Mark Lawler
Professor, Clinical Medicine

Biography

Professor Lawler graduated from the Genetics Department, Trinity College Dublin (TCD) (1985). He is Associate Professor in Experimental Haematology/ Oncology, TCD, Chief Molecular Geneticist at St James's Hospital, Honorary Associate Professor in Oncogenetics, Smurfit Institute of Genetics, TCD and Visiting Professor in Medical Genetics and Molecular Medicine, University of Chieti, Italy. He has an active research group working on the molecular basis of cancer, with emphasis on translating this knowledge to biomarker discovery and novel anti-cancer approaches. He has published over 100 articles in international peer review journals. He has been honoured with numerous awards including the Vander Molen Prize for Leukaemia Research, the Ely Lilly Prize, the Ulster Cancer Foundation Prize and he has received both the St Lukes Medal and the Graves Medal for research. He is currently President of the Irish Association for Cancer Research, an all Ireland association for cancer researchers. He is a member of the Ireland/Northern Ireland/ National Cancer Institute Cancer Consortium Scientific Advisory Group and has recently been appointed as Chair of the Scholar Exchange Group. He is a founder member and one of the coordinators of the MSc in Molecular Medicine, TCD. He is founder and Chairperson of the highly successful Cancer Conference which has now become an annual event on the calendar. Professor Lawler was recently Director of Post-graduate Teaching and Learning in the School of Medicine, Trinity College Dublin and has a significant commitment to scholar exchange. He also is firmly committed to outreach and has participated in a number of community initiatives including "Your Health is your Wealth" and "Wise up! Its your life too!". He is married to Ruth and they have two daughters, Sarah and Emily.

Publications and Further Research Outputs

Peer-Reviewed Publications

Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46 Journal Article, 2013 DOI

Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM., PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British Journal of Cancer, 104, (2), 2011, p281 - 289 Journal Article, 2011 DOI

Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507 Journal Article, 2010 DOI

Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300 Journal Article, 2010 TARA - Full Text

Greene LM, Nathwani SM, Bright SA, Fayne D, Croke A, Gargliardi M, Mc Elligott AM, O'Connor L, Carr M, Keely NO, O'Boyle NM, Carroll P, Sarkadi B, Conneally E, Lloyd DG, Lawler M, Meegan MJ, Zisterer DM, The vascular targeting agent Combretastatin-A4 and a novel cis-restricted {beta}-lactam analogue CA-432 induce apoptosis in human chronic myeloid leukemia cells and in ex vivo patient samples including those displaying multidrug resistance., The Journal of Pharmacology and Experimental Therapeutics, 335, (2), 2010, p302 - 313 Journal Article, 2010 DOI

Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment , Biochemical Pharmacology, 80, 2010, p31 - 38 Journal Article, 2010 DOI

Marignol, L., Foley, R., Southgate, T.D., Coffey, M., Hollywood, D., Lawler, M., Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro., The Journal of Gene Medicine , 11, (2), 2009, p169-179 Journal Article, 2009 DOI

Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M., Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches., British Journal of Haematology, 144, (1), 2009, p107-115 Journal Article, 2009 DOI

Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, Lawler M, The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers., Cancer biology & therapy, 8, (2), 2009, p118-24 Journal Article, 2009 TARA - Full Text

Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, Laure Marignol, Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity., Radiation Research, 172, (4), 2009, p405 - 413 Journal Article, 2009

Veale EB, Frimannsson DO, Lawler M, Gunnlaugsson T, 4-Amino-1,8-naphthalimide based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds, Organic Letters, 11, (18), 2009, p4040-4043 Journal Article, 2009 DOI

Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. , The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells, Biochemical Pharmacology, 77, (3), 2009, p310-321 Journal Article, 2009 DOI URL

Greene, LM, Campiani, GC, Lawler, M, Williams, DC and Zisterer, DM, BubR1 is Required for a Sustained Mitotic Spindle checkpoint arrest in Human Cancer cells treated with a tubulin-targetting pyrrolo-1,5-benzoxazepine, Molecular Pharmacology, 73, (2), 2008, p419 - 430 Journal Article, 2008 DOI URL

Marignol L, Coffey M, Lawler M, Hollywood D., Hypoxia in prostate cancer: a powerful shield against tumour destruction?, Cancer Treatment Review, 34, (4), 2008, p313-327 Journal Article, 2008 DOI

Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y., A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin., Journal of Molecular Medicine, 86, (4), 2008, p457-469 Journal Article, 2008 DOI

Marignol L, Robson T, McCarthy HO, Worthington J, Murray MM, Hollywood D, Lawler M, Hirst DG., The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?, Journal of Gene Medicine, 10, (9), 2008, p1032-1038 Journal Article, 2008 DOI

Murphy TM, Perry AS, Lawler M., The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer., Endocrine-Related Cancer , 15, (1 ), 2008, p11-25 Journal Article, 2008 DOI

McCann S, Passweg J, Bacigalupo A, Locasciulli A, Locatelli F, Ryan J, Schrezenmeier H, Lawler M., The influence of cyclosporin alone, or cyclosporin and methotrexate, on the incidence of mixed haematopoietic chimaerism following allogeneic sibling bone marrow transplantation for severe aplastic anaemia., Bone Marrow Transplant., 39, (2), 2007, p109-114 Journal Article, 2007 DOI

Perry AS, Liyanage H, Lawler M, Woodson K., Discovery of DNA hypermethylation using a DHPLC screening strategy., Epigenetics, 2, (1), 2007, p43-49 Journal Article, 2007 URL

Langabeer SE, Ni Ainle F, Conneally E, Lawler M., Incidence and significance of the JAK2 V617F mutation in patients with chronic myeloproliferative disorders., Irish Journal of Medical Science, 176, (2), 2007, p105-109 Journal Article, 2007 DOI

Saldanha J, Silvy M, Beaufils N, Arlinghaus R, Barbany G, Branford S, Cayuela JM, Cazzaniga G, Gonzalez M, Grimwade D, Kairisto V, Miyamura K, Lawler M, Lion T, Macintyre E, Mahon FX, Muller MC, Ostergaard M, Pfeifer H, Saglio G, Sawyers C, Spinelli O, van der Velden VH, Wang JQ, Zoi K, Patel V, Phillips P, Matejtschuk P, Gabert J., Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements., Leukemia, 21, (7), 2007, p1481-1487 Journal Article, 2007 DOI

Marignol L, Coffey M, Hollywood D, Lawler M., Radiation to Control Transgene Expression in Tumors., Cancer Biological Therapy, 6, (7), 2007, p1005 - 1012 Journal Article, 2007 URL

Perry AS, Loftus B, Moroose R, Lynch TH, Hollywood D, Watson RW, Woodson K, Lawler M., In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer., British Journal of Cancer, 96, (10), 2007, p1587-1594 Journal Article, 2007 DOI

Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297 Journal Article, 2007 DOI

Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de Sanjosé S, Foretova L, Maynadié M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M., Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma., Human Molecular Genetics, 16, (24), 2007, p3117-3127 Journal Article, 2007 DOI

Boublikova L, Kalinova M, Ryan J, Quinn F, O'Marcaigh A, Smith O, Browne P, Stary J, McCann SR, Trka J, Lawler M., Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring, Leukemia, 20, (2), 2006, p254 - 263 Journal Article, 2006 DOI

Hayat A, O'Brien D, O'Rourke P, McGuckin S, Fitzgerald T, Conneally E, Browne PV, McCann SR, Lawler MP, Vandenberghe E., CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia., Leukemia Lymphoma, 47, (11), 2006, p2371-2379 Journal Article, 2006 DOI

O'Donghaile D, Hayden PJ, McCarron SL, Doyle EM, Lawler M, Browne PV, Conneally E, Vandenberghe E, McCann SR., Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor., European Journal of Haematology, 76, (3), 2006, p258-260 Journal Article, 2006 DOI

Perry, A.S., Foley, R., Woodson, K., Lawler, M., The emerging roles of DNA methylation in the clinical management of prostate cancer , Endocrine-Related Cancer, 13, (2), 2006, p357-377 Journal Article, 2006 DOI

Boublikova L, Kalinova M, Ryan J, Quinn F, O'Marcaigh A, Smith O, Browne P, Stary J, McCann SR, Trka J, Lawler M., Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring., Leukemia., 20, (2), 2006, p254-263 Journal Article, 2006 DOI

Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70 Journal Article, 2006 DOI

Hayden PJ, Crampe M, Lawler M, Conneally E., McCann SR., Vandenberghe E., Browne PV., Use of DLI to achieve complete donor chimerism in a patient receiving systemic immunosuppression for refractory AIHA post-NST., Bone Marrow Transplant, 36, 2005, p735-736 Journal Article, 2005 DOI

Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363 Journal Article, 2005

Marignol L, Lawler M, Coffey M, Hollywood D., Achieving Hypoxia-Inducible Gene Expression in Tumors., Cancer Biological Therapy, 4, (4), 2005, p359-364. Journal Article, 2005 URL

McCann SR, Crampe M, Molloy K, Lawler M. , Hemopoietic chimerism following stem cell transplantation., Transfus Apheresis Sci. , 32, (1), 2005, p55-61. Journal Article, 2005 DOI

Tracey L, Pérez-Rosado A, Artiga MJ, Camacho FI, Rodríguez A, Martínez N, Ruiz-Ballesteros E, Mollejo M, Martinez B, Cuadros M, Garcia JF, Lawler M, Piris MA, The expression of the NF-kB targets BCL2 and BIRC5/Survivin characterize small B-cell and aggressive B-cell lymphomas respectively, Journal of Pathology, 206, (2), 2005, p123-134 Journal Article, 2005 DOI

Dean J, McCarthy D, Lawler M, Doherty DG, O' Farrelly C, Golden-Mason L., Characterization of NKR(+) T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical Immunology, 114, (1 ), 2005, p42-51 Journal Article, 2005 DOI

P. J. Hayden, N. Gardiner, K. Molloy, J. Ryan, M. Lawler and S. R. McCann, Pure red cell aplasia after a major ABO-mismatched bone marrow transplant for chronic myeloid leukaemia: response to re-introduction of cyclosporin, Bone Marrow Transplantation, 33, (4), 2004, p459-461 Journal Article, 2004 DOI

L. Tracey, I. Spiteri, P. Ortiz, M. Lawler, M. A. Piris and R. Villuendas, Transcriptional response of T cells to IFN-alpha: changes induced in IFN-alpha-sensitive and resistant cutaneous T cell lymphoma, Journal of Interferon & Cytokine Research, 24, (3), 2004, p185-95 Journal Article, 2004 DOI

R. Foley, M. Lawler and D. Hollywood, Gene-based therapy in prostate cancer, Lancet Oncology, 5, (8), 2004, p469-79 Journal Article, 2004 DOI

Gupta V, Ball SE, Yi QL, Sage D, McCann SR, Lawler M, Ortin M, Freires M, Hale G, Waldmann H, Gordon-Smith EC, Marsh JC., Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia., Biology of Blood and Marrow Transplant., 10, (12), 2004, p867-876 Journal Article, 2004 DOI

Foley, R., Hollywood, D., Lawler, M., Molecular pathology of prostate cancer: The key to identifying new biomarkers of disease , Endocrine-Related Cancer , 11, (3), 2004, p477-488 Journal Article, 2004 DOI

M. M. Mc Gee, L. M. Greene, S. Ledwidge, G. Campiani, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL, The Journal of pharmacology and experimental therapeutics, 310, (3), 2004, p1084-1095 Journal Article, 2004 URL DOI URL

Crean CW, Camier R, Lawler M, Stevenson C, Davies RJ, Boyle PH, Kelly JM., Synthesis of N3- and 2-NH(2)-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene., Organic and Biomolecular Chemistry, 2, (24), 2004, p3588-3601 Journal Article, 2004 DOI

Swords R, Hayden PJ, Molloy K, Lawler M, Browne PV, Murphy PT., Successful induction of molecular remission with single-agent anti-CD33 antibody (gemtuzumab ozogamicin) in chemotherapy-refractory relapse of acute myeloid leukaemia post-BMT., European Journal of Haematology, 73, (6), 2004, p450-451 Journal Article, 2004 DOI

L. Tracey, R. Villuendas, A. M. Dotor, I. Spiteri, P. Ortiz, J. F. Garcia, J. L. Peralto, M. Lawler and M. A. Piris, Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study, Blood, 102, (3), 2003, p1042-1050 Journal Article, 2003 URL

S. R. McCann, K. Gately, E. Conneally and M. Lawler, Molecular response to imatinib mesylate following relapse after allogeneic SCT for CML, Blood, 101, (3), 2003, p1200-1 Journal Article, 2003 URL

C. W. Cream, Y. T. Kavanagh, C. M. O'Keeffe, M. P. Lawler, C. Stevenson, R. J. Davies, P. H. Boyle and J. M. Kelly, Targeting of photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene using oligonucleotide-conjugates containing [Ru(phen)3](2+)-like photosensitiser groups, Photochemical & photobiological sciences, 1, (12), 2002, p1024-33 Journal Article, 2002 URL

L. A. Mynett-Johnson, C. Keenan, I. L. Black, W. J. Livingstone, M. Lawler, H. M. Roche, B. White, M. J. Gibney, P. McKeon and O. P. Smith, Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population, Irish journal of medical science, 171, (1), 2002, p37-9 Journal Article, 2002 URL

M. Lawler, A. Locasciulli, D. Longoni, R. Schiro and S. R. McCann, Leukaemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anaemia, Bone Marrow Transplantation, 29, (5), 2002, p453-456 Journal Article, 2002 DOI

M. M. Mc Gee, G. Campiani, A. Ramunno, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells, The Journal of Biological Chemistry, 277, (21), 2002, p18383-18389 Journal Article, 2002 DOI URL URL

R. Pawson, M. N. Potter, P. Theocharous, M. Lawler, M. Garg, J. A. Yin, K. Rezvani, C. Craddock, S. Rassam and H. G. Prentice, Treatment of relapse after allogeneic bone marrow transplantation with reduced intensity conditioning (FLAG +/- Ida) and second allogeneic stem cell transplant, British journal of haematology, 115, (3), 2001, p622-9 Journal Article, 2001 URL

K. Cwynarski, R. Goulding, C. Pocock, F. Dazzi, C. Craddock, J. Kaeda, E. Olavarria, E. Kanfer, J. Apperley, M. Lawler and J. M. Goldman, Immune haemolytic anaemia following T cell-depleted allogeneic bone marrow transplantation for chronic myeloid leukaemia: association with leukaemic relapse and treatment with donor lymphocyte infusions, Bone marrow transplantation, 28, (6), 2001, p581-6 Journal Article, 2001 URL

M. Lawler, Prospective chimerism analysis, the time is now but can we respond?, Leukemia, 15, (12), 2001, p1992-4 Journal Article, 2001 URL

M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of pharmacology and experimental therapeutics, 296, (1), 2001, p31-40 Journal Article, 2001 URL

M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of Pharmacology and Experimental Therapeutics, 296, (1), 2001, p31-40 Journal Article, 2001 URL URL

L. Galligan, W. Livingstone, Y. Volkov, K. Hokamp, C. Murphy, M. Lawler, K. Fukudome and O. Smith, Characterization of protein C receptor expression in monocytes, British journal of haematology, 115, (2), 2001, p408-14 Journal Article, 2001 URL

D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (Pt 6), 2001, p704-6 Journal Article, 2001 URL

D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (6), 2001, p704-706 Journal Article, 2001 URL URL

M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myeloid leukemia (cml) cells by bypassing the apoptotic suppressor bcr-abl, TheScientificWorldJournal [electronic resource], 1, (1 Suppl 3), 2001, p109 Journal Article, 2001 URL

W. J. Livingstone, C. Keenan, B. White, L. Mynett-Johnson, M. Lawler, P. Mayne and O. P. Smith, Prevalence of the factor VR506Q mutation in two Irish control populations: use of a novel nested polymerase chain reaction approach, British journal of haematology, 111, (2), 2000, p559-61 Journal Article, 2000 URL

C. Keenan, W. J. Livingstone, B. White, L. Mynett-Johnson, S. Cusack, M. Lawler and O. P. Smith, Prevalence of the prothrombin G20210A mutation in the Irish populations: use of a novel polymerase chain reaction approach, Blood coagulation & fibrinolysis, 11, (7), 2000, p669-72 Journal Article, 2000 URL

C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs, Short Report: Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen, British journal of haematology, 111, (3), 2000, p797-800 Journal Article, 2000 URL

M. Schmidt-Supprian, C. Murphy, B. While, M. Lawler, A. Kapurniotu, W. Voelter, O. Smith and J. Bernhagen, Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes, European cytokine network, 11, (3), 2000, p407-13 Journal Article, 2000 URL

B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, M. Lawler, L. O'Neill, D. Kelleher, H. P. Schwarz and O. P. Smith, Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British journal of haematology, 110, (1), 2000, p130-4 Journal Article, 2000 URL

N. Gardiner, S. R. McCann, J. O'Riordan and M. Lawler, Chimerism following donor lymphocyte infusion for chronic myeloid leukemia, Blood, 93, (8), 1999, p2748-9 Journal Article, 1999 URL

M. Lawler, Molecular Medicine and Molecular Pathology for Hematologists: II. Lets go Techno; Principles of the Molecular Technologies and their Applications in Haematology, Hematol, 4, (2), 1999, p127-135 Journal Article, 1999 URL

M. O'Donovan, J. M. Russell, J. J. O'Leary, J. A. Gillan, M. P. Lawler and E. F. Gaffney, Abl expression, tumour grade, and apoptosis in chondrosarcoma, Molecular pathology, 52, (6), 1999, p341-4 Journal Article, 1999 URL

M. Lawler, Molecular Medicine and Molecular Pathology for Haematologists: I. Gene Speak made Easy: An Overview of Genes and Gene Expression, Hematol, 4, (1), 1999, p59-66 Journal Article, 1999 URL

M. Deane, M. Koh, L. Foroni, G. Galactowicz, A. V. Hoffbrand, M. Lawler, L. Secker-Walker and H. G. Prentice, FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission, Bone marrow transplantation, 22, (12), 1998, p1137-43 Journal Article, 1998 URL

H. Gowing, E. Braakman, A. Hagenbeek, M. Lawler, S. R. McCann, D. H. Pamphilon and A. C. Martens, Influence of ultraviolet-B irradiation on engraftment, graft-versus-host disease and graft-versus-leukemia effect in a rat model for allogeneic bone marrow transplantation, Bone marrow transplantation, 21, (8), 1998, p801-7 Journal Article, 1998 URL

J. Briones, A. Urbano-Ispizua, M. Lawler, C. Rozman, N. Gardiner, P. Marin, C. Salgado, P. Feliz, S. McCann and E. Montserrat, High frequency of donor chimerism after allogeneic transplantation of CD34+-selected peripheral blood cells, Experimental hematology, 26, (5), 1998, p415-20 Journal Article, 1998 URL

N. Gardiner, M. Lawler, J. M. O'Riordan, C. Duggan, M. De Arce and S. R. McCann, Monitoring of lineage-specific chimaerism allows early prediction of response following donor lymphocyte infusions for relapsed chronic myeloid leukaemia, Bone marrow transplantation, 21, (7), 1998, p711-9 Journal Article, 1998 URL

H. Rozemuller, W. Terpstra, E. J. Rombouts, M. Lawler, C. Byrne, D. J. FitzGerald, R. J. Kreitman, J. J. Wielenga, B. Lowenberg, I. P. Touw, A. Hagenbeek and A. C. Martens, GM-CSF receptor targeted treatment of primary AML in SCID mice using Diphtheria toxin fused to huGM-CSF, Leukemia, 12, (12), 1998, p1962-70 Journal Article, 1998 URL

N. Gardiner, M. Lawler, J. O'Riordan, M. DeArce, P. Humphries and S. R. McCann, Persistent donor chimaerism is consistent with disease-free survival following BMT for chronic myeloid leukaemia, Bone marrow transplantation, 20, (3), 1997, p235-41 Journal Article, 1997 URL

N. Gardiner, M. Lawler, J. O'Riordan, M. De'Arce and S. R. McCann, Donor chimaerism is a strong indicator of disease free survival following bone marrow transplantation for chronic myeloid leukaemia, Leukemia, 11 Suppl 3, 1997, p512-5 Journal Article, 1997 URL

M. Lawler, Leukaemogenesis, gene interplay, and the role of the haemopoietic environment, Radiation oncology investigations, 5, (3), 1997, p154-7 Journal Article, 1997 URL

J. Hudson, S. Chown, M. Lawler, C. Duggan, I. J. Temperley and L. Secker-Walker, Severe aplastic anaemia in association with a unique constitutional translocation 46,XY,t(6;10)(q13;q22)c, British journal of haematology, 99, (3), 1997, p520-1 Journal Article, 1997 URL

S. Norris, M. Lawler, S. McCann, J. Hegarty and C. O'Farrelly, Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance, Hepatology (Baltimore, Md), 26, (4), 1997, p848-52 Journal Article, 1997 URL

D. Green, M. Lawler, M. Rosen, S. Bloom, M. Duerden, R. Turba, H. Kern, K. Kirschner and D. Ronin, Recombinant human erythropoietin: effect on the functional performance of anemic orthopedic patients, Archives of physical medicine and rehabilitation, 77, (3), 1996, p242-6 Journal Article, 1996 URL

P. Ljungman, M. Lawler, B. Lonnqvist, O. Ringden and A. Shanwell, Rejection of the second allogeneic graft in a patient with severe aplastic anemia reversed by antilymphocyte globulin and donor lymphocyte infusions, Bone marrow transplantation, 18, (6), 1996, p1179-81 Journal Article, 1996 URL

D. S. O'Briain, O. Sheils, S. McElwaine, S. R. McCann and M. Lawler, Sorting out mix-ups. The provenance of tissue sections may be confirmed by PCR using microsatellite markers, American journal of clinical pathology, 106, (6), 1996, p758-64 Journal Article, 1996 URL

P. Kelly, H. Staunton, M. Lawler, P. Brennan, S. Jennings, E. R. Unger, J. H. Sung and M. A. Farrell, Multifocal remitting-relapsing cerebral demyelination twenty years following allogeneic bone marrow transplantation, Journal of neuropathology and experimental neurology, 55, (9), 1996, p992-8 Journal Article, 1996 URL

P. A. O'Neill, M. Lawler, R. Pullens, T. Kloosterman, J. Hudson, A. C. Martens, P. J. Hendrikx, H. Gowing, C. Byrne, A. Hagenbeek, D. H. Pamphilon and S. R. McCann, PCR amplification of short tandem repeat sequences allows serial studies of chimaerism/engraftment following BMT in rodents, Bone marrow transplantation, 17, (2), 1996, p265-71 Journal Article, 1996 URL

K. M. O'Boyle and M. Lawler, D2 receptor agonists and partial agonists: relationship between receptor binding measures and functional activity, Biochemical Society transactions, 24, (1), 1996, p183-8 Journal Article, 1996 URL

K. Molloy, N. Goulden, M. Lawler, J. Cornish, A. Oakhill, D. Pamphilon, M. Potter, C. Steward, K. Langlands, P. Humphries and S. R. McCann, Patterns of hematopoietic chimerism following bone marrow transplantation for childhood acute lymphoblastic leukemia from volunteer unrelated donors, Blood, 87, (7), 1996, p3027-31 Journal Article, 1996 URL

M. Hamblin, J. C. Marsh, M. Lawler, S. R. McCann, N. Wickham, L. Dunlop, S. Ball, E. G. Davies, G. Hale, H. Waldmann and E. C. Gordon-Smith, Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors, Bone marrow transplantation, 17, (5), 1996, p819-24 Journal Article, 1996 URL

R. Kumar-Singh, D. G. Bradley, G. J. Farrar, M. Lawler, S. A. Jordan and P. Humphries, Autosomal dominant retinitis pigmentosa: a new multi-allelic marker (D3S621) genetically linked to the disease locus (RP4), Human genetics, 96, (4), 1995, p502 Journal Article, 1995 URL

G. Socie, M. Lawler, E. Gluckman, S. R. McCann and O. Brison, Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era, Leukemia research, 19, (8), 1995, p497-504 Journal Article, 1995 URL

N. J. Philpott, J. C. Marsh, T. O. Kumaran, A. Yardumian, M. Lawler, S. R. McCann and E. C. Gordon-Smith, Successful bone marrow transplant for Fanconi anaemia in transformation, Bone marrow transplantation, 14, (1), 1994, p151-3 Journal Article, 1994 URL

J. G. Hudson, M. Lawler and D. H. Pamphilon, Ultraviolet irradiation for the prevention of graft-versus-host disease and graft rejection in bone marrow transplantation, Bone marrow transplantation, 14, (4), 1994, p511-6 Journal Article, 1994 URL

S. R. Mc Cann, M. Lawler, N. Gardiner, J. O'Riordan, P. Humphries and M. De Arce, Donor leukemia following allogeneic bone marrow transplantation, Leukemia, 8 Suppl 1, 1994, pS133-5 Journal Article, 1994 URL

P. Ljungman, M. Lawler, B. Asjo, G. Bogdanovic, K. Karlsson, C. Malm, S. R. McCann, O. Ringden and G. Gahrton, Infection of donor lymphocytes with human T lymphotrophic virus type 1 (HTLV-I) following allogeneic bone marrow transplantation for HTLV-I positive adult T-cell leukaemia, British journal of haematology, 88, (2), 1994, p403-5 Journal Article, 1994 URL

M. Lawler, P. Humphries, C. O'Farrelly, H. Hoey, O. Sheils, M. Jeffers, D. S. O'Briain and D. Kelleher, Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum, Gut, 35, (9), 1994, p1226-32 Journal Article, 1994 URL

S. R. McCann and M. Lawler, Mixed chimaerism; detection and significance following BMT, Bone marrow transplantation, 11, (2), 1993, p91-4 Journal Article, 1993 URL

D. H. Pamphilon, J. M. Cornish, S. Goodman, L. Ball, M. Lawler, S. McCann, P. Humphries and A. Oakhill, Successful second unrelated donor BMT in a child with juvenile chronic myeloid leukaemia: documentation of chimaerism using the polymerase chain reaction, Bone marrow transplantation, 11, (1), 1993, p81-4 Journal Article, 1993 URL

S. R. McCann, M. Lawler and A. Bacigalupo, Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia, Leukemia & lymphoma, 10, (6), 1993, p419-25 Journal Article, 1993 URL

E. L. Blundell, D. H. Pamphilon, N. A. Anderson, R. R. Slade, P. A. Burton, A. Martin, T. Ray, B. A. Bradley, M. Lawler, P. Humphries and et al., Transfusion-associated graft-versus-host disease, monoclonal gammopathy and PCR, British journal of haematology, 82, (3), 1992, p622-3 Journal Article, 1992 URL

M. A. De Arce, C. Costigan, J. R. Gosden, M. Lawler and P. Humphries, Further evidence consistent with Yqh as an indicator of risk of gonadal blastoma in Y-bearing mosaic Turner syndrome, Clinical genetics, 41, (1), 1992, p28-32 Journal Article, 1992 URL

S. R. McCann, M. Lawler, P. Humphries, A. Bacigalupo, M. Podesta, F. Frassoni, M. T. Van Lint and A. Marmont, Recurrence of Philadelphia chromosome-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia: confirmation by microsatellite studies, Blood, 79, (10), 1992, p2803-5 Journal Article, 1992 URL

P. Browne, M. Lawler and S. R. McCann, Donor cell leukaemia after bone marrow transplantation for severe aplastic anaemia, Bone marrow transplantation, 7 Suppl 2, 1991, p100 Journal Article, 1991 URL

P. V. Browne, M. Lawler, J. O'Riordan, P. Humphries and S. R. McCann, Early detection of leukaemic relapse after bone marrow transplantation using the polymerase chain reaction, Bone marrow transplantation, 7, (2), 1991, p167-9 Journal Article, 1991 URL

P. V. Browne, M. Lawler, P. Humphries and S. R. McCann, Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia, The New England journal of medicine, 325, (10), 1991, p710-3 Journal Article, 1991 URL

M. Lawler, P. Humphries and S. R. McCann, Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction, Blood, 77, (11), 1991, p2504-14 Journal Article, 1991 URL

R. Kumar-Singh, D. G. Bradley, G. J. Farrar, M. Lawler, S. A. Jordan and P. Humphries, Autosomal dominant retinitis pigmentosa: a new multi-allelic marker (D3S621) genetically linked to the disease locus (RP4), Human genetics, 86, (5), 1991, p502-4 Journal Article, 1991 URL

S. R. McCann, M. Lawler and P. Humphries, Mixed chimaerism, British journal of haematology, 77, (2), 1991, p257 Journal Article, 1991 URL

M. A. De Arce, D. Mulherin, P. McWilliam, M. Lawler, M. X. FitzGerald and P. Humphries, Frequency of deletion 508 among Irish cystic fibrosis patients, Human genetics, 85, (4), 1990, p403-4 Journal Article, 1990 URL

G. J. Farrar, P. McWilliam, D. G. Bradley, P. Kenna, M. Lawler, E. M. Sharp, M. M. Humphries, H. Eiberg, P. M. Conneally, J. A. Trofatter and et al., Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity, Genomics, 8, (1), 1990, p35-40 Journal Article, 1990 URL

M. M. Humphries, D. Sheils, M. Lawler, G. J. Farrar, P. McWilliam, P. Kenna, D. G. Bradley, E. M. Sharp, E. F. Gaffney, M. Young and et al., Epidermolysis bullosa: evidence for linkage to genetic markers on chromosome 1 in a family with the autosomal dominant simplex form, Genomics, 7, (3), 1990, p377-81 Journal Article, 1990 URL

M. Lawler, S. R. McCann, E. Conneally and P. Humphries, Chimaerism following allogeneic bone marrow transplantation: detection of residual host cells using the polymerase chain reaction, British journal of haematology, 73, (2), 1989, p205-10 Journal Article, 1989 URL

P. McWilliam, G. J. Farrar, P. Kenna, D. G. Bradley, M. M. Humphries, E. M. Sharp, D. J. McConnell, M. Lawler, D. Sheils, C. Ryan and et al., Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3, Genomics, 5, (3), 1989, p619-22 Journal Article, 1989 URL

Research Expertise

Description

Molecular and cellular biology of cancer; Apoptosis and cancer. Cell cycle control and its manipulation in malignancy. Cellular and molecular mechanisms regulating and resisting apoptosis. Novel pro-apoptotic drug development; Genetics of B cell malignancies; Understanding DNA repair processes in Multiple Myeloma; Chimeric status and outcome following stem cell transplantation for severe aplastic anaemia: Chimerism and minimal residual disease in haematological malignancy. Study of molecular response to Imatinib Mesylate in patients relapsing following stem cell transplantation for Chronic Myeloid Leukaemia. Naphthalimides as novel anti cancer agents; Molecular basis of prostate cancer. Epigenetic control of gene transcription; hypoxia and prostate cancer; suicide gene therapy approaches in prostate cancer; molecular diagnostics

Keywords

Apoptosis and cancer; Cell cycle control and its manipulation in malignancy; Cellular and molecular mechanisms regulating and resisting apoptosis; Chimaeric status of long-term survivors of stem cell transplantation for severe aplastic anaemia. Study of quality of life and chimaerism in T cell lineages. An attempt to understand late graft rejection.; Chimeric status and outcome following stem cell transplantation for severe aplastic anaemia: the influence of GvHD prophylaxis.; Chimerism and minimal residual disease in haematological malignancy; Modes of assessment of fetal wellbeing; Nonlinear Dynamics and Systems; Study of molecular response to Imatinib Mesylate in patients relapsing following stem cell transplantation for Chronic Myeloid Leukaemia.; Study of the incidence of Autologous recovery following stem cell transplantation for severe aplastic anaemia in Europe in conjunction with the European Group for Blood and Bone Marrow transplantation. (EBMT).; Transcriptional regulation

Recognition

Representations

Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes

Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.

Chairperson, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).

Chairperson, Prostate Cancer Research Consortium, Multi-centred consortium focused on the development of new diagnostic, prognostic and therapeutic agents for application in prostate cancer.

Copy, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole body

Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's

Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics

Awards and Honours

FRCPath on the basis of published work Royal College of Pathologists, London 2006

44th Annual Graves Medal Lecture Health Research Board and Royal Academy of Medicine in Ireland 2004

.7th Annual Ulster Cancer Foundation Award Lecture 2001

MRCPath on the basis of published worksRoyal College of Pathologists London 1999

22nd Annual St Lukes Medal Lecture St Lukes Institute and Royal Academy of Medicine in Ireland 1996

Ely Lilly Prize European Blood and Marrow Transplant Conference Garmisch Partenkirchen, Germany

Vander Molen Prize for Leukaemia Research British Society of Haematology 1991