Richard Porter
Associate Professor, Biochemistry

Biography

Dr. Porter did his undergraduate degree in Biochemistry at Trinity College. This was followed by a Ph.D. with Prof. John M. Scott in the area of carbon-one metabolism and a three year postdoctoral position at the Department of Biochemistry University of Cambridge UK with Martin D. Brand. Dr. Porter's research focuses on understanding mammalian energy metabolism. His research achievements are based ideas founded in solid science, a substantial grant base, the quality of the researchers that he recruits, the advanced technology in the laboratory and his collaborations with prominent international laboratories, both academic and industrial.

He has been a lecturer and Principal Investigator in Trinity since 1997, was appointed Director of Teaching and Learning in the School of Biochemistry & Immunology (Postgraduate) from 2004-2008 & 2016-2017, was elected for two terms as Head of Biochemistry from 2011-2017, and was elected Fellow of Trinity College Dublin since 2007. He has over 60 publications in peer reviewed scientific journals and currently has over €0.75M in research grants. He is an editor with a leading Elsevier Journal (Biochimica Biophysica Acta) in the field of Bioenergetics and is regularly invited to give lectures at Conferences, Universities and Research Institutes. He teaches many aspects of biochemistry to scientists, medical students, pharmacists at all levels within the University and has received a Provost Teaching Award. He is on the management committee of several International Scientific Societies, including the European Bioenergetics Conference, MITOEAGLE COST and the International Union of Biochemists and Molecular Biologists (IUBMB) Nominating Committee. He regularly participates in scientific outreach projects such as the "Fat" exhibition in the Science Gallery. Richard also acts a consultant for Price Waterhouse Coopers in the area of R&D Tax Credits and as a product consultant for Phoenix Green. His research resulted in the recently patented World's First Nutrigenomic Product for Thoroughbred Horses, now sold as EnerGene-Q10 by Plusvital. [See recent press coverage: http://www.tcd.ie/news_events/articles/world-s-first]. Furthermore, in addition to basic research grants from Science Foundation Ireland, The Health Research Board, Teagasc and Trinity, he has aEnterprise Ireland Innovation Partnership Programme grant in collaboration with Plusvital and collaborations with Artelo Inc.

Publications and Further Research Outputs

Peer-Reviewed Publications

Sadhbh O'Neill, Richard K. Porter, Vanesa G. Martinez, Lorraine, O'Driscoll , 2-Deoxy-D-Glucose preferentially inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype , 2018 Working Paper, 2018

Clare McKenna, An examination of the molecular control of feed efficiency in beef cattle, 2018 Thesis, 2018

Aasander Frostner E, Acuna-Castroviejo D, Ahn B, Alves MG, Amati F, Aral C, Arandarcikaite O, Bailey DM, Bakker BM, Bastos Sant'Anna Silva AC, Battino M, Beard DA, Ben-Shachar D, Bishop D, Borutaite V, Breton S, Brown GC, Brown RA, Buettner GR, Burtscher J, Calabria E, Calbet JA, Calzia E, Cardoso LHD, Carvalho E, Casado Pinna M, Cervinkova Z, Chang SC, Chaurasia B, Chen Q, Chicco AJ, Chinopoulos C, Clementi E, Coen PM, Collin A, Crisostomo L, Das AM, Davis MS, De Palma C, Dias TR, Distefano G, Doerrier C, Drahota Z, Duchen MR, Ehinger J, Elmer E, Endlicher R, Fell DA, Ferko M, Ferreira JCB, Filipovska A, Fisar Z, Fischer M, Fisher JJ, Fornaro M, Galkin A, Garcia-Roves PM, Garcia-Souza LF, Garten A, Genova ML, Giovarelli M, Gonzalez-Armenta JL, Gonzalo H, Goodpaster BH, Gorr TA, Gourlay CW, Granata C, Grefte S, Haas CB, Haavik J, Han J, Harrison DK, Hellgren KT, Hernansanz-Agustin P, Holland OJ, Hoppel CL, Houstek J, Hunger M, Iglesias-Gonzalez J, Irving BA, Iyer S, Jackson CB, Jadiya P, Jang DH, Jansen-Duerr P, Jespersen NR, Jha RK, Kaambre T, Kane DA, Kappler L, Karabatsiakis A, Keijer J, Keppner G, Klingenspor M, Komlodi T, Koopman WJH, Kopitar-Jerala N, Krako Jakovljevic N, Kuang J, Kucera O, Labieniec-Watala M, Lai N, Laner V, Larsen TS, Lee HK, Lemieux H, Leeuwenburgh C, Lerfall J, Liu J, Lucchinetti E, MacMillan-Crow LA, Makrecka-Kuka M, Malik AN, Markova M, Menze MA, Meszaros AT, Michalak S, Moisoi N, Molina AJA, Montaigne D, Moore AL, Mracek T, Muntane J, Muntean DM, Murray AJ, Nemec M, Neuzil J, Newsom S, Nozickova K, O'Gorman D, Oliveira PF, Oliveira MT, Oliveira PJ, Orynbayeva Z, Pak YK, Palmeira CM, Patel HH, Pecina P, Pelnena D, Pereira da Silva Grilo da Silva F, Pesta D, Petit PX, Pichaud N, Piel S, Pirkmajer S, Porter RK, Pranger F, Prochownik EV, Pulinilkunnil T, Puurand M, Radenkovic F, Radi R, Ramzan R, Reboredo P, Renner-Sattler K, Robinson MM, Roesland GV, Rohlena J, Rolo AP, Ropelle ER, Rossiter HB, Rybacka-Mossakowska J, Saada A, Safaei Z, Salin K, Salvadego D, Sandi C, Scatena R, Schartner M, Scheibye-Knudsen M, Schilling JM, Schlattner U, Schoenfeld P, Schwarzer C, Scott GR, Shabalina IG, Sharma P, Sharma V, Shevchuk I, Siewiera K, Silber AM, Singer D, Smenes BT, Soares FAA, Sobotka O, Sokolova I, Spinazzi M, Stankova P, Stier A, Stocker R, Sumbalova Z, Suravajhala P, Swerdlow RH, Swiniuch D, Szabo I, Tanaka M, Tandler B, Tavernarakis N, Tepp K, Thyfault JP, Tomar D, Towheed A, Tretter L, Trifunovic A, Trivigno C, Tronstad KJ, Trougakos IP, Tyrrell DJ, Urban T, Valentine JM, Velika B, Vendelin M, Vercesi AE, Victor VM, Villena JA, Vitorino RMP, Vogt S, Volani C, Votion DM, Vujacic-Mirski K, Wagner BA, Ward ML, Watala C, Wei YH, Wieckowski MR, Williams C, Wohlwend M, Wolff J, Wuest RCI, Zaugg K, Zaugg M, Zischka H, Zorzano A, Supporting:, Bernardi P, Boetker HE, Borsheim E, Bouitbir J, Coker RH, Dubouchaud H, Durham WJ, Dyrstad SE, Engin AB, Gan Z, Garlid KD, Haendeler J, Hand SC, Hepple RT, Hickey AJ, Hoel F, Kainulainen H, Khamoui AV, Kowaltowski AJ, Krajcova A, Lane N, Lenaz G, Liu SS, Mazat JP, Methner A, Nedergaard J, Pallotta ML, Parajuli N, Pettersen IKN, Porter C, Sazanov LA, Skolik R, Sonkar VK, Vieyra A, Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology, CELL METABOLISM, 2018 Journal Article, 2018

The role of calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue. in, editor(s)Carlos Palmiera , Methods in Molecular Biology , 2018, [Kieran J Clarke & Richard K. Porter ] Book Chapter, 2018

Mary F Rooney, Emmeline W Hill, Vincent P. Kelly, Richard K. Porter , The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion, 2018 Working Paper, 2018

Petr Je ek, Martin Jabůrek and Richard K. Porter , Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1 , Biochimica Biophysica Acta, 2018 Review Article, 2018

McKenna C, Porter RK, Keogh K, Waters SM, McGee M and Kenny DA, Residual feed intake phenotype and gender affect the expression of key genes of the lipogenesis pathway in adipose tissue of beef cattle, 2018 Working Paper, 2018

McKenna C, Porter RK, Waters SM, Cormican P, McGee M, Kelly AK and Kenny D, An examination of the transcriptional control of energetic efficiency in skeletal muscle and hepatic tissue from beef cattle divergent for residual feed intake, 2018 Working Paper, 2018

Geoghegan, F. and Buckland, R.J. and Rogers, E.T. and Khalifa, K. and O'Connor, E.B. and Rooney, M.F. and Behnam-Motlagh, P. and Nilsson, T.K. and Grankvist, K. and Porter, R.K., Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells, Oncotarget, 8, (55), 2017, p94711-94725 Journal Article, 2017 DOI

Richard K. Porter, Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells, , 'Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment (MITOEAGLE)',, Barcelona University, Institut D'Estdies Catalan, Spain, Mar 2017, 2017, COST MITOEAGLE Invited Talk, 2017

Emma B. O'Connor, Richard K. Porter and Patrick T. Walsh , A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, Keystone Meeting, Dublin, Ireland, Royal Dublin Society, May 29-June 2, 2017, 2017 Meeting Abstract, 2017

Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter, Genotype variation at the MSTN locus is associated with skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses., Gruppo Italiano di Biomembrane e Bioenergetica, Cantania, Italy, June 14-16, 2017, edited by Paolo Bernardi (Padova), Alessandro Giuffrè (Roma), Giovanna Lippe (Udine), Vito De Pinto (Catania), Francesco Francia (Bologna), Cesare Indiveri (Calabria), Luigi Palmieri (Bari), Claudia Piccoli (Foggia). , 2017 Meeting Abstract, 2017

Richard K. Porter, Discovering Bioenergetic Anticancer Targets in vitro , Measuring Metabolic Engines and Fuels-Seahorse Users Meeting 18.5.17, Weizmann Institute, Israel, May 2017, 2017, Agilent & Weizmann Institute Invited Talk, 2017

Marilena Karavyraki, A bioenergetic comparison of dysplastic and cancerous oral cells, Irish Division of the International Dental Research Association (IADR) Annual Division Meeting, Belfast, Northern Ireland, November, edited by Irish Division of the International Dental Research Association (IADR , 2017 Meeting Abstract, 2017

Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM, Porter RK., Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells., Oncology letters, 14, (5), 2017, p6298-6306 Journal Article, 2017 DOI

Richard K. Porter, Mary Rooney, Emmeline Hill, Lisa Katz, '"A Genotype Specific Neutraceutical for Horses". ', Murgitroyd, European Patent No. 17190252.1 , 2017 Patent, 2017 Other

Marilena Karavyraki & Richard K. Porter, Mitochondrial Function and Morphology Linked to Metabolic Differences in Normal, Dysplastic and Cancerous Oral Cells , Mitochondria in Physiology Workshop (MiPs) , Schroecken, Austria, June, edited by Erich Gnaiger , 2017 Meeting Abstract, 2017

Vanesa G. Martinez, John Crown, Richard K. Porter, Lorraine O'Driscoll, Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer, International Journal of Cancer, 140, (12), 2017, p2771 - 2784 Journal Article, 2017 DOI URL

Mary F. Rooney, The Biochemical and Bioenergetic Consequences of the Myostatin SNP g.66493737C>T and SINE insertion 227 bp polymorphism in Skeletal Muscle of Thotoughbred Horses, Trinity College Dublin, 2017 Thesis, 2017

Richard K. Porter, Bioenergetics in Cancer , "The role of mitochondria in lifestyle and metabolic syndrome - MITOEAGLE perspectives", Hradec Králové University Czech Republic., Nov 2017, 2017, COST MITOEAGLE Invited Talk, 2017

Rooney, M.F. and Porter, R.K. and Katz, L.M. and Hill, E.W., Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse, PLoS ONE, 12, (11), 2017 Journal Article, 2017 TARA - Full Text DOI

Richard K. Porter, Cellular Oxygen Consumption as an index of Metabolic Activity,, Clinical Research Development Ireland Workshop, Trinity Biomedical Research Institute, Dec 2017, 2017, CRDI Invited Talk, 2017

Richard K. Porter, Mitochondrial function and dysfunction in cancer , MiPs School, , Obergurgl, Austria , July 2017, 2017, Mitochondria in Physiology Society (MiPS) Invited Talk, 2017

Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter , MSTN genotype variation affects skeletal muscle mitochondrial abundance and fibre composition in untrained Thoroughbred horses,, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2016 (EBEC 2016), Riva del garda, July 2-7, 2016, edited by Paolo Bernardi , Volume 1857, 2016, ppp44- Meeting Abstract, 2016 DOI

Emma B. O ' Connor , Richard K. Porter , Patrick T. Walsh , A Role for Mitochondrial Uncoupling Protein 3 (UCP3) in T-cell function, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2016 (EBEC 2016), Riva del garda, July 2-7, 2016, edited by Paolo Bernardi , Elsevier, 2016, pppe98- Meeting Abstract, 2016 DOI

Martin DS, Leonard S, Devine R, Redondo C, Kinsella GK, Breen CJ, McEneaney V, Rooney MF, Munsey TS, Porter RK, Sivaprasadarao A, Stephens JC, Findlay JB., Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice., J Mol Endocrinol , 56, (3), 2016, p261 - 271 Journal Article, 2016 DOI

C.McKenna R.K.Porter, S.Waters and D.Kenny, Mitochondrial abundance and respiratory chain activities in muscle of cattle divergent in residual feed intake, European Federation of Animal Science (EAAP), Belfast UK, 29 Aug - 2 Sept 2016, Wageningen Academic Publisher, 2016 Meeting Abstract, 2016

C.McKenna R.K.Porter, S.Waters and D.Kenny, Mitochondrial abundance and respiratory chain activities in muscle of cattle divergent in residual feed intake, EAAP, Belfast UK, 29 Aug - 2 Sept 2016, Wageningen Academic Publisher, 2016 Meeting Abstract, 2016

Richard K. Porter, The Role of Mitochondrial Uncoupling Proteins in Thymus and Immune Cell Function, Visiting Professor, University of St. Andrews, Scotland, , April 2016, 2016 Invited Talk, 2016

Richard K. Porter, Energy Metabolism in Immune cells , Joint Weizmann-TBSI Immunology Meeting, Weizmann Institute, Israel, (Jun 2015), 2015 Invited Talk, 2015

Richard K. Porter, The Role of Mitochondrial Uncoupling Proteins (UCP's) in Thymocyte/T-Cell Development and Function, Visiting Professor, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University in Poznań, Poland , (Oct 2015) , 2015, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University in Poznań, Poland Invited Talk, 2015

Fintan Geoghegan, Cancer Cell Bioenergetics in response to Anti-cancer Agents, Trinity College Dublin, 2015 Thesis, 2015

Richard K. Porter, Thymocyte/T-cell function and mitochondrial uncoupling proteins, Ireland China Partnership, Guangzhou Medical Centre, Mainland China, , (Mar 2015) , 2015 Invited Talk, 2015

Clarke, K.J., Carroll, A.M., O'Brien, G., Porter, R.K. , Detection of UCP1 protein and measurements of dependent GDP-sensitive proton leak in non- phosphorylating thymus mitochondria, Methods in Molecular Biology, 1241, 2015, p123-135 Journal Article, 2015 DOI

Mary F Rooney, Emmeline W Hill, Lisa M Katz and Richard K Porter, MSTN GENOTYPE VARIATION EFFECTS SKELETAL MUSCLE MITOCHONDRIAL ABUNDANCE IN UNTRAINED THOROUGHBRED HORSES., International Biochemistry of Exercise Conference (IBEC), Sao Paulo, Brazil, 07-09 Sep 2015 , 2015 Meeting Abstract, 2015

Richard K. Porter, Energy Metabolism in Immune cells , Taichung University Taiwan, , (Oct 2014) , 2014, Lee-Feng Chien Invited Talk, 2014

Richard K. Porter, Mitochondrial Uncoupling Protein 1 and Immune Cell Function, 48th Annual Scientific Meeting of the European Society for Clinical Investigation, , Utrecht, The Netherlands,, (May 2014), 2014, European Society for Clinical Investigation, Invited Talk, 2014

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907 Journal Article, 2014 TARA - Full Text DOI

Richard K. Porter, Mitochondrial Efficiency and Basal Metabolic rate in Mammals, University of Warwick, UK, , (Jan 2014) , 2014 Invited Talk, 2014

Breen EP, Pilgrim W, Clarke KJ, Yssel C, Farrell M, Zhou J, Murphy PV, Porter RK. , Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths., Journal of Chemical Biology, 6, (3), 2013, p121 - 133 Journal Article, 2013 TARA - Full Text URL

Richard K. Porter, Efficiency of Mitochondrial Function in Mammals, University of Umeå, Sweden., (Nov 2013) , 2013 Invited Talk, 2013

Orlagh Kelly, Investigations into the physiological function mitochondrial uncoupling protein 3, Trinity College Dublin, 2013 Thesis, 2013

Clarke, KJ, Porter, RK, Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 45, (1), 2013, p81-89 Journal Article, 2013 DOI

Porter, R.K., Studies on the function and regulation of mitochondrial uncoupling proteins, Advances in Experimental Medicine and Biology, 748, 2012, p171 - 184 Journal Article, 2012

Orlagh M. Kelly, Yvonne M. McNamara, Lars H. Manzke, Mary J. Meegan, Richard K. Porter, The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Rats/Mice, Mitochondrion, 12, (1), 2012, p110-9 Journal Article, 2012 TARA - Full Text

Richard K. Porter, Mitochondrial Uncoupling Protein 1 (UCP1) turnover and function, European Bioenergetics Conference 2012 (EBEC 2012), Freiburg, Germany, , (Sep 2012) , 2012, EBEC Invited Talk, 2012

Lars Manzke, An Investigation of the Physiological and pathological Role of Uncoupling Proteins, Trinity College Dublin, 2012 Thesis, 2012

Clarke, KJ, Adams, AE, Manzke, LH, Pearson, TW, Borchers, CH, Porter, RK, A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1), BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1817, (10), 2012, p1759-1767 Journal Article, 2012 DOI

L.H. Manzke, K.J. Clarke, R.K. Porter, Upregulation of mitochondrial glycerol-3-phosphate dehydrogenase abundance in brown adipose tissue mitochondria from UCP1 knock-out mice, Biochimica et Biophysica Acta (BBA) - Bioenergetics, European Bioenergetics Conference 2012 (EBEC 2012), Freiburg, Germany, 15-20 September 2012, (1817), 2012, pps43- Meeting Abstract, 2012 DOI

Richard K. Porter, Regulation of metabolism in Cancer and Immune Cells Symposium in Trinity College Dublin, Irish Area Section of the Biochemical Society (IASBS), Trinity College Dublin, (Nov 2012) , 2012, Richard K. Porter Invited Talk, 2012

Richard K. Porter, "The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Mice" , COST meeting Wageningen University, The Netherlands, April 2011, Wageningen University, The Netherlands, April 2011, 2011, COST Mitofood Invited Talk, 2011

Orlagh M. Kelly, Richard K. Porter, Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice, Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1807, (9), 2011, p1064-1074 Journal Article, 2011 TARA - Full Text

Alison E. Adams, Investigation into the physiological expression and function of mitochondrial uncoupling protein 1 (UCP1) in the thymus., 2011 Thesis, 2011

Kieran J. Clarke, An investigation into the role and regulation of uncoupling protein 1 (UCP 1), Trinity College Dublin, 2011 Thesis, 2011

Richard K. Porter, The Preservation of in vivo Phosphorylated and Activated Uncoupling Protein 3 (UCP3) in Isolated Skeletal Muscle Mitochondria following Administration of 3,4-Methylenedioxymethamphetamine (MDMA aka Ecstasy) to Mice , Mitochondria in Physiology Society (MiPS) meeting,, University of Bordeaux, France, (Sep 2011) , 2011, MiPS Invited Talk, 2011

Richard K. Porter, "Mitochondrial Uncoupling Protein Regulation", International Congress on Obesity, Sockholm, Sweden, July, 2010, International Congress on Obesity Invited Talk, 2010

Alison E. Adams, Orlagh M. Kelly, Richard K.Porter, R. K., Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number, Biochimica et Biophysica Acta (BBA) - Bioenergetics, 16th European Bioenergetics Conference, Warsaw, 17-22 July, edited by L. Wojtczak and K. Zabłocki , 1797, (6-7), Elsevier, 2010, pp807-816 Conference Paper, 2010 TARA - Full Text

Richard K. Porter, "Investigation into the role of uncoupling protein 3 in the thymus and spleen", COST meeting Coimbra University, Portugal, September 2010, Universiy of Coimbra, Portugal, September 2010, 2010, COST Mitofood Invited Talk, 2010

Richard K. Porter, "Mitochondrial Uncoupling Protein Regulation" , European Bioenergetics Conference (EBEC) , Warsaw, Poland, July 2010, 2010, European Bioenergetics Conference (EBEC) Invited Talk, 2010

Andrea Dlaskovà, Kieran J. Clarke, Richard K. Porter, R.K. , The role of UCP 1 in the production of reactive oxygen species by mitochondria isolated from brown adipose tissue, Biochimica Biophysica Acta (Bioenergetics), 1797, (8), 2010, p1470 - 1476 Journal Article, 2010 TARA - Full Text

Niaobh O'Donoghue, Trevor Sweeney, Robin Donagh, Kieran Clarke and Richard K. Porter , Control of Choline Oxidation in Rat Kidney Mitochondria, Biochimica Biophysica Acta (Bioenergetics), 1787, 2009, p1135 - 1139 Journal Article, 2009 TARA - Full Text

Richard K. Porter, "Efficiency of Energy Transduction in Mammals" , Invitation to Nencki Institute Warsaw, Poland., Nencki Institute Warsaw, Poland., July, 2009, Adam Szewczyk Invited Talk, 2009

Richard K. Porter, "Mitochondrial Uncoupling Protein 1 and Immune Function" , COST meeting , Balearic Islands University, Palma, Mallorca, Spain., March, 2009, COST Mitofood Invited Talk, 2009

Murphy, James E.J. and Porter, Richard K. , The Control of Oxidative Phosphorylation in the Adrenal Gland Cell Line (Y1), Advances in Experimental Medicine and Biology, 645, 2009, p35 - 41 Journal Article, 2009

Adams A.E. Porter R.K. , Apoptosis in thymocytes from UCP 1 wild-type and UCP 1 knock-out mice, EBEC 2008 Short reports, EBEC 2008, Trinity College Dublin, 19-24July 2008, edited by Richard K. Porter & Gavin Davey , 1777, 2008, ppS44- Meeting Abstract, 2008

Richard K. Porter, "The Role Uncoupling Proteins in Immune Function" , European Bioenergetics Conference (EBEC) July 2008 Dublin. , Dublin, Ireland, July, 2008, European Bioenergetics Conference (EBEC) Invited Talk, 2008

Dlaskova, A. & Porter R.K., regulation of H2O2 generation by uncoupling protein UCP 1 in BAT and thymus mitochondria, EBEC 2008 Short reports, EBEC 2008, Trinity College Dublin, 19-24 July 2008, edited by Richard K. Porter & Gavin Davey , 1777, Elsevier, 2008, ppS65- Meeting Abstract, 2008

Davey G. & Porter Richard K., Bioenergetics: Going from Strength to strength, Biochimica Biophysica Acta (Bioenergetics), EBEC 2008, Trinity College Dublin, 19-24 July 2008, edited by Richard K. Porter & Gavin Davey , 1777, (7-8), Elsevier, 2008, pp549 - 549 Meeting Abstract, 2008

Porter Richard K., Preface, EBEC Short reports, EBEC 2008, Trinity College Dublin, 19-24 July 2008, edited by Richard K. Porter & Gavin Davey , 1777, Elsevier, 2008, ppS1- Meeting Abstract, 2008

Porter R.K. & Fallon P.G., mitochondrial UCP 1 and thymus function, EBEC 2008 Short Reports, EBEC 2008, Trinity College Dublin, 19-24 July 2008, edited by Richard K. Porter & Gavin Davey , 1777, 2008, ppS34- Meeting Abstract, 2008

Adams, Alison E., Carroll, Audrey M., Fallon, Padraic G. & Porter, Richard K., Mitochondrial uncoupling protein 1 expression in thymocytes, Biochimica Biophysica Acta (Bioenergetics), 1777, (7-8), 2008, p772 - 775 Journal Article, 2008

Richard K. Porter, "Choline Oxidation in Kidney Mitochondria" , COST meeting, University of Stockholm, Sweden., May , 2008, COST Mitofood Invited Talk, 2008

Porter Richard K., uncoupling protein 1: A short-circuit in the Chemiosmotic process, the Journal of Bioenergetics and Biomembranes, 40, 2008, p457 - 461 Journal Article, 2008

Carroll, Audrey M., Porter, Richard K. & Morrice, Nicolas A., Identification of serine phosphorylation in mitochondrial uncoupling protein 1, Biochimica Biophysica Acta (Bioenergetics), 1777, (7-8), 2008, p1060 - 1065 Journal Article, 2008

Biochimica Biophysica Acta (Bioenergetics), Netherlands, Elsevier, [eds.], 2008-2016 Editorial Board, 2008

Clarke K.J. & Porter R.K. , The effect of preserving covalent modification of mitochondria by phosphorylation on oxygen consumption by mitochondria isolated from brown adipose tissue and thymus, EBEC 2008 Short Reports, EBEC 2008, Trinity College Dublin, 19-24 July 2008, edited by Richard K. Porter & Gavin Davey , 1777, Elsevier, 2008, ppS54- Meeting Abstract, 2008

Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117 Journal Article, 2008 DOI TARA - Full Text

Adams AE, Carroll AM, Fallon PG, Porter RK., Mitochondrial uncoupling protein 1 expression in thymocytes., Biochimica et Biophysica Acta (BBA) - Bioenergetics , 1777, (7-8), 2008, p772 - 776 Journal Article, 2008 TARA - Full Text DOI

Richard K. Porter, "Regulation of UCP function" , Harden Conference, , Ambelside UK , September , 2007, Guy Brown & Michael Murphy Invited Talk, 2007

Richard K. Porter, "A Role for Uncoupling Proteins in Thymus Function" , International Society for Oxygen Transport in Tissues" (ISOTT) , Uppsala University, Sweden, September , 2007, ISOTT co-chaired with Britten Chance Invited Talk, 2007

Richard K. Porter, "Molecular mechanisms in metabolic and oxidative stress - role of mitochondria" , NutriGenomic Organization" (NuGO) Conference, Cork, May, 2007, Michael Gibney Invited Talk, 2007

Beck V, Jabùrek M, Demina T, Rupprecht A, Porter RK, Jezek P, Pohl EE., Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers., FASEB J, 21, (4), 2007, p1137-1144 Journal Article, 2007

Adams, A.E., Hanrahan, O., Nolan, D.N., Voorheis, H.P. Fallon, P. and Porter, R.K., Images of Mitochondrial UCP 1 in Mouse Thymocytes using Confocal Microscopy, Biochimica Biophysica Acta (Bioenergetics), 1777, 2007, p115 - 117 Journal Article, 2007

Porter, R.K., A New Look at Mitochondrial Uncoupling Protein 1, Biochimica Biophysica Acta, 1757, 2006, p446 - 448 Journal Article, 2006

Brennan, C.M., Breen, E.P. and Porter, R.K., Cold acclimation and oxygen consumption in the thymus, Biochimica Biophysica Acta (Bioenergetics), 1757, (11), 2006, p1463-1468 Journal Article, 2006

Breen, E.P., Gouin, S., Brennan, C.M., Murphy, A.F., Haines, L.R., Pearson, T.W., Murphy, P.V. and Porter, R.K., On the mechanism of mitochondrial uncoupling protein 1 function, Journal of Biological Chemistry, 281, 2006, p2114 - 2119 Journal Article, 2006

Brennan, C.M. & Porter R.K., The effects of acute and endurance exercise on UCP 3 protein expression in mouse gastrocnemius, plantaris, soleus and EDL muscles, EBEC Short Reports, EBEC 2006, Moscow, July, edited by V. Borisov , 14, Elsevier/Biochimica Biophysica Acta (Bioenergetics), 2006, pp363- Meeting Abstract, 2006

Richard K. Porter, "A New Look at Mitochondrial Uncoupling Protein 1" , European Bioenergetics Conference (EBEC) , Moscow State University, Russia, July, 2006, Vladimir Schulachev Invited Talk, 2006

Beck, V., Jabùrek, M., Breen, E.P., Porter, R.K., Je ek, P. and Pohl, E.E. , A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1., Biochimica Biophysica Acta (Bioenergetics), 1757, 2006, p474 - 479 Journal Article, 2006

Gouin, S.G., Breen, E.P., Pilgrim, W., Murphy, P.V. & Porter R.K., Elucidation of the mechanism of mitochondrial uncoupling protein using a synthetic glycolipid, Bioscience 2005, Glasgow, Scotland. UK, 2005 Meeting Abstract, 2005 URL

Clare M. Brennan, Investigations into the Physiological Expression of UCP1 and UCP3, Trinity College Dublin, 2005 Thesis, 2005

Gouin, S.G., Breen, E.P., Pilgrim, W., Murphy, P.V., Porter R.K., Elucidation of the mechanism of mitochondrial uncoupling protein function using a synthetic glycolipid, Mitochondria in Physiology, MiP2005, 2005 Journal Article, 2005 URL

Richard K. Porter, "Mitochondrial Coupling" , Mitochondria in Physiology Conference, , Schröcken, Austria, July, 2005, Erich Gnaiger Invited Talk, 2005

Eamon P. Breen, Detection, Expression and Elucidation of the Mechanism of Action of Mitochondrial Uncoupling protein 1, Trinity College Dublin, 2005 Thesis, 2005

Gouin, S.G, Pilgrim, W., Porter, R.K. and Murphy, P.V., Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins, Carbohydrate Research, 340, 2005, p1547 - 1552 Journal Article, 2005 URL URL

Carroll, A.M., Haines, L.R., Pearson, T.W., Fallon, P., Walsh, C., Brennan, C., Breen, E.P. & Porter, R.K., Detection of a functioning UCP 1in Thymus, Journal of Biological Chemistry, 280, 2005, p15534 - 15543 Journal Article, 2005

Carroll, A.M., Haines, L.R., Pearson, T.W., Fallon, P.G., Walsh, C.M., Brennan, C., Breen, E. & Porter, R.K., Identification of a functioning mitochondrial uncoupling protein 1 in thymus, Journal of Biological Chemistry, 280, 2005, p155534 - 155543 Journal Article, 2005 TARA - Full Text DOI

Carroll, A.M., Haines, L.R., Pearson, T.W., Brennan, C., Breen, E. & Porter, R.K., Identification of a functioning uncoupling protein 1 in rat thymus, EBEC Short Report, 13, 2004, pp203 Conference Paper, 2004

Audrey M. Carroll, An Investigation into the Expression and Physiological Function of Mitochondrial Uncoupling Proteins, Trinity College Dublin, 2004 Thesis, 2004

Richard K. Porter, "Detection of a functioning UCP 1 in Thymus" , Bioscience 2004 Conference, , Glasgow, Scotland., 2004, The UK Biochemical Society Invited Talk, 2004

Carroll, A.M. & Porter, R.K., Starvation sensitive UCP 3 expression in rat thymus and spleen, Biochim. Biophys. Acta, 1700, 2004, p145 - 150 Journal Article, 2004 URL

Carroll, A.M., Haines, L.R., Pearson, T.W., Brennan, C., Breen, E.P. & Porter R.K., Immunodetection of UCP 1 in Rat Thymus, Biochemical Society Transactions, 32, (6), 2004, p1066 - 1067 Journal Article, 2004 URL

Cadenas, S., Jekabsons, M.B., Carroll, A.M., Porter, R.K. & Brand, M.D., Rat muscle mitochondria treated with Dowex are GDP insensitive, 674th Biochemical Society Meeting, 29, 2003, pp123 Meeting Abstract, 2003

Brennan, C.M., McElligott, A.M., Warmington, S.A. and Porter, R.K., Skeletal muscle uncoupling protein 3 expression following endurance swimming training in mice, Proceedings of the 674th Biochemical Society Meeting, Trinity College Dublin, July, 2003 Meeting Abstract, 2003

Oliver J. P. Joyce, Factors Effecting Mitochondrial Efficiency, Trinity College Dublin, 2003 Thesis, 2003

Cunningham, O., McElligott, A.M., Carroll, A.M., Breen, E., Reguenga, C., Oliveira, M.E.M, Azevedo, J.E. & Porter, R.K., Selective Detection of UCP 3 Expression in Skeletal Muscle: Effect of Thyroid Status and Temperature Acclimation, Biochim. Biophys. Acta, 1604, 2003, p170 - 179 Journal Article, 2003 URL

Brennan, C.M., McElligott, A.M., Warmington, S.A. & Porter, R.K., Skeletal muscle uncoupling protein 3 expression following endurance swimming training in mice, 674th Biochemical Society Meeting, 29, 2003, pp120 Meeting Abstract, 2003

Joyce, O.J.P., Farmer, M.K. Tipton, K.F. & Porter, R.K., Oxidative Phosphorylation by in situ Synaptosomal Mitochondria from Whole Brain of Young and Old Rats, J. Neurochem., 86, 2003, p1032 - 1041 Journal Article, 2003 URL

Brennan, C.M, McElligott, A.M. Warmington, S.A. & Porter, R.K., Skeletal muscle uncoupling protein-3 expression following endurance swimming training in mice, Proceedings of the Journal of Physiology, 543, 2002, pp119 Conference Paper, 2002

Brennan, C.M. McElligott, A.M., Warmington, S.A. and Porter, R.K., Skeletal muscle uncoupling protein-3 expression following endurance swimming training in mice, Proceedings of the Physiological Society, The Journal of Physiology, University of Liverpool, July, 543, (P), 2002, pp119p Meeting Abstract, 2002 URL

Breen, E.P. & Porter, R.K., Discriminatory antibody raised to UCP-3 used to detect protein in a number of systems, 674th Biochemical Society Meeting, 29, 2001, pp120 Meeting Abstract, 2001

Maguire, D.J., Joyce, O. & Porter, R.K., Mitoprotein separation on 2-D Native Blue Gels; Miniaturization and resolution of extraction artefacts, Human Genetics Society of Australasia Meeting, 2001 Meeting Abstract, 2001

Porter, R.K., Allometry of mammalian cellular oxygen consumption, Cellular and Molecular Life Sciences, 58, 2001, p815 - 822 Journal Article, 2001 URL

Cunningham, O, Carroll, A.M. & Porter R.K., RT-PCR evidence for the expression of UCP-2 in spleen and murine macrophage cell line (J774), 674th Biochemical Society Meeting, 29, 2001, pp119 Meeting Abstract, 2001

Porter, R.K., Mitochondrial Proton Leak: A Role for Uncoupling Proteins 2 & 3 ?, Biochim. Biophys. Acta, 1504, (1), 2001, p120 - 127 Journal Article, 2001 URL

Porter, R.K., Mammalian mitochondria; inner membrane cationic and neutral amino acid carriers, Biochim. Biophys. Acta, 1459, 2000, p356 - 362 Journal Article, 2000 URL

Richard K. Porter, Leptin and Efficiency of Oxidative Phosphorylation,, European Congress on Obesity, Trinity College Dublin, 1999, Fred Andrews Invited Talk, 1999

Richard K. Porter, Indirect measurement of mitochondrial proton leak and its application,, International Congress on Obesity, Quebec, Canada, 1999, Claude Bouchard Invited Talk, 1999

Porter, R.K., Joyce, O.J.P., Farmer, M.K., Heneghan, R., Tipton, K.F, Andrews, J. F., McBennett, S.M., Lund, M.D., Jensen, C.H. & Melia, H.P, Indirect measurement of mitochondrial proton leak and its application, International Journal of Obesity, 23, 1999, pS12 - S18 Journal Article, 1999 URL

Hazel P. Melia, Investigations into the Efficiency of Mitochondrial Unction, Trinity College Dublin, 1999 Thesis, 1999

Melia, H.P. Andrews, J.F., McBennett, S.M. & Porter, R.K., Leptin and Efficiency of Oxidative Phosphorylation, FEBS Letts., 458, 1999, p261 - 264 Journal Article, 1999 URL

Porter, R.K. & Andrews, J.F., Effects of leptin on mitochondrial 'proton leak' and uncoupling proteins: implications for mammalian energy metabolism, Proceedings of the Nutrition Society, 57, 1998, p455 - 460 Journal Article, 1998 URL

Porter, R.K., Hulbert, A.J. and Brand, M.D., Allometry of Mitochondrial Proton Leak: Influence of Membrane Surface Area and Fatty Acid Composition, The American Journal of Physiology, 271, 1996, pR1550 - R1560 Journal Article, 1996 URL

Porter, R.K. & Brand M.D., Cellular oxygen consumption depends on body mass, American Journal of Physiology, 269, (1 part 2), 1995, pR226 - R228 Journal Article, 1995 URL

Porter, R.K. and Brand, M.D., Mitochondrial Proton Conductance and H+/O Ratio are Independent of Electron Transport Rate in Isolated Hepatocytes, Biochemical Journal, 310, 1995, p379 - 382 Journal Article, 1995 URL

Porter, R.K. and Brand, M.D., Causes of the Differences in Respiration Rate of Hepatocytes from Mammals of Different Body Mass, The American Journal of Physiology, 269, 1995, pR1213 - R1224 Journal Article, 1995 URL

Brand, M.D., Chien, L.-F., Ainscow, E.K., Rolfe, D.F.S. & Porter, R.K., Causes and Functions of Mitochondrial Proton Leak, Biochimica Biophysica Acta, 1187, 1994, p132 - 139 Journal Article, 1994 URL

R. K. Porter, J. M. Scott and M. D. Brand, Characterization of betaine efflux from rat liver mitochondria, Biochimica et biophysica acta, 1141, (02-Mar), 1993, p269-74 Journal Article, 1993 URL

Kaplan, C.P., Porter, R.K. and Brand, M.D., The Choline Transporter is the Major Site of Control of Choline Oxidation in Isolated Rat Liver Mitochondria, FEBS Letters, 321, 1993, p24 - 26 Journal Article, 1993 URL

Porter, R.K. and Brand, M.D., Body Mass Dependence of Proton Leak in Mitochondria and its Relevance to Metabolic Rate, Nature, 362, 1993, p628 - 630 Journal Article, 1993 URL

Porter, R.K. and Brand, M.D., Mitochondrial Properties Affecting Proton Leak Kinetics in Mammals of Different Body Mass, 646th Biochemical Society Meeting, 1993 Meeting Abstract, 1993

R. K. Porter, J. M. Scott and M. D. Brand, Choline transport into rat liver mitochondria, Biochemical Society transactions, 20, (3), 1992, p248S Journal Article, 1992 URL

R. K. Porter, J. M. Scott and M. D. Brand, Choline transport into rat liver mitochondria. Characterization and kinetics of a specific transporter, The Journal of biological chemistry, 267, (21), 1992, p14637-46 Journal Article, 1992 URL

R. K. Porter, J. M. Scott and M. D. Brand, The nature of betaine efflux from rat liver mitochondria, Biochemical Society transactions, 20, (3), 1992, p247S Journal Article, 1992 URL

Richard K. Porter, Choline and Betaine Transport in Rat Liver Mitochondria, Trinity College Dublin, 1991 Thesis, 1991

Non-Peer-Reviewed Publications

Richard K. Porter, Preface: From the Organizers, European Bioenergetics Conference (EBEC) 2008, Trinity College Dublin, July, edited by Richard K. Porter , 2008 Meeting Abstract, 2008

Research Expertise

Description

1. Equine skeletal muscle bioenergetics and metabolism: We have recently elucidated the biochemical basis of the crucial performance defining myostatin polymorphism in Thoroughbred Horses (Rooney et al 2018, submitted). In addition, we uncovered a bioenergetic difference associated with the myostatin polymorphism in Thoroughbred Horses (Rooney et al 2017) we patented the discovery through TCD & UCD, and a licence to use that IP was granted to PluVital to produce the first Nutrigemonic nutrient for Thoroughbred horses [World's First Nutrigenomic Product for Thoroughbred Horses, now sold as EnerGene-Q10 by Plusvital. See recent press coverage: http://www.tcd.ie/news_events/articles/world-s-first].We also currently have an Enterprise Ireland Innovation Partnership Programme grant to develop an in vitro assay system for skeletal muscle of Thoroughbred horses.I currently have Dr. Mary Rooney (postdoc) and Caitriona Curley (research assistant) working on that project. 2. Bioenergetics of Immune cell Function: We have made the novel discovery that the mitochondrial inner membrane transporter, namely mitochondrial uncoupling protein 3 (UCP3), can influence T-cell activation in vitro (O'Connor et al, 2016). We are currently investigating the role of this protein on T-cell activation in vivo. 3. Metabolic Efficiency: We have just completed a project characterising (a)bioenergetic and metabolic gene expression and (b) mitochondrial function in cattle of the same mass but different residual food intake. Several publications (Mckenna et al., 2018) are in the pipeline. 4. Cancer: We have a major Marie Curie grant to characterise the bioenergtic capacity of oral squamous cancer cells, with view to finding novel anti-cancer targets (Karavyraki et al., 2017). 5. Diabetes: We currently have a collaboration with Dr Neil Docherty Professor Carel le Roux and Professor Michael Cowleyin in the area of Diabetes on Alpha Melanocyte Stimulatory Hormone and Improvements in Glucose Tolerance in Humans: Role of Enhanced Skeletal Muscle Glucose Uptake and Utilisation.

Projects

  • Title
    • Assessment of the Energetic Benefits of Plusvital Supplements/Nutrients on Thoroughbred Horses
  • Funding Agency
    • Enterprise Ireland & Plusvital Grant No. 20160503
  • Date From
    • 2017
  • Date To
    • 2019
  • Title
    • Energy Metabolism in Oral Cancers
  • Funding Agency
    • Marie Skłodowska-Curie
  • Date From
    • 2017
  • Date To
    • 2020
  • Title
    • An examination of the biochemical control of cellular energetic efficiency in muscle of beef cattle divergently selected for residual feed intake (RFI)
  • Summary
    • (i) To establish and physiologically characterise two populations of cattle, genetically and phenotypically divergent in energetic efficiency (based on residual feed intake - RFI) (ii) To examine changes in temporal gene expression in muscle tissue of cattle divergent in energetic efficiency (iii) To examine the premise that efficiency of energy transduction in cattle is a function of mitochondrial abundance and mitochondrial functional efficiency. (iv) To examine the expression of cellular proteins differentially expressed between energetically efficient and inefficient animals will be examined using targeted and global approaches. (v) To: i) conduct a bioinformatical analysis of the mitochondrial data (Task 2) transcription profiles (Task 3) and proteomic data (Task 4); ii) integrate physiological, mitochondrial, transcriptional and proteomic data important to the regulation of energetic efficiency and iii) identify potential biomarkers for selection of cattle which have a superior ability for muscle energetic efficiency.
  • Funding Agency
    • Teagasc
  • Date From
    • 2014
  • Date To
    • 2018
  • Title
    • Tryptophan metabolites affecting platelet function
  • Funding Agency
    • Trinity College Dublin - Dean of Medicine Research Initiative
  • Date From
    • 2016
  • Date To
    • 2018
  • Title
    • Mitochondrial Proteome
  • Summary
    • Investigation and identification of novel mitochondrial transporters/ transporter regulators. [Euros 1.2M] Collaborators: Keith Tipton, Gavin Davey and Caroline Jefferies
  • Funding Agency
    • Marie Curie
  • Date From
    • January 2007
  • Date To
    • January 2009
  • Title
    • The Role of UCP3 in Immune Cell function
  • Funding Agency
    • Trinity College Dublin- Scott Fellowship
  • Date From
    • 2014
  • Date To
    • 2018
  • Title
    • Metabolic Efficiency in Thoroughbred Horses in collaboration
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2012
  • Date To
    • 2016
  • Title
    • The mechanism of function mitochondriual uncoupling proteins
  • Funding Agency
    • Science Foundation Ireland (SFI)
  • Date From
    • January 2007
  • Date To
    • September 2010
  • Title
    • The role of Mitochondrial Efficiency in Thymus Function
  • Funding Agency
    • The Health Research Board of Ireland
  • Date From
    • 1 October 2008
  • Date To
    • 30 september 2011
  • Title
    • Alpha Melanocyte Stimulatory Hormone and Improvements in Glucose Tolerance in Humans: Role of Enhanced Skeletal Muscle Glucose Uptake and Utilisation
  • Funding Agency
    • Health Research Board
  • Date From
    • 2018
  • Title
    • Cancer and Inflammation: Metabolic evaluation and intervention in cancer cells,
  • Funding Agency
    • PRTLI5
  • Date From
    • 2012
  • Date To
    • 2016

Keywords

(HUMAN); (RAT LIVER); (SKELETAL MUSCLE); Ageing, memory and other cognitive processes; Analytical Techniques; Basic Skills Education; Biochemistry, Carbohydrates; Biochemistry, Lipids; Biochemistry, metabolism; Biochemistry, Proteins; BODY-MASS; BOVINE; BRAIN; BROWN-ADIPOSE-TISSUE; Diabetes & Obesity; Diabetes and diabetic complications; Drug discovery; Energy Chemical Sciences; EQUINE; Immune system; Innate immunology; Life Sciences; Lipids, steroids, membranes; Membrane Transport; Membrane transport, structure and dynamics; Metabolic Biology; Metabolism and metabolic diseases; Mitochondria; Neuroscience; ORAL-CANCER; OXYGEN CONSUMPTION; Photosynthesis; Proteins, enzymology and protein engineering; Thermal Effects

Recognition

Representations

Representative for Ireland on the European Bioenergetics Conference Committee 2004-present

Representative for Ireland on the International Union of Biochemists and Molecular Biologists (IUBMB) Nominating Committee 2012-present

Representative for Ireland on the MITOEAGLE COST Action 2016 -present

Representative for Ireland on the MITOFOOD COST Action 2005-2009

Chairman of European Bioenergetics Conference 2008 (EBEC 2008)[www.tcd.ie/Biochemistry/ebec2008/][ebec2008@tcd.ie] 2008

Ireland Representation on the COST B10 'Brain Damage and Repair' group. 2000-2004

Awards and Honours

Awarded commendation for Teaching by Trinity College Dublin (Provosts' Teaching Award) July 2014

Lucker-Cobbe Award

Fellow of Trinity College Dublin 2007

Memberships

Treasurer of the Irish Area Section of the Biochemical Society (IASBS) 2009 – 2012

Member of The European Bioenergetics Conference Committee 2004 – present

Member of the The UK Biochemical Society 1986 – 2016

Member of the Irish Area Section of the Biochemical Society 2006 – present

Member of the International Society for Oxygen Transport in Tissues (ISOTT) 2007 – 2008

Appointed to the Bioenergetics and Metabolism Theme Panel III of the Biochemical Society. 2004 – 2007

Editor of Elsevier's Biochimica Biophysica Acta (Bioenergetics) 2008 – present