness p21-regulating mRNA and microRNA signatures in recurrent ovarian cancer patient samples., Journal of ovarian research, 5, (1), 2012, p2 Journal Article, 2012

Karl Egan., Darragh Crowley., Paul Smyth, Sharon O'Toole, Cathy Spillane, Cara Martin, Michael Gallagher, Aoife Canney, Lucy Norris, Niamh Conlon, Lynda McEvoy2, Brendan Ffrench2, Britta Stordal, Helen Keegan, Stephen Finn, Victoria McEneaney, Alex Laios, Jens Ducre, Eimear Dunne, Leila Smith, Michael Berndt, Orla Sheils, Dermot Kenny, John O'Leary, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011 Journal Article, 2011 TARA - Full Text

O'Hurley G, Perry AS, O'Grady A, Loftus B, Smyth P, O'Leary JJ, Sheils O, Fitzpatrick JM, Hewitt SM, Lawler M, Kay EW, The role of secreted frizzled-related protein 2 expression in prostate cancer., Histopathology, 59, (6), 2011, p1240-1248 Journal Article, 2011 DOI

O'Hurley G, O'Grady A, Smyth P, Byrne J, O'Leary JJ, Sheils O, Watson RW, Kay EW, Evaluation of Zinc-alpha-2-Glycoprotein and Proteasome Subunit beta-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, 2010 Journal Article, 2010 DOI

Flavin RJ, Smyth PC, Laios A, O'Toole SA, Barrett C, Finn SP, Russell S, Ring M, Denning KM, Li J, Aherne ST, Sammarae DA, Aziz NA, Alhadi A, Sheppard BL, Lao K, Sheils OM, O'Leary JJ, Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22, (2), 2009, p197-205 Journal Article, 2009 DOI

Flavin R, Smyth P, Barrett C, Russell S, Wen H, Wei J, Laios A, O'Toole S, Ring M, Denning K, Li J, Aherne S, Sammarae D, Aziz NA, Alhadi A, Finn SP, Loda M, B S, Sheils O, O'Leary JJ, miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19, (4), 2009, p641-7 Journal Article, 2009 DOI

Flavin, R.J., Smyth, P.C., Laios, A., O'Toole, S.A., Barrett, C., Finn, S.P., Russell, S., (...), O'Leary, J.J. , Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma, Modern Pathology , 22, (2), 2009, p197-205 Journal Article, 2009 DOI

Flavin R, Jackl G, Finn S, Smyth P, Ring M, O'Regan E, Cahill S, Unger K, Denning K, Jinghuan Li Aherne S, Tallini G, Gaffney E, O'Leary JJ, Zitzelsberger H, Sheils O, RET/PTC rearrangement occurring in primary peritoneal carcinoma., International journal of surgical pathology, 17, (3), 2009, p187-97 Journal Article, 2009 DOI

Stephen G. Maher, Charles M. Gillham, Shane P. Duggan, Paul C. Smyth, Nicola Miller, Cian Muldoon, Kenneth J. O'Byrne, Orla M. Sheils, Donal Hollywood, John V. Reynolds, Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer., Annals of surgery, 250, (5), 2009, p729-37 Journal Article, 2009 DOI

Gallagher MF, Flavin RJ, Elbaruni SA, McInerney JK, Smyth PC, Salley YM, Vencken SF, O'Toole SA, Laios A, Lee MY, Denning K, Li J, Aherne ST, Lao KQ, Martin CM, Sheils OM, O'Leary JJ, Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients., Journal of ovarian research, 2, 2009, p19 Journal Article, 2009 DOI TARA - Full Text

Flavin RJ, Smyth PC, Finn SP, Laios A, O'Toole SA, Barrett C, Ring M, Denning KM, Li J, Aherne ST, Aziz NA, Alhadi A, Sheppard BL, Loda M, Martin C, Sheils OM, O'Leary JJ, Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21, (6), 2008, p676-84 Journal Article, 2008 DOI

Li J, Smyth P, Cahill S, Denning K, Flavin R, Aherne S, Pirotta M, Guenther SM, O'Leary JJ, Sheils O, Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials., BMC biotechnology, 8, 2008, p10 Journal Article, 2008 DOI

O'Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O'Leary JJ, p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas., Human pathology, 39, (3), 2008, p452-8 Journal Article, 2008 DOI

Denning K, Smyth P, Cahill S, Li J, Flavin R, Aherne S, O' Leary JJ, Sheils O, ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells., Molecular cancer, 7, 2008, p44 Journal Article, 2008 DOI

Aherne ST, Smyth PC, Flavin RJ, Russell SM, Denning KM, Li JH, Guenther SM, O'Leary JJ, Sheils OM, Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling., Molecular cancer, 7, 2008, p89 Journal Article, 2008 DOI

Denning KM, Smyth PC, Cahill SF, Finn SP, Conlon E, Li J, Flavin RJ, Aherne ST, Guenther SM, Ferlinz A, O'Leary JJ, Sheils OM, A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20, (10), 2007, p1095-102 Journal Article, 2007 DOI

Li J, Smyth P, Flavin R, Cahill S, Denning K, Aherne S, Guenther SM, O'Leary JJ, Sheils O, Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells., BMC biotechnology, 7, 2007, p36 Journal Article, 2007 DOI

Cahill S, Smyth P, Denning K, Flavin R, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 6, 2007, p21 Journal Article, 2007 DOI

Flavin R, Smyth P, Crotty P, Finn S, Cahill S, Denning K, Jinghuan Li O'Regan E, O'Leary J, Sheils O, BRAF T1799A mutation occurring in a case of malignant struma ovarii., International journal of surgical pathology, 15, (2), 2007, p116-20 Journal Article, 2007 DOI

Finn SP, Smyth P, Cahill S, Streck C, O'Regan EM, Flavin R, Sherlock J, Howells D, Henfrey R, Cullen M, Toner M, Timon C, O'Leary JJ, Sheils OM, Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy., Virchows Archiv : an international journal of pathology, 450, (3), 2007, p249-60 Journal Article, 2007 DOI

Finn S, Smyth P, O'Regan E, Cahill S, Toner M, Timon C, Flavin R, O'Leary J, Sheils O, Low-level genomic instability is a feature of papillary thyroid carcinoma: an array comparative genomic hybridization study of laser capture microdissected papillary thyroid carcinoma tumors and clonal cell lines., Archives of pathology & laboratory medicine, 131, (1), 2007, p65-73 Journal Article, 2007 DOI

Cahill S, Smyth P, Finn SP, Denning K, Flavin R, O'Regan EM, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 5, 2006, p70 Journal Article, 2006 DOI

O'Regan EM, Toner ME, Smyth PC, Finn SP, Timon C, Cahill S, Flavin R, O'Leary JJ, Sheils O, Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients., Head & neck, 28, (4), 2006, p330-8 Journal Article, 2006 DOI

O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ, Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 16, (2), 2006, p834-42 Journal Article, 2006 DOI

Smyth P, Finn S, Cahill S, O'Regan E, Flavin R, O'Leary JJ, Sheils O, ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma., International journal of surgical pathology, 13, (1), 2005, p1-8 Journal Article, 2005

Finn SP, Smyth P, O'regan E, Cahill S, Flavin R, O'leary J, Sheils O, Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes., Virchows Archiv : an international journal of pathology, 445, (4), 2004, p396-404 Journal Article, 2004 DOI

Smyth P, Finn S, O'Leary J, Sheils O, Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues., Diagnostic molecular pathology : the American journal of surgical pathology, part B, 12, (1), 2003, p44-9 Journal Article, 2003

Finn SP, Smyth P, O'Leary J, Sweeney EC, Sheils O, Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma., The Journal of clinical endocrinology and metabolism, 88, (2), 2003, p938-41 Journal Article, 2003 DOI

Smyth P, Sheils O, Finn S, Martin C, O'Leary J, Sweeney EC, Real-time quantitative analysis of E-cadherin expression in ret/PTC-1-activated thyroid neoplasms., International journal of surgical pathology, 9, (4), 2001, p265-72 Journal Article, 2001