Dr. Barry Moran
Experimental Officer, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Borkner L, Curham LM, Wilk MM, Moran B, Mills KHG., IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils., Mucosal immunology, 2021
Anindya Mukhopadhya, Jessie Santoro, Barry Moran, Zivile Useckaite, Lorraine O'Driscoll , Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula is of milk, Food Chemistry, 353, 2021, p129309-
Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U., Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint., JCI insight, 5, (21), 2020
Lecordier L, Uzureau S, Vanwalleghem G, Deleu M, Crowet JM, Barry P, Moran B, Voorheis P, Dumitru AC, Yamaryo-Botté Y, Dieu M, Tebabi P, Vanhollebeke B, Lins L, Botté CY, Alsteens D, Dufrêne Y, Pérez-Morga D, Nolan DP, Pays E., The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity., iScience, 23, (9), 2020, p101476
Sulaimani J, Cluxton D, Clowry J, Petrasca A, Molloy OE, Moran B, Sweeney CM, Malara A, McNicholas N, McGuigan C, Kirby B, Fletcher JM., Dimethyl fumarate modulates the Treg-Th17 cell axis in patients with psoriasis., The British journal of dermatology, 2020
Useckaite Z, Mukhopadhya A, Moran B, O'Driscoll L., Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation., Scientific reports, 10, (1), 2020, p19020
Edwards, S.C. and Sutton, C.E. and Ladell, K. and Grant, E.J. and McLaren, J.E. and Roche, F. and Dash, P. and Apiwattanakul, N. and Awad, W. and Miners, K.L. and Lalor, S.J. and Ribot, J.C. and Baik, S. and Moran, B. and McGinley, A. and Pivorunas, V. and Dowding, L. and Macoritto, M. and Paez-Cortez, J. and Slavin, A. and Anderson, G. and Silva-Santos, B. and Hokamp, K. and Price, D.A. and Thomas, P.G. and McLoughlin, R.M. and Mills, K.H.G., A population of proinflammatory T cells coexpresses αβ and γΎ T cell receptors in mice and humans, Journal of Experimental Medicine, 217, (5), 2020
Fletcher JM, Moran B, Petrasca A, Smith CM., IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa., Clinical and experimental immunology, 201, (2), 2020, p121-134
Moran B, Gallagher C, Tobin AM, Fletcher JM., Enrichment of polyfunctional IL-17 producing T cells in paradoxical psoriasis skin lesions., The Journal of investigative dermatology, 2019
J. Musilova, B. Moran, C.M. Sweeney, A. Malara, A. Zaborowski, R. Hughes, D.C. Winter, J.M. Fletcher, B. Kirby, Enrichment of Plasma Cells in the Peripheral Blood and Skin of Patients with Hidradenitis Suppurativa, Journal of Investigative Dermatology, 2019
Ui Mhaonaigh, A. and Coughlan, A.M. and Dwivedi, A. and Hartnett, J. and Cabral, J. and Moran, B. and Brennan, K. and Doyle, S.L. and Hughes, K. and Lucey, R. and Floudas, A. and Fearon, U. and McGrath, S. and Cormican, S. and De Bhailis, A. and Molloy, E.J. and Brady, G. and Little, M.A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies, Frontiers in Immunology, 10, (2603), 2019
Cluxton D, Petrasca A, Moran B, Fletcher JM, Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis, Frontiers in Immunology, 10, 2019, p115-
Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U, Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis., JCI Insight, 3, (23), 2018, p95228-
Barry Moran, Cheryl M. Sweeney, Rosalind Hughes, Anna Malara, Shivashini Kirthi, Anne-Marie Tobin, Brian Kirby, Jean M. Fletcher, Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy, Journal of Investigative Dermatology, 137, (11), 2017, p2389--2395
Mothiram U, Brennan PC, Lewis SJ, Moran B, Robinson J, Digital radiography exposure indices: A review., Journal of medical radiation sciences, 61, (2), 2014, p112-8
Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80
Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282
Moran B, Blanco-Fernández A, Gardner R, Tigges J, Toxavidis V, Daley JF, Remote access technology offers tremendous possibilities to the cytometry community., Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83, (12), 2013, p1062-5
Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191
Dunne PJ, Moran B, Cummins RC and Mills KH , CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. , The Journal of Immunology, 183, 2009, p400 - 410
Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, Tubridy N and Mills KHG, CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis, Journal of Immunology, 183, 2009, p7602 - 7610
Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C and Mills KHG, Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta, Journal of Immunology, 181, (7), 2008, p4485 - 4494
Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky GA, Shattil SJ. , ADAP is required for normal {alpha}IIb{beta}3 activation by VWF/GP Ib-IX-V and other agonists., Blood , Vol 109, (3), 2007, p1018 - 1025
Soriani A, Moran B, De Virgilio M, Kawakami T, Altman A, Lowell C, Eto K and Shattil SJ, A role for PKCtheta in outside-in alphaIIb,beta3 signaling, Journal of Thrombosis and Haemostasis, 4, 2006, p648 - 655
Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, and Leavitt AD, Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function, Journal of Thrombosis and Haemostasis, 4, 2006, p436 - 442
Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, and Shattil SJ, PTP-1B is an essential positive regulator of platelet integrin signaling , Journal of Cell Biology, 170, (5), 2005, p837 - 845
Shields DC, Fitzgerald AP, O'Neill PA, Muckian C, Kenny D, Moran B, Cannon CP, Byrne CE, Fitzgerald DJ., The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists, Pharmacogenomics Journal, 2, (3), 2002, p182 - 190
Research Expertise
Description
Dr Barry Moran runs the Flow Cytometry Facility, within the Trinity Biomedical Sciences Institute. Flow cytometry is a complex technology used to interrogate the phenotype and function of cells in many areas of life science and biomedical research, including immunology and cancer. It involves sensitive, precision-based cellular analysis of multiple parameters on individual cells at incredibly high speeds. Millions of data points can be generated per second, requiring sophisticated analysis tools. Key infrastructure within TBSI's Flow Cytometry Facility include high-end platforms (high-speed cell sorter, imaging cytometer, high-dimensional spectral analyser) and four advanced cytometer analysers. Dr Moran has a particular interest in immune dysfunction in the skin, primarily in the disease hidradenitis suppurativa.Recognition
Memberships
International Society for Advancement of Cytometry
Royal Microscopical Society
Irish Society for Immunology
British Society for Immunology
Cytometry Society of Ireland