Sinead Murphy
CONSULTANT NEUROLOGIST / CLINICAL SENIOR, School Office - Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Stela Lefter, Orla Hardiman, Russell L. McLaughlin, Sinead M. Murphy, Michael Farrell, Aisling M. Ryan, A novel MYH7 Leu1453pro mutation resulting in Laing distal myopathy in an Irish family, Neuromuscular Disorders , 25, (2), 2015, p155 - 160 Journal Article, 2015

Daniela Ernst*, Sinéad M Murphy*, Karthik Sathiyanadan, Yu Wei, Alaa Othman, Matilde Laurá, Yo-Tsen Liu, Anke Penno, Julian Blake, Michael Donaghy, Henry Houlden, Mary M Reilly#,, Thorsten Hornemann , Novel HSAN1 mutation in Serine-Palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity, Neuromolecular Medicine , 2015 Journal Article, 2015 DOI

A. M. Rossor*, E. C. Oates*, H. K. Salter, Y. Liu, S. M. Murphy, R. Schule, M. A. Gonzales, M. Scoto, R. Phadke, C. A. Sewry, H. Houlden, A. Jordanova, I. Tournev, T. Chamova, I. Litvinenko, S. Zuchner, D. N. Herrmann , J. Blake, J. E. Sowden, G. Acsadi, M. L. Rodriguez, M. P. Menezes, N. F. Clarke, M. Auer Grumbach, S. L. Bullock, F. Muntoni, M. M. Reilly , K. N. North, Phenotypic and molecular insights into Spinal Muscular Atrophy due to mutations in BICD2, Brain , 138, (2), 2015, p293 - 310 Journal Article, 2015 TARA - Full Text

Ramdharry GM, Pollard A, Anderson C, Laura M, Murphy SM, Dudziec M, Dewar EL, Hutton E, Grant R, Reilly MM, A Pilot Study of Proximal Strength Training in Charcot Marie Tooth Disease, Journal of the Peripheral Nervous System , 2015 Journal Article, 2015 DOI

Vera Fridman, Sinéad M Murphy, The spectrum of axonopathies: From CMT2 to HSP, Neurology , 83, (7), 2014, p580 - 581 Journal Article, 2014

Reza Sadjadi, Mary M. Reilly, Michael E. Shy, Davide Pareyson, Matilde Laura, Sinead Murphy, Shawna M.E. Feely, Tiffany Grider, Chelsea Bacon, Giuseppe Piscosquito, Daniela Calabrese, Ted M. Burns, Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis, Journal of the Peripheral Nervous System, 19, (3), 2014, p192 - 196 Journal Article, 2014

Judith Conroy, Paul McGettigan, Raymond Murphy, David Webb, Sinéad M Murphy, Blathnaid McCoy, Christine Albertyn, Dara McCreary, Cara McDonagh, Orla Walsh, SallyAnn Lynch, Sean Ennis, A novel locus for episodic ataxia - UBR4 the likely candidate, European Journal of Human Genetics , 22, (4), 2014, p505 - 510 Journal Article, 2014

C Marquz-Infante, SM Murphy, L Mathew, A Alsanousi, MP Lunn, S Brandner, T Yousry, J Blake, MM Reilly, Asymmetric sensory ganglionopathy: a case series, Muscle & Nerve, 48, (1), 2013, p145 - 150 Journal Article, 2013

S M Murphy*, D Ernst*, Y Wei, M Laurà, Y-T Liu, J Polke, J Blake, J Winer, H Houlden, T Hornemann, M M Reilly, Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2, Neurology , 80, 2013, p1 - 6 Journal Article, 2013

James C Stevens, Sinéad M Murphy, Indran Davagnanam, Rahul Phadke, Glenn Anderson, Suran Nethisinghe, Fion Bremner, Paola Giunti, Mary M Reilly, The ARSACS phenotype can include supranuclear gaze palsy and skin lipofuscin deposits, Journal of Neurology, Neurosurgery and Psychiatry, 84, (1), 2013, p114 - 116 Journal Article, 2013

DNA testing in hereditary neuropathies in, editor(s)G. Said, C. Krarup , Handbook of Clinical Neurology 3rd Series Peripheral Nerve Disorders, Elsevier, 2013, pp213 - 212, [2. Sinéad M Murphy, Matilde Laurá, Mary M Reilly] Book Chapter, 2013

Robert DS Pitceathly, Sinéad M Murphy, Ellen Cottenie, Annapuma Chalasani, Mary G Sweeney, Cathy Woodward, Ese E Mudanohwo, Iain Hargreaves, Simon Heales, John Land, Janice L Holton, Henry Houlden, Julian Blake, Michael Champion, Frances Flinter, Stephanie Robb, Rupert Page, Michael Rose, Jaqueline Palace, Carol Crowe, Cheryl Longman, Michael P Lunn, Shamima Rahman, Mary M Reilly, Michael G Hanna, Genetic dysfunction of mitochondrial complex V can cause axonal Charcot-Marie-Tooth disease, Neurology , 79, 2012, p1145 - 1154 Journal Article, 2012

Murphy SM, Laura M, Fawcett K, Pandraud A, Liu YT, Davidson GL, Rossor AM, Polke JM, Castleman V, Manji H, Lunn MP, Bull K, Ramdharry G, Davis M, Blake JC, Houlden H, Reilly MM, Charcot-Marie-Tooth disease: frequency of genetic subtypes and guidelines for genetic testing., Journal of neurology, neurosurgery, and psychiatry, 83, (7), 2012, p706-10 Journal Article, 2012

Sinéad M Murphy, Gabrielle L Davidson, Sebastian Brandner, Henry Houlden, Mary M Reilly, Mutation in FAM134B causing severe hereditary sensory neuropathy, Journal of Neurology, Neurosurgery and Psychiatry , 83, (1), 2012, p119 - 120 Journal Article, 2012

Sinéad M Murphy, Carly Siskind, Richard Ovens, James Polke, Matilde Laura, Henry Houlden, Raymond PJ Murphy, Michael E Shy, Mary M Reilly, X-inactivation pattern in females with CMTX1, Neuromuscular Disorders , 22, 2012, p617 - 621 Journal Article, 2012

Sinéad M Murphy, Usman Khan, Constantine Alifrangis, Steven Hazell, David Hrouda, Julian Blake, Joanna Ball, Carolyn Gabriel, Pierre Markarian, Jeremy Rees, Abid Karim, Michael J Seckl, Michael P Lunn, Mary M Reilly, Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes, Journal of Neurology, Neurosurgery and Psychiatry , 83, (2), 2012, p232 - 233 Journal Article, 2012

Davidson G, Murphy S, Polke J, Laura M, Salih M, Muntoni F, Blake J, Brandner S, Davies N, Horvath R, Price S, Donaghy M, Roberts M, Foulds N, Ramdharry G, Soler D, Lunn M, Manji H, Davis M, Houlden H, Reilly M, Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort., Journal of neurology, 259, (8), 2012, p1673-85 Journal Article, 2012

Hereditary amyloid neuropathy. in, editor(s)C. J. Matthias, R. Bannister , Autonomic Failure: a textbook of clinical disorders of the autonomic nervous system., 2012, [Sinéad M Murphy, Mary M Reilly.] Book Chapter, 2012

Sinéad M Murphy, The genetics of Charcot-Marie-Tooth Disease., CML Neurology, 28, (1), 2012, p1 - 14 Journal Article, 2012

Fawcett KA, Murphy SM, Polke JM, Wray S, Burchell VS, Manji H, Quinlivan RM, Zdebik AA, Reilly MM, Houlden H, Comprehensive analysis of the TRPV4 gene in a large series of inherited neuropathies and controls., Journal of neurology, neurosurgery, and psychiatry, 83, (12), 2012, p1204-9 Journal Article, 2012

PJ Arthur-Farraj, SM Murphy, M Laura, MP Lunn, H Manji, J Blake, G Ramdharry, Z Fox, MM Reilly, Hand weakness in CMT1X. , Neuromuscular Disorders , 22, 2012, p622 - 626 Journal Article, 2012

Murphy SM, Puwanant A, Griggs RC, Unintended effects of orphan product designation for rare neurological diseases., Annals of neurology, 72, (4), 2012, p481-90 Journal Article, 2012

Jaffer F, Murphy SM, Scoto M, Healy E, Rossor AM, Brandner S, Phadke R, Selcen D, Jungbluth H, Muntoni F, Reilly MM, BAG3 mutations: another cause of giant axonal neuropathy., Journal of the peripheral nervous system : JPNS, 17, (2), 2012, p210-6 Journal Article, 2012

Rossor AM, Murphy S, Reilly MM, Knee bobbing in Charcot-Marie-Tooth disease., Practical neurology, 12, (3), 2012, p182-3 Journal Article, 2012

Rossor AM, Davidson GL, Blake J, Polke JM, Murphy SM, Houlden H, Innes A, Kalmar B, Greensmith L, Reilly MM, A novel p.Glu175X premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2., Journal of the peripheral nervous system : JPNS, 17, (2), 2012, p201-5 Journal Article, 2012

Murphy SM, Herrmann DN, McDermott MP, Scherer SS, Shy ME, Reilly MM, Pareyson D, Reliability of the CMT neuropathy score (second version) in Charcot-Marie-Tooth disease., Journal of the peripheral nervous system : JPNS, 16, (3), 2011, p191-8 Journal Article, 2011

Reilly MM, Murphy SM, Laurá M, Charcot-Marie-Tooth disease., Journal of the peripheral nervous system : JPNS, 16, (1), 2011, p1-14 Journal Article, 2011

Sinéad M Murphy, Reliability of the CMT Neuropathy Score (second version) in Charcot-Marie-Tooth , International CMT Consortium, Potomac,, MD, July 2011, 2011 Oral Presentation, 2011

Sinéad M Murphy, A painful neuropathy., Irish Neuromuscular Association meeting, Ireland, May 2011, 2011 Oral Presentation, 2011

Sinéad M Murphy, X-inactivation in females with CMTX1, Irish Neurological Association (INA) , Ireland, May 2011, 2011 Oral Presentation, 2011

Sinéad M Murphy, Matilde Laurá, Mary M Reilly., Hereditary Neuropathies, EPub www.ebrainjnc.com Module 014_006, 2011eBrain session , 2011 Journal Article, 2011

Sinéad M Murphy, SPTLC2 case presentation. , British Peripheral Nerve Society, Kings Hospital, London, 21 October 2011, 2011 Oral Presentation, 2011

Sinéad M Murphy, Mary M Reilly. , Amyloid neuropathies., Advances in Clinical Neuroscience and Rehabilitation, 11, (1), 2011, p16 - 19 Journal Article, 2011

Sinead M Murphy, Charcot-Marie-tooth disease: genetic diagnoses in a specialist clinic, Association of British Neurologists, Brighton, 2011, 2011 Oral Presentation, 2011

Siskind CE, Murphy SM, Ovens R, Polke J, Reilly MM, Shy ME, Phenotype expression in women with CMT1X., Journal of the peripheral nervous system : JPNS, 16, (2), 2011, p102-7 Journal Article, 2011

Murphy SM, Laurá M, Blake J, Polke J, Bremner F, Reilly MM, Conduction block and tonic pupils in Charcot-Marie-Tooth disease caused by a myelin protein zero p.Ile112Thr mutation., Neuromuscular disorders : NMD, 21, (3), 2011, p223-6 Journal Article, 2011

Smith LJ, Murphy SM, Holmes P, Reilly MM, Reiniger L, Thom M, Lunn MP, A painful right leg., BMJ (Clinical research ed.), 342, 2011, pd1009 Journal Article, 2011

Murphy SM, Polke J, Manji H, Blake J, Reiniger L, Sweeney M, Houlden H, Brandner S, Reilly MM, A novel mutation in the nerve-specific 5'UTR of the GJB1 gene causes X-linked Charcot-Marie-Tooth disease., Journal of the peripheral nervous system : JPNS, 16, (1), 2011, p65-70 Journal Article, 2011

Cerebrovascular Disease in, editor(s)T.E. Andreoli, I.J. Benjamin, R.C. Griggs, E.J. Wing , Andreoli and Carpenter's Cecil Essentials of Medicine., Philadelphia, Saunders Elsevier, 2010, pp1123 - 1135, [Sinéad M Murphy, Timothy J Counihan.] Book Chapter, 2010

Sinead Murphy, 6. Mutations in FAM134B cause hereditary sensory and autonomic neuropathy II, Irish Neurological Association, Belfast, 2010, 2010 Oral Presentation, 2010

Shiv Saidha, Sinead Murphy, Aoife Ronayne, Peter McCarthy, Michael Hennessy, Timothy Counihan., Treatment of anti-glutamic acid decarboxylase antibody associated limbic encephalitis with mycophenolate mofetil., Journal of Neurology, 257, (6), 2010, p1035 - 1038 Journal Article, 2010

Ryan D, Murphy SM, Hennessey MJ, Bilateral posterior cerebral artery infarction., BMJ case reports, 2010, 2010 Journal Article, 2010 DOI

Cortical Syndromes. in, editor(s)T.E. Andreoli, I.J. Benjamin, R.C. Griggs, E.J. Wing , Andreoli and Carpenter's Cecil Essentials of Medicine. , Philadelphia, Saunders Elsevier, 2010, pp1068 - 1071, [Sinéad M Murphy, Timothy J Counihan.] Book Chapter, 2010

Shiv Saidha, Sinead Murphy, Peter McCarthy, Philip Mayne, Michael Hennessy. , L-2-hydroxyglutaric aciduria diagnosed in an adult presenting with acute deterioration. , Journal of Neurology, 257, (1), 2010, p146 - 148 Journal Article, 2010

Sinéad M Murphy, ARSACS case presentation. , British Peripheral Nerve Society, October 2009, 2009 Oral Presentation, 2009

Treatment of the epilepsy patient with concomitant medical conditions in, editor(s)J.A. French, N Delanty , Therapeutic Strategies in Epilepsy, Oxford, Clinical Publishing, 2009, pp229 - 249, [Sinéad M Murphy, Norman Delanty] Book Chapter, 2009

Sinead Madeleine Murphy, Michael A Farrell, Michael J Hennessy, Postpartum relapsing sensory neuritis responsive to intravenous immunoglobulin, Journal of Neurology, 256, (12), 2009, p2085 - 2086 Journal Article, 2009

S Murphy, G Gorman, C Beetz, P Byrne, M Dytko, P McMonagle, K Kinsella, M Farrell, M Hutchinson, Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic and neuropathological evidence, Neurology , 73, 2009, p378 - 384 Journal Article, 2009

Smyth A, Murphy SM, Counihan TJ, An unusual cause of cavernous sinus syndrome., BMJ case reports, 2009, 2009 Journal Article, 2009 DOI

Sinead Murphy, 8. Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic and neuropathological evidence, Irish Institute of Clinical Neuroscience (IICN) Registrar's Prize meeting , 2008, 2008 Oral Presentation, 2008

SM Murphy, D McIntyre, B McAdam, JT Moroney, Transthoracic echocardiography is not useful in the routine investigation of ischaemic stroke or TIA, Irish Medical Journal , 101, (5), 2008, p106 - 106 Journal Article, 2008

SM Murphy, A Rogers, M Hutchinson, N Tubridy, Counting the cost of complementary and alternative therapies in an Irish neurological clinic, European Journal of Neurology , 15, (12), 2008, p1380 - 1383 Journal Article, 2008

Sinead M Murphy, John Thornton, Joan T Moroney., Spontaneous intra-luminal carotid thrombus in association with multiple myeloma., BloodMed on-line 1/7/07, 2007 Journal Article, 2007

Sinéad M Murphy, Infarct volume and apraxia of speech in acute ischaemic hemispheral stroke. , European Neurological Society (ENS) , June 2007, 2007 Oral Presentation, 2007

Sinead M Murphy, John P O'Dwyer, Philip Murphy, Joan T Moroney, Cerebral ischaemia and intracerebral haemorrhage in the hypereosinophilic syndrome., BloodMed on-line 15/6/07, 2007 Journal Article, 2007

Sinead Murphy, Complementary medicine in neurology: little evidence, huge costs, so why is everyone doing it? , Royal Academy of Medicine of Ireland (RAMI) / IICN meeting , 2007, 2007 Oral Presentation, 2007

Sinéad M Murphy, Cerebral ischaemia and intracerebral haemorrhage in association with the hypereosinophilic syndrome (HES)., RAMI / IICN Diaspora Meeting , October 2006, 2006 Oral Presentation, 2006

Sinéad M Murphy, Infarct volume and apraxia of speech in acute ischaemic hemispheral stroke., RAMI / IICN Diaspora Meeting , October 2006, 2006 Oral Presentation, 2006

Sinéad M Murphy, Cerebral ischaemia and intracerebral haemorrhage in association with the hypereosinophilic syndrome., Association of British Neurologists (ABN) , October 2006, 2006 Oral Presentation, 2006

Sinéad M Murphy, Apraxia of speech, orofacial apraxia, and linguistic dysprosody after acute ischaemic stroke: challenging traditional thinking., ENS, June 2006, 2006 Oral Presentation, 2006

S Murphy, B McNamara, How well is peripheral neuropathy investigated? An audit from a regional neurophysiology department, Irish Journal of Medical Science , 175, (1), 2006, p54 - 56 Journal Article, 2006

Sinéad M Murphy, Paraneoplastic disease masquerading as Sneddon's Syndrome., RAMI Registrar's Prize Meeting., 2005, 2005 Oral Presentation, 2005

Sinéad M Murphy, Prospective Study of Speech Recovery in Acute Ischaemic Stroke: Preliminary findings in 10 patients., INA, June 2005, 2005 Oral Presentation, 2005

38. A McKeon, S Murphy, B McNamara, DQ Ryder, R Galvin, Isolated hypoglossal nerve palsy due to compression by a dissecting vertebral artery., European Journal of Neurology , 53, (3), 2005, p162 - 164 Journal Article, 2005

Sinéad M Murphy, Apraxia of Speech and Linguistic Dysprosody following Acute Ischaemic Stroke. Challenging Traditional Teaching. , November 2005, RAMI Registrar's Prize meeting, 2005 Oral Presentation, 2005

Sinéad M Murphy, How well is peripheral neuropathy investigated? An audit from a regional neurophysiology department., INA, June 2004, 2004 Oral Presentation, 2004

Non-Peer-Reviewed Publications

Petya Bogdanova-Mihaylova, Christelle Oliver-Dussault, Peter Moloney, Sinéad M Murphy, Multiple sclerosis, Hospital Doctor of Ireland, 2013 Journal Article, 2013

S Murphy, B Sweeney, Review of recent articles on the topic of Neurology., Hospital Doctor of Ireland, 1, 2004, p49 - 53 Journal Article, 2004

S Murphy, B Sweeney., Current Therapies in Multiple Sclerosis and Future Options. , Irish Medical Times , 38, (15), 2004, p28 - 30 Journal Article, 2004

Recognition

Awards and Honours

Travel fellowship, Peripheral Nerve Society 2011

Harold Millar prize for best presentation, Irish Neurological Association 2011

Travel grant, Dept. of Molecular Neuroscience, UCL Institute of Neurology, Queen Square 2011

NIH Rare Disease Inherited Neuropathy Consortium fellowship to fund a clinical / research fellowship in inherited neuropathies 2010

The Dr. Richard Steevens' Scholarship, Health Services Executive (HSE) to fund a clinical fellowship in peripheral nerve disorders in Queen Square, London 2009

Bursary EFNS 2008

Travel grant, ENS 2006

RAMI (Royal Academy of Medicine of Ireland) / IICN (Irish Institute of Clinical Neurosciences) Diaspora Registrar's Prize in Neurology - Research 1st prize 2006

RAMI / IICN Diaspora Registrar's Prize in Neurology - Case Report 2nd prize 2006

Irish Heart Foundation Grant for MD research project 2005

TCD Entrance Exhibition Award 1994

The Isabella Mulvaney Exhibition 1994

Ethel M Glorney Trust Prize 1994

The Applied Maths prize 1994

The Jellicoe scholarship 1994

The Trench scholarship 1994

Memberships

RCPI

RCPI 2002 – current