Mark William Robinson
Research Assistant Professor, Trinity Translational Medicine Institute

Publications and Further Research Outputs

Peer-Reviewed Publications

Robinson MW, Hughes J, Wilkie GS, Swann R, Barclay ST, Mills PR, Patel AH, Thomson EC and McLauchlan J., Tracking TCRβ sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region. , Frontiers in Immunology, 7, 2016, p131- Journal Article, 2016

Robinson M.W, Harmon C, O'Farrelly C, Liver immunology and its role in inflammation and homeostasis, Cellular and Molecular Immunology, 13, (3), 2016, p267 - 276 Journal Article, 2016 DOI TARA - Full Text URL

Harmon C, Robinson MW, Fahey R, Whelan S, Houlihan DD, Geoghegan J, O'Farrelly C. , Tissue-resident Eomes(hi) T-bet(lo) CD56(bright) NK cells with reduced proinflammatory potential are enriched in the adult human liver. , European Journal of Immunology , 46, (9), 2016, p2111 - 2120 Journal Article, 2016

Swann RE, Mandalou P, Robinson MW, Ow MM, Foung SKH, McLauchlan J, Patel AH, and Cramp ME. , Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection. , Journal of Viral Hepatitis , 23, (11), 2016, p873 - 880 Journal Article, 2016

Kelly A, Robinson MW, Roche G, Biron CA, O'Farrelly C, Ryan EJ., Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive Via the JAK-STAT Pathway., Journal of Interferon & Cytokine Research , 36, (12), 2016, p671 - 680 Journal Article, 2016

Robinson MW, Aranday-Cortes E, Gatherer D, Swann R, Liefhebber JMP, Da Silva Filipe A, Sigruener A, Barclay ST, Mills PR, Patel AH and McLauchlan J. , Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C., Liver International , 35, (10), 2015, p2256 - 2264 Journal Article, 2015

Robinson MW, McGuinness D, Swann R, Barclay S, Mills PR, Patel AH, McLauchlan J, Shiels PG., Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease, Aging Cell, 12, (6), 2013, p1141 - 1143 Journal Article, 2013 URL

Research Expertise

Description

My research focuses on liver cirrhosis, which occurs when normal liver tissue is replaced by scar tissue, leading to the eventual failure of normal liver functions. My research links three Dublin hospitals that currently caring for patients with liver cirrhosis and exploits new discoveries in liver immunology, specifically around tissue-resident immune cells, to identify immunological markers to predict the presence and rate of progression of liver cirrhosis.