Aengus O Marcaigh
CONSULTANT HAEMATOLOGIST, Haematology

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Rafferty C, O'Brien M, Smyth E, Keane S, Robinson H, Lynam P, O'Marcaigh A, Smith OP, Administration of G-CSF from day +6 post-allogeneic hematopoietic stem cell transplantation in children and adolescents accelerates neutrophil engraftment but does not appear to have an impact on cost savings., 2016 Journal Article, 2016

O'Rafferty C, Kelly J, Storey L, Ryan C, O'Marcaigh A, Smith O, Child and adolescent Down syndrome-associated leukaemia: the Irish experience., 2015 Journal Article, 2015

Connor S, O'Brien M, Irvine A, O'Marcaigh A, Smith O, C3-C4 shingles post haematopoietic stem-cell transplantation., 2015 Journal Article, 2015

O'Rafferty C, McElligott F, Storey L, O'Marcaigh A, Smith O, Pneumatosis intestinalis and imatinib mesylate., 2014 Journal Article, 2014

O'Connell N, Goodyer M, Gleeson M, Storey L, Williams M, Cotter M, O'Marcaigh A, Smith O, Successful treatment with rituximab and mycophenolate mofetil of refractory autoimmune hemolytic anemia post-hematopoietic stem cell transplant for dyskeratosis congenita due to TINF2 mutation., 2014 Journal Article, 2014

Leahy TR, Smith OP, Bacon CL, Storey L, Lynam P, Gavin PJ, Butler KM, O'Marcaigh AS, Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study., 2013 Journal Article, 2013

Scanlan B, Nadeem M, Ryan M, Smith O, O'Marcaigh A, Coghlan D, Acute leukaemia presenting with isolated bone pain., 2013 Journal Article, 2013

McElnea EM, van der Spek N, Smith O, Fitzsimon S, Patel CK, O'Marcaigh A, Revesz syndrome masquerading as bilateral cicatricial retinopathy of prematurity., 2013 Journal Article, 2013

Rao U, Piccin A, Malone A, O'Hanlon K, Breatnach F, O'Meara A, McDermott M, Butler K, O'Sullivan N, Russell J, O'Marcaigh A, Smith OP, Utility of bronchoalveolar lavage in the diagnosis of pulmonary infection in children with haematological malignancies., 2013 Journal Article, 2013

McHugh J, Storey L, Bacon L, O'Marcaigh A, O'Sullivan M, Smith O, Paediatric follicular lymphoma., 2013 Journal Article, 2013

Krawczyk J, Haslam K, Lynam P, Kelly J, Storey L, O'Marcaigh A, Langabeer SE, Smith OP, No prognostic impact of P2RY8-CRLF2 fusion in intermediate cytogenetic risk childhood B-cell acute lymphoblastic leukaemia., 2013 Journal Article, 2013

Krawczyk J, Maguire S, Sandys N, Kelly J, Ryan C, O'Marcaigh A, Storey L, Rooney S, Phillips C, Smith OP, In search of Pinkel's children: unravelling the biological heterogeneity of childhood acute lymphoblastic leukaemia by genotype and treatment molecular response., 2013 Journal Article, 2013

Methodology in, editor(s)Grenfell, M , Pierre Bourdieu: Key Concepts, Durham, Acumen, 2012, pp213 - 228, [Grenfell, M ] Book Chapter, 2012

Le G, Lynam P, Lawlor E, O'Meara A, Smith O, O'Marcaigh A, Paediatric umbilical cord blood transplantation., 2012 Journal Article, 2012

O'Brien D, Lim CH, Farrell M, O'Marcaigh A, Rawluk D, Fitzpatrick F, Smyth E, Invasive intracerebral fungal infection in a leukaemic patient., 2012 Journal Article, 2012

Gleeson M, O'Marcaigh A, Cotter M, Brosnahan D, Vulliamy T, Smith OP, Retinal vasculopathy in autosomal dominant dyskeratosis congenita due to TINF2 mutation., 2012 Journal Article, 2012

Krawczyk J, McDermott M, Irvine AD, O'Marcaigh A, Storey L, Smith O, Skin involvement in Down syndrome transient abnormal myelopoiesis., British journal of haematology, 157, (3), 2012, p280 Journal Article, 2012

Owens C, Mannion D, O'Marcaigh A, Waldron M, Butler K, O'Meara A, Indications for admission, treatment and improved outcome of paediatric haematology/oncology patients admitted to a tertiary paediatric ICU., 2011 Journal Article, 2011

Haslam K, Molloy K, Langabeer S, Smyth E, O'Marcaigh A, Smith OP, Stable low-level donor-cell engraftment in a patient with X-linked lymphoproliferative disease following matched unrelated allo-SCT., 2011 Journal Article, 2011

Strahm B, Nöllke P, Zecca M, Korthof ET, Bierings M, Furlan I, Sedlacek P, Chybicka A, Schmugge M, Bordon V, Peters C, O'Marcaigh A, de Heredia CD, Bergstraesser E, Moerloose BD, van den Heuvel-Eibrink MM, Starý J, Trebo M, Wojcik D, Niemeyer CM, Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study., 2011 Journal Article, 2011

Bruneau JC, O'Marcaigh A, Smith OP, Gemtuzumab ozogamicin (Mylotarg) upregulates tissue factor expression but not secretion of inflammatory cytokines TNF-alpha or IL-8., 2010 Journal Article, 2010

Malone A, Langabeer S, O'Marcaigh A, Storey L, Bacon CL, Smith OP, A doctor(s) dilemma: ETV6-ABL1 positive acute lymphoblastic leukaemia., 2010 Journal Article, 2010

Langabeer SE, Owen CJ, McCarron SL, Fitzgibbon J, Smith OP, O'Marcaigh A, Browne P, A novel RUNX1 mutation in a kindred with familial platelet disorder with propensity to acute myeloid leukaemia: male predominance of affected individuals., 2010 Journal Article, 2010

Sargent J, O'Marcaigh A, Smith O.P., Butler K, Gavin G, O'Sullivan M, Candida albicans - associated necrotizing vasculitis producing life-threatening gastrointestinal hemorrhage., Human Pathology, 41, (4), 2010, p602-604 Journal Article, 2010 DOI

J Bruneau, A O'Marcaigh, O.P. Smith, Pro-inflammatory and pro-coagulant properties of 6-thioguanine and 6-mercaptopurine: implications for their potential role in the development of sinusoidal obstructive syndrome, Leukemia & Lymphoma, 51, (1), 2010, p164-167 Journal Article, 2010 DOI

Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M., Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches., British Journal of Haematology, 144, (1), 2009, p107-115 Journal Article, 2009 DOI

Piccin A, Smith OP, Murphy C, O'Marcaigh A, Corbally M, Mc Mahon C., Splenectomy in sickle cell anaemia: a cause of further crises?, British Journal of Haematology, 145, (1), 2009, p144-146 Journal Article, 2009 DOI

Piccin A, O'Marcaigh A, Deiratany S, Mc Mahon C, Smith OP., Severe gastrointestinal haemorrhage, first manifestation of neonatal haemophilia A, Haemophilia, 15, (3), 2009, p817-819 Journal Article, 2009 DOI

O'Regan GM, Irvine AD, Yao N, O'Marcaigh A, Sheridan-Pereira M, Phelan E, McDermott MB, Twomey A, Russell J, Watson R, Mediastinal and neck kaposiform hemangioendothelioma: report of three cases., Pediatric dermatology, 26, (3), 2009, p331-7 Journal Article, 2009

, 11th Meeting of the Irish Society of Human Genetics, Friday 12th September 2008., 2009 Journal Article, 2009

Chong AL, Clinton F, Breatnach F, O'Marcaigh A, Butler K, O'Meara A, Cytomegalovirus infection in paediatric haemopoietic stem cell transplantation., 2008 Journal Article, 2008

Hasle H, Abrahamsson J, Arola M, Karow A, O'Marcaigh A, Reinhardt D, Webb DK, van Wering E, Zeller B, Zwaan CM, Vyas P, Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML., 2008 Journal Article, 2008

Kelly K, McMahon C, Langabeer S, Eliwan H, O'Marcaigh A, Smith OP., Congenital JAK2V617F polycythemia vera: where does the genotype-phenotype diversity end?, Blood, 112, (10), 2008, p4356-4357 Journal Article, 2008 DOI

Piccin, A., Russell, J.D., Fleming, P., Butler, K., McDermott, M., Smith, O.P., O'Marcaigh, A., Invasive rhino-maxillary mucormycosis diagnosed before HSCT, Pediatric Blood and Cancer , 50, (2), 2008, p393-395 Journal Article, 2008 DOI

McGovern E, Fleming P, O'Marcaigh A, The dental management of five paediatric patients with a history of acute intermittent porphyria., 2007 Journal Article, 2007

Yoshimi A, Mohamed M, Bierings M, Urban C, Korthof E, Zecca M, Sykora KW, Duffner U, Trebo M, Matthes-Martin S, Sedlacek P, Klingebiel T, Lang P, Führer M, Claviez A, Wössmann W, Pession A, Arvidson J, O'Marcaigh AS, van den Heuvel-Eibrink MM, Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia., 2007 Journal Article, 2007

Oshea J, Smith O, O'Marcaigh A, McMahon C, Geoghegan R, Cotter M., Breaking bad news--parents' experience of learning that their child has leukaemia., Irish Medical Journal, 100, (9), 2007, p588-590 Journal Article, 2007

Bond, J., Shahdadpuri, R., Mc Mahon, C., O'Marcaigh, A., Cotter, M., Smith, O. , Successful treatment of acute Epstein-Barr virus infection associated with X-linked lymphoproliferative disorder with rituximab [1] , Pediatric Blood and Cancer, 49, (5), 2007, p761-762 Journal Article, 2007 DOI

Norton A, Fisher C, Liu H, Wen Q, Mundschau G, Fuster JL, Hasle H, Zeller B, Webb DK, O'Marcaigh A, Sorrell A, Hilden J, Gamis A, Crispino JD, Vyas P, Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome., 2007 Journal Article, 2007

Boublikova L, Kalinova M, Ryan J, Quinn F, O'Marcaigh A, Smith O, Browne P, Stary J, McCann SR, Trka J, Lawler M., Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring, Leukemia, 20, (2), 2006, p254 - 263 Journal Article, 2006 DOI

Rao A, Hills RK, Stiller C, Gibson BE, de Graaf SS, Hann IM, O'Marcaigh A, Wheatley K, Webb DK, Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials., 2006 Journal Article, 2006

Rees DC, Iolascon A, Carella M, O'marcaigh AS, Kendra JR, Jowitt SN, Wales JK, Vora A, Makris M, Manning N, Nicolaou A, Fisher J, Mann A, Machin SJ, Clayton PT, Gasparini P, Stewart GW, Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia., 2005 Journal Article, 2005

Piccin A, O'Marcaigh A, Smith O, O'Riordan J, Crowley M, Vandenberg E,Gardiner N, McCann S., Outcome of bone marrow transplantation in acquired and inherited aplastic anaemia in the Republic of Ireland, Irish Journal of Medical Sciences , 174, (3), 2005, p13 - 19 Journal Article, 2005

Ahmed, M., Sternberg, A., Hall, G., Thomas, A., Smith, O., O'Marcaigh, A., Wynn, R., (...), Smith, O.P., Vyas, P., Natural history of GATA1 mutations in Down syndrome , Blood, 103, (7), 2004, 2480-2489 Journal Article, 2004 DOI

McCullough SJ, Neat MJ, Power M, O'marcaigh A, Trisomy 6 in a child with acute megakaryoblastic leukemia (AML-M7)., 2004 Journal Article, 2004

Cotter M, Rooney S, O'Marcaigh A, Smith OP, Successful use of gemtuzumab ozogamicin in a child with relapsed CD33-positive acute lymphoblastic leukaemia., 2003 Journal Article, 2003

Watters K, O'Marcaigh A, Canny G, Russell J, Management of a large bronchial haemangioma in an infant., 2003 Journal Article, 2003

Cunningham J, Sales M, Pearce A, Howard J, Stallings R, Telford N, Wilkie R, Huntly B, Thomas A, O'Marcaigh A, Will A, Pratt N, Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?, 2002 Journal Article, 2002

Kamaluddin M, McNally P, Breatnach F, O'Marcaigh A, Webb D, O'Dell E, Scanlon P, Butler K, O'Meara A, Potentiation of vincristine toxicity by itraconazole in children with lymphoid malignancies., 2001 Journal Article, 2001

O'Marcaigh AS, DeSantes K, Hu D, Pabst H, Horn B, Li L, Cowan MJ, Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans., 2001 Journal Article, 2001

McDermott MB, Corbally MT, O'Marcaigh AS, Extracutaneous Sweet syndrome involving the gastrointestinal tract in a patient with Fanconi anemia., 2001 Journal Article, 2001

Ryan M, Yeo S, Maguire A, Webb D, O'Marcaigh A, McDermott M, Butler K, O'Meara A, Rhinocerebral zygomycosis in childhood acute lymphoblastic leukaemia., 2001 Journal Article, 2001

Birnbaum RA, O'Marcaigh A, Wardak Z, Zhang YY, Dranoff G, Jacks T, Clapp DW, Shannon KM, Nf1 and Gmcsf interact in myeloid leukemogenesis., 2000 Journal Article, 2000

Rice M, Breen CJ, O'Meara A, Breatnach F, O'Marcaigh AS, Stallings RL, Comparative genomic hybridization in pediatric acute lymphoblastic leukemia., 2000 Journal Article, 2000

Kwong PC, O'Marcaigh AS, Howard R, Cowan MJ, Frieden IJ, Oral and genital ulceration: a unique presentation of immunodeficiency in Athabascan-speaking American Indian children with severe combined immunodeficiency., 1999 Journal Article, 1999

Gaine SP, O'Marcaigh AS, Pulmonary alveolar proteinosis: lung transplant or bone marrow transplant?, 1998 Journal Article, 1998

O'Marcaigh AS, Betcher DL, Dexrazoxane (ICRF-187): a cardioprotective agent during anthracycline chemotherapy., 1997 Journal Article, 1997

O'Marcaigh AS, Cowan MJ, Bone marrow transplantation for inherited diseases., 1997 Journal Article, 1997

O'Marcaigh AS, Puck JM, Pepper AE, De Santes K, Cowan MJ, Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred., 1997 Journal Article, 1997

O'Marcaigh AS, Shannon KM, Role of the NF1 gene in leukemogenesis and myeloid growth control., 1997 Journal Article, 1997

O'Marcaigh AS, Gilchrist GS, Dose reduction of chemotherapeutic agents after weight loss., 1997 Journal Article, 1997

O'Marcaigh AS, Nichols WL, Hassinger NL, Mullins JD, Mallouh AA, Gilchrist GS, Owen WG, Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia., 1996 Journal Article, 1996

O'Marcaigh AS, Betcher DL, Cyclosporine., 1996 Journal Article, 1996

Kaditis AG, O'Marcaigh AS, Rhodes KH, Weaver AL, Henry NK, Yield of positive blood cultures in pediatric oncology patients by a new method of blood culture collection., 1996 Journal Article, 1996

O'Marcaigh AS, Johnson CM, Smithson WA, Patterson MC, Widemann BC, Adamson PC, McManus MJ, Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2., 1996 Journal Article, 1996

O'Marcaigh AS, Betcher DL, Busulfan., 1996 Journal Article, 1996

O'Marcaigh AS, Ledger GA, Roche PC, Parisi JE, Zimmerman D, Aromatase expression in human germinomas with possible biological effects., 1995 Journal Article, 1995

O'Marcaigh AS, Betcher DL, The vinca alkaloids., 1995 Journal Article, 1995

O'Marcaigh AS, Betcher DL, Gilchrist GS, Variation in the practice of dose reduction of chemotherapeutic agents after weight loss or amputation., 1995 Journal Article, 1995

van Son JA, O'Marcaigh AS, Edwards WD, Julsrud PR, Danielson GK, Successful resection of thoracic aortic aneurysms in Wiskott-Aldrich syndrome., 1995 Journal Article, 1995

O'Marcaigh AS, Schmalz BJ, Shaughnessy WJ, Gilchrist GS, Successful hemostasis during a major orthopedic operation by using recombinant activated factor VII in a patient with severe hemophilia A and a potent inhibitor., 1994 Journal Article, 1994

O'Marcaigh AS, Betcher DL, Amphotericin B and its lipid formulations., 1994 Journal Article, 1994

O'Marcaigh AS, MacLellan-Tobert SG, Porter CJ, Tilt-table testing and oral metoprolol therapy in young patients with unexplained syncope., 1994 Journal Article, 1994

Bryant WP, O'Marcaigh AS, Ledger GA, Zimmerman D, Aqueous vasopressin infusion during chemotherapy in patients with diabetes insipidus., 1994 Journal Article, 1994

O'Marcaigh AS, Koenig WJ, Rosekrans JA, Berseth CL, Cessation of unsuccessful pediatric resuscitation--how long is too long?, 1993 Journal Article, 1993

O'Marcaigh AS, Jacobson RM, Estimating the predictive value of a diagnostic test. How to prevent misleading or confusing results., 1993 Journal Article, 1993

Berger TM, Cook WJ, O'Marcaigh AS, Zimmerman D, Acute pancreatitis in a 12-year-old girl after an erythromycin overdose., 1992 Journal Article, 1992

O'Marcaigh AS, Folz LB, Michels VV, Umbilical morphology: normal values for neonatal periumbilical skin length., 1992 Journal Article, 1992

Research Expertise

Keywords

Anticancer therapies; CHILDHOOD CANCERS; CLINICAL-TRIALS; MULTINATIONAL CLINICAL-TRIALS; PAEDIATRICS; PEDIATRIC ONCOLOGY; PEDIATRIC-ONCOLOGY-GROUP; RANDOMIZED CLINICAL-TRIAL; Synthesis & testing of novel anticancer drugs for leukaemia

Recognition

Representations

Member of the National Cancer Control Programme (NCCP) Expert Advisory Group (EAG) on Intrathecal Cytotoxic Medication. Representing Paediatrics. 2014 - present

Member of the National Cancer Control Programme (NCCP) Expert Advisory Group (EAG) on Haematological Malignancy. Representing Paediatrics. 2015 - present

Vice-chair OLCHC Research Ethics Committee. Representing Clinical Paediatrics. 2009 - 2012

Member of the Clinical Advisory Committee of the joint National Haematopoietic Stem Cell Transplant Centres (SJH/OLCHC/IBTS. Representing Paediatric Transplantation. 2005 - present

Registered Cancer Therapy Evaluation Program (CTEP) investigator, National Cancer Institute, USA. CTEP Investigator ID 46386 May 2015

Awards and Honours

Irish Healthcare Awards. Winner of 'Best Patient Educational Initiative' for the development of a national programme for the administration of home chemotherapy by parents. 2013

American Society of Hematology Travel Award 1996

Balfour Award nomination for Excellence in Research by a fellow of Mayo Graduate School of Medicine, Mayo Clinic 1995

Paediatric Emeritus Award for Academic Achievement as a fellow of Mayo Graduate School of Medicine, Mayo Clinic 1992

Prize for best paper by a resident or fellow at Northwestern Pediatric Society Annual Scientific Meeting, Chicago, USA 1991

Paediatric Resident Recognition Award for Excellent Performance as a fellow of Mayo Graduate School of Medicine, Mayo Clinic, USA 1991

14 written citations by the Dean, Mayo Medical School, in recognition of exceptional teaching to medical students. 1990-1994

Entrance Exhibition Award, Trinity College Dublin 1982

Memberships

Fellowship of the Royal College of Physicians of Ireland. June 4 1999 – present

Membership of the Faculty of Paediatrics, RCPI. 1998 – present

Membership of the Faculty of Pathology, RCPI. 2000 – present

Fellowship of the American Academy of Pediatrics Jan 1 1998 – present

American Society of Haematology 1990 – present

American Society of Pediatric Hematology and Oncology 1990 – present

Irish Paediatric Association 1997 – present

Irish Haematology Society 1997 – present