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Dr. Niall Pender
Associate Professor in Applied Clinical , Clinical Medicine
Associate Professor in Applied Clinical , Psychology
Associate Professor in Applied Clinical , Trinity Inst. of Neurosciences (TCIN)

Biography

Dr Niall Pender has been Head of Department of Psychology and Principal Clinical Neuropsychologist at Beaumont Hospital Dublin since 2003, in addition to his work at the Hermitage Medical Clinic, Lucan since 2010. Prior to this he was consultant neuropsychologist and clinical lead of the Neuro-behavioural Rehabilitation Unit at the Royal Hospital for Neuro-disability, London and honorary lecturer at the Institute of Psychiatry, London.

He is also an Associate Professor in Neuropsychology at the Academic Unit of Neurology, School of Medicine Trinity College Dublin and Honorary Clinical Associate Professor at the Royal College of Surgeons in Ireland.

He works as a clinical neuropsychologist with people who have suffered neurological/neurosurgical injuries and illness with a special interest in the cognitive, emotional and behavioural changes seen in neurodegenerative diseases and acquired brain injuries.

Niall completed his primary BA degree in Psychology at UCD in 1991 followed by an MSc in Neuropsychology at the University of Wales in 1992. He undertook his clinical psychology training (MSc, 1993-1996) at the Institute of Psychiatry, King's College London where he also subsequently completed his PhD in Neuropsychology in 2005. He completed his post-qualification Diploma in Clinical Neuropsychology at the Institute of Psychiatry in 1997 while working as a neuropsychologist at the Lishman Brain Injury Unit, Maudsley Hospital,London.

Niall is currently Chair of the Board of Headway (the national acquired brain injury charity), and is a member of the Boards of the Motor Neurone Disease Research Foundation, and the Neurological Alliance of Ireland. He has been working as a medico-legal expert witness in civil and criminal cases for 23 years.

Publications and Further Research Outputs

Peer-Reviewed Publications

Marta Pinto-Grau, Sarah O'Connor, Lisa Murphy, Emmet Costello, Mark Heverin, Alice Vajda, Orla Hardiman & Niall Pender, Validation and standardization of the Psycholinguistic Assessments of Language Processing in Aphasia (PALPA), Aphasiology, 2021 Journal Article, 2021 DOI

Marta Pinto-Grau, Bronagh Donohoe, Sarah O'Connor, Lisa Murphy, Emmet Costello, Mark Heverin, Alice Vajda, Orla Hardiman, Niall Pender, Patterns of Language Impairment in Early ALS, Neurology: Clinical Practice, 2021 Journal Article, 2021 DOI

E Costello, T Burke, K Lonergan, N Pender, M Mulrooney, An investigation of the use of standardised leaving certificate performance as a method of estimating pre-morbid intelligence, Irish Journal of Psychological Medicine, (1), 2020, p1 - 9 Journal Article, 2020

Tom Burke, Marta Pinto-Grau, Emmet Costello, Colm Peelo, Katie Lonergan, Mark Heverin, Orla Hardiman, Niall Pender, The reading the mind in the eyes test short form (A & B): validation and outcomes in an amyotrophic lateral sclerosis cohort, The reading the mind in the eyes test short form (A & B): validation and outcomes in an amyotrophic lateral sclerosis cohort, (6), 2020, p1 - 9 Journal Article, 2020 DOI

Tom Burke, Ruth Monaghan, Derval McCormack, Clodagh Cogley, Marta Pinto-Grau, Sarah O'Connor, Bronagh Donohoe, Lisa Murphy, Sean O'Riordan, Ihedinachi Ndukwe, Michael Hutchinson, Niall Pender, Fiadhnait O'Keeffe, Social cognition in cervical dystonia: A case-control study, Clinical Parkinsonism & Related Disorders, 3, 2020 Journal Article, 2020 DOI

Eoin O'Keeffe, Eoin Kelly, Yuzhe Liu, Chiara Giordano, Eugene Wallace, Mark Hynes, Stephen Tiernan, Aidan Meagher, Chris Greene, Stephanie Hughes, Tom Burke, John Kealy, Niamh Doyle, Alison Hay, Michael Farrell, Gerald Grant, Alon Friedman, Ronel Veksler, Michael Molloy, James Meaney, Niall Pender, David Benjamin Camarillo, Colin Doherty, Matthew Campbell, Dynamic blood brain barrier regulation in mild head trauma, Journal of Neurotrauma, 37, (2), 2020, p347 - 356 Journal Article, 2020 URL

Niamh A Merriman, Carlos Bruen, Ashleigh Gorman, Frances Horgan, David J Williams, Niall Pender, Elaine Byrne, Anne Hickey, "I'm just not a Sudoku person": analysis of stroke survivor, carer, and healthcare professional perspectives for the design of a cognitive rehabilitation intervention, Disability and rehabilitation, 2020 Journal Article, 2020 URL

McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020 Journal Article, 2020 DOI

Marie Ryan, Emmet Costello, Mark A Doherty, Caroline McHutchinson, Mark Heverin, Russell L McLaughlin, Sharon Abrahams, Niall Pender, Orla Hardiman, Cognitive dysfunction in pre-symptomatic C9orf72 carriers , Neurology, AACN Annual Conference, 94, 2020 Oral Presentation, 2020 URL

Pender N, Pinto-Grau M, Hardiman O., Cognitive and behavioural impairment in amyotrophic lateral sclerosis, Current Opinion in Neurology, 33, (5), 2020, p649 - 654 Journal Article, 2020 DOI

Tom Burke, Alan Carr, Ann Loughnane, Paula Corr, Deirdre Nolan, Deirdre Coffey, Alan O'Hare, Diane Gillan, Mohsen Javadpour, Niall Pender, Cognitive Impairment in Angiographically Negative Subarachnoid Haemorrhage: A case-matched prospective study 1-year post-incident, Cortex, 128, (4), 2020, p49 - 60 Journal Article, 2020 DOI

O'Brien H, Tracey MJ, Ottewill C, O'Brien ME, Morgan RK, Costello RW, Gunaratnam C, Ryan D, McElvaney NG, McConkey SJ, McNally C, Curley GF, MacHale S, Gillan D, Pender N, Barry H, de Barra E, Kiernan FM, Sulaiman I, Hurley K., An integrated multidisciplinary model of COVID-19 recovery care., Irish Journal of Medical Sciences, Sept, 2020 Journal Article, 2020

Alice V Stanton, Kirstyn James, Margaret M Brennan, Fiona O'Donovan, Fahad Buskandar, Kathleen Shortall, Thora El-Sayed, Jean Kennedy, Heather Hayes, Alan G Fahey, Niall Pender, Simon AM Thom, Niamh Moran, David J Williams, Eamon Dolan, Omega-3 index and blood pressure responses to eating foods naturally enriched with omega-3 polyunsaturated fatty acids: a randomized controlled trial, Scientific Reports, 10, (1), 2020, p1 - 10 Journal Article, 2020

Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, Karavasilis E, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. , Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. , J Neurol Sci. , 2020 Journal Article, 2020 DOI

Rangariroyashe H Chipika, Eoin Finegan, Stacey Li Hi Shing, Mary C McKenna, Foteini Christidi, Kai Ming Chang, Mark A Doherty, Jennifer C Hengeveld, Alice Vajda, Niall Pender, Siobhan Hutchinson, Colette Donaghy, Russell L McLaughlin, Orla Hardiman, Peter Bede, "Switchboard" malfunction in motor neuron diseases: selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis, NeuroImage: Clinical, 27, (5), 2020 Journal Article, 2020 DOI

Merriman NA, Gillan D, Pender N, Williams DJ, Horgan F, Sexton E, Johnston M, Bennett KE, Donnelly NA, Wren MA, Hickey A., The StrokeCog study: development and description of a cognition-focused psychological intervention to address cognitive impairment following stroke., Psychological Health, 14, 2020, p1 - 18 Journal Article, 2020

Alice Stanton, Kathleen Shortall, Thora El-Sayed, Margaret Brennan, Fahad Buskandar, Fiona O'Donovan, Kirstyn James, Jean Kennedy, Heather Hayes, Bronagh Owens, Alan Fahey, Niall Pender, Niamh Moran, David Williams, Eamon Dolan, Plasma and Tissue Bioavailability and Blood Pressure Lowering Effects of Omega-3 Polyunsaturated Fatty Acids from Commonly Eaten, Naturally Enriched, Foods, Proceedings of the Nutrition Society, 79, 2020 Journal Article, 2020 DOI

Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B., Patterned functional network disruption in amyotrophic lateral sclerosis. , Human Brain Mapping, 40, (16), 2019, p4827 - 4842 Journal Article, 2019 URL

Hickey A, Merriman NA, Bruen C, Mellon L, Bennett K, Williams D, Pender N, Doyle F. , Psychological interventions for managing cognitive impairment after stroke, Cochrane Database of Systematic Reviews , 2019 Journal Article, 2019

McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B., Neurophysiological markers of network dysfunction in neurodegenerative diseases, Neuroimage Clin, 22, 2019, p101706- Journal Article, 2019 TARA - Full Text URL

Niamh A Merriman, Eithne Sexton, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Nora-Ann Donnelly, Niall Pender, David J Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey, Addressing cognitive impairment following stroke: systematic review and meta-analysis of non-randomised controlled studies of psychological interventions, BMJ open, 9, (2), 2019, pe024429- Journal Article, 2019 URL

Finegan E, Li Hi Shing S, Chipika, RH, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Pender N, McLaughlin RL, Hardiman O, Bede P., Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling., Neuroimage Clin., 2019 Journal Article, 2019

Emmet Costello, Katie Lonergan, Caoifa Madden, Meadhbh O'Sullivan, Iain Mays, Mark Heverin, Marta Pinto-Grau, Orla Hardiman & Niall Pender, Equivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS),, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2019 Journal Article, 2019 DOI

Burke, T., Wilson-O'Raghallaigh J, Maguire S., Galvin , M., Heverin, M., Hardiman, O., Pender, Niall , Group Interventions for Amyotrophic Lateral Sclerosis Caregivers in Ireland: a randomised controlled trial protocol, BMJ Open, (September), 2019 Journal Article, 2019 DOI

Rogers, M. and Boland, B. and Clarke, S. and Craven, A. and Fassbender, C. and Gill, M. and Hardiman, O. and Henshall, D.C. and Lynch, T. and Mitchell, K. and Pender, N. and Rogan, C. and Roche, R.A.P., Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council, European Journal of Neuroscience, 49, (11), 2019, p1362-1370 Journal Article, 2019 TARA - Full Text DOI

Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Pender N, Hardiman O, Bede P, The clinical and radiological profile of primary lateral sclerosis: a population-based study., Journal of Neurology, 2019 Journal Article, 2019

Bahman Nasseroleslami, Stefan Dukic, Roisin Mc Mackin, Amina Coffey, Antonio Fasano, Rangariroyashe Chipika, Marta Pinto-Grau, Tom Burke, Emmet Costello, Parameswaran Iyer, Mark Heverin, Niall Pender, Peter Bede, Orla Hardiman, Neuroelectric Biomarkers of Network Dysfunction in Amyotrophic Lateral Sclerosis (P1. 4-006), Neurology, 92, (15), Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 2019, ppP1. 4-006- Conference Paper, 2019

Elliott,N., Pembroke, S., Quirke, M.,Pender, N., & Higgins, A., Disclosure strategies in adults with epilepsy when telling, "I have epilepsy": The How2tell study, Epilepsia, 2019 Journal Article, 2019 DOI

Dysfunction of attention switching networks in amyotrophic lateral sclerosis, Roisin McMackin, Stefan Dukic, Michael Broderick, Parameswaran M Iyer, Marta Pinto-Grau, Kieran Mohr, Rangariroyashe Chipika, Amina Coffey, Teresa Buxo, Christina Schuster, Brighid Gavin, Mark Heverin, Peter Bede, Niall Pender, Edmund C Lalor, Muthuraman Muthuraman, Orla Hardiman, Bahman Nasseroleslami, NeuroImage: Clinical, 22, (101707), 2019 Journal Article, 2019

Marie Ryan, Mark Heverin, Niall Pender, Russell McLaughlin, Orla Hardiman, Heritability of ALS: A Population-based study over 24 years.(S54. 001), Neurology, American Academy of Neurology, 92, (15), Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 2019, ppS54. 001- Conference Paper, 2019

Monaghan, R., McCormack, D., Ndukwe, I., Burke, T., Pender, N., O'Riordan, S., Hutchinson, M. and O'Keeffe, F., , Social Cognition, Neuropsychological functioning & Mood Disorder in Cervical Dystonia (CD, Movement Disorders, 34, 2019, p1314- Journal Article, 2019

Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O., Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis., Cereb Cortex, 29, (1), 2019, p27 - 41 Journal Article, 2019

Burke, S., Campbell, D., Dineen, B., Burke, T., & Pender, N., Evaluating the Levels of Cognitive Impairment in Pre-manifest and Manifest Huntington's Disease Patients Compared to Controls. A Comprehensive Analysis of the ENROLL-HD Database, IRISH JOURNAL OF MEDICAL SCIENCE, 188, (12), Springer London, 2019, pp359 - 359 Poster, 2019

Fiona O'Donovan, Síle Carney, Jean Kennedy, Heather Hayes, Niall Pender, Fiona Boland, Alice Stanton, Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies , BMJ Open, 9, 2019 Journal Article, 2019 URL

Eoin Finegan, Rangariroyashe Chipika, Taha Omer, Mark A. Doherty, Alice Vajda, Russell L. McLaughlin, Niall Pender, Orla Hardiman, Peter Bede, Extra-Motor Pathology in ALS-FTD: Looking Beyond C9orf72, Neurology, 90, (15 Supplement), 2018, pS25.003 Journal Article, 2018

Bahman Nasseroleslami, Stefan Dukic, Michael Broderick, Kieran Mohr, Christina Schuster, Brighid Gavin, Russell McLaughlin, Mark Heverin, Alice Vajda, Parameswaran Iyer, Niall Pender, Peter Bede, Edmund Lalor, Orla Hardiman, Decreased EEG Spectral Power and Increased Cortico-Cortical Connectivity Correlate with Structural MRI Changes in Amyotrophic Lateral Sclerosis (P2. 036), Neurology, American Academy of Neurology Annual Conference, 10/04/2018, 90, (15), Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 2018, ppp2.036- Conference Paper, 2018

Peter Bede, Eoin Finegan, Rangariroyashe Chipika, Taha Omer, Niall Pender, Siobhan Hutchinson, Orla Hardiman, Characterisation of basal ganglia pathology in frontotemporal dementia: a connectivity-based multimodal neuroimaging study, Neurology, 90, (15 Supplement), 2018, pS34.002 Journal Article, 2018

Ryan, M. and Heverin, M. and Doherty, M.A. and Davis, N. and Corr, E.M. and Vajda, A. and Pender, N. and McLaughlin, R. and Hardiman, O., Determining the incidence of familiality in ALS, Neurology: Genetics, 4, (3), 2018 Journal Article, 2018 TARA - Full Text DOI

Niamh A Merriman, Eithne Sexton, Nora-Ann Donnelly, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Niall Pender, David Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey, Managing cognitive impairment following stroke: protocol for a systematic review of non-randomised controlled studies of psychological interventions, BMJ open, 8, (1), 2018 Journal Article, 2018

Burke, T., Hardiman, O., Pinto-Grau, M, Longergan, K., Heverin, M., Tobin, K., Staines, A. Galvin, M., and Pender, N, , Longitudinal Predictors of Caregiver Burden in Amyotrophic Lateral Sclerosis: A population-based cohort of patient-caregiver dyads., Journal of Neurology , 2018 Journal Article, 2018

Tom Burke, Marta Pinto Grau, Katie Lonergan, Peter Bede, Orla Hardiman, Niall Pender, Cognitive Change in Cognitively Intact Amyotrophic Lateral Sclerosis: Reliable Change Index in a population-based cohort.(P5. 197), Neurology, American Academy of Neurology Annual Conference, 2018, 90, (15 Suppl), Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 2018, pp197- Conference Paper, 2018

M Ryan, M Doherty, M Heverin, N Pender, R McLaughlin, O Hardiman, Oligogenic and discordant inheritance: a population based genomic study of Irish kindreds carrying the C9orf72 repeat expansion, EUROPEAN JOURNAL OF NEUROLOGY, 25, 2018, p509 - 509 Journal Article, 2018

Pinto-Grau, M., Hardiman, O., & Pender, N. (2018, The Study of Language in the Amyotrophic Lateral Sclerosis-Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives., Neuropsychology review, 2018, p1 - 18 Journal Article, 2018

Tom Burke, Orla Hardiman, Marta Pinto Grau, Katie Lonergan, Katy Tobin, Anthony Staines, Miriam Galvin, Niall Pender, Longitudinal Predictors of Caregiver Burden in Amyotrophic Lateral Sclerosis: A population-based cohort of cognitively intact patient-caregiver dyads.(P5. 198), Neurology, American Academy of Neurology, 2018/4/10, 90, (15), Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 2018, ppP5.198- Conference Paper, 2018

The impact of cognitive and behavioural change on quality of life of caregivers and patients with ALS and other neurological conditions in, editor(s)Francesco Pagnini & Zachary Simmons , Amyotrophic Lateral Sclerosis: Understanding and Optimizing Quality of Life and Psychological Well-being, UK, OUP, 2018, pp151 - 162, [Tom Burke, Miriam Galvin, Sinead Maguire, Niall Pender, Orla Hardiman] Book Chapter, 2018

Tom Burke, Stephanie Hughes, Alan Carr, Mohsen Javadpour, Niall Pender, A Systematic Review of Cognitive Outcomes in Angiographically Negative Subarachnoid Haemorrhage, 28, (4), 2018, p453 - 469 Journal Article, 2018 URL

I Caramlau, J Gallagher, B Hannon, L O'connor, T Mannion, E Kennedy, L Masterson, L O'neill, L Peotta, S Clarke, N Pender, B Mcadam, Comprehensive heart failure self-management programme: evaluation of a pilot group intervention, EUROPEAN JOURNAL OF HEART FAILURE, 20, 2018, p84 - 85 Journal Article, 2018

Bede P, Omer T, Finegan E, Chipika RH, Iyer PM, Doherty MA, Vajda A, Pender N, McLaughlin RL, Hutchinson S, Hardiman O., Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study., Brain Imaging Behav, 2018, p1 - 19 Journal Article, 2018 DOI

Crockford, C. and Newton, J. and Lonergan, K. and Chiwera, T. and Booth, T. and Chandran, S. and Colville, S. and Heverin, M. and Mays, I. and Pal, S. and Pender, N. and Pinto-Grau, M. and Radakovic, R. and Shaw, C.E. and Stephenson, L. and Swingler, R. and Vajda, A. and Al-Chalabi, A. and Hardiman, O. and Abrahams, S., ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS, Neurology, 91, (15), 2018, pE1370-E1380 Journal Article, 2018 TARA - Full Text DOI

Miriam Galvin,Sile Carney, Bernie Corr, Iain Mays, Niall Pender, Orla Hardiman, Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis, · BMJ Open , 8, (1), 2018, pe018721- Journal Article, 2018 TARA - Full Text DOI

Pinto-Grau M, Costello E, O'Connor S, Elamin M, Burke T, Heverin M, Pender N,, Hardiman O, Assessing behavioural changes in ALS: cross-validation of ALS-specific measures., Journal of Neurology, 2017, p1397 - 1401 Journal Article, 2017 DOI

Tom Burke, Marwa Elamin, Marta Pinto Grau, Katie Lonergan, Peter Bede, Mark Heverin, Alice Vajda, Russell McLaughlin, Niall Pender, Orla Hardiman, Distinct Behavioural Phenotypes in ALS: A Population Based Factor Analysis (P6. 314), Neurology, 88, (16 (Suppl)), 2017 Conference Paper, 2017

Tom Burke, Marta Pinto Grau, Katie Lonergan, Marwa Elamin, Peter Bede, Emmet Costello, Orla Hardiman, Niall Pender, Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study, Neurology, 88, (16 (Suppl)), 2017 Conference Paper, 2017

Burke, Galvin, Pint-Grau, Lonergan, Madden, Mayes, Carney, Hardiman, Pender , Niall, Caregivers, of patients with ALS: Investigating Quality of Life, Caregivers, Burden, Service Engagement and Patient Survival, Journal Of Neurology doi:10.1007/s00415-017-8448-5, 2017 Journal Article, 2017

Margaret O'Brien, Tom Burke, Mark Heverin, Alice Vajda, Russell McLaughlin, John Gibbons, Susan Byrne, Marta Pinto-Grau, Marwa Elamin, Niall Pender, Orla Hardiman, Clustering of neuropsychiatric disease in first-degree and second-degree relatives of patients with amyotrophic lateral sclerosis, JAMA neurology, 74, 2017, p1425-1430 Journal Article, 2017

Tom Burke, Marta Pinto-Grau, Katie Lonergan, Peter Bede, Meabhdh O'Sullivan, Mark Heverin, Alice Vajda, Russell L McLaughlin, Niall Pender, Orla Hardim an, Behavioural Subphenotypes in ALS: A Population Based Factor Analysis Approach, Annals of Clinical and Translational Neurology, 2017 Journal Article, 2017

Eoin O'Keefe1, Eoin Kelly2, Eugene Wallace2, Chris Greene1, Stephanie Hughes3, John Kealy1, Niamh Doyle3, Marian M. Humphries1, Michael Farrell4, Gerald A. Grant5, Alon Friedman6,7, Ronel Veksler6, Michael G. Molloy8, James F. Meaney9, Niall Pender3, Colin P. Doherty2 and Matthew Campbell1 , Dynamic blood brain barrier regulation in sub-concussive brain injuries, Fluids and Barriers of the CNS, 20th International Symposium on Signal Transduction at the Blood-Brain Barriers, 14(Suppl 2):27, 2017 Conference Paper, 2017

Parameswaran Mahadeva Iyer, Kieran Mohr, Michael Broderick, Brighid Gavin, Tom Burke, Peter Bede, Marta Pinto-Grau, Niall P. Pender, Russell McLaughlin, Alice Vajda, Mark Heverin, Edmund C. Lalor, Orla Hardiman and Bahman Nasseroleslami , Mismatch negativity as an indicator of cognitive sub-Domain Dysfunction in amyotrophic lateral sclerosis. , Frontiers in Neurology, 8, 2017 Journal Article, 2017

Christopher Crockford, Judith Newton, Katie Lonergan, Caoifa Madden, Iain Mays, Meabhdh O'Sullivan, Emmet Costello, Marta Pinto-Grau, Alice Vajda, Mark Heverin, Niall Pender, Ammar Al-Chalabi, Orla Hardiman, Sharon Abrahams, Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1 - 9 Journal Article, 2017 TARA - Full Text

Tom Burke, Marta Pinto Grau, Katie Lonergan, Marwa Elamin, Peter Bede, Emmet Costello, Orla Hardiman, Niall Pender, Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study , Neurology, AAN Annual Conference, 88, 2017, ppp6.326- Conference Paper, 2017

Bahman Nasseroleslami, Michael Broderick, Kieran Mohr, Stefan Dukic, Brighid Gavin, Amina Coffey, Roisin McMackin, Christina Schuster, Tom Burke, Marta Pinto-Grau, Russel McLaughlin, Niall Pender, Peter Bede, Mark Heverin, Alice Vajda, Parameswaran Mahadeva Iyer, David M Halliday, Madeleine M Lowery, Richard G Carson, Edmund C Lalor, Orla Hardiman, Impairment of cortico-cortical and cortico-muscular communication in amyotrophic lateral sclerosis, Irish Journal of Medical Sciences, 186, 2017 Journal Article, 2017

Taha Omer, Eoin Finegan, Siobhan Hutchinson, Mark Doherty, Alice Vajda, Russell L McLaughlin, Niall Pender, Orla Hardiman, Peter Bede, Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, (18), 2017, p611-623 Journal Article, 2017 DOI

Bahman Nasseroleslami, Michael Broderick, Kieran Mohr, Christina Schuster, Brighid Gavin, Russell McLaughlin, Mark Heverin, Alice Vajda, Parameswaran Iyer, Niall Pender, Peter Bede, Edmund Lalor, Orla Hardiman, EEG Measures of Altered Cortico-Cortical Connectivity Correlate with Structural MRI Changes in Amyotrophic Lateral Sclerosis , Neurology, 88, (16 (Suppl)), 2017 Conference Paper, 2017

The Impact of Cognitive and Behavioural Change on QoL of Caregivers and Patients with ALS and other Neurological Conditions in, editor(s)F. Pagnini, & Z. Simmons (Eds.) , Amyotrophic Lateral Sclerosis: Understanding and Optimizing Quality of Life and Psychological Well-Being, UK, OUP, 2017, [Galvin, M., Burke, T., Pender, N., & Hardiman, O.] Book Chapter, 2017

Burke T, Lonergan K, Pinto-Grau M, Elamin M, Bede P, Madden C, Hardiman O & Pender N., Visual Encoding, Consolidation, and Retrieval in Amyotrophic Lateral Sclerosis: Executive Function as a Mediator, and Predictor of Performance., Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017, p1-9 Journal Article, 2017 DOI

Pembroke, S, Higgins, A., Pender, N, Elliott, N , Becoming comfortable with "my" epilepsy: strategies that patients use in the journey from diagnosis to acceptance, Epilepsy & Behavior, 70, 2017, p217 - 223 Journal Article, 2017 DOI URL

Elamin M, Pinto-Grau M, Burke T, Bede P, Rooney J, O†Sullivan M, Lonergan K, Kirby E, Quinlan E, Breen N, Vajda A, Heverin M, Pender N, Hardiman O, Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI), Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (1-2), 2016, p68-73 Journal Article, 2016 URL DOI

Burke T, Pinto-Grau M, Lonergan K, Elamin M, Bede P, Costello E, Hardiman O, Pender N, Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study, PLoS One, 11, (8), 2016, pe0160850- Journal Article, 2016 DOI TARA - Full Text

The role of Neuropsychology in Neurodegeneration in, editor(s)O. Hardiman et al , Neurodegenerative Disorders: A clinical guide. 2nd Edn, Netherlands, Springer, 2016, [Elamin, M., Bak, T., Doherty, C., Pender, N., & Abrahams, S] Book Chapter, 2016

Burke T, Elamin M, Bede P, Pinto-Grau M, Lonergan K, Hardiman O, Pender N, Discordant Performance on the 'Reading the Mind in the Eyes' Test, Based on Disease Onset in Amyotrophic Lateral Sclerosis, Amyotroph Lateral Scler Frontotemporal Degener, 17, (7-8), 2016, p467-472 Journal Article, 2016 DOI

Huntington's disease. in, editor(s)O. Hardiman et al , Neurodegenerative Disorders: A clinical guide. 2nd Edn., Netherlands, Springer, 2016, [Burke, T., Doherty, C., Koroshetz, W., & Pender, N. ] Book Chapter, 2016

Pinto-Grau M, Burke T, Lonergan K, McHugh C, Mays I, Madden C, Vajda A, Heverin M, Elamin M, Hardiman O, Pender N, Screening for cognitive dysfunction in ALS: validation of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) using age and education adjusted normative data, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18, (1-2), 2016, p99-106 Journal Article, 2016 DOI URL

Burke T, Elamin M, Galvin M, Hardiman O, Pender N, Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors, Journal of Neurology, 262, (6), 2015, p1526 - 1532 Journal Article, 2015 URL DOI

Burke T, Elamin M, Galvin M, Gallagher L, Hardiman O, Pender N, Erratum to: Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors, Journal of neurology, 262, (12), 2015, p2799- Journal Article, 2015 URL DOI

Iyer P.M, Egan C, Pinto-Grau M, Burke T, Elamin M, Nasseroleslami B, Pender N, Lalor E.C, Hardiman O, Functional connectivity changes in resting-state EEG as potential biomarker for Amyotrophic Lateral Sclerosis, PLoS ONE, 10, (6), 2015, 012868- Journal Article, 2015 URL TARA - Full Text DOI

Burke T, Healy D, Casey P, Hardiman O, Pender N, Atypical social cognitive processing in premotor Huntington†s disease: a single case study, Irish Journal of Psychological Medicine, 2015, p1-6 Journal Article, 2015 DOI URL

Burke T, Elamin M, Galvin M, Gallagher L, Hardiman O, Pender N, Erratum: Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors. [J Neurol, (2015) 262, (1526-1532), DOI 10.1007/s00415-015-7746-z], 2015, - 2799 Miscellaneous, 2015 DOI URL

Elamin M, Bede P, Montuschi A, Pender N, Chio A, Hardiman O, Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm, Journal of Neurology, 262, (6), 2015, p1447-1454 Journal Article, 2015 TARA - Full Text DOI

Burke,T., Pinto-Grau M., Elain, M., Bede, P., Hardiman, O., & Pender, N., Practice Effects Across Eighteen Months on Neuropsychological Measures of Executive Functioning., Irish Journal of Psychology., 2015 Journal Article, 2015

McCarthy, A., Lonergan, R., Olszewska, D.A., O'Dowd, S., Cummins, G., Magennis, B., Fallon, E.M., Pender, N., Huey, E.D., Cosentino, S., O'Rourke, K., Kelly, B.D., O'Connell, M., Delon, I., Farrell, M., Spillantini, M.G., Rowland, L.P., Fahn, S., Craig, P., Hutton, M., Lynch, T., Closing the tau loop: The missing tau mutation, Brain, 138, (10), 2015, p3100-3109 Journal Article, 2015 URL DOI

Burke T, Wynne B, O'Brien C, Elamin M, Bede P, Hardiman O, Pender, N, Retrospective Investigations of Practice Effects on Repeated Neuropsychological Measures of Executive Functioning, The Irish Journal of Psychology, (April), 2015 Journal Article, 2015 DOI

Salomone S, Robertson IH, Lynch T, Balsters JH, Fearon C, Marnane M, Pender NP, Dockree PM, The effects of immunologic brainstem encephalopathy on cognitive function following awakening from a progressive autoimmune coma., Neurocase, 20, (5), 2014, 569-580 Journal Article, 2014 Other DOI TARA - Full Text

Magee J.A, Burke T, Delanty N, Pender N, Fortune G.M, The economic cost of nonepileptic attack disorder in Ireland, Epilepsy and Behavior, 33, 2014, p45 - 48 Journal Article, 2014 DOI URL

Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B, O'Brien C, Phukan J, Lynch C, Pender N, Hardiman O, Cognitive changes predict functional decline in ALS: A population-based longitudinal study., Neurology, 2013 Journal Article, 2013

P. Bede, A. Bokde, M. Elamin, S. Byrne, R.L. McLaughlin, N. Jordan, H. Hampel, L. Gallagher, C. Lynch, A.J. Fagan, N. Pender, O. Hardiman, Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality, Journal of Neurology, Neurosurgery & Psychiatry, 84, (7), 2013, p766 - 773 Journal Article, 2013 DOI

Bede P1, Bokde AL, Byrne S, Elamin M, McLaughlin RL, Kenna K, Fagan AJ, Pender N, Bradley DG, Hardiman O., Multiparametric MRI study of ALS stratified for the C9orf72 genotype, Neurology, 81, (4), 2013, p361-369 Journal Article, 2013 TARA - Full Text DOI

Hoerold D, Pender, N, & Robertson IH , Metacognitive and online error awareness deficits after prefrontal cortex lesions, Neuropsychologia. , 51, (3), 2013, p385 - 391 Journal Article, 2013 DOI TARA - Full Text

Gallagher, J., Heverin, M., McHugh, C., Graham, T., Hannon, B., Pender, N. & McAdam, B, Changes in illness beliefs are associated with enhanced outcomes in cardiac rehabilitation - even in patients with Type D personality., Journal of Cardiopulmonary Rehabilitation & Prevention, 33, (5), 2013, p328-339 Journal Article, 2013

Pazderska A, O'Connell M, Pender N, Gavin C, Murray B, O'Dowd S, Insights into thermoregulation: A clinico-radiological description of Shapiro syndrome, Journal of the Neurological Sciences, 329, (1-2), 2013, p66 - 68 Journal Article, 2013 URL DOI

H. Maher, N. Pender, N. Delanty, C. Doherty, T. Burke, The nature and extent of cognitive disruption in mesial temporal lobe epilepsy relative to unaffected siblings and healthy controls, Epilepsia, 54, 2013, p27-28 Journal Article, 2013 DOI

Bede, P, Elamin, M, Byrne, S, McLaughlin, RL, Kenna, K, Vajda, A, Pender, N, Bradley, DG, Hardiman, O, Basal ganglia involvement in amyotrophic lateral sclerosis, NEUROLOGY, 81, (24), 2013, p2107-2115 Journal Article, 2013

Bede, P, Bokde, ALW, Byrne, S, Elamin, M, McLaughlin, RL, Kenna, K, Fagan, AJ, Pender, N, Bradley, DG, Hardiman, O, Multiparametric MRI study of ALS stratified for the C9orf72 genotype, NEUROLOGY, 81, (4), 2013, p361-369 Journal Article, 2013 DOI

Byrne S, Elamin M, Bede P, Shatunov A, Walsh C, Corr B, Heverin M, Jordan N, Kenna K, Lynch C, McLaughlin RL, Iyer PM, O'Brien C, Phukan J, Wynne B, Bokde AL, Bradley DG, Pender N, Al-Chalabi A, Hardiman O, Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study., Lancet neurology, 11, (3), 2012, p232-40 Journal Article, 2012 DOI

Howley S.A, Prasad S.E, Pender N.P, Murphy K.C, Relationship between reaction time, fine motor control, and visual-spatial perception on vigilance and visual-motor tasks in 22q11.2 Deletion Syndrome, Research in Developmental Disabilities, 33, (5), 2012, p1495 - 1502 Journal Article, 2012 URL DOI

O'Dowd S, Curtin D, Waite A.J, Roberts K, Pender N, Reid V, O'Connell M, Williams N.M, Morris H.R, Traynor B.J, Lynch T, C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism, Movement Disorders, 27, (8), 2012, p1072 - 1074 Journal Article, 2012 URL DOI

Magee J.A, Pender N.P, Abrahams S, Thornton J, Delanty N, Fortune G.M, A comparison of propofol and amobarbital for use in the Wada test, Seizure, 21, (5), 2012, p399 - 401 Journal Article, 2012 URL DOI

Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, Hampel H, Gallagher L, Lynch C, Fagan AJ, Pender N, Hardiman O, Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality., Journal of neurology, neurosurgery, and psychiatry, 84, (7), 2012, p766-73 Journal Article, 2012 DOI

Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O, The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study., Journal of neurology, neurosurgery, and psychiatry, 83, (1), 2012, p102-8 Journal Article, 2012 DOI

Lewis, CC., Gallagher, J., Heverin, M., McHugh, C., Doyle, F., Pender, N. and McAdam, B., Single Centre Study Examines Illness Beliefs, Coping and Self-Management in an Ambulatory Irish Heart Failure Population, Journal of Cardiac Failure, 18, (8), 2012, pS83-S83 Journal Article, 2012

Elamin M, Pender N, Hardiman O, Abrahams S, Social cognition in neurodegenerative disorders: a systematic review., Journal of neurology, neurosurgery, and psychiatry, 83, (11), 2012, p1071-9 Journal Article, 2012 DOI

J.A. Magee, E.T. Burke, N..P Pender, N. Delanty, G.M. Fortune, Illness perception, quality of life and coping styles in patients admitted to an epilepsy monitoring unit., Epilepsia, 253, 2012, p213-213 Journal Article, 2012

Gallagher, J., Heverin, M., McHugh, C., Graham, T., Hannon, B., Pender, N. and McAdam, B, Barriers to Cardiac Rehabilitation in Ireland - a single centre experience. , Journal of Cardiopulmonary Rehabilitation & Prevention, 32, (4), 2012, p226-37 Journal Article, 2012

Clune-Ryberg M, Blanco-Campal A, Carton S, Pender N, OBrien D, Phillips J, Delargy M, Burke T, The contribution of retrospective memory, attention and executive functions to the prospective and retrospective components of prospective memory following TBI, Brain Injury, 25, (9), 2011, p819 - 831 Journal Article, 2011 DOI URL

Huntington's disease. in, editor(s)O. Hardiman and C. Doherty , Neurodegenerative Disorders: A Clinical Guide, Netherlands, Springer, 2011, [Pender, N, Koroshetz, W ] Book Chapter, 2011

Elamin M, Phukan J, Bede P, Jordan N, Byrne S, Pender N, Hardiman O, Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia., Neurology, 76, (14), 2011, p1263-9 Journal Article, 2011 DOI

Doyle, N., Stapleton, T., Nolan, C., Pender, N., and O'Brien, D., A pilot study to explore the use of the Sensory Modality Assessment and Rehabilitative Technique (SMART) with low awareness state patients in an acute hospital settig., Physical Therapy Review, Rehabilitation and Therapy Research Society, Dublin, 15, (2), Maney Publishing, 2010, pp123 - 123 Meeting Abstract, 2010

Dunlea, O. Doherty, C.P. Farrell, M. Fitzsimons, M. O'Brien, D. Murphy, K. MacMackin, D. Pender, N. Staunton, H. Phillips, J. Delanty, N., The Irish epilepsy surgery experience: Long-term follow-up, Seizure, 19, (4), 2010, p247 - 252 Journal Article, 2010 URL DOI

Phukan, J., Hardiman, O., Jordan, N., Gallagher, L., Pender, N., A population-based longitudinal study of cognitive and behavioural impairment in amyotrophic lateral sclerosis, Journal of Neurology, Neurosurgery and Psychiatry, 81, (11), 2010, pe25 Journal Article, 2010

Phukan J, Ali E, Pender N.P, Molloy F, Hennessy M, Walsh R.J, Hardiman O, Huntington's disease presenting as amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 11, (4), 2010, p405 - 407 Journal Article, 2010 URL DOI

Phukan J, Pender N.P, Hardiman O, Cognitive impairment in amyotrophic lateral sclerosis, Lancet Neurology, 6, (11), 2007, p994 - 1003 Journal Article, 2007 DOI URL

Outcome measures on inpatient cognitive-behavioural units: A review. in, editor(s)S. Fleminger and J. Powell , Evaluation of Outcomes in Brain Injury Rehabilitation , UK, Psychology Press: UK., 1999, pp345 - 361, [Pender, N.P. & Fleminger, S.F. ] Book Chapter, 1999

Pender N, Fleminger S, Outcome measures on inpatient cognitive and behavioural units: An overview, Neuropsychological Rehabilitation, 9, (3-4), 1999, p345 - 361 Journal Article, 1999 DOI URL

Goldstein L.H, Pender N, Parshall A.M, Fenwick P.B.C, Patients' and referring doctors' perceptions of treatment on an in-patient neuropsychiatry/epilepsy unit: A study of three cohorts, Seizure, 6, (1), 1997, p13 - 20 Journal Article, 1997 URL DOI

Research Expertise

Projects

  • Title
    • Defining the complex needs of ALS caregivers.
  • Summary
    • Hardiman, O, Galvin, M, Pender N (Co-PI), Burke, T. (2016)
  • Funding Agency
    • American ALS Association.
  • Date From
    • 2016
  • Title
    • Examining the beneficial effects of Omega 3-PUFA / Vitamin B enrichment of chicken meat and eggs on cognitive functioning.
  • Summary
    • Alice Stanton & Niall Pender (2016).
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2016
  • Title
    • Concussion: A Longitudinal study in amateur and professional athletes.
  • Summary
    • Doherty, C, Pender, N (Co-PI), et al. (2015).
  • Funding Agency
    • St James' Hospital
  • Date From
    • 2015
  • Title
    • A longitudinal study of the evolution of language changes in Motor Neuron Disease (MND)
  • Summary
    • Hardiman, O (PI), Pender N (PI) and Pinto-Grau M. .A longitudinal study of the evolution of language changes in Motor Neuron Disease (MND): Neuropsychology and Neuroimaging correlates of language performance in MND.
  • Funding Agency
    • Application Number 30/579.
  • Date From
    • 2015
  • Title
    • A study of the absorption, distribution and cardiovascular benefits for hums of eating chicken-meat and eggs enriched with Omega-3 PUFAS over a 6 month period.
  • Summary
    • Prof. A. Stanton, Dr. E. Dolan, Prof. N. Moran, Prof. D. Williams, Dr. N. Pender, Dr. A. Fahey, Ms. K. Shortall, Ms. T. El-Sayed, RCSI & Beaumont Hospital, Dublin (RCSI).
  • Funding Agency
    • Devenish Nutrition
  • Date From
    • 2015
  • Title
    • The StrokeCog study
  • Summary
    • Hickey, A, N.Pender, D Williams, Bennett, K, Horgan, F. Wren M-A. The StrokeCog study: modelling and modifying the consequences of stroke-related cognitive impairment through intervention. (Co-applicant).
  • Funding Agency
    • Inter-disciplinary Capacity Enhancement
  • Date From
    • 2014
  • Title
    • Neuropsychology of Huntington's disease.
  • Summary
    • Pender, N. Neuropsychology of Huntington's disease.
  • Funding Agency
    • Huntington's Disease Association of Ireland
  • Date From
    • 2015
  • Title
    • ENROLL-HD: An international longitudinal observational trial of Huntingotn's disease
  • Summary
    • Irish site lead for this multi-centre longitudinal observational trial of Huntington's disease.
  • Funding Agency
    • CHDI/Quintiles
  • Date From
    • September 2015
  • Title
    • Neuropsychological and Functional Correlates of Social Cognition in Neurodegenerative diseases
  • Summary
    • Evaluating social cognitive processes in patients Huntington's disease and Motor Neurone Disease
  • Funding Agency
    • Irish Institute of Clinical Neuroscience/Novartis
  • Date From
    • 2013
  • Title
    • Novel biomarkers of ALS subphenotypes using advanced imaging and spectral EEG technology
  • Summary
    • Professor O. Hardiman, Professor A. Bokde, Dr N. Pender, Dr E. Lalor
  • Funding Agency
    • HRB HRA-POR-2013-246
  • Date From
    • 2013
  • Title
    • The collaborative development of an evidence-based educational resource for self-disclosure strategies for people with epilepsy
  • Summary
    • Elliot, N, Dohery, C, White, M, Pender, N. Et al
  • Funding Agency
    • MRCGP Brainwave
  • Date From
    • 2013

Recognition

Representations

Chair of the Board of Directors, Headway Ireland June 2014-

Member of the Board of Directors, Research Motor Neurone October 2013-

President, Irish Brain Council June 2015-

Founding Member, Irish Brain Council May 2015

President, Psychological Society of Ireland 2009-2010

Member of the Council of the Psychological Society of Ireland. 2006-2011

Founding member and Chair, Division of Neuropsychology, Psychological Society of Ireland 2005-2007

Member, Expert Advisory Panel, Multiple Sclerosis Society of Ireland 2016-

Member, Ethics Oversight Committee, National Living Related Donor Programme. 2010-

Member, Beaumont Hospital Research (Medical) Ethics Committee 2011-2016

Member of the Board for the Neurological Alliance of Ireland. 2019-present

Member, Research Group, National Health and Social Care Professional Office, HSE. Sept 2020-Present

Memberships

Psychological Society of Ireland 2005

British Psychological Society 1992

British Neuropsychological Society 1995

Royal Academy of Medicine In Ireland 2018

Medico-Legal Society of Ireland 2010