Mary O'Sullivan
Research Fellow, Clinical Medicine
Associate Research Lecturer, Molecular Medicine Ireland

Publications and Further Research Outputs

Peer-Reviewed Publications

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 Journal Article, 2016 TARA - Full Text URL DOI

Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368-79 Journal Article, 2016 TARA - Full Text URL

O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54 Journal Article, 2016 URL

Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152 Journal Article, 2016 URL

Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167 Journal Article, 2016 URL DOI

O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J., Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis., American Journal of Respiratory and Critical Care Medicine, 190, (12), 2014, p1430 - 1436 Journal Article, 2014 URL

Lawlor C, O'Sullivan MP, Rice B, Dillon P, Gallagher PJ, O'Leary S, Shoyele S, Keane J, Cryan SA, Therapeutic aerosol bioengineering of targeted, inhalable microparticle formulations to treat Mycobacterium tuberculosis (MTb)., Journal of Materials Science. Materials in Medicine, 23, (1), 2012, p89 - 98 Journal Article, 2012 DOI

Verma NK, Conroy J, Lyons PE, Coleman J, O'Sullivan MP, Kornfeld H, Kelleher D, Volkov Y, Autophagy induction by silver nanowires: A new aspect in the biocompatibility assessment of nanocomposite thin films., Toxicology and Applied Pharmacology, 264, (3), 2012, p451-61 Journal Article, 2012 DOI

Mercedes González-Juarrero, and Mary P. O'Sullivan, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells, Tuberculosis, 91, (1), 2011, p86-92 Journal Article, 2011 TARA - Full Text

Ryan RC, O'Sullivan MP, Keane J, Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells., BMC Microbiology, 11, 2011, p237- Journal Article, 2011 TARA - Full Text

Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA., Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb., Tuberculosis, 91, (1), 2011, p93 - 97 Journal Article, 2011

Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA, The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Molecular Pharmaceutics, 8, (4), 2011, p1100 - 1112 Journal Article, 2011 DOI

O'Leary S, O'Sullivan MP, Keane J., IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages., American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180 Journal Article, 2011

González-Juarrero M, O'Sullivan MP, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells., Tuberculosis (Edinburgh, Scotland), 91, (1), 2010, p86 - 92 Journal Article, 2010 DOI

Kelly, DM, ten Bokum, AM, O'Leary, SM, O'Sullivan, MP, Keane, J, Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection., Infection and Immunity, 76, (1), 2008, p351 - 360 Journal Article, 2008 TARA - Full Text DOI

O'Sullivan, MP, O'Leary, S, Kelly, DM, Keane, J, A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection., Infection and Immunity, 75, (4), 2007, p1984 - 1993 Journal Article, 2007 TARA - Full Text DOI

Tyner, JW, Uchida, O, Kajiwara, N, Kim, EY, Patel, AC, O'Sullivan, MP, Walter, MJ, Schwendener, RA, Cook, DN, Danoff, TM, Holtzman, MJ, CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection., Nature Medicine, 11, (11), 2005, p1180 - 1187 Journal Article, 2005 DOI

O'Sullivan, MP, Tyner, JW, Holtzman, MJ, Apoptosis in the airways: another balancing act in the epithelial program., American Journal of Respiratory Cell and Molecular Biology, 29, (1), 2003, p3 - 7 Journal Article, 2003 DOI

Holtzman, MJ, Morton, JD, Shornick, LP, Tyner, JW, O'Sullivan, MP, Antao, A, Lo, M, Castro, M, Walter, MJ, Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm., Physiological Reviews, 82, (1), 2002 Journal Article, 2002 DOI

Jayaraman, S, Castro, M, O'Sullivan, M, Bragdon, MJ, Holtzman, MJ, Resistance to Fas-mediated T cell apoptosis in asthma., Journal of Immunology (Baltimore, Md. : 1950), 162, (3), 1999 Journal Article, 1999

Zhang, V, O'Sullivan, M, Hussain, H, Roswit, WT, Holtzman, MJ, Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2., Biochemical and Biophysical Research Communications, 227, (2), 1996 Journal Article, 1996 DOI

O'Sullivan M, Clancy JM, Roche JF, Corrigan OI, Controlled delivery of oestradiol-17-b from silastic implants: in vitro and in vivo evaluation., European Journal of Drug Metabolism and Pharmacokinetics, Spec No 3, 1991, p478-82 Journal Article, 1991

Non-Peer-Reviewed Publications

Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter] Book Chapter, 2000

Research Expertise

Projects

  • Title
    • Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
  • Funding Agency
    • HRB
  • Date From
    • 2013
  • Date To
    • 31-12-2017
  • Title
    • Development of inhaled medicines for treatment of Tuberculosis
  • Funding Agency
    • HRB
  • Date From
    • 2012
  • Date To
    • 2016
  • Title
    • The mechanism of macrophage cell death in response to M. tuberculosis infection and its role in the fate of mycobacteria
  • Funding Agency
    • SFI
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Particle engineering to target interferon-gamma to alveolar macrophages for the adjunct treatment of multi-drug resistant tuberculosis
  • Funding Agency
    • HRB
  • Date From
    • 2007
  • Date To
    • 2011
  • Title
    • Leveraging autophagy to direct an inhales TB vaccine to dendritic cell autophagosomes for better antigen presentation
  • Funding Agency
    • Dean's Research Initiatives Research Fund
  • Date From
    • 2016
  • Date To
    • 2017
  • Title
    • Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
  • Summary
  • Funding Agency
    • Health Research Board/ Irish Thoracic Society
  • Date From
    • 1-1-2017
  • Date To
    • 31-12-2018

Keywords

Apoptosis; Autophagy; Caspase proteases; CELL DEATH; Host, Pathogen interactions; Imaging Techniques; Immunology; Infectious diseases; Inflammation; Innate immunology; Intra and intercellular signalling; Mycobacterium tuberculosis

Recognition

Representations

Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004

Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics

Awards and Honours

Dean's Research Initiatives Research Fund Bursary February 2016

American Thoracic Society Travel Award 2007

Irish Thoracic Society Award for Best Oral Presentation 2008

Memberships

American Association for the Advancement of Science 1995 – Present

American Thoracic Society 2009