Kenneth Hun Mok
Associate Professor, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, DIABETES, 63, (6), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

Rehman, S., Ikram, M., Khan, A., Min, S., Azad, E., Hofer, T.S., Mok, K.H., Baker, R.J., Blake, A.J., Rehman, S.U., New dicoumarol sodium compound: Crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, (1), 2013, p110- Journal Article, 2013 DOI

Xie, Y., Min, S., Harte, N.P., Kirk, H., O'Brien, J.E., Voorheis, H.P., Svanborg, C., Hun Mok, K., Electrostatic interactions play an essential role in the binding of oleic acid with α-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications, Proteins: Structure, Function and Bioinformatics, 81, (1), 2013, p1-17 Journal Article, 2013 DOI

Rehman, S., Ikram, M., Baker, R.J., Zubair, M., Azad, E., Min, S., Riaz, K., Mok, K.H., Rehman, S.-U., Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives, Chemistry Central Journal, 7, (1), 2013, p68- Journal Article, 2013 DOI

Ho, J.C.S., Storm, P., Rydström, A., Bowen, B., Alsin, F., Sullivan, L., Ambite, I., Mok, K.H., Northen, T., Svanborg, C., Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): Unique and shared effects on signaling and death, Journal of Biological Chemistry, 288, (24), 2013, p17460-17471 Journal Article, 2013 DOI

Rehman, S, Ikram, M, Khan, A, Min, S, Azad, E, Hofer, TS, Mok, KH, Baker, RJ, Blake, AJ, Rehman, SU, New dicoumarol sodium compound: crystal structure, theoretical study and tumoricidal activity against osteoblast cancer cells, Chemistry Central Journal, 7, 2013, p110- Journal Article, 2013 TARA - Full Text DOI

Sullivan, L.M., Mok, K.H., Brodkorb, A., The formation of an anti-cancer complex under simulated gastric conditions, Food Digestion, 4, (1), 2013, p7-18 Journal Article, 2013 DOI

Min, SY, Meehan, J, Sullivan, LM, Harte, NP, Xie, YJ, Davey, GP, Svanborg, C, Brodkorb, A, Mok, KH, Alternatively folded proteins with unexpected beneficial functions, Biochemical Society Transactions, 40, 2012, p746-751 Journal Article, 2012 DOI

Li ková K, Auty MAE, Chaurin V, Min S, Mok KH, O'Brien N, Kelly AL, Brodkorb, A, Cytotoxic complexes of sodium oleate with β-lactoglobulin., European Journal of Lipid Science and Technolology, 113, (10), 2011, p1207 - 1218 Journal Article, 2011 DOI

Ivanov, KL, Lukzen, NN, Morozova, OB, Mok, KH, Yurkovskaya, AV, Quantitative Approach to CIDNP in Proteins with Several Polarizable Residues on the Surface, Applied Magnetic Resonance , 41, 2011, 251-266 Journal Article, 2011 DOI

Mossberg A, Mok KH, Morozova-Roche LA, Svanborg C, Structure and function of human α-lactalbumin made lethal to tumour cells (HAMLET)-type complexes, FEBS Journal, 277, (22), 2010, p4614 - 4625 Journal Article, 2010 DOI

Yoon JW, Wilson SP, Mok KH, A highly efficient blocked Gibbs sampler reconstruction of multidimensional NMR spectra, Journal of Machine Learning Research, Workshop & Conference Proceedings, 13th International Conference on Artificial Intelligence and Statistics (AISTATS), Chia Laguna Resort, Sardinia, Italy, 13-15 May 2010, edited by Yee Whye Teh, Mike Titterington , 9, 2010, pp940 - 947 Conference Paper, 2010 TARA - Full Text URL

Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nuñez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA, Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß in type 2 diabetes., Nature immunology, 11, (10), 2010, p897-904 Journal Article, 2010

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2010, Registered Republic of Korea Patent No. 2003-32468 Patent, 2010

Pettersson-Kastberg J, Aits S, Gustafsson L, Mossberg A-K, Storm P, Trulsson M, Persson F, Mok KH, Svanborg C, Can misfolded proteins be beneficial? The HAMLET case. (Review), Annals of Medicine, 41, (3), 2009, p162 - 176 Journal Article, 2009 DOI

Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C, Mok KH, Alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding, Journal of Molecular Biology, 394, (5), 2009, p994 - 1010 Journal Article, 2009 DOI

Wilhelm K, Darinskas A, Noppe W, Duchardt E, Mok KH, Vukojević V, Schleucher J, Morozova-Roche LA, Protein oligomerization induced by oleic acid at the solid-liquid interface--equine lysozyme cytotoxic complexes, FEBS Journal, 276, (15), 2009, p3975 - 3989 Journal Article, 2009 DOI

Day IJ, Maeda K, Paisley HJ, Mok KH, Hore PJ, Refolding of RNase A monitord by real-time photo-CIDNP NMR spectroscopy, Journal of Biomolecular NMR, 44, (2), 2009, p77 - 86 Journal Article, 2009 DOI

Bernard E, Parthsarathi L, Cho M-K, Aylward K, Raab M, Daxecker H, O'Dushlaine CT, Shields DC, Devocelle M, Keyes T, Cosgrave L, O'Neill S, Mok KH, Moran N, Ligand Switching in Cell-Permeable Peptides: Manipultation of the alpha integrin signature motif, ACS Chemical Biology, 4, (6), 2009, p457 - 471 Journal Article, 2009 DOI

Gattin Z, Riniker S, Hore PJ, Mok KH, van Gunsteren WF, Temperature and urea induced denaturation of the TRP-cage mini protein TC5b: A simulation study consistent with experimental observations, Protein Science, 18, (10), 2009, p2090 - 2099 Journal Article, 2009 DOI

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2008, US Patent No. 7,314,867 (1 Jan 2008) Patent, 2008

Mok KH (Inventor), Mok KH (Assignee), Pharmazeutische Zusammensetzung mit einem Retro-Inverso Isomerpeptid, 2007, Deutsches Patent DE 60308710 Patent, 2007

Mok KH, Kuhn LT, Goez M, Day IJ, Lin JC, Andersen NH, Hore PJ, A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein, Nature, 447, (7140), 2007, p106 - 109 Journal Article, 2007 DOI URL

Mok KH, Pettersson J, Orrenius S, Svanborg C, HAMLET, protein folding, and tumour cell death (Mini review), Biochemical and Biophysical Research Communications, 354, (1), 2007, p1 - 7 Journal Article, 2007 DOI

Mok KH (Inventor), Mok KH (Assignee), Pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Irish Patent Register No. 1549334 (27 Sep 2006) Patent, 2006

Goez M, Kuprov I, Mok KH, Hore PJ, Novel pulse sequences for time-resolved photo-CIDNP, Molecular Physics, 104, (10-11), 2006, p1675 - 1686 Journal Article, 2006

Mok KH (Inventor), Mok KH (Assignee), A pharmaceutical composition comprising a retro-inverso isomer peptide, 2006, Reg European Patent No. 1549334 (27 Sep 2006) Patent, 2006

Shin C, Mok KH, Han JH, Ahn JH, Lim Y, Conformational analysis in solution of gastrin releasing peptide, Biochemical and Biophysical Research Communications, 350, (1), 2006, p120 - 124 Journal Article, 2006 DOI

Goez, M, Mok KH, Hore PJ, Photo-CIDNP Experiments with an Optimized Presaturation Pulse Train, Gated Continuous Illumination, and a Background-Nulling Pulse Grid, Journal of Magnetic Resonance, 177, (2), 2005, p236 - 246 Journal Article, 2005 DOI

Mok KH, Nagashima T, Day IJ, Hore PJ, Dobson CM, Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins, Proceedings of the National Academy of Sciences of the USA, 102, (25), 2005, p8899 - 8904 Journal Article, 2005 DOI URL

Mok KH (Inventor), Mok KH (Assignee), Improvements to retro-inverso isomers, 2005, Registered UK Patent No. 2389043 (27 July 2005) Patent, 2005

Mok KH, Hore PJ, Photo-CIDNP NMR methods for studying protein folding (Review), Methods, 34, (1), 2004, p75 - 87 Journal Article, 2004 DOI

Morozova OB, Yurkovskaya AV, Sagdeev RZ, Mok KH, Hore PJ, Time-Resolved CIDNP Study of Native-State Bovine and Human alpha-Lactalbumins, Journal of Physical Chemistry B, 108, (39), 2004, p15355 - 15363 Journal Article, 2004

Mok KH, Nagashima T, Day IJ, Jones JA, Jones CJV, Dobson CM, Hore PJ, Rapid Sample-Mixing Technique for Transient NMR and Photo-CIDNP Spectroscopy: Applications to Real-Time Protein Folding, Journal of the American Chemical Society, 125, (41), 2003, p12484 - 12492 Journal Article, 2003

Lee H, Mok KH, Muhandiram DR, Park K-H, Suk J-E, Kim D-H, Chang J, Sung YC, Choi KW, Han K-H, Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53, Journal of Biological Chemistry, 275, (38), 2000, p29426 - 29432 Journal Article, 2000

Lee HS, Chung J-S, Chung K-T, Mok KH, Kim K-W, Ha S-H, Koh HK, Kim HS, Cheil Jedang Corporation, Homogeneous and Cost-Efficient Purification of Human G-CSF using Preparative Reverse-Phase HPLC, 2000 Patent, 2000

Cho J-H, Mok KH, Olivera BM, McIntosh JM, Park K-H, Han K-H, NMR Solution Conformation of Alpha-Conotoxin AuIB, an Alpha3Beta4 Subtype-Selective Neuronal Nicotinic Acetylcholine Receptor Antagonist, Journal of Biological Chemistry, 275, (12), 2000, p8680 - 8685 Journal Article, 2000

Ha S-H, Koh HK, Oh MS, Kim HS, Chung K-T, Lee HS, Mok KH, Cheil Jedang Corporation, Molecular cloning, engineering, and expression of human granulocyte colony stimulating factor (G-CSF), 2000, Registered Republic of Korea Patent No. 0262867 Patent, 2000

Koh HK, Chung K-T, Lee HS, Mok KH, Oh MS, Ahn D-H, Kim C-H, Ha B-J, Lee K-H, Cheil Jedang Corporation, Expression Vector and Producing Strain Containing an Insulin Fusion Protein Gene which Allows Efficient Production of Human Insulin, 1999, Registered Rep of Korea Patent No. 0202958 Patent, 1999

Mok KH, Han K-H, NMR Solution Conformation of an Antitoxic Analog of Alpha-Conotoxin GI: Identification of a Common Nicotinic Accetylcholine Receptor Alpha-1 Subunit Binding Surface for Small Ligands and Alpha-Conotoxins, Biochemistry, 38, (37), 1999, p11895 - 11904 Journal Article, 1999

Research Expertise

Projects

  • Title
    • Decoupling pH and Ionic Effect in Protein Super-Concentrates
  • Funding Agency
    • Dept of Agriculture, Food and the Marine
  • Date From
    • Nov 2012
  • Date To
    • Oct 2016
  • Title
    • Development of novel anti-obesity (serum-triglyceride level-lowering) peptidomimetic compounds
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Jan 2009
  • Date To
    • Jan 2010
  • Title
    • BioA-Lac - Bioactive protein complexes in milk
  • Funding Agency
    • Dept of Agriculture, Fisheries, and Food (DAFF)
  • Date From
    • Nov 2008
  • Date To
    • Oct 2012
  • Title
    • Protein Folding/Misfolding in Medicine and the Design of Protein-Based Biomaterials: A Biophysical Approach
  • Funding Agency
    • Vetenskapsrådet (The Swedish Research Council)
  • Date From
    • Jan 2008
  • Date To
    • Dec 2010
  • Title
    • Amyloid fibril growth and the control of morphology
  • Date From
    • January 2007
  • Title
    • Biomolecular and photo-CIDNP NMR spectroscopy of partially-folded protein intermediates and ultra-fast folding miniproteins
  • Date From
    • January 2007

Keywords

Alzheimer's Disease; Biochemistry; Biochemistry, Proteins; Biological Instrumentation; Biomolecular Science; Biophysics; Chemical Biology; Chromatography; Dementia/ Alzheimer's Disease; Drug Development; MAGNETIC RESONANCE (MR); Molecular Biology; Molecular Biophysics; Molecular mechanisms underlying apoptosis & cell cycle; Nano Biotechnology; Nanostructures; Nanotechnology; neurodegeneration; Neurodegenerative Diseases/Disorders; NMR; NMR SPECTROSCOPY; NUCLEAR-MAGNETIC-RESONANCE; Obesity; PROTEIN CONFORMATIONS; PROTEIN FIBRILLOGENESIS; protein folding; PROTEIN STRUCTURES; PROTEIN-FOLDING KINETICS; PROTEIN-PROTEIN INTERACTIONS; PROTEIN-STRUCTURE; Proteins and Macromolecules; Proteins, enzymology and protein engineering; PROTON NMR; PROTON NUCLEAR MAGNETIC RESONANCE; Spectroscopy; Structural Biology; Structural Biology, Determination, Function

Recognition

Representations

Management Committee Member and Ireland Representative; European Network for Hyperpolarisation Physics and Methodology in NMR and MRI - COST (European Cooperation in Sci and Tech) Action TD 1103 2012-2014

Co-Editor; Protein NMR: Modern Techniques and Biomedical Applications; Biological Magnetic Resonance series, Springer Science+Business Media, LLC, New York. (Expected publication date: 2013) 2012

Editorial Board, Dataset Papers in Physics, Biological Physics section. 2012

ULTRA Programme Advisor, Ministry of Education, Science and Technology, Republic of Korea 2008

Awards and Honours

Citation of Merit, Ministry of Foreign Affairs and Trade, Republic of Korea Jan 2011

ULTRA Programme Advisor, Ministry of Education, Science and Technology, Republic of Korea Aug 2009

KOSEF Postdoctoral Fellowship, Korea Science and Engineering Foundation June 1998

Chevening Scholarship, UK Foreign and Commonwealth Office May 2001

NIH National Research Service Award Predoctoral Fellowship Aug 1987

Memberships

The Undergraduate Awards of Ireland and Northern Ireland, Life Sciences Panel Member Sep 2010