Paul Kenna
Research Fellow, Genetics

Publications and Further Research Outputs

Peer-Reviewed Publications

Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Jane Farrar G, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy., European journal of human genetics : EJHG, 21, (1), 2013, p62-8 Journal Article, 2013 TARA - Full Text DOI

N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy, Eur J Hum Genet, 21, (1), 2013, p62-68 Journal Article, 2013 DOI

Farrar, G.J., Chadderton, N., Kenna, P.F., Millington-Ward, S, Mitochondrial disorders: aetiologies, models systems, and candidate therapies, Trends in Genetics, 2013, p00-00 Journal Article, 2013 TARA - Full Text DOI

Palfi, A., Chadderton, N., McKee, A.G., Blanco Fernandez, A., Humphries, P., Kenna, P.F., Farrar, G.J., Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus, Human Gene Therapy, 23, (8), 2012, p847-858 Journal Article, 2012 DOI TARA - Full Text

Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M, Kiang AS, Humphries P, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European journal of human genetics : EJHG, 20, (1), 2012, p64-8 Journal Article, 2012 DOI

Farrar GJ, Millington-Ward S, Chadderton N, Humphries P, Kenna PF, Gene-based therapies for dominantly inherited retinopathies., Gene therapy, 19, (2), 2012, p137-44 Journal Article, 2012 DOI

Sophia Millington-Ward, Naomi Chadderton, Mary O'Reilly, Arpad Palfi, Tobias Goldmann, Claire Kilty, Marian Humphries, Uwe Wolfrum, Jean Bennett, Peter Humphries, Paul F Kenna and G Jane Farrar, Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa, Molecular Therapy, 2011 Journal Article, 2011 TARA - Full Text

Campbell M, Humphries MM, Nguyen ATH, Gobbo OL, Tam LCS, Suzuki M, Hanrahan F, Ozaki E, Farrar G-J, Kiang A-S, Kenna PF, Humphries P. , Systemic low-molecular weight drug delivery to pre-selected neuronal regions, EMBO Molecular Medicine, 3, (4), 2011, p235-245 Journal Article, 2011 TARA - Full Text

Bowne, S.J., Humphries, M.M., Sullivan, L.S., Kenna, P.F., Tam, L.C.S., Kiang, A.S., Campbell, M., (...), Humphries, P. , Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (European Journal of Human Genetics (2011) 19 (1074-1081) DOI: 10.1038/ejhg.2011.86), 2011, - 1109 Miscellaneous, 2011 DOI

Mansergh FC, Vawda R, Millington-Ward S, Kenna PF, Haas J, Gallagher C, Wilson J, Humphries P, Ader M, Farrar GJ., Loss of photoreceptor potential from retinal progenitor cell cultures, despite improvements in survival, Experimental Eye Research, 91, (4), 2010, p500 - 512 Journal Article, 2010 DOI Other

Palfi A, Millington-Ward S, Chadderton N, O'Reilly M, Goldmann T, Humphries MM, Li T, Wolfrum U, Humphries P, Kenna PF, Farrar GJ., Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene, Human Gene Therapy, 21, (3), 2010, p311-323 Journal Article, 2010 DOI

Campbell M, Nguyen AT, Kiang AS, Tam L, Kenna PF, Dhubhghaill SN, Humphries M, Farrar GJ, Humphries P, Reversible and size-selective opening of the inner Blood-Retina barrier: a novel therapeutic strategy., Advances in Experimental Medicine and Biology, 664, (Part 3), 2010, p301-8 Journal Article, 2010 DOI

Tam LC, Kiang AS, Campbell M, Keaney J, Farrar GJ, Humphries MM, Kenna PF, Humphries P, Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)., Human Molecular Genetics, 19, (22), 2010, p4421-36 Journal Article, 2010

Lawrence C. S. Tam, Anna-Sophia Kiang, Matthew Campbell, James Keaney, G. Jane Farrar, Marian M. Humphries, Paul F. Kenna and Pete Humphries, Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Human Molecular Genetics, 19, (22), 2010, p4421-4436 Journal Article, 2010 TARA - Full Text

Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P, Protection of photoreceptors in a mouse model of RP10., Advances in Experimental Medicine and Biology, 664, (Part 5), 2010, p559-65 Journal Article, 2010 DOI

Bujakowska KM, Maubaret C, Chakarova CF, Tanimoto N, Beck SC, Fahl E, Humphries MM, Kenna P, Makarov E, Makarova O, Paquet-Durand F, Ekström P, van Veen T, Leveillard T, Humphries P, Seeliger M, Bhattacharya SS, Study of gene targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP), Investigative Ophthalmology & Visual Science, 50, (12), 2009 Journal Article, 2009 DOI

Palfi A, Ader M, Kiang AS, Millington-Ward S, Clark G, O'Reilly M, McMahon HP, Kenna PE, Humphries P, Farrar GJ, RNAi-based suppression and replacement of rds-peripherin in retinal organotypic culture, HUMAN MUTATION, 27, (3), 2006, p260 - 268 Journal Article, 2006

Aherne A, Kennan A, Kenna PE, McNally N, Farrar GJ, Humphries P, Molecular mechanisms of photoreceptor degeneration in RP caused by IMPDH1 mutations, RETINAL DEGENERATIVE DISEASES ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 572, 2006, p81 - 87 Journal Article, 2006

Kiang AS, Palfi A, Ader M, Kenna PF, Millington-Ward S, Clark G, Kennan A, O'Reilly M, Tam LCT, Aherne A, McNally N, Humphries P, Farrar GJ, Toward a gene therapy for dominant disease: Validation of an RNA interference-based mutation-independent approach, MOLECULAR THERAPY, 12, (3), 2005, p555 - 561 Journal Article, 2005

Millington-Ward S, McMahon HP, Allen D, Tuohy G, Kiang AS, Palfi A, Kenna PF, Humphries P, Farrar GJ, RNAi of COL1A1 in mesenchymal progenitor cells, EUROPEAN JOURNAL OF HUMAN GENETICS, 12, (10), 2004, p864 - 866 Journal Article, 2004

McMahon HP, Allen D, Humphries P, Kenna PF, Millington-Ward S, Farrar GJ, Mutation-independent gene therapy strategy for osteogenesis imperfecta, AMERICAN JOURNAL OF HUMAN GENETICS, 73, (5), 2003, pp622 - 622 Meeting Abstract, 2003

Keegan DJ, Kenna P, Humphries MM, Humphries P, Flitcroft DI, Coffey PJ, Lund RD, Lawrence JM, Transplantation of syngeneic Schwann cells to the retina of the rhodopsin knockout (Rho(-/-)) mouse, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 44, (8), 2003, p3526 - 3532 Journal Article, 2003

Gearo"id Tuohy, Sophia Millington-Ward, Paul F. Kenna, Peter Humphries, and G. Jane Farrar, Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain , Investigative Ophthalmology and Visual Science, 43, 2002, p3583 - 3589 Journal Article, 2002 TARA - Full Text

Non-Peer-Reviewed Publications

O'Reilly M, Cronin T, O'Neill B, Palfi A, Kenna P, Humphries P, Farrar J, Generation and analysis of a transgenic mouse model with a modified human rhodopsin replacement gene with therapeutic potential, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU573 - U573 Meeting Abstract, 2004

Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179 Meeting Abstract, 2004

O'Reilly M, O'Neill B, Palfi A, Kenna P, Humphries P, Farrar J, Generation and analysis of a transgenic mouse model with a modified human rhodopsin replacement gene with therapeutic potential, AMERICAN JOURNAL OF HUMAN GENETICS, 73, (5), 2003, pp625 - 625 Meeting Abstract, 2003