Neil Frankish
Associate Professor, Pharmacy

Publications and Further Research Outputs

Peer-Reviewed Publications

Nazir I, Ur Rahman N, Alvi Z, Hafizur Rahman M, Sendker J, Zhang T, Frankish N, Sheridan H., Erratum: Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models., Planta medica, 2017 Journal Article, 2017 DOI

Imran Nazir, Nisar ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan, Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models*, Planta Medica, 83, 2017, p1-9 Journal Article, 2017 DOI

N Frankish, H Sheridan -, 'COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASE ', USPTO, 20,150,141,523,, 2015, Trino Therapeutics Ltd. Patent, 2015 URL

Tao Z, Paluch K, Scalabrino G, Frankish N, Healy AM, Sheridan H, Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 2015, p286 - 299 Journal Article, 2015 URL TARA - Full Text

Frankish N, A study to assess the safety and tolerability of PH46A in healthy volunteers, to measure drug levels in these subjects and to determine the effect of food on the drug's absorption, 2014, - Miscellaneous, 2014 DOI

SHERIDAN, Helen; (IE). FRANKISH, Neil; (IE), VENANTIUS LIMITED, INDANE DIMERS FOR USE IN THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASE, 2013, WO/2013/014660 Patent, 2013 URL

Zhang T, Bandero V, McCabe T, Frankish N, Sheridan H, 2-(Di-phenyl-methyl-idene)-2,3-di-hydro-1H-inden-1-one., Acta crystallographica. Section E, Structure reports online, 69, (Pt 8), 2013, po1306-7 Journal Article, 2013 TARA - Full Text DOI

Frankish N, Sheridan H, 6-(methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoate (PH46A): a novel small molecule with efficacy in murine models of colitis., Journal of medicinal chemistry, 55, (11), 2012, p5497-505 Journal Article, 2012

Zhang T, McCabe T, Marzec B, Frankish N, Sheridan H, N-Cyclo-pentyl-N-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetamide., Acta crystallographica. Section E, Structure reports online, 68, (Pt 4), 2012, po958 Journal Article, 2012

Frampton CS, Zhang T, Scalabrino GA, Frankish N, Sheridan H, (1S)-1-Phenylethanaminium 4-{[(1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl]methyl}benzoate., Acta crystallographica. Section C, Crystal structure communications, 68, (Pt 8), 2012, po323-6 Journal Article, 2012

N Frankish and Helen Sheridan, Venantius Ltd., COMPOUNDS FOR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE, 2011, 61/510,628 Patent, 2011

N Frankish and Helen Sheridan, Venantius Ltd., COMPOUNDS FOR USE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE, 2011, 61/510,675. Patent, 2011

Frankish, N. de Sousa Menezes, F. Mills, C. Sheridan, H., Enhancement of insulin release from the beta-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside, Planta Med, 76, (10), 2010, p995-7 Journal Article, 2010 DOI

Passante E, Frankish N, Deficiencies in elements involved in TLR4-receptor signalling in RBL-2H3 cells., Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59 Suppl 2, 2010, pS185-6 Journal Article, 2010

Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930 Journal Article, 2009 DOI

Passante, E. Ehrhardt, C. Sheridan, H. Frankish, N., Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 58 , (Suppl 1), 2009, p11-2 Journal Article, 2009 DOI

E Passante, C Ehrhardt, H Sheridan, N Frankish, RBL-2H3 cells are an imprecise model for mast cell mediator release, Inflamm Res, 58, (9), 2009, p611-618 Journal Article, 2009 DOI

Passante, E. Frankish, N., The RBL-2H3 cell line: its provenance and suitability as a model for the mast cell, Inflamm Res, 58, (11), 2009, p737-45 Journal Article, 2009

H. Sheridan, N. H. Frankish, BRA101, A NOVEL SMALL MOLECULE WITH PROFOUND EFFICACY IN MURINE DSS-COLITIS, Gut, Gastro 2009, London, 21-25 November 2009, 58, (Suppl II), 2009, ppA454 Meeting Abstract, 2009

Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22 Journal Article, 2009

H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387 Journal Article, 2008 DOI

Fábio de Sousa Menezes, Andréa Barreto Mattos Minto, Halliny Siqueira Ruela, Ricardo Machado Kuster, Helen Sheridan, Neil Frankish, Hypoglycemic activity of two Brazilian Bauhinia species: Bauhiniaforfi cata L. and Bauhinia monandra Kurz., Brazilian Journal of Pharmacognosy, 17, ((1)), 2007, p8 - 13 Journal Article, 2007

J.Coppins, I. Hook, C. Nestor, H. Sheridan, N. Frankish, C. Ehrhardt., Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Royal Academy of Medicine in Ireland, Winter meeting, Dublin City University, 2007, 2007 Conference Paper, 2007

Sheridan, H., Frankish, N. H. & Farrell, R, Smooth muscle relaxant activity of pterosin Z and related compounds, Planta Medica, 65, 1999, p271 - 272 Journal Article, 1999

Farrell, R., Frankish, N.H.., & Sheridan, H., Synthesis and antispasmodic activity of analogues of Natural pterosins, European Journal of Medicinal Chemistry, 34, 1999, p953 - 966 Journal Article, 1999

Anka G Ehrhard, Neil Frankish & Gerrit Isenberg, A large conductance K+ channel that is inhibited by the cytoskeleton in the smooth muscle cell line DDT1 MF-2, Jounal of Physiology, 496, (3), 1996, p663 - 676 Journal Article, 1996

H Sheridan, S Lemon, N Frankish, P Mcardle, T Higgins, JP James, P Bhandari , Synthesis and Antispasmodic Activity of Nature Identical Substituted Indanes and Analogues, European Journal of Medicinal Chemistry, 25, (7), 1990, p603 - 608 Journal Article, 1990

Frankish, N. H., A low-cost system for on-line analysis of cardiovascular data, British Journal of Pharmacology, 86, 1985, pp762- Meeting Abstract, 1985

Frankish, N. H., Verapamil and bepridil on potassium-evoked contractures of guinea-pig ileum., British Journal of Pharmacology, (80), 1983, pp610- Meeting Abstract, 1983

A. M. Barrett, N. H. Frankish and M. S. Yates, Effect of calcium antagonists on pulmonary haemodynamics, British Journal of Pharmacology, 74, 1981, pp946 - 947 Meeting Abstract, 1981

N. H. Frankish and I. J. Zeitlin, The effect of diet on tissue levels on kinin-forming enzyme in blood-free rat gastrointestinal tract, Journal of Physiology, 298, 1980, p361 - 370 Journal Article, 1980

Bile may be a stimulus for the activation of duodenal kallikrein during digestion in, editor(s)G. L. Haberland and U. Hamberg. , Current Concepts in Kinin Research, 1978, pp43 - 46, [N. H. Frankish and I. J. Zeitlin] Book Chapter, 1978

Bile may be a stimulus for the activation of duodenal kallikrein during digestion in, editor(s)G. L. Haberland and U. Hamberg. , Current Concepts in Kinin Research, 1978, pp43 - 46, [N. H. Frankish and I. J. Zeitlin] Book Chapter, 1978

Frankish, N. H. and Zeitlin, I. J., Kallikrein release from rat duodenum stimulated by bile acids and other factors, Journal of Physiology, 273, 1977, pp60 - 61 Meeting Abstract, 1977

Frankish, N. H. and Zeitlin, I. J., The assay of tissue kallikrein in rat intestine, British Journal of Pharmacology, (59), 1977, pp571- Meeting Abstract, 1977

Non-Peer-Reviewed Publications

Neil Frankish and helen Sheridan, 'Compounds for use in the treatment of inflammatory Bowel Disease', USP, 9,586,885 B2, 2017, Venantius Ltd. Patent, 2017 URL

Neil Frankish and Helen Sheridan, Trino Therapeutics Ltd, 2011 Campus Company, 2011 URL

E Passante, C Ehrhardt, H Sheridan, N Frankish, Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 37th Annual Meeting of the European Histamine Release Society, Stockholm, Sweden, 07-10/05/2008, 58, (S1), 2009, pp11-12 Meeting Abstract, 2009

E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9 Meeting Abstract, 2007

E Passante, S Endter, MH Tindal, MR Pankratz, NH Frankish, C Ehrhardt, Albuterol is net absorbed across human bronchial epithelial cell layers in an enantiomer-dependent fashion, FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp881.2 Meeting Abstract, 2007

N Frankish, H Sheridan -, 'Compounds for use in the treatment of immune related inflammatory disease', UPTO, 20 July 2011, Venantius Patent, URL

Research Expertise

Description

Current research is largely concerned with finding novel drugs to treat auto-immune inflammatory disease such as multiple sclerosis and rheumatoid arthritis. Many of the classic immunosuppressive drugs available have a less than satisfactory toxicology profile. More recent monoclonal antibody anti-TNF therapy may be subject to auto-antibody formation and confer susceptibility to opportune infections. The research group concentrates on small molecule inhibitors, novel indane dimer derivatives, and their effects on several systems, including isolated T-cells and mast cells in culture and in vivo disease models.

Projects

  • Title
    • Effect of novel indanes on mast cell function
  • Summary
    • Novel indanes will be investigated on mast cell function and degrnaulation using harvested peritoneal mast cells, and mast cell lines such as RBL-3H3 and LAD2. Mediators studied will include histamine, cytokines etc.
  • Date From
    • 1/10/05
  • Title
    • Assessment of Novel Indanes as potential anti-asthmatic drugs
  • Summary
    • Novel indane compounds have been studied using mouse and rat bronchoalveolar lavage models of asthma, looking at cell recruitment into the lung, together with cytokine profiles, and their comparison with existing immunosupppression drugs.
  • Date From
    • 9/2005
  • Date To
    • 6/2006
  • Title
    • Studies on LFA-1 stimulated T-cell Motility
  • Summary
    • A range of novel compounds are being studied on their effects on LFA-1 mediated HUT-78 T-cell motility.
  • Date From
    • 9/2004
  • Title
    • Novel indanes as potential therapies for auto-immune disease
  • Summary
    • Novel indane compounds are being assessed in a variety of in vitro and in vivo models of auto-immune disease.
  • Funding Agency
    • Commercially funded
  • Date From
    • 1999
  • Title
    • Effect of Extracts of Isodon & Bauhinia Species on Inflammation
  • Summary
    • Extracts of several species of Isodon and Bauhinia are being studied on a range of innflammatory mediators and in vivo inflammatory models.
  • Date From
    • 10/2005

Keywords

Applied information systems; Autoimmune and hypersensitivity diseases; Autoimmunity; Cardiovascular and molecular pharmacology; Chronic inflamation; Commercialisation of scientific research; Computerised clinical systems; Cytoskelton, cell division; Digestive Diseases & Disorders; Digestive System; Drug Development; Drug discovery, profiling, targeting; Gastrointestinal Diseases/Disorders; Immune System; Immune System Disorders; Immunoassays; Immunopathology; Immunosuppression; Inflammation; Inflammatory Bowel Disease; Information management; Pharmaceuticals; Pharmacology; Pharmacy; Transplantation immunology, tolerance and rejection

Recognition

Memberships

British Pharamacologigal Society 1979 – Present