Dr. Mary O'Sullivan
Research Fellow, Clinical Medicine
Associate Research Lecturer, Trinity Translational Medicine Institute
Publications and Further Research Outputs
Peer-Reviewed Publications
Bahlool AZ, Cavanagh B, Sullivan AO, MacLoughlin R, Keane J, Sullivan MPO, Cryan SA., Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2024, p106734
Bedard M, van der Niet S, Bernard EM, Babunovic GH, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB., A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages., The Journal of clinical investigation, 2023, pe161944
Triglia D, Gogan KM, Keane J, O'Sullivan MP., Glucose metabolism and its role in the maturation and migration of human CD1c+ dendritic cells following exposure to BCG., Frontiers in cellular and infection microbiology, 13, 2023, p1113744
Bahlool AZ, Grant C, Cryan SA, Keane J, O'Sullivan MP., All trans retinoic acid as a host-directed immunotherapy for tuberculosis., Curr Res Immunol, 3, 2022, p54-72
Bahlool AZ, Fattah S, O'Sullivan A, Cavanagh B, MacLoughlin R, Keane J, O'Sullivan MP, Cryan SA., Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis., Pharmaceutics, 14, (8), 2022, p1745
O'Leary S, Bahlool AZ, O'Connor G, Cryan SA, Keane JM, O'Sullivan MP., An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis., Journal of visualized experiments : JoVE, (174), 2021
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020
O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165
Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449
O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54
Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152
Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167
O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J., Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis., American Journal of Respiratory and Critical Care Medicine, 190, (12), 2014, p1430 - 1436
Lawlor C, O'Sullivan MP, Rice B, Dillon P, Gallagher PJ, O'Leary S, Shoyele S, Keane J, Cryan SA, Therapeutic aerosol bioengineering of targeted, inhalable microparticle formulations to treat Mycobacterium tuberculosis (MTb)., Journal of Materials Science. Materials in Medicine, 23, (1), 2012, p89 - 98
Verma NK, Conroy J, Lyons PE, Coleman J, O'Sullivan MP, Kornfeld H, Kelleher D, Volkov Y, Autophagy induction by silver nanowires: A new aspect in the biocompatibility assessment of nanocomposite thin films., Toxicology and Applied Pharmacology, 264, (3), 2012, p451-61
Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA., Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb., Tuberculosis, 91, (1), 2011, p93 - 97
Mercedes González-Juarrero, and Mary P. O'Sullivan, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells, Tuberculosis, 91, (1), 2011, p86-92
Ryan RC, O'Sullivan MP, Keane J, Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells., BMC Microbiology, 11, 2011, p237-
O'Leary S, O'Sullivan MP, Keane J., IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages., American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180
O'Sullivan, M. P., O'Leary, S., Prentice, M. B., Keane, J., Macrophage Responses to a Clinical Isolate of Mycobacterium tuberculosis, Irish Journal of Medical Science, 180, 2011, pS444
Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA, The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Molecular Pharmaceutics, 8, (4), 2011, p1100 - 1112
González-Juarrero M, O'Sullivan MP, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells., Tuberculosis (Edinburgh, Scotland), 91, (1), 2010, p86 - 92
Lawlor, C., O'Sullivan, M., O'Leary, S., Bowie, R., Keane, J., Gallagher, P. J., Cryan, S. A., A study of the interaction of novel, coated microparticles with alveolar macrophages and their application in tuberculosis treatment via inhalation, Drug Discovery Today, 15, (23-24), 2010, p1107
O'Sullivan, M. P., Ryan, R., O'Leary, S., Keane, J., Human Macrophages Infected with Mycobacterium tuberculosis Undergo a Non-Apoptotic Form of Cell Death., American Journal of Respiratory and Critical Care Medicine, 179, 2009
Kelly, DM, ten Bokum, AM, O'Leary, SM, O'Sullivan, MP, Keane, J, Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection., Infection and Immunity, 76, (1), 2008, p351 - 360
O'Sullivan, MP, O'Leary, S, Kelly, DM, Keane, J, A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection., Infection and Immunity, 75, (4), 2007, p1984 - 1993
Tyner, JW, Uchida, O, Kajiwara, N, Kim, EY, Patel, AC, O'Sullivan, MP, Walter, MJ, Schwendener, RA, Cook, DN, Danoff, TM, Holtzman, MJ, CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection., Nature Medicine, 11, (11), 2005, p1180 - 1187
O'Sullivan, MP, Tyner, JW, Holtzman, MJ, Apoptosis in the airways: another balancing act in the epithelial program., American Journal of Respiratory Cell and Molecular Biology, 29, (1), 2003, p3 - 7
Holtzman, MJ, Morton, JD, Shornick, LP, Tyner, JW, O'Sullivan, MP, Antao, A, Lo, M, Castro, M, Walter, MJ, Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm., Physiological Reviews, 82, (1), 2002
Jayaraman, S, Castro, M, O'Sullivan, M, Bragdon, MJ, Holtzman, MJ, Resistance to Fas-mediated T cell apoptosis in asthma., Journal of Immunology (Baltimore, Md. : 1950), 162, (3), 1999
Zhang, V, O'Sullivan, M, Hussain, H, Roswit, WT, Holtzman, MJ, Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2., Biochemical and Biophysical Research Communications, 227, (2), 1996
O'Sullivan M, Clancy JM, Roche JF, Corrigan OI, Controlled delivery of oestradiol-17-b from silastic implants: in vitro and in vivo evaluation., European Journal of Drug Metabolism and Pharmacokinetics, Spec No 3, 1991, p478-82
Non-Peer-Reviewed Publications
Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter]
Research Expertise
Projects
- Title
- Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
- Funding Agency
- TTMI BEHR funding
- Title
- Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
- Funding Agency
- Trinity Translational Medicine Institute Bursary
- Title
- Correcting Pulmonary Immunity through manipulation of CFTR
- Funding Agency
- HRCI/HRB
- Date From
- 2021
- Date To
- 2023
- Title
- Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
- Funding Agency
- HRB
- Date From
- 2013
- Date To
- 31-12-2017
- Title
- Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy
- Funding Agency
- HRB
- Date From
- 2019
- Title
- Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
- Funding Agency
- Health Research Board/ Irish Thoracic Society
- Date From
- 1-1-2017
- Date To
- 31-12-2018
- Title
- Leveraging autophagy to direct an inhales TB vaccine to dendritic cell autophagosomes for better antigen presentation
- Funding Agency
- Dean's Research Initiatives Research Fund
- Date From
- 2016
- Date To
- 2017
- Title
- Development of inhaled medicines for treatment of Tuberculosis
- Funding Agency
- HRB
- Date From
- 2012
- Date To
- 2016
- Title
- The mechanism of macrophage cell death in response to M. tuberculosis infection and its role in the fate of mycobacteria
- Funding Agency
- SFI
- Date From
- 2008
- Date To
- 2012
- Title
- Particle engineering to target interferon-gamma to alveolar macrophages for the adjunct treatment of multi-drug resistant tuberculosis
- Funding Agency
- HRB
- Date From
- 2007
- Date To
- 2011
Recognition
Representations
Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Awards and Honours
Dean's Research Initiatives Research Fund Bursary
American Thoracic Society Travel Award
Irish Thoracic Society Award for Best Oral Presentation
Memberships
American Association for the Advancement of Science
American Thoracic Society